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Romania
Citizenship:
Romania
Ph.D. degree award:
1993
Mrs.
Anca
Roseanu Constantinescu
PhD
Senior researcher, group leader
-
INSTITUTUL DE BIOCHIMIE
Researcher
>20
years
Personal public profile link.
Curriculum Vitae (26/02/2024)
Expertise & keywords
Cell biology
Inflammation
Infection
Nanotechnology
enzimology
Inflammation
Nanomedicine
Infection
Cell biology
Nanotechnology
Biocompatibility
Cell signalling
Cell proliferation
Intracellular trafficking
mammalian cells interactions with materials
Projects
Publications & Patents
Entrepreneurship
Reviewer section
Next generation of orthopaedic implants based on new Ti bioalloy functionalized with hybrid biomimetic coatings
Call name:
Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1994
2014
-
2017
Role in this project:
Partner team leader
Coordinating institution:
INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA
Project partners:
INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE BIOCHIMIE (RO); TEHNOMED IMPEX CO S.A. (RO)
Affiliation:
INSTITUTUL DE BIOCHIMIE (RO)
Project website:
http://ppam.inflpr.ro/ORTHOBIOMIM.htm
Abstract:
The main objective of ORTHO-BIOMIM project is to obtain competitive and original products, namely advanced orthopaedic implants based on a new Ti-Ta-Nb alloy, which are functionalized by laser based technique (Matrix Assisted Pulsed Laser Evaporation) with complex hybrid biomimetic coatings (Lactofferin, Hydroxyapatite, Polyethilenglycol-Polycaprolactone synthetic copolymer functionalized with methyl ether group, Lf_HA_PEG-PCL-Me). The proposed approach relies on applied experimental research involving strongly interdisciplinary domains (i.e. material science, mechanics, laser physics, chemistry, microbiology, biomedicine), combined with industrial research activities, development.
The strategic key points for obtaining orthopaedic implant with enhanced characteristics within ORTHOBIOMIM project are:
• New and highly biocompatible Titanium (Ti)–based alloy containing non-toxic components (Ti-Ta-Nb) obtained by levitation technique with enhanced properties (low corrosion, mechanical resistance, elastic modulus etc.) working as implant body;
• Improved mechanical characteristics of the alloy obtained by its thermo-mechanical processing;
• Alloy biofunctionalization with complex hybrid coatings having multiple functionalities (biodegradable, bioresorbable, increased capacity osteogenic, osteoconductive and osteoinductive, anti-inflammatory ) by laser methods (MAPLE).To mimic the process of osseointegration, these coatings will be composed of natural biodegradable compounds, namely lactoferrin (Lf) and hydroxyapatite (HA), and a antifouling synthetic copolymer functionalized with methyl ether PEG-PCL-Me);
• Highly flexible methods for obtaining alloy processing and functionalization, allowing control defined composition, chemistry and surface topography when both alloy and the coating / film hybrid biomimetic functional.
The implications anticipated within ORTHOBIOMIM project development are related to major scientific benefits by increasing national competitiveness and visibility in research, development and innovation, but also to social and economic benefits . In the social context, in addition to the involvement of a large number of youth in the project and creating jobs, a very important benefit provided by this project is given by the envisaged faster osseointegration and long lifespan of the implant. This might be of crucial importance for those patients whose health status and life will be enhanced through the use of new medical implants by reducing risks of infection and thus reduce costs for medication or those necessary to replace a failed implant.
By the proposed objectives and approach, the project is aligned with the main points defined Partner Program, which promotes the applied inter and trans-disciplinary research in micro and nanostructured advanced materials for applications in medical field.
Read more
FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.2882, O: 146]