BrainMap

Mr. Antonio Marian Radoi

PhD

Researcher/CS I - INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Researcher

ResearcherID: C-5820-2011

Expertise & keywords

Hybrid flexible interface for energy purposes Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-1095 2015 - 2017

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/hyflep/

Abstract:

The driving motivation of this project proposal dwells in the development and investigation of graphene based materials (Gbm) suitable to be integrated in novel types of photovoltaic devices (PV) based on Gbm/Silicon heterostructures. Distinct from the already existing technologies based on graphene films and flakes that are very popular nowadays, the accent will be on graphene quantum dots (GQD), appealing in terms of energy level alignment, thus allowing probing new horizons in PV technology. Silicon heterojunctions formed with carbon based materials represent a solution because they can be considered as active photogeneration sites, percolated network for charge transport and charge carriers collection. Since the efficiency of a PV solar cell mainly depends on the ability of incident photons absorption and equally generated carriers collection, a targeted approach envisaging the development of a nanostructurated hybrid photovoltaic (PV) device, relaying on the use of flexible nanopatterned substrate (nanoSi) and graphene quantum dots (GQDs) is herein proposed.

Multiplexed platform for HPV genotyping – MultiplexGen Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1434 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); GENETIC LAB S.R.L. (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/multiplexgen/index.php

Abstract:

MultiplexGen project addresses a current problem in medical diagnosis, detection in an accurate and specific way of Human papillomavirus (HPV) and sets out to explore specific solutions from micro- nanotechnology to overcome the limitations of the conventional tests, which are not quantitative and exclude multiplexing. The aim of the project is to develop a high sensitivity multiplexed platform which consists of different functional levels, and as a consequence is generic named “multilevel system”. It is based on hybrid organic-inorganic / bio-nonbiological assemblies able to enhance diagnostic capabilities by exploiting the bridge between bio-systems and micro-nanotechnologies, thus overcoming many of the limitations of the existing methods for Human papillomavirus (HPV) detection and genotyping.
This proposal has evolve as a result of numerous discussions initiated by researchers from the clinical laboratory - SME – GeneticLab with their colleagues from Laboratory of Nanobiotechnology - IMT (LN-IMT) about various specific issues they encountered in their activity related to HPV genotyping by capillary electrophoresis kit, which are identified as primary technical and scientific barriers that will be lifted by carrying out the present project. The long time collaboration encouraged them to believe that IMT will find a technological answer to the problem posed by the classical diagnosis method, and furthermore, Centre of Applied and Organic Chemistry - UB (CAOC) will provide a theoretical understanding of the processes and phenomena taking place in HPV genotyping.
The issues supposed to be solved related to the mentioned thematic area, which represents the secondary objectives of the project, are encompassing the fundamental and technological knowledge and are parts of our functional model demonstration, as following: (i) to obtain a microarray based technology for accurate HPV genotyping; (ii) to improve the up to now reported results in terms of sensitivity / selectivity by connecting the biochip to a microfluidic system; (iii) to indicate the optimum design for biochip to allow parallel detection and in this way confirmation of results; (iv) to propose a heterogeneous technology for integration and 3D packaging and correpondingly a functional hybrid assembly of all these modules for a further disposable system developing.
Therefore, an extensive investigation and optimization of the benefits that our knowledge in genetics, microfluidic technology, microarray technology, surface biofunctionalization, as well as opto-electrical read-out signal analyses are able to bring a valuable tool to a medical diagnostic laboratory, a chip class of devices, with important specific HPV detection / genotyping application. For example, combining the fields of microfluidics and DNA microarrays, the advantages of both directions can be exploited simultaneously, mediated by valuable new knowledge about biointeractions and biohybrid assembling.
Besides the envisaged final outcome of this project, the functional model of hybrid multilevel system for HPV genotyping, the modules and even more, each specific technology improvement are of high value by themselves each of them being independently used thenceforth. State-of-the-art scientific results in all of the disciplines involved will be the direct project outcomes, which will be proven by the publications on microfluidics, on-chip sample preparation, and on clinical comparison of HPV detection technologies in international journals and at international conferences.

Improved production methods to minimize metallic nanoparticles’ toxicity – less classic, more green Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1780 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); AGHORAS INVENT SRL (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/lesmorenano/

Abstract:

The demand for engineered nanoparticles (ENPs) comes from the great promise for major advances in different areas of applications, practically all fields of knowledge being in some way or another related with nanomaterials. Among the different kinds of ENPs, the special properties of metallic NPs (MeNPs) make them attractive for most of the domains, from opto-electronic industry to biomedicine. As a result of these applications, MeNPs exposure to the environment and humans is becoming increasingly widespread.
The present proposal lies in this very context of the nanotoxicology, and it has taken shape as a result of numerous discussions initiated by researchers from a small enterprise which develop and put on the market novel cosmetic products based on different types of nanoparticles – Aghoras Invent SRL – and consequently has a direct interest in analyzing their potential adverse effects.
The aim of this project is to provide a better understanding of MeNPs safety and a basis for health and risk assessment. Consequently, an intensive work on hazard characterization and impact assessment of selected nanoparticles and economically relevant products is proposed. In this context, the end-of-project results will be: (i) as technological development, from experimental point of view, different sizes/shapes of Au, Ag and PtNPs, relevant for skin care products’ development, will be obtained using both, conventional chemical reduction and eco-friendly methods. Stable and homogenous metallic nanoparticle colloidal dispersions with specific size ranges are aimed, using eco-friendly processes and the chemical reduction routes; appropriated surface functionalization will be also realized, since it provides stability, solubility and retention of optical properties in various media; (ii) as a nanoparticle properties’ study, advanced equipments for analytical characterization will be used and also, the up to date nanotoxicology specific in vitro tests will be used to accomplish the final proposed objective of this project, giving a strong support for a correct decision. Furthermore, this project aims to extend the use of existing ‚state of the art’ methods.
In summary, this project addresses: ¤ increased concern of national and international regulatory organizations; ¤ reticence of companies and manufacturers of developing NP based products and technologies in absence of clear safety standards; ¤ nanotoxicology emerging research field; ¤ assessing NP toxicology an extreme complex research effort due to a large multitude of NP variables; ¤ imperative necessity to find effective countermeasures to the potential hazards represented by NPs; ¤ green synthesis as a route for diminishing / elimination of NP adverse effects on health and environment.
It will provide our contribution to the common efforts of research community offering answers about the potential toxicological effects of three classes on MeNPs and also proposing fabrication alternative, to minimize the negative consequences as greener pathways to nanoproducts.

Immunoassay Lab-on-a-chip for cellular apoptosis study Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0052 2012 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Project website: http://www.imt.ro/cellimmunochip

Abstract:

The ambitious goal of this project is to combine fundamental research with complex applicative research in order to bring important scientific contributions both on the theoretical level and on the experimental one, in a high-end field: bio-nano-engineering, a new field in Romania and in expansion stage worldwide. Bio-nano-engineering assumes the integration of the physico-chemical processes with the biological ones by involving complex systems realized on the micro or nano scale, the applications of these systems being found in biomedicine The aim of this project is the development (design, fabrication and characterisation) of a versatile lab-on-a-chip integrated system, which is composed of a microfluidic platform, an interdigitated micro/nano-electrodes electrochemical biosensor and an array of spin valves for superparamagnetic nanoparticles - based immunoassay, and will be applied to the study of cellular apoptosis and detection of specific antigens as clinical diagnostics application. The screening reaction is based on a competitive immunoassay, enhanced by using functionalized superparamagnetic nanoparticles, prepared through a simple and reliable surface modification and protein conjugation process. The main advantage of this system is its re-usability. Also, its configuration can be changed easily so the user can try several electrode configurations with the same holder. Moreover, because the functionalized nanoparticles are magnetically trapped above the electrodes, the user can adjust the fluid flow rate to the kinetic parameters of chemical reactions under study to optimize detection. The superparamagnetic nanoparticles can be trapped by polarization of the spin valve array and can be released by blocking the magnetic field. We shall demonstrate how to take further advantage of the microfluidic system to determine enzyme activities or concentrations, as flow velocity can be adjusted to the rate of the reactions under study.

Graphene nanoelectronic devices for high frequency applications Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0071 2011 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT Bucureşti

Project partners: INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT Bucureşti (RO)

Affiliation:

Project website: http://www.imt.ro/grafenerf/

Abstract:

The project will explore the graphene devices for ultrafast communications beyond 60 GHz. Similar to the famous Moore law, the Edholm law states that the need for higher bandwidths in wireless communications will double every 18 months. Today, for the wireless LANs, the carrier frequencies are around 5 GHz and the data rates are 110-200 Mb/s. However, according to Edholm law, wireless data rates around 1-5 Gb/s are required in few years from now. This means that the carrier frequencies for wireless communications should become higher than 60 GHz. However, in this bandwidth the devices and circuits able to form a wireless link at room temperature are very scarce. This limitation is due to relative high charge scattering rate and relative low mobilities encountered in all semiconductors at room temperature. So, in few years the ever increasing demand for ultrafast wireless communications will not be fully satisfied using the existing semiconducting technologies. To solve this expected bottleneck , we propose a radical solution which consists in using other materials and circuit configurations to fulfill the clear tendencies indicated by Edholm law. More specifically, we intend to design, fabricate and test miniaturized devices which work beyond 40 GHz based on graphene. Why graphene? Graphene has mobilities which are greater by orders of magnitude compared to compound semiconductors and other important properties outperforming any known material.

Efficient electrochemical catalysis and regeneration of nicotinamide adenine dinucleotide at layer-by-layer self-assembled doped membranes Call name: Projects for Young Research Teams - TE-2010 call
PN-II-RU-TE-2010-0044 2010 - 2013

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MICROTEHNOLOGIE DIN BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MICROTEHNOLOGIE DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU MICROTEHNOLOGIE DIN BUCURESTI (RO)

Project website: http://www.imt.ro/NADH/

Abstract:

The need for an efficient catalysis and regeneration process involving the nicotinamide adenine dinucleotide is justified, by its economical weight as well as by its valuable applications in the biotechnology field. Nanostructured materials exhibit interesting properties which favour the electrochemical detection of NADH. Obstacles for the effective use of nicotinamide adenine dinucleotide include the need of high overpotentials for direct oxidation or reduction of the cofactor, electrode fouling, dimerization of the cofactor, etc. Nevertheless, to promote economically efficient processes, the regeneration of the pyridine cofactor remains a key problem to solve. A platform for various dehydrogenase based bioassays should be obtained by developing an electrochemical probe based on layer-by-layer self-assembled doped metallic nanoparticles membranes. When using nanoparticles for catalysis two main issues are raising: the stabilization the particles while retaining sufficient catalytic activity and the problematic separation of the catalytic particles from the reaction product and unused reactants at the end of the reaction. One solution may be the immobilization of the nanoparticles in thin membranes, minimizing the mass transfer limitations. A generic platform offering a fast regeneration and an efficient catalysis of coenzyme is the goal of this proposal. The motivation, the goals, the team and the methodology are fully described in this research proposal.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects