BrainMap

Mr. Adrian Stoian

PhD

Assistant Professor - Academia Fortelor Terestre Nicolae Balcescu din Sibiu

Researcher | Teaching staff

Web of Science ResearcherID: https://www.webofscience.com/wos/author/record/ABG-8027-2021

Curriculum Vitae (16/10/2023)

Expertise & keywords

Genomic mapping of population from polluted area with radioactivity and heavy metals to increase national security Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0737 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO); INSTITUTUL ONCOLOGIC PROF.DR.I.CHIRICUTA CLUJ-NAPOCA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (RO); INSTITUTUL DE BIOCHIMIE (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO)

Affiliation: INSTITUTUL ONCOLOGIC PROF.DR.I.CHIRICUTA CLUJ-NAPOCA (RO)

Project website: http://www.umfcluj.ro/component/content/article/8-ro/532-genomic-mapping-of-population-from-polluted-area-with-radioactivity-and-heavy-metals-to-increase-national-security-artemis?Itemid=216

Abstract:

The ARTEMIS project represents a complex approach to major environmental issues.ARTEMIS aims to follow new ways of controlling the population exposure to polluting agents(presents in water and soil),with a major role in cancer occurrence,following the evolution of genomic alterations,in the population that inhabits the NW of ROMANIA.The proposed consortium is composed of 5 well-known members of Romania’s research community,which are planning to develop innovative technologies for the prevention of oncological pathologies,following environmental pollution.The consortium,by being balanced between National Research and Development Institutes, Research Institutes belonging to the Academy of Medical Science and Universities create collaboration at national level in the study of molecular profiles among the affected population versus the cancer incidence from areas with clean environment.The consequence of a clean environment is followed by an improved quality of life of the population from decontaminated areas and a greater national security.The disease occurrences due to the contamination of the main natural resources with I-131 and heavy metals, with direct effects on the accumulation of mutations at the genomic level,could be limited through ARTEMIS.Chernobyl or the mine exploitation are in close connection with the reported higher incidence of cancer.The main objective is the identification of genome alterations and evaluation of the cancer tendency to be more frequent in the analyzed population.The consortium proposes 5 ARTEMIS projects,which approach a new and complex perspective of environmental resources pollution,considering the development of a regional strategy for reducing pollution.The final results are:the initiation of an inter-institutional collaboration with a common agenda and research interests,creating new jobs for the young researchers at the early stage of their career,at European standards,and the creation of a population genomic map of NW Romania.

Innovative molecularly imprinted plasmonic nanosensing platform for ultrasensitive and selective bioanalysis using interfacial liquid-state surface enhanced Raman spectroscopy Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2016-0628 2018 - 2020

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website: https://sites.google.com/view/mipnano-ilsers/

Abstract:

All over the world, billions of dollars are spent annually on chemical/biological detections related to medical diagnosis, environmental monitoring and food safety because lab analysis using expensive equipment is usually cumbersome and time-consuming. Therefore, there has been a pressing societal need for the development of chemo/biosensors for the detection of various target analytes (biomarkers), which are less expensive, simpler to construct and operate, and may offer the choice of portability. Highly specific targeting and sensitive detection of low abundance protein biomarkers, especially those monitored in non-invasive biological samples (tears, sweat, urine), are of utmost importance in supporting early diagnosis and prognosis of diseases, and assessing fast and personalized therapeutic response. Recent developments of novel chemosensory materials and fabrication technologies provide many potential opportunities for the development of a new generation of chemo/biosensors based on novel sensing concepts, by combining the unique binding selectivity offered by molecularly imprinted polymers and the benefits of metallic nanostructures as Raman enhancers undergoing self-orientation at an immiscible liquid interface for additional signal boost. Understanding how composite nanostructures (MIP-shell type gold nanorods) affect LSPR properties, tuning their binding properties for tailored SERS detection selectivity and sensitivity, study their interaction with a protein biomarker (thrombin) by using fingerprint type vibrational spectra, correlate experimental findings with computational chemistry data, promote innovative analytical assemblies (interfacial liquid state SERS) prone to portability, and last but not least, validate their performances in some of the most pressing biomedical applications (fast and non-invasive screening of diseases based on trace levels of protein biomarkers) are important issues to address and milestones to reach in the current project.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects