BrainMap

Mrs. Andreea Mariana Negrescu

Research Assistant

Research Assistant - UNIVERSITATEA BUCURESTI

Researcher

Andreea-Mariana Negrescu completed her Bachelor degree in Biochemistry in 2016 and a Master degree in Biochemistry and Molecular Biology in 2018, both within the Faculty of Biology, University of Bucharest. In 2021 she finished her PhD, getting a degree in Biology (University of Bucharest). She is currently holding the position of Scientific Researcher in the Biochemistry and Molecular Biology Department, Faculty of Biology, University of Bucharest. Since 2018 she was involved in multiple research projects related to material science, biocompatibility, osteoimmunomodulation, immune response and drug delivery systems.

Web of Science ResearcherID: DIA-0026-2022

Expertise & keywords

Novel technology for implants manufacturing from 3D printable reinforced composite filaments for guided bone regeneration Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1650 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: http://www.florinmiculescu.ro/bonegapfill/

Abstract:

Compared to the limited market of products destined for bone reconstructive surgery and the high-patient-risks of current approaches, this project is a necessity to solve the absence of 3D products with optimal geometry, internal architecture and mechanical properties for customized compatibility with natural bone and a rapid repair of defects with variable dimensions. The overall goal of the project is to develop and promote a new reproducible and sustainable manufacturing technology for the products fabrication by 3D printing, using as platform the previously implemented technology for the synthesis of hydroxyapatite derived from bovine bone biogenic resources and the project team`s experience in the field. Composite filaments with printable features will be obtained based on natural hydroxyapatite and two polymers, one of which will be of natural origin. Also, superior and adaptable mechanical characteristics will be ensured by reinforcing the ceramic matrix with multi-layer graphene-based materials. Further, the filaments will be used for 3D printing of products with regular and random internal architecture (based on a new STL file developed within the project). Afterwards, the products will be tested as to evaluate their performance as potential bone replacements. In this regard, a patent application will be filed. The proposed topic is new and challenging for the project team, but all the premises are fulfilled through the team`s synergy and previous research experience. The concept and experimental testing of the possibility of embedding naturally derived ceramic particles into a polymer matrix of natural origin were also demonstrated and reported by the team members as viable for achieving the project objectives.

Breast implants silicon outshell bioinstructive engineering for preventing microbial and fibrosis development Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2375 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation:

Project website: https://ancabonciuub.wixsite.com/breaslife

Abstract:

Breast cancer is a significant public health issue for women and it is currently targeted by the national strategies for health outcomes. Considering both physical and psychological impacts on health-related quality of life, a large percentage of women with a mastectomy will choose breast reconstruction by implants. One inevitable consequence of silicone breast implantation and foreign body response is the capsular contracture, which often leads to health complications, need for revision surgery, etc. Hence, the main objective of the BreasLIfe project is to design, develop, and obtain new silicone out shell bioinstructive interfaces of breast implant with specific modulated characteristics (in terms of surface topography, chemistry,wear-resistant) for a final antibacterial and low inflammatory response that could lead to a reduced capsular contracture.

The approached innovative bioengineering solutions for achieving this objective refers to:

1)multi-architectural 2 and the 3-dimensional surface texturing of silicone for reducing the wear and friction of implant biointerfaces surface, inhibiting bacteria and fibrosis;

2)surface chemistry by using the synergetic effect of zwitterionic polymers, antifibrotic and anti-inflammatory compounds ( i.e., pirfenidone, Lactoferricin);

3)surface multiple specific functionalizations by laser techniques for the embedding of bioactive synergetic compounds(antifibrotic and anti-inflammatory)in a biodegradable zwitterionic polymer coating.

Advanced Innovative approaches for predictable regenerative medicine Call name:
PN-III-P1-1.2-PCCDI-2017-0782 2018 - 2020

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (); INSTITUTUL ONCOLOGIC PROF.DR.I.CHIRICUTA CLUJ-NAPOCA ()

Affiliation:

Project website:

Abstract:

The aim of the project is to create a consortium with complementary

research experience in the field of regenerative medicine, which will

efficiently use the human resource and modern research infrastructures

newly created for the implementation of innovative technologies, with

the aim of developing and transferring the results to the economic

environment. The overall objective of REGMED is to increase the

institutional performance of the involved research structures in the

approach of innovative techniques with applicability in regenerative

medicine, in accordance with the priorities of public relevance and

intelligent specialization related to HEALTH.

REGMED addresses the following topics: (1) Osteoimmunomodulation

as a predictive factor of bone tissue regeneration efficiency (Project 1-

BONE); (2) Biocompatible system for assisting peripheral nerve

regeneration (Project 2-NERVE); (3) Cellular and molecular mechanisms

involved in regenerative processes of soft tissues (Project 3 SOFT); (4)

Modulation of tumor microenvironment using intelligent systems for

mammary reconstruction (Project 4-TUMOR).

The estimated results of REGMED are: (i) strengthening a highly

specialized consortium in Regenerative Medicine and its sustainability

by developing a common CDI program; (ii) creating and supporting 12

new jobs; (iii) achievement of new products with controlled release

properties for the regeneration of bone tissue, soft tissues, peripheral

nerves and breast tissue post-mastectomy, resulting in 4 submitted

patent applications; (iv) strengthening the capacity of institutions with

opportunities for relaunching and training the human resources from the

involved institutions in modern technologies by experience exchanges;

(v) Improving the offer of research services on the erris.gov.ro platform;

(vi) scientific input (min 10 ISI articles, min 20 papers at conferences)

and (vii) transfer of project results to the economic environment.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects