BrainMap

Mrs. Anca Mitroi

Researcher I - SPITALUL CLINIC JUDETEAN DE URGENTA CONSTANTA

Other affiliations

Researcher II - UNIVERSITATEA OVIDIUS (Romania)

Researcher | Scientific reviewer

Curriculum Vitae (17/04/2024)

Expertise & keywords

Mobilitate cercetător Anca Mitroi Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori, 2019
PN-III-P1-1.1-MC-2019-1539 2019 - 2019

Role in this project:

Coordinating institution: UNIVERSITATEA OVIDIUS

Project partners: UNIVERSITATEA OVIDIUS (RO)

Affiliation: UNIVERSITATEA OVIDIUS (RO)

Project website:

Abstract:

European Human Genetics Conference Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2018-2208 2018 -

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA OVIDIUS

Project partners: UNIVERSITATEA OVIDIUS (RO)

Affiliation: UNIVERSITATEA OVIDIUS (RO)

Project website:

Abstract:

project title Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2017-2118 2017 -

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA OVIDIUS

Project partners: UNIVERSITATEA OVIDIUS (RO)

Affiliation: UNIVERSITATEA OVIDIUS (RO)

Project website:

Abstract:

Hepatocellular carcinoma stratification based on noninvasive markers Call name: EEA Research Programme under EEA Financial Mechanism 2009-2014
EEA-JRP-RO-NO-2013-1-0363 2013 -

Role in this project: Key expert

Coordinating institution: INSTITUTUL CLINIC FUNDENI

Project partners: INSTITUTUL CLINIC FUNDENI (RO); UNIVERSITATEA "TITU MAIORESCU" (RO); UNIVERSITATEA OVIDIUS (RO); Norwegian University of Science and Technology (NO); Nuclear Organization and Oncogenesis Unit (INSERM U993) at the Institut Pasteur (FR)

Affiliation: UNIVERSITATEA OVIDIUS (RO)

Project website:

Abstract:

The major goal of the project “Hepatocellular carcinoma stratification based on noninvasive markers” (HEPMARK) in accordance the EEA Research Programme objectives is to stimulate multidisciplinary research by creating and supporting a network for translational science that brings together scientists from Romania, Norway and France.

HEPMARK proposes a concept of research that would identify using expression miRNAs expression, a high-risk group of patients with liver cancer who may develop intrahepatic recurrence/ distant metastasis. Currently is an unmet need to improve the accuracy of hepatocellular carcinoma (HCC) score stratification by incorporation of new non-invasive molecular assays. Moreover, the possibilities to develop the new systems that predict the likelihood of recurrence after curative treatment, including miRNA and angiogenetic factors are needed. Thus, our hypothesis is that primary liver cancers release miRNAs within exosomes transported in the peripheral blood that facilitate the metastatic niche. We intend to use miRNA circulating and angiogenic panel for HCC patients’ stratification. More accurate preoperative selection criteria will allow better patient selection and better allocation of the HCC patients in case of curative treatment.

The project specific objectives are:

Obj_1: To quantify the expression of microRNA species in serum exosomes from patients with non-metastatic HCC and distant metastases/ intrahepatic recurrence

Obj_2: To characterize angiogenic plasma biomarker patterns of HCC and imaging biomarkers in correlation with microRNA markers

Obj_3: To characterize epigenetic changes (DNA and histones) resulting in microtranscriptomic alterations

Obj_4: To create new clinical guidelines for the use of serum and tissue tumor markers for early detection, as well as for differentiation between HCC patients (patients’ stratification).

The project will achieve the following results with practical relevance:

1. Identification of circulating microRNAs as biomarkers of HCC for detection and evaluation of disease aggressiveness in patients at risks

2. Development of a panel of circulating microRNAs, proteins and imaging parameters as biomarkers of response in HCC

3. To test prospectively biomarker candidates for optimization and future translation in clinical practice guidelines for patient’s stratification depending on selected markers

4. Integration of Romanian research groups into a strong network with proficiency in HCC translational research

The strong points that guarantee the success of the project are:

- the proposed project continues the research interest of consortium in the field of molecular biology of HCC which have investigated molecular predictive factors from tissue specimens. One of the strengths of the current project is that it expands the pannel of molecular markers with microRNA species in serum exosomes quantified in patients’ blood samples.

- the consortium has already created a functional network that may easily sustain the fulfillment of present project.

- The consortium is formed by renowned scientists in the field of molecular biology, genomics and clinical practice as sustained by their recent publications in Nature Genetics, PlosOne, Cancer Res. etc, which is the guarantee for a good management of the research outputs.

- The sample size is statistically valid

The results of this project will impact directly the strategic area of health care by improving the quality of clinical decision –making for a specific group of HCC patients.

Our findings may have significant translational relevance for development of new molecularly targeted therapies for patients with HCC. We intend to exploit this knowledge to develop targeted therapies of HCC based on the microRNA dysregulation.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects