BrainMap

Alexandra Busuioc

- INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Student

Web of Science ResearcherID: not public

Curriculum Vitae (14/11/2025)

Expertise & keywords

Protein amyloid aggregates – polyphenol interaction for food and pharmaceutics application Call name: P 5.2 - SP 5.2.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - Competiția 2023
PN-IV-P2-2.1-TE-2023-0189 2025 - 2026

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website:

Abstract:

The misfolding of proteins and their subsequent assembly into amyloid fibrils are pathological hallmarks of different types of amyloidosis. Therefore, decoding of the aggregation processes represents a crucial step towards diagnosis and therapy of the disease. On the other hand, amyloid fibrils are considered as promising building blocks for novel biomaterials with potential applications for targeted drug delivery or improved food products. We propose a physical-chemical approach intended to characterize the interaction of polyphenols with several model protein aggregates, with emphasis on amyloid-like fibrils obtained in diverse experimental conditions (temperature, salt, pH). We will study the protein denaturation and aggregation kinetics to estimate the molecular mechanisms that govern these processes. The calorimetric and spectroscopic methods will provide new information concerning polyphenol influence on protein aggregates. The main objective of the project is the development of a young, independent research team focused on a deeper insight into the action of polyphenols on the protein aggregation process, a way to understand the features of aggregates and amyloid-like structures with applications in pharmaceutical and food industry.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects