BrainMap

Alina Morosan

- UNIVERSITATEA NAȚIONALĂ DE ȘTIINȚĂ ȘI TEHNOLOGIE POLITEHNICA BUCUREȘTI

Researcher

Web of Science ResearcherID: https://publons.com/researcher/AAX-3438-2020

Expertise & keywords

Innovative multifunctional nanoparticle-mediated delivery of antimicrobial peptide for improved performance of medical implants Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0884 2017 - 2019

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://lspi.inflpr.ro/2017/BIOMATE142/

Abstract:

Antimicrobial agents have dramatically reduced the number of deaths from infectious diseases since their introduction 70 years ago. However, through overuse and misuse, many micro-organisms have become resistant to them.

Antimicrobial peptides (AMP) are gaining increasing interest as potential therapeutics due to their ability to kill antibiotic-resistant bacteria and their potential as antibioﬁlm agents. Since AMPs target bacterial membranes, it will likely be difficult for microorganisms to develop resistance to AMPs.

In this Project, we will use antimicrobial peptides nanoencapsulated in mesoporous biopolymeric/magnetic nanoparticle composites materials.

The nanovectors will be delivered to implant surfaces as thin coatings via laser light, using a deposition technique called MAPLE (Matrix Assisted Pulsed Laser Evaporation).

The deposited nanoparticle layers will be thoroughly investigated by AFM (surface roughness of coatings, surface parameters, 3D surface profiles), SEM (particles shape, coalescence, diameter assessment), TEM (biopolymer crystallinity, visualization of composing layers), XRD (crystallinity of composing elements), FTIR (comparison of functional peaks from both targets and coatings spectra) and adherence tests at the substrate-nanocoating interfaces.

The antimicrobial activity will be assessed on planktonic and biofilm embedded in ESKAPE Gram-negative rods pathogens.

Biocompatibility and antibacterial efficiency of nanovectors will be tested in a final in vivo step on white holoxenic mice.

The absolute novelty of this project consists of establishing novel antimicrobial strategy with preventive and therapeutic value for the management of antimicrobial resistance. Another proposal breakthrough consists of performing a slight modification of the MAPLE experimental set-up by using a cooler for the substrate also - reverse MAPLE that is supposed to increase the porosity of deposited nanocomposite and thus increase its adsorption capacity.

Thin film nano-transistors implemented by nanotechnologies and organic technologies at room temperature Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0480 2017 - 2019

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: https://www.dcae.pub.ro/en/proiecte/13/tftnanoel/

Abstract:

The main objective of this project is the fabrication and development of some electronic devices, having all in common a technology based on nano-core-shell NCS nanocomposite type. In IEEE Spectrum (2014), some NASA researchers claimed that the vacuum transistors or transistors made by Nothing are the immediate future devices suitable for co-integration within CMOS ICs. We start this project from preliminary results, developed in a POSDRU PostDoc Project (closed in 2013), accompanied by 12 papers, 2 patent about Organic thin film transistors (OTFT) and so called Nothing On Insulator (NOI) transistor - as exponents of thin film on insulator devices. For the first time, is offered a real solution to manufacture the NOI transistor, particularly by NCS-multi-layers assembling, validated by experimental tests. The CNT-related materials are promising to create NOI devices and are selected as alternative nanomaterials. Despite to a rapid progress of technology, OTFT with reasonable electronic characteristics, in absence of toxic precursors, remains a serious challenge. To improve the OTFT device performances we envisage the structure optimization by Silvaco tools simulations. To fabricate OTFT we select green routes, electing nanocomposites coated by green organic conductive polymers doped with organic ions to offer p or n type semiconductor behavior. This proposal has an interdisciplinary character, create a bridge nanotechnology for simple-TFT, SOI/NOI transistors and OTFT, get an innovative character by NCS nanocomposites and green-polymers used in nanoelectronics, respond to the international demands about other devices than CMOS to be co-integrated and offer room temperature technology for transistors, avoiding ultra-expensive clean room conditions. The disseminations mainly envisage papers publishing in ISI journals with accent to red-yellow code, conferences participation, 1 patent, 1 book or chapter, 1 IEEE Workshop, 1 Colloquium, 2 socio-cultural meetings.

Prototype for pharmaceutical products with controlled drug release based on chitosan - zeolite composite Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2016-0160 2016 - 2018

Role in this project:

Coordinating institution: BIOTEHNOS SA

Project partners: BIOTEHNOS SA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE CRAIOVA (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://biotehnos.ro/PROZECHIMED

Abstract:

The project proposes development of a technology validated at laboratory level TRL4 to a technology demonstrated at industrial level TRL6,to obtain a prototype for two pharmaceuticals/medical devices for topical local use, which allows slow release of the active principle from zeolite-chitosan. The innovative technologyresults in a product design where the bioactive substance is loaded onto MCM41 zeolite and in chitosan coating. Biocomplexes contain active ingredients obtained through validated laboratory technologies in Biotehnos, a company interested in manufacturing pharmaceutical products with agreaterquality/price ratio for therapy of high incidence diseases, like chronic wounds and acne vulgaris. Chronic wounds are complications that occur in diabetes, varicose ulcers, and bedsores. A disease with significant psychological, social and emotional component is acne vulgaris, one of the mostprevalent infectious diseases. Promoting the scientific and technological relationship of Univ. and an SME, the common goal is the innovation ofa prototype capitalized in drug industry, whose effect results from the concerted action of the combination of plant active ingredients and MCM41 entrappedin chitosan complex. The prototype will be an optimized system that will undergo multiparameter analysis to control for loading capacity and desorption of pharmaceutical substance to increase the reliability of laboratory tests in relation to the real system. Interaction and specific mechanisms of action of the prototype will be investigated by dedicated in vitro experiments and controlled release of the active substance from the prototype will be demonstrated by performancetests.Validation of the prototype is done by transferring the technology at pilot level with characterization of technical details, possible scale effects, technological challenges and confirmation of the pharmacological effect of the product for anti-acne and chronic wounds therapy in preclinical studies.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects