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Romania
Citizenship:
Ph.D. degree award:
Gabriela
Ionita
-
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU
Researcher | PhD supervisor
Personal public profile link.
Curriculum Vitae (20/02/2024)
Expertise & keywords
Spramolecular Chemistry
Gels
epr spectrosopy
Soft matter
Proteins
biogels
freeradicals
Water purification
Biomolecules
epr spectrosopy
Spectroscopy
Projects
Publications & Patents
Entrepreneurship
Reviewer section
Design of new nanocellulose-based gas-carrier systems
Call name:
P 4 - Proiecte de cercetare exploratorie - PCE-2021
PN-III-P4-PCE-2021-0435
2022
-
2024
Role in this project:
Coordinating institution:
Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti
Project partners:
Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)
Affiliation:
Project website:
https://icechim.ro/celgas-en/
Abstract:
Severe oxygen deprivation can cause significant problems in chronic wounds, during organ preservation and implantation, or in cases of trauma, hemorrhagic shock, or viral pneumonia. Oxygen prevents wound infection, increases cell viability after implantation and could be an effective treatment in viral pneumonia. Currently, there is no viable solution to deliver oxygen to the grafts during the healing period and to administrate a large volume of oxygen to patients who suffered profound oxygen deprivation. The scope of the CELGAS project is to develop innovative oxygen-carrying systems capable of supplying oxygen in a controlled manner to injured tissue/ implants or intravenously. The innovative oxygen-carrying systems will ensure controlled release of oxygen for long periods of time, will have a high stability, biodegradability, will not be cytotoxic and will have a nanometric size, essential for intravenous administration to avoid vascular obstruction. In CELGAS, the problem will be addressed using nanocellulose and nanocellulose/biopolymer to encapsulate oxygen-generating species or to obtain oxygen-containing nanobubbles. The biopolymers to be used are selected from poly (3-hydroxybutyrate), medium chain length polyhydroxyalkanoates and polylactic acid. The design of the new systems will be based on improved methods and an efficient characterization that will allow the achievement of the objectives.
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Innovative technique for treating collagen matrices with gamma radiation as a green alternative
Call name:
P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală - PD-2021
PN-III-P1-1.1-PD-2021-0189
2022
-
2024
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I.
Project partners:
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE-I.N.C.D.T.P. BUCURESTI SUCURSALA BUCURESTI INSTITUTUL DE CERCETARE PIELARIE - INCALTAMINTE I.C.P.I. (RO)
Affiliation:
Project website:
https://www.incdtp.ro/icpi/proiecte.html
Abstract:
The aim of the GAMMA-COLL project is to investigate the influence of ions and radicals generated by gamma radiation on collagen in the complex matrix of raw hides, classic tanned (with basic chromium salts) or ecological (with aldehydes and synthetic tannins), in order to develop experimental models of green technologies, alternatives to the use of chemicals. The design of experimental models of antibacterial and antifungal conservation technologies for raw hides or tanned leathers, aim at eliminating pollution with sodium chloride and volatile organic substances biocides, corrosive materials, difficult to remove from wastewater, toxic and with potential allergen for end consumers of leather products. Elucidating the crosslinking or cleavage processes of the collagen molecule in the complex matrix of the leather, in various environmental conditions, under the influence of gamma radiation, will bring important contributions to leather science and engineering with the potential to develop alternative ecological technologies to use chemicals with pollutant potential.
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Multi-stimuli responsive PAA decorated with host and guest units
Call name:
P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală - PD-2021
PN-III-P1-1.1-PD-2021-0169
2022
-
2024
Role in this project:
Coordinating institution:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU
Project partners:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)
Affiliation:
Project website:
https://www.icf.ro/pr_2022/MSPAA-HG.pdf
Abstract:
The project aims to obtain a series of polyacrylic acid (PAA) derivatives decorated with host and guest units, and to explore their properties. By appending host and guest units to PAA chains and mixing the corresponding new polymers, we expect to modify and to control their behavior in solutions and to obtain gel systems. In this way will be possible to create topological cross-links based on host-guest interactions, which have the advantage of being reversible and movable. The polymers will be characterized through physicochemical methods such as rheology, dynamic light scattering, and various types of spectroscopies, which will provide global information about the systems. In order to obtain local and dynamic information, the electron paramagnetic resonance (EPR) spectroscopy will be used. As such, polymers will be labeled with paramagnetic moieties. The pillars of the proposal are: 1) the synthesis of a series of PAA decorated with hosts units (cyclodextrin) and guest units (adamantine and azobenzene); 2) the analysis of polymers in different systems using local information provided by EPR spectra in correlation with global information provided by physicochemical methods. PAA and 3) evaluation of encapsulation and release properties of the new modified-PAA hydrogels. The results obtained in the frame of this project have the potential to be relevant for academic scientists and also to be appealing for biomedical applications.
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SOFT INTERACTIONS IN POLYMER AND HYBRID HYDROGELS INVESTIGATED BY ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY
Call name:
P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0734
2017
-
2019
Role in this project:
Coordinating institution:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU
Project partners:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)
Affiliation:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)
Project website:
http://www.icf.ro/pr_2017/CTR_86-2017/index.html
Abstract:
The project aim is to approach structural aspects of polysaccharide hydrogels with self-healing properties or represented by interpenetrating polymer networks (IPN) using electron paramagnetic resonance (EPR) spectroscopy. This is a physico-chemical method that provides highly specific local information on the environment around the paramagnetic species in a range of several nanometers. As polysaccharides are diamagnetic, spin labelling will be a necessary step in studying these hydrogels by EPR, in order to obtain information that can be further exploited in tailoring the properties of a particular hydrogel.
The major goals of this project are: 1) to get insight into the formation of hydrogels resulted through noncovalent assembly of polysaccharides, and 2) to analyse gel properties and some processes, taking place inside the hydrogel network, which can generate hybrid materials, all these in connection with their possible applications. The goals will be pursued by following five research objectives:
O1. Design of spin labelled self-healing hydrogels based on host-guest interactions
O2. Design of interpenetrating polymer network (IPN) hydrogels involving polysaccharides and the study of their behaviour by EPR spectroscopy
O3. Exploration of mesh size using EPR measurements and distribution of spin probes in the non-homogeneous systems represented by polysaccharide hydrogels
O4. Obtaining hybrid materials represented by self-healing and IPN polysaccharide hydrogels and inorganic nanoparticles
O5. Investigation of processes occurring in alginate/hyaluronic acid hydrogels embedded with riboflavin and irradiated with UVA light
Although the main technique will be EPR spectroscopy, the research will involve additional investigations and characterization by other techniques like porosimetry, electron microscopy, thermal analysis, rheology, fluorescence and IR spectroscopy, all readily available in our institute.
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Organic functionalized graphene oxide- a composite material for multiple applications
Call name:
P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0187
2017
-
2019
Role in this project:
Coordinating institution:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU
Project partners:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)
Affiliation:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)
Project website:
http://www.icf.ro/pr_2017/Contract_77-2017.pptx
Abstract:
Graphene oxide (GO) is a 2D material obtained from graphite by oxidation, containing functional groups like carbonyl, carboxyl, epoxy and hydroxyl. These make GO very attractive, due to the possibility of functionalization with different compounds of interest. While a lot of investigations have been performed on graphene or GO, there are still some unclear issues or divergent results. For example, one of the less studied problems is the nature of the unpaired electrons in such materials and their contribution towards properties. Our first aim is to elucidate this issue by using multi-frequency electron paramagnetic resonance (EPR or ESR), being an important step forward in understanding the active centers in GO, getting deeper information about electronic and magnetic properties of GO. The second aim of the project has a more practical approach (making use of covalent organic chemistry), following the functionalization of GO with organic compounds of interest (like crown ethers or stable free radicals), to achieve highly functional materials for different applications. Exploring and developing this area can contribute to the increase of practical applications, with a possible large benefit for technology and industry. The specific objectives of the proposed project are: i) synthesis and structural characterization of GO (different size/morphology, no. of layers, degrees of oxidation); ii) elucidation of the spin type and their distribution into GO (C- or O-centered, on edge or within 2D structure); iii) functionalization of GO with stable free radicals, crown ethers or other compounds; iv) studies about the capacity of the functionalized GO to capture metal ions or oxidize organic pollutants (i.e. for wastewater treatment); v) optimization of the processes and building a composite GO/silica material (with improved properties, for further applications).
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AN EXPERIMENTAL APPROACH USING ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY ON TEARS ANALYSES FOR OPTIMAL TREATMENT OF DRY EYE SYNDROME ASSOCIATED WITH KERATOCONUS DISEASE
Call name:
P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0187
2017
-
2018
Role in this project:
Coordinating institution:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU
Project partners:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); OFTACLINIC GRUP SRL (RO)
Affiliation:
INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)
Project website:
http://www.icf.ro/Research/proiecte.html
Abstract:
This project is intended to generate a new protocol in optimisation of the eye drops treatment for dry eye syndrome (DES) associated with keratoconus (KC) disease, based on data provided by electron paramagnetic resonance spectroscopy (EPR. DES seems to become more prevalent disorder, it is considered that almost 30% of the world -wide population it is affected.
KC is an eclectic/dystrophy disease of the eye which causes an irregularly shaped cornea leading to severe impairment of vision, with a prevalence of approximately 1:2000. Dre eye is also a symptom in KC, some studies indicating that dry eye is one of multifactorial etiology of KC. Corneal collagen cross-linking (CXL) based on the combined use of the photosensitizer riboflavin and UVA light of 370 nm is a relatively new method in KC treatment. Taking the advantage of EPR spectroscopy methods, the objectives of our project are:
1 - analysis of the EPR spectra of various spin probes introduced in tears samples obtained from normal patients and those affected by DES;
2 - identification of reactive radical species in tear film formed after instillation of keratoconus eye with riboflavin followed by UVA irradiation;
3- analysis of the hyaluronic acid influence on physico-chemical properties of tears secretion. This will provide information on the optimal concentration of the hyaluronic acid in eye drops.
The project starts from a general technological concept TLR2 reflecting the potential of the EPR spectroscopy to describe changes in dynamic and structure of the proteins which can be apply to correlate with the symptoms of a specific disease in particular, dry eye disease. In this way, we will generate an analytical proof of the disease based on collection of data which will be an early proof of concept in laboratory models. Thus, our proposal can be considered that start from a TRL2 product and is materialised in a technology validated in laboratory (TRL3).
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Exploring gels containing cyclodextrins by EPR spectroscopy: structure, properties, applications
Call name:
Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0328
2011
-
2016
Role in this project:
Coordinating institution:
Institutul de Chimie Fizica "Ilie Murgulescu" al Academiei Romane
Project partners:
Institutul de Chimie Fizica "Ilie Murgulescu" al Academiei Romane (RO)
Affiliation:
Institutul de Chimie Fizica "Ilie Murgulescu" al Academiei Romane (RO)
Project website:
http://www.icf.ro/pr_2011/PN-II-ID-PCE-2011-3-0328.ppt
Abstract:
The project aim is to explore the formation and properties of some gel systems using EPR spectroscopy in order to obtain information about gel fibres formation, dynamic of molecules inside the gel network and factors which influence this, and also of monitoring processes inside gels. The research activities will be focused on cyclodextrins containing gels based both on covalent polymeric network and on supramolecular interactions. Organogels based on assembly of other low molecular mass gelators will also be studied. EPR spectroscopy has been chosen as a main tool for investigation of gels systems because, despite the complexity of the system, the information will focus only upon the paramagnetic species. This information refers to local polarity around paramagnetic moiety, dynamic on the nanosecond time scale, and interactions between adjacent paramagnetic moieties on the nanometer scale. Various spin probes are available to use as reporters by introducing in gel systems, but the new approach will be to spin label the molecules participating in gel fibres formation. In this way it is possible to monitor the gelation process and also to get information on gels fibres dynamic. Other physicochemical methods (e.g. ATR-FTIR, fluorescence, UV-Vis spectroscopy, rheometry) will be used in order to complete the investigation on gels.
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Multifunctional organic stable radicals in supramolecular high-spin architectures and materials
Call name:
Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0408
2011
-
2016
Role in this project:
Key expert
Coordinating institution:
Universitatea din Bucuresti
Project partners:
Universitatea din Bucuresti (RO)
Affiliation:
Project website:
http://www.chimie.unibuc.ro/cercetare/organica/PNII-ID-PCE-2011-3-0408/
Abstract:
New multifunctional organic stable free (poly)radicals of different types will be obtained and used as building blocks for supramolecular architectures and materials with high-spin properties. The synthesis of such radicals (organic spins) will be conducted in a way to achieve in the same molecule tailored moieties that can be involved in supramolecular bonds (H-bonds, pi-stacking, donor-acceptor, charge-transfer, etc.). Thus, the new compounds may contain aromatic-, polynitro-, urea-, amino-, carboxyl-, or macrocyclic crown ether moieties, which are well known to form supramolecular architectures. These multifunctional (poly)radicals will be used to build supramolecular assemblies through non-covalent bonds, resulting supramolecular systems that can act as high-spin materials, due to co-operative spin-spin interactions. Cucurbiturils, a category of macrocyclic compounds containing urea moieties, will be used to control the size and stability of the supramolecular architectures, tuning the spin-spin interactions. Different types of nanoparticles labelled with organic spins will be also obtained and involved in supramolecular architectures. Classical organic chemistry and analytical measurements will be used for the design and full characterization of the new compounds, as well for their supramolecular assemblies; (para)magnetic measurements will provide information about spin distribution, inter-spin distance and exchange, and magnetic behaviour.
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FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.2781, O: 242]