BrainMap

ADINA LIANA RADUCAN

- UNIVERSITATEA BUCURESTI

Researcher | Teaching staff | Manager

Expertise & keywords

Advanced nanoparticle-based materials with synergistic effect on neuronal oxidative stress and beta-amyloid fibrillation for preventive treatment in Alzheimer's disease Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4657 2020 - 2022

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://www.icechim-pd.ro/ro/syst_heter/sisteme_heterogene_nanonerves.html

Abstract:

This project aims to develop and to validate a new product and its technology with application in preventive treatment of Alzheimer's disease. This new product includes bioactive ingredients with effect on neuronal oxidative stress (curcumin) and beta-amyloid fibrillation (Ag and ZnO functionalized nanoparticles), and a nanocarrier (PEG-functionalized silica particles), that can act itself as a beta-amyloid fibrillation inhibitor. The main project novelty is related to: (i) study of the interaction of new formulations based on Ag or ZnO NPs and Curcumin encapsulated in functionalized silica NPs with beta amyloid fibrils and (ii) a sistematic and rational scientific approach to strike a balance between the effect of modifying the kinetics of amyloid beta fibril formation and the prevention of toxic effects (otherwise known) on neurons. Project objectives are: (i) to optimize product components and to improve their compatibility; (ii) to develop demonstration model, through components integration and (iii) to test and to validate the demonstration model, on laboratory conditions. Objectives are related to different TRLs: improved compatibility and optimal composition of new formulations based on Ag or ZnO NPs and Curcumin encapsulated in functionalized silica NPs (1st objective) allow properties analysis and improvement (TRL 3). Components integration (2nd objective) and product testing in laboratory conditions (3rd objective) permit technological development up to TRL 4.

Interinstitutional program of developing advanced eco-nanotechnology solutions for multifunctional treatments of leather and textile materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0743 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEXTILE SI PIELARIE - INCDTP BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://www.nipne.ro/proiecte/pn3/7-proiecte.html

Abstract:

Developing integrated functionalization eco nano technologies using physical techniques (gamma irradiation, plasma activation, electrodeposition) and nanocomposites with antibacterial, antistatic or hydrophobization properties will produce textile and leather materials with multifunctional advanced properties. Replacing and reducing volatile organic compounds that negatively impact the environment will set the premises of transferring advanced technologies to companies manufacturing medical articles, protection equipment, sports equipment or for other applications and creating thus new research services by PHYSforTeL consortium partners to the benefit of the traditional industrial sector of textile and leather industry.

Multidisciplinary platform for integrative and systematic research of tangible and non-tangible cultural heritage and identities in Romania Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0686 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE ARHEOLOGIE "VASILE PIRVAN" (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); UNIVERSITATEA DE VEST TIMISOARA (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE IN INFORMATICA - ICI BUCURESTI (RO); UNIVERSITATEA OVIDIUS (RO); UNIVERSITATEA DIN ORADEA (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://patcultro.unibuc.ro

Abstract:

The present project represents an original approach, from an inter-, pluri-, multi- and transdisciplinary perspective of the 6th domains - Patrimony and cultural identity. Through the structure of the consortium, the management of the project, the objectives proposed by the component projects, through the synergies and complementarities obtained, undoubtedly presents a high degree of feasibility, being a sophisticated, integrative and exhaustive approach for Romania. Its results will have an impact both on the national and international scientific communities, but also on the broad public, contributing through the proposed activities to the consolidation, development, and improvement of the RDI system in our country, and indirectly to the training of the future specialists from the Romanian research.

The final goal of the project is to create a complex interdisciplinary/multidisciplinary platform for integrated and systematic research of tangible and non-tangible cultural identities and heritage in Romania.

The consortium that will implement this complex project is coordinated by the University of Bucharest (CO-UB), in partnership with the "Vasile Parvan" Institute of Archeology of the Romanian Academy (P1-IAB), the National Institute for Research and Development for Physics and Nuclear Engineering " Horia Hulubei "(P2-IFIN-HH)," Al. I. Cuza "University of Iasi (P3-UAIC), West University of Timisoara (P4-UVT), National Institute of Research and Development for Material Physics (P5-INCDFM), the "Ovidius" University of Constanta (P6-UOC) and the University of Oradea (P7-UO). The way of geographic distribution at the level of Romania ensures a good regional representation of the legal entities represented within the consortium in this project. The combination of five universities and three national research institutes is the ideal combination to support and implement such a complex project.

Innovative technologies based on polymers for the obtaining of new advanced materials Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0428 2018 - 2021

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU ELECTROCHIMIE SI MATERIE CONDENSATA - INCEMC TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=41&lang=ro

Abstract:

The project is aimed at using the expertise that involved in consortium entities acquired in materials science. The consortium consists of three representative national institutes: INCD for Chemistry and Petrochemistry – ICECHIM Bucharest, INCD for Electrochemistry and Condensed Matter - INCEMC Timisoara and INCD of Chemical Pharmaceutical - ICCF Bucharest, and of two prestigious universities: University POLITEHNICA of Bucharest and the University of Bucharest and a remarkable institute of Romanian Academy: Institute of Macromolecular Chemistry – Petru Poni Iasi. Although having great tradition and noteworthy results, the first five institutions face a series of problems, from the lack of financial funds, equipment and the aging employees for ICCF and partly for INCEMC and ICECHIM, to the lack of highly qualified staff required for recent investments in equipment for all 5 institutions. In this respect, the project attempts relaunching the activity in the first 5 institutions of the consortium, by putting together the existing competencies, so as to develop new technologies in order to obtain new materials with high performance properties. Given that, 3 of the research teams are specialized in polymers (ICECHIM, Petru Poni and UPB) the developed technologies will use the polymers as intermediates or as a component in the finished product. To this end it is envisaged getting the titanium nitride for prosthetic coatings via inorganic-organic polymer nanocomposites, obtaining photocatalytic materials and antibacterial coatings by sol- gel reactions, obtaining of short-life or one-time use biomaterials from aliphatic polyesters and micro or nanocellulose and the development of new polyphase materials with medium or long life, based on biopolymers, through 3D printing. The project intends the full use of A1, A2, B and C checks in order to increase the institutional performance of partners.

SOL-2020-2 5. The development of innovative decontamination solutions against SARS-CoV-2 virus (surfaces, equipments, close and open spaces) Call name: P 2 - SP 2.1 - Soluţii - 2020 - 2
PN-III-P2-2.1-SOL-2020-2-0399 2020 - 2020

Role in this project:

Coordinating institution: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie

Project partners: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNITATEA MILITARA 02433 BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); SPITALUL UNIVERSITAR DE URGENTA BUCURESTI (RO); STIMPEX S.A. (RO)

Affiliation:

Project website: https://www.nbce.ro/?page_id=895

Abstract:

The project's scope consist in the development of an innovative decontamination solution, with antimicrobial and antiviruses effects, using a mixture of quaternary ammonium salts and gold or silver nanoparticles as active compounds, and also the development of a complex system for solution dispersion.

Contributions to enhancing the Sanimed SRL’s competitiveness by the knowledge assimilation and potential production implementation of some 3D collagen-polymer hybrid matrices intended to tissue repair Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0397 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://www.unibuc.ro/prof/micut_m/

Abstract:

The project proposal mainly aims at knowledge transfer to economic operator regarding the obtaining and development of 3D collagen-polymer hybrid biomaterials intended to biomedical applications. The practical implementation of the proposal should lead to enhancing competitiveness of private economic entity in order to develop itself in the near and middle-term future. In line with economic partner, the public entities University of Bucharest and ICECHIM (project partners) have identified aspects of scientific and technological existing at private partner, the weaknesses and strengths of these aspects, as a useful basis for designing new collagen-based hybrid biomaterials. In addition, the purpose that such kind of biomaterials be used in the process of tissue repair requires accounting a number of key characteristics against which it is possible to design, realize and develop this kind of hybrid collagen-polymer system: biocompatibility, bioresorbability, mechanical properties, internal and external morphology and manufacturing technology.

Oxide nanomaterials with photocatalytic properties applied in the advanced degradation of the xenobiotic compounds in the water Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0031 2012 - 2016

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE -DEZVOLTARE PENTRU ECOLOGIE INDUSTRIALA - ECOIND (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://www.icf.ro/pr_2011/MC/MC.html

Abstract:

Most of the research in the field of nanoscience is dedicated to the development of synthesis routes to nanoparticles and nanostructures. There are many novel properties and applications of nanoparticles demonstrated: from catalysis, environmental remediation, biomedical to information displays, and electronics.

Among the various photocatalysts, titania occupies a very important place. Recently, titanium dioxide has been extensively used for the decomposition of environmental pollutants as a possible alternative to conventional water treatment technologies.

The concept of the present project is to use sol-gel un-doped and doped-TiO2 (with transitional metals) nanopowders photocatalysts as friendly materials for the environment in the advanced degradation of xenobiotic compounds from waste water resulted from industrial activities.

The novelty and the importance of this project consist in the art to build the TiO2-based nanomaterials and to establish their photocatalytic performances in a proper equipment with solar energy for the water depollution.

The project has a distinct complexity degree through its modality of tackling which refer to the synthesis of the doped-photocatalysts, photocatalytic processes and fluctuating context regarding the wastewaters with different proveniences.

Considering the competence of the partners which form the consortium in different but complementary research fields (such as: the synthesis and characterization of nanopowders, the depollution of the water, and the kinetic evaluation of the degradation procedures) as well as the special results obtained in the previous projects together with the target of the central and local environment authorities regarding the diminution of the pollution with toxic, xenobiotic compounds, it can be appreciated that the present project proposal is viable and successfully conceived.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects