BrainMap

Anamaria Zaharia

Dr. eng.

Scientific Researcher - Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Researcher

ResearcherID: https://www.researchgate.net/profile/Anamaria_Zaharia_lungu

Curriculum Vitae (26/09/2019)

Expertise & keywords

“New drug delivery systems based on micro/nanogel composites containing natural bioactive substances” Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0953 2015 - 2017

Role in this project: Project coordinator

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim-rezultate.ro/proiect.php?id=22

Abstract:

The overall objective of the project consists of obtaining micro/nanoparticles of covalently crosslinked hydrogels based on polyethylene glycol and aliphatic polyamines (injectable micro/nanogels) having embedded both natural nanozeolites but also of natural bioactive substances in their polymer structure, with potential pharmaceutical applications. These new micro/nanogel composite structures are of great interest as they are aimed at being used as devices for subcutaneous or intravenous injection, ensuring the release of bioactive substances in hard-to-reach areas (by macroscopic hydrogels). The role of natural nanozeolites incorporation is to allow for a much slower and controlled release of the embedded active substances and to improve the viscoelastic features of hydrogels. Nowadays bioactive substances play an important role in the development of controlled release systems in medicinal chemistry for the production of new drugs with fewer side effects. The use of phytoextracts as bioactive substances is a big challenge of the project proposal. These new micro/nanodevices with controlled release will have significant influence, both nationally and internationally on the scientific, social and economic field. The results will be disseminated as follows: three articles published in ISI journals; three scientific communications at international conferences, and patenting of any original aspect.

Cellular materials with thermal insulation and fire resistance properties, via energetic efficient recycling process of PET wastes, for minimizing heat loss in civil and industrial buildings Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1388 2014 - 2017

Role in this project:

Coordinating institution: CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU"

Project partners: CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); EUROPLASTIC S.R.L. (RO)

Affiliation:

Project website: http://ccocdn.ro/index.php?id=21

Abstract:

The present project proposal refers to a sustainable process of obtaining rigid polyurethane (PUR) foams, cellular materials with excellent thermal insulating and fire resistance properties. The process consists in chemically recycling poly(ethylene terephthalate) (PET) wastes, using as depolymerization and/or modification agents renewable materials, mainly carbohydrates and natural oils derivatives. Novel modified organocatalytic systems, different from conventional metallic compounds, will be developed and optimised in order to increase process performance, maximize energy efficiency and eliminate the need for solvents
The scientific challenge of the project consists in tailoring the novel catalytic systems, in order to drastically reduce energy consumption associated to the depolymerization reactions of PET wastes (in particular in the presence of some renewable materials), and enhance catalytic activity for these specific reactants, by using theoretical modelling, as well as experimental studies. In this respect, researh will be conducted in two main directions: i) modifying existing organocatalysts, in order to improve their performance or their stability; ii) proposing new organocatalyst that have not been used yet in catalyzed PET solvolysis. A library of new modified organocatalysts and/or combinations thereof, with synergistic effect, suitable for selective solvolytic attack of PET by various cleavage agents, will be, finally, provided. Optimal versions will be selected, in order to be used to further develop the technology for rigid PUR foams preparation, from PET wastes and renewable resources.
Lab-scale technologies for synthesis of selected catalysts will furnish information, useful for modifying commercial organocatalysts into new structures, or use new organocatalysts for PET chemical recycling, in order to apply such energy efficient technologies, on industrial scale.
The main objective of the project consists in developing a series of oligoester-poliols with tuned chemical structure (i.e. rigid and/or flexible moieties content) and properties (adequate for specific applications), starting from PET wastes and renewable materials, by using the correlations between reaction parameters (including organocatalysts), the products’ chemical structure and target properties. Using these oligoesters and designing the foams formulations, polyurethane and polyisocyanurate thermo-insulating rigid foams with tailored chemical structure will be obtained, adapted for various applications and showing (in some imbodiments) improved physico-mechanical and fire resistance properties The innovative and flexible pilot-scale technology for oligoester-polyols synthesis, using organocatalysts, as well as PET wastes and renewable resources as raw materials, would represent an exemplary case of meeting “green chemistry” standards by drastically reducing experimental conditions, eradicating the need for organic solvents, recycling a plastic waste which is accumulating in landfields and is not biodegradable, and providing, instead, innovative eco-friendly products, for long term applications. A innovative and flexible pilot-scale technology for PUR thermo-insulating rigid foams preparation using the respective oligoester-polyols will be developed, as well.
As a total result, a sustainable technology, with low energy consumption, significantly reducing the price of rigid polyurethane foams, would provide an exceptional solution to replace materials commonly used for insulation in buildings with new materials exhibiting outstanding properties and available for various applications, from building envelope to insulations for utility routes.

DRUG DELIVERY HYBRIDS BASED ON POLYMERS AND POROUS CLAY HETEROSTRUCTURES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1432 2012 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO); METAV - CERCETARE DEZVOLTARE S.R.L. (RO)

Affiliation:

Project website: http://www.tsocm.pub.ro/cercetare/DELPOCLAY

Abstract:

The research project is focused on the synthesis of new hybrid materials based on polymers and various organophylized porous clay heterostructures designed for controlled delivery of drugs which exhibit a low water solubility and high toxicity.

SUPERABSORBENTS BIOPOLYMER MATERIALS FOR AGRICULTURE USES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0115 2012 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Affiliation:

Project website: http://www.sabiom.ro

Abstract:

The aim of the SABIOM project is to obtain new superabsorbent materials which could be used in agriculture for water reserving and soil conditioning, starting from biopolymers and using especially green chemistry methods.The superabsorbent materials which will be prepared will also have the capacity of active agrochemicals delivery to the plants in order to protect them against different diseases or to enhance their growth. The novelty of this project is to use bacterial cellulose and other biopolymers in order to obtain superabsorbent hydrogels. This choice was determined by the fact that the majority of the superabsorbent polymers used as commercial products are synthetic polymers as crosslinked polyacrylates or polyacrylamide, and hydrolized cellulose polyacrylonitrile (PAN) or starch-PAN graft copolymers. This project is enrolled in the research efforts which are devoted to develop natural-based superabsorbent polymers starting from polysaccharides and polypeptides (proteins).

EXPLOITATION OF SPONTANEOUS FLORA RESOURCES BY NANOTECHNOLOGY FOR THE OBTAINING OF HIGH BIOACTIVE HYPERICIN CONCENTRATES Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0548 2012 - 2016

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation:

Project website: http://www.icechim-pd.ro/en/pol_hitech/polimeri_hitech_spoflorahyp_en.html

Abstract:

The naphthodianthrones hypericin and pseudohypericin occur in the flowers and leaves of SJW. Hypericin act as an antibiotic and non-specific kinase inhibitor. Hypericin, is being clinically evaluated as an antiviral agent in the treatment of human immunodeficiency virus (HIV) infection. Hypericin was proven to be anti cholesterol and useful for blood circulation. In addition, hypericin is under research as an agent in photodynamic diagnosis (PDD) and therapy (PDT), of cancer.
The project target is to elaborate the production technologies for molecular imprinting of polymers with hypericin 1 enantiomer and for using these new materials in selective separations (MISPE), in order to obtain high bioactive concentrates of hypericin. This will allow the better exploitation of the resources of spontaneous flora and hereby to obtain by the “green chemistry” approaches dietary supplements able to prevent or to cure some diseases of the population. The main novelty of the project proposal is that it is intended to obtain molecularly imprinted polymer materials using as template the enantiomer 1 of hypericin, the materials being appropriate for preparative extraction of this enantiomer from primary SJW extracts. The second novelty of the project is the identification of technological parameters for MISPE separation of hypericin on the new materials. The third novelty of the project is the obtaining of high bioactive dietary supplements (concentrates) of hypericin. The many original idea involved in the project realization insures the deposition of at least 2 patent askings.
The hypericin concentrates that we intend to produce from St. John’s Wort are a world novelty. Such products are not yielded in Romania or abroad. Their enhanced bioactivity in preventing or curing some very dangerous diseases such as cancer, HIV, blood circulation disorders and depressions, will enable them to penetrate quickly on national and European markets.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects