BrainMap

Alexandru Mihai

Assistent Researcher - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher | PhD student

Web of Science ResearcherID: FZG-9326-2022

Curriculum Vitae (20/09/2021)

Expertise & keywords

3D laser printed absorbable scaffolds with a prolonged biomechanical stability in human body fluids. Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-0992 2021 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: https://www.icf.ro/pr_2020/PCE-234-2021/index.html

Abstract:

Novel biomaterials for temporary orthopedic implants are one of the most challenging areas of exploratory research in advanced materials. Third generation biomaterials are designed to be both resorbable and bioactive, that is, the implant will be temporary, and once implanted, it will help the body heal itself. The aim of this project is to progress toward a novel absorbable scaffold biomaterial for temporary orthopedic implants, through hierarchically structured surfaces that protect the scaffold, effective to convey higher corrosion tolerance and increased scaffold strength retention for extended periods in body fluids while at the same time capable to stimulate human osteoblast cell proliferation behavior. Specific objectives are (i) the design and fabrication of 3D printed scaffold structures with biocompatible elements by rapid solidification from melt through laser additive manufacturing-3D printing; (ii) the development of original cost-effective surface modification procedures for surface protected scaffolds (SPS) with enhanced corrosion tolerance and bioactivity; (iii) the determination of bare and SPS corrosion rates and corrosion mechanisms in human physiological fluids of pH and chloride concentrations reproducing the most exigent conditions for implant use; and (iv) the assessment of the scaffold-cell constructs to initiate tissue repair processes and osteogenesis; contributing to Romanian research with: 1 patent, 4 scientific articles, 6 conference presentations

Ternary alloy with antibacterial properties and non-toxic alloying elements for various implants. Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1054 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: https://www.icf.ro/pr_2019/ZIRTAAG/Zirtaag.html

Abstract:

The project seeks to promote young researchers or future researchers that are eager to improve the quality of life by creating and testing out new non-toxic alloys with antibacterial properties. Through theoretical modelling and utilizing modern casting techniques we will obtain an alloy that has superior properties and lower costs than existing ones and that can be used for orthopedic and dental implants alike. The alloy is to be subjected to specific electrochemichal and corrosion tests and also in-vitro cell growth tests. Surface analysis wil be made using modern techniques such as SEM, XPS and AFM.

SOFT INTERACTIONS IN POLYMER AND HYBRID HYDROGELS INVESTIGATED BY ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0734 2017 - 2019

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2017/CTR_86-2017/index.html

Abstract:

The project aim is to approach structural aspects of polysaccharide hydrogels with self-healing properties or represented by interpenetrating polymer networks (IPN) using electron paramagnetic resonance (EPR) spectroscopy. This is a physico-chemical method that provides highly specific local information on the environment around the paramagnetic species in a range of several nanometers. As polysaccharides are diamagnetic, spin labelling will be a necessary step in studying these hydrogels by EPR, in order to obtain information that can be further exploited in tailoring the properties of a particular hydrogel.

The major goals of this project are: 1) to get insight into the formation of hydrogels resulted through noncovalent assembly of polysaccharides, and 2) to analyse gel properties and some processes, taking place inside the hydrogel network, which can generate hybrid materials, all these in connection with their possible applications. The goals will be pursued by following five research objectives:

O1. Design of spin labelled self-healing hydrogels based on host-guest interactions

O2. Design of interpenetrating polymer network (IPN) hydrogels involving polysaccharides and the study of their behaviour by EPR spectroscopy

O3. Exploration of mesh size using EPR measurements and distribution of spin probes in the non-homogeneous systems represented by polysaccharide hydrogels

O4. Obtaining hybrid materials represented by self-healing and IPN polysaccharide hydrogels and inorganic nanoparticles

O5. Investigation of processes occurring in alginate/hyaluronic acid hydrogels embedded with riboflavin and irradiated with UVA light

Although the main technique will be EPR spectroscopy, the research will involve additional investigations and characterization by other techniques like porosimetry, electron microscopy, thermal analysis, rheology, fluorescence and IR spectroscopy, all readily available in our institute.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects