BrainMap

Bianca-Iulia Ciubotaru

Assistant Professor, Researcher - UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI

Other affiliations

Researcher - INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (Romania)

Researcher | Teaching staff

Expertise in the field of applied engineering sciences, with the qualification of medical bioengineer granted after passing the exam completion and learning outcomes through the study program in the application of the principles of physics, chemistry, mathematics and engineering principles for the study of biology, medicine, as well as behavior or health. Knowledge of the basic principles of the functioning, characteristics and applications of medical devices, together with the operating principles of medical devices for applying the techniques of collecting, analyzing and processing medical signals. Knowledge of the types of biomaterials and skills in their processing for obtaining and using implantable medical devices and individual control devices, as well as skills in the synthesis and evaluation of bioactive compounds and in the application of biotechnological processes. Skills for developing strategies in clinical and administrative decision making in healthcare systems.

Web of Science ResearcherID: not public

Curriculum Vitae (16/01/2023)

Expertise & keywords

Silsesquioxanes-based materials obtained by photo-induced thiol-ene reaction, for environmental applications (CO2 capture) Call name: PNCDI IV, P 5.8 - SP 5.8.3 - Proiecte de mobilitate, PM-RO-TR-2024
PN-IV-P8-8.3-PM-RO-TR-2024-0046 2025 - 2026

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); Bogazici University (TR)

Affiliation:

Project website:

Abstract:

The project aims to develop, through a cost-reasonable approach, a method for obtaining new silsesquioxanes based materials using photo-induced thiol-ene reaction in order to use them for environmental applications, as active materials with user-controlled adaptability for integrated management of the CO2 gas separation.The eficient capture of CO2 due to the logical design of new silsesquioxanes-materials with enriched functionality is an important step in diminished CO2 emissions.The new materials synthesized in this project by using click photo-induced thiol-ene addition reaction between octavinyl-T8-silsesquioxane and thioalkylcarboxylic acids, and their transition metal complexes will be confirmed, characterized and applied as new hybrid materials for selective CO2 capture. Then they will be analyzed in terms of thermal stability, morphology and moisture, N2 and CO2 sorption, for determining the best conditions for designing the POSS materials with the highest CO2 adsorption performance. The possibilities of structural diversification are enhancing the application potential. The CO2 capture property attributed to the materials’ high microporosity and well-dispersed sulfur functionality throughout the carbon framework of the material can be improved. The new POSS-materials with heteroatom doping as efficient adsorbents for the selective capture of CO2, represent a good solution for effective CO2 mitigation.

Nanocomposite Materials with Thermoregulation through Multiple Mechanisms, Usable in Multiple Climate Zones Across a Wide Temperature Range Call name: PNCDI IV, SP 5.7.1 - Proiect experimental demonstrativ
PN-IV-P7-7.1-PED-2024-2073 2025 - 2026

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); MAJUTEX S.R.L. (RO)

Affiliation:

Project website:

Abstract:

Currently, >40% of commercial energy use is directed for heating and cooling of buildings, driven by the requirement to maintain a tight temperature envelope for human comfort. Taking inspiration from capabilities of mirror comb-footed spider (Thwaitesia sp.) to adjust very fast its shape, color, and light reflection, this project proposes the development of an innovative biomimetic platform as thermoregulatory composite material. Thus the advantages of passive strategies for thermal comfort (low cost, straightforward implementation, and energy efficiency) will be brought together with the fast on-demand control capabilities of active strategies for thermal comfort. The data input from the commercial partner will help in the process of insight-driven product creation, and it will be applied for the development of a minimal viable product at laboratory scale in the form of a thermoregulatory clothing which can satisfy consumer demands for an extended range of temperatures. This product will expand the thermal envelope of the user by biomimetically tuning on demand the heat exchange through four different mechanisms (conductivity, convection, radiation and evaporation). The composite materials developed in this project will be based on silicone chemistry. The clothing made with such materials will regulate a heat flux of >100 W/m2, where the fast adjustment of the temperature envelope for the user will require only a transient mechanical power input for actuation of

Silicone-based modular artificial sensing skin for MMOD impact damage detection and evaluation system in spacecraft Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0156 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://icmpp.ro/silartskin/index.php

Abstract:

Spacecrafts (such as CubeSat) in low Earth orbit (LEO) are exposed to several hazardous environments including the impact made by micrometeoroids and orbital debris (MMOD). There are 500,000 pieces of debris that are currently tracked and there are more than one million small debris pieces that can’t be tracked due to their small size. Collision results made by a piece of space debris can cause mechanical damage, material degradation, and, occasionally, the catastrophic breakup of operational spacecraft. Expeditions like Apollo 13 or STS-107 failed due to the lack of identification of external damages in the spacecraft. The project aims to develop a large-scalable method and a modular sensing technology based on silicone elastomers suppressing the disadvantages of other technologies intensely studied at the day. Basically, the proposed project aims to determine in real-time when an MMOD impact has occurred on a spacecraft shield or structure, area of the impact, depth, and importantly, where it occurred. Moreover, the proposed sensing technology will be operating on a wide temperature range (-70 to more than 150 oC), being lightweight and able to give real-time feedback to the operator, can detect simultaneous multiple damage impacts of different projectile sizes, as well as recovering the original shape after taking damage will be possible (self-healing properties).

Emerging 2D materials based on two-dimensional permethylated metal-organic networks Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2000 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://2dpermosil.ro/

Abstract:

After the discovery of graphene with the set of properties that essentially distinguish it from other allotropes of carbon, ultra-thin layered materials, classified as 2D nanomaterials, enjoy a growing interest due to their unique properties. In this context, very recently become of interest 2D MOFs. But in the crystallization process, 2D layers stack on the basis of intermolecular interactions, leading to higher dimensional materials. To manifest behavioral particularities specific to a 2D material, they must be isolated individually or in multilayers with thickness/surface aspect ratio as small, which is a challenge that seek solutions through different approaches (top-down or bottom-up). The project idea is to design and synthesize two-dimensional metal-organic networks with extremely weak intermolecular interactions, which facilitate delamination in nanosheets. The originality and the key to success in this approach is the use of ligands containing permethylated silicon units which by their natural exposure shield the structure and prevent the establishment of noticeable interactions. New ligands and combinations thereof will be prepared and used to coordinate various metal ions or clusters. Nanosheets formed will be evaluated as such, but also the effect of their incorporation in silicone matrices for the development of materials responsive to stimuli. Their common nature creates the premises for a better compatibility and forming advanced composites.

Mimicking living matter mechanisms by five-dimensional chemistry approaches Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0050 2018 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.intelcentru.ro/5D-nanoP/

Abstract:

Mimicking the living matter mechanism of cooperation by complementarity represents one of the most challenging tasks of supramolecular chemistry. For now the solution consists in using particularly designed molecular unimers, endowed with the necessary amount of chemical information.

The 5D-nanoP project is dedicated to interfacing the fundamental research area of constitutional dynamic chemistry with the practical approaches of medicinal chemistry and biomedical applications. In the spirit of a metaphor of Jean-Marie Lehn (Nobel Prize in Chemistry, 1987), the project aims to materialize the concept of 5D chemistry in designing, synthesizing, characterizing, and using molecules with conditional affinity, to build versatile supramolecular nanoplatforms able to vectorize compounds of pharmaceutical or biochemical relevance, and genetic actuators, all of them involved in physiologic and pathologic processes at cell- and tissue-level.

The project will add the layer of 5D chemistry over the backgrounds of molecular assembling line techniques to produce particulate nanoplatforms, self-assemblable in the virtue of the chemical information stored by the designed unimer molecules. Two modern techniques of building dynamic chemical structures will be considered: (i) the use of self-immolative linkers, and (ii) the space stepwise and time phased (microfluidic) assisted synthesis. To prove the applicability of the produced nanoplatforms, an ex vivo cell cultivation system will be developed to emulate tissue/tumor niches.

Eight teams will be involved in the 5D-nanoP project to cover the main addressed research areas: (i) the in silico molecular design, (ii) the development of a unimers chemical library, (iii) the development of a molecular assembling line, (iv) the conjugation of the developed platforms with chemical species of biomedical interest, (v) the build of ex vivo emulating niches, and (vi) the bio-oriented assessment of nanoconstructs efficacy.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects