BrainMap

Mrs. Andreea Mariana Negrescu

Research Assistant

Research Assistant - UNIVERSITATEA BUCURESTI

Other affiliations

Scientific Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (Romania)

Researcher

Andreea-Mariana Negrescu completed her Bachelor degree in Biochemistry in 2016 and a Master degree in Biochemistry and Molecular Biology in 2018, both within the Faculty of Biology, University of Bucharest. In 2021 she finished her PhD, getting a degree in Biology (University of Bucharest). She is currently holding the position of Scientific Researcher in the Biochemistry and Molecular Biology Department, Faculty of Biology, University of Bucharest. Since 2018 she was involved in multiple research projects related to material science, biocompatibility, osteoimmunomodulation, immune response and drug delivery systems.

Web of Science ResearcherID: DIA-0026-2022

Expertise & keywords

Biomimetic hydrogel dressings containing natural therapeutic agents developed by radiation synthesis Call name: P 5.2 - SP 5.2.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - Competiția 2023
PN-IV-P2-2.1-TE-2023-0453 2025 - 2027

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation:

Project website: http://hydro-thera.arert.inflpr.ro

Abstract:

Hydrogel dressings are the best alternative for treating severe, acute and chronic wounds. In the case of classic dressings, their removal creates discomfort and pain in the wound. This discomfort can be avoided if natural therapeutic agents are incorporated into hydrogel dressings that are easy to remove from the wound and absorb exudate. The scientific importance of this project is given by the development of biomimetic dressings in the form of hydrogel added with natural therapeutic agents for the healing of skin wounds with cicatrizing and anti-inflammatory effect, with a controllable degree of elasticity and a high degree of absorption of wound exudate. The biomimetic dressing in the form of hydrogel will be produced by mixtures of natural polymers that are biocompatible and non-toxic to biological tissues. To achieve the proposed goal, natural therapeutic agents (standardized Aloe Vera extract) will be added to the hydrogels for rapid healing and wound treatment. To increase the efficiency of obtaining the biomimetic dressing, the hydrogel will be produced in a single technological step by electron beam synthesis, simultaneously ensuring the cross-linking and final sterilization of the product. The hydrogel dressing will support cell viability and proliferation and facilitate the release of active principles to ensure the desired therapeutic effect.

Novel designed strategy for antibacterial interfaces mediated by synergically topographical features and plasma treatment for dentistry application Call name: PNCDI IV, SP 5.7.1 - Proiect experimental demonstrativ
PN-IV-P7-7.1-PED-2024-0808 2025 - 2027

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); ADA DENTAL CENTER SRL (RO)

Affiliation:

Project website: https://ancabonciuub.wixsite.com/nostradentro

Abstract:

As dental plaque-associated periimplantitis is a condition bearing great similarity to periodontal disease it is of outcome importance to design and obtain a specific biointerface to minimize the bacteria adhesion and provide an efficient mucosa implant interface similar to a natural tooth, in such a way that the host-microbe homeostasis at the implant-mucosa interface is maintained. Within this context, the NoStraDent project scope is to obtain new interfaces with hindering bacteria capacities and provide an optimized surface for epithelial adhesion and low inflammation, with a long service life, thus avoiding a new or repeated dental procedure.

The NoStraDent project demonstration model in obtaining designed biointerfaces to minimize the bacteria adhesion and provide an efficient mucosa implant interface similar to the natural tooth is based on two main directions/objectives:

-Biomimetic antimicrobial multilevel structuring technology based on femtosecond laser-controlled structuring, including a design of interrupted patterns in bacteria size ranges disposed hierarchically in a controlled way

-Surface chemistry modification by plasma technology to add a level of structuring to that obtained by laser processing, as well as tuning the chemistry of the obtained architectures by plasma processing

The obtained biointerfaces will be validated at the laboratory level by biological testing in microorganisms and mammalian(relevant for gingival tissue).

Novel technology for implants manufacturing from 3D printable reinforced composite filaments for guided bone regeneration Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1650 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: http://www.florinmiculescu.ro/bonegapfill/

Abstract:

Compared to the limited market of products destined for bone reconstructive surgery and the high-patient-risks of current approaches, this project is a necessity to solve the absence of 3D products with optimal geometry, internal architecture and mechanical properties for customized compatibility with natural bone and a rapid repair of defects with variable dimensions. The overall goal of the project is to develop and promote a new reproducible and sustainable manufacturing technology for the products fabrication by 3D printing, using as platform the previously implemented technology for the synthesis of hydroxyapatite derived from bovine bone biogenic resources and the project team`s experience in the field. Composite filaments with printable features will be obtained based on natural hydroxyapatite and two polymers, one of which will be of natural origin. Also, superior and adaptable mechanical characteristics will be ensured by reinforcing the ceramic matrix with multi-layer graphene-based materials. Further, the filaments will be used for 3D printing of products with regular and random internal architecture (based on a new STL file developed within the project). Afterwards, the products will be tested as to evaluate their performance as potential bone replacements. In this regard, a patent application will be filed. The proposed topic is new and challenging for the project team, but all the premises are fulfilled through the team`s synergy and previous research experience. The concept and experimental testing of the possibility of embedding naturally derived ceramic particles into a polymer matrix of natural origin were also demonstrated and reported by the team members as viable for achieving the project objectives.

Breast implants silicon outshell bioinstructive engineering for preventing microbial and fibrosis development Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2375 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation:

Project website: https://ancabonciuub.wixsite.com/breaslife

Abstract:

Breast cancer is a significant public health issue for women and it is currently targeted by the national strategies for health outcomes. Considering both physical and psychological impacts on health-related quality of life, a large percentage of women with a mastectomy will choose breast reconstruction by implants. One inevitable consequence of silicone breast implantation and foreign body response is the capsular contracture, which often leads to health complications, need for revision surgery, etc. Hence, the main objective of the BreasLIfe project is to design, develop, and obtain new silicone out shell bioinstructive interfaces of breast implant with specific modulated characteristics (in terms of surface topography, chemistry,wear-resistant) for a final antibacterial and low inflammatory response that could lead to a reduced capsular contracture.

The approached innovative bioengineering solutions for achieving this objective refers to:

1)multi-architectural 2 and the 3-dimensional surface texturing of silicone for reducing the wear and friction of implant biointerfaces surface, inhibiting bacteria and fibrosis;

2)surface chemistry by using the synergetic effect of zwitterionic polymers, antifibrotic and anti-inflammatory compounds ( i.e., pirfenidone, Lactoferricin);

3)surface multiple specific functionalizations by laser techniques for the embedding of bioactive synergetic compounds(antifibrotic and anti-inflammatory)in a biodegradable zwitterionic polymer coating.

Advanced Innovative approaches for predictable regenerative medicine Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0782 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (RO); INSTITUTUL ONCOLOGIC PROF.DR.I.CHIRICUTA CLUJ-NAPOCA (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: https://unibuc.ro/cercetare/promovarea-rezultatelor-cercetarii/proiecte-de-cercetare/proiecte-cu-finantare-nationala/65pccdi-2018/

Abstract:

Considering that HEALTH is one of the main areas of public priority, the approach of interdisciplinary researches with applicability in Regenerative Medicine can significantly contribute to improving the quality of life of patients with tissue defects. The aim of the project is to create a consortium with complementary research experience in the field of regenerative medicine, which will efficiently use the human resource and modern research infrastructures newly created for the implementation of innovative technologies, with the aim of developing and transferring the results to the economic environment. The project aims to develop new technological products in the form of biocompatible biomaterials designed for bone reconstruction (P1), nerves (P2), soft tissues (P3) and breast reconstruction after tumor resection (P4).

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects