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Romania
Citizenship:
Israel
Ph.D. degree award:
2020
Dmitri
Toren
Ph.D.
Postdoctoral researcher
-
INSTITUTUL DE BIOCHIMIE
Other affiliations
PhD
-
Ben-Gurion University of the Negev
(
Israel
)
Co-Founder and Researcher
-
CELLFABRIK S.R.L.
(
Romania
)
Researcher | Entrepreneur | Consultant
14
years
Web of Science ResearcherID:
D-2974-2018
Personal public profile link.
Expertise & keywords
Aging
mitochondrial genome
Molecular biology
Bioinformatics
Systems biology
Transcriptomics
Genomics
Sequencing
Projects
Publications & Patents
Entrepreneurship
Reviewer section
Multi-omics prediction system for prioritization of gerontological interventions
Call name:
POC-A1-A1.1.4-E-2015
2016
-
2020
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL DE BIOCHIMIE
Project partners:
INSTITUTUL DE BIOCHIMIE ()
Affiliation:
INSTITUTUL DE BIOCHIMIE ()
Project website:
http://www.aging-research.group/gerontomics/
Abstract:
Organismal ageing is a biological process defined by a progressive loss of viability and an exponential increase in fragility. With the current advances in high-throughput technologies many of the molecular aspects of ageing can now be easily screened at various “omics” levels (e.g.: genomic, transcriptomic, epigenomic, etc), using a wide range of models and starting from various hypotheses (e.g.: analysis of “normal” ageing, long- and short-lived mutants, calorically restricted animals, etc). However, with relation to integration, the field of biogerontology, as it currently stands, is still missing a cohesive approach and is lacking an integrative view on how to combine all these molecular measurements. This project will use a systems biology approach to combine genomics, transcriptomics and epigenomics data from various models of ageing in order to create a large-scale data-driven analysis and prediction platform for experimental interventions in gerontology. Using this platform, we first aim to analyze the multidimensional data in a holistic way, using network-based methods, in order to identify conserved and/or specific signatures of ageing. These common and complementary patterns will provide more insights into the mechanisms of ageing and offer the scientific community a data-generated knowledge base of the molecular actors (and their interactions), which play a role in lifespan determination. Next, we aim to test the performance of this computational platform in identifying new longevity regulators by validating its predictive power, first against a priori published results and then, in vivo, by testing lifespan and healthspan of C. elegans mutants under epistatic interventions. Lastly, we aim to build around the software platform and the generated knowledge base a web framework that allows users to access, analyze and build upon the data, in an efficient, easy-to-use manner, providing the scientific community with a suite of tools for guiding wet-lab experiments in gerontology.
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FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
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