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Romania
Citizenship:
Ph.D. degree award:
Alexandra
Ciorita
-
INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M
Other affiliations
PhD Student
-
UNIVERSITATEA BABES BOLYAI
(
Romania
)
Teaching staff | Other
Publons/ResearcherID:
not public
Personal public profile link.
Expertise & keywords
Microbiology
cell cultures
Electron microscopy
Projects
Publications & Patents
Entrepreneurship
Reviewer section
Partnership for the transfer of innovative technologies and advanced materials in the field of visual arts (production, preservation, restoration)
Call name:
ID P_40_374
2016
-
2021
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA BABES BOLYAI
Project partners:
UNIVERSITATEA BABES BOLYAI (); CORAMI FUNZIONE SRL (); DUCT SRL (); CENTRUL IT PENTRU STIINTA SI TEHNOLOGIE S.R.L. (); CENTRUL DE COMPETENTA IN ELECTROSTATICA SI ELECTROTEHNOLOGII S.R.L. (); DANART IMPORT EXPORT SRL (); ZAREDARTE SRL (); ARS VITREARUM AMAGA S.R.L. ()
Affiliation:
UNIVERSITATEA BABES BOLYAI ()
Project website:
http://tematicart.granturi.ubbcluj.ro/
Abstract:
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Characterization of the sub-cellular effects of functionalised magnetic nanoparticles in targeted anti-tumor therapy
Call name:
Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0608
2015
-
2017
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA BABES BOLYAI
Project partners:
UNIVERSITATEA BABES BOLYAI (RO)
Affiliation:
UNIVERSITATEA BABES BOLYAI (RO)
Project website:
http://poravpaul.wix.com/cellspion
Abstract:
Having unique magnetic properties, super-paramagnetic nanoparticles (SPIONs) are an efficient vector for anti-tumor targeted therapy, non-viral gene therapy, magnetic resonance imaging contrast agent, and thus personalized medicine. SPIONs are cheap and easy to synthesize, have determined dimensions, can be functionalized and loaded with various substances, and they can transport a certain drug to a certain area of the body in a targeted way, being conducted by magnet. They can be, this way, monitored in real time and at the area of interest SPIONs combine the chemical effect of the drug with the physical effect of the magnetic fluids induced hyperthermia, which generates selectively local overheating through an external magnetic field. In spite of all this promising features, there is still a certain holdback for using SPIONs as a nanotherapy method. This happens mostly because of the fact that nanomedicine is a new domain and because of the lack of coherence in all studies involving NPs in medical applications. Through our project we intend to integrate all aspects regarding cell-NPs interactions and to eliminate all dissonances that shows when passing from a certain study system to another (in vitro-2D-3D-in vivo), finally leading us to obtain coherent data. This is why this study is needed, a complete, integrating and complex study, which starts from NPs synthesis, bioavailability, cytostatic loading, fluorescent loading, in vitro and then in vivo, up to clearance.
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FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.5574, O: 129]