BrainMap

Mrs. Camelia-Paula Stefanache

Scientific Researcher IIIrd Degree, PhD

Researcher - INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT

Researcher

Web of Science ResearcherID: B-7059-2019

Curriculum Vitae (22/09/2021)

Expertise & keywords

Hybrid bio-systems enriched with biotechnological extracted oils and applicability in skin tissue engineering Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2229 2022 - 2024

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation:

Project website: https://hytechskin.wordpress.com/

Abstract:

Infections are a common problem associated with dermal wounds, contributing to tissue degeneration and, in extreme cases, leading to death. In this context, hydrogels with antimicrobial activity become indispensable for covering the surfaces of implants or for direct treatment of wounds to prevent or even inhibit existing infections. The main goal of the project is the development of a new strategy for the preparation of a hybrid gel biostructure based on a natural / synthetic polymer matrix enriched with active antibacterial ingredients extracted from aromatic plants. The new gels will be the main component of a new patch improved with antibacterial compounds obtained from bio-extracts. The project will bring clear results in the field of biotechnology supporting the use of new components with therapeutic activity extracted from plants.

DEVELOPMENT OF INSTRUMENTS AND STRATEGIES FOR HIGHER VALORIZATION OF NATURAL RESOURCES FOR IMPROVING THEIR SUSTAINABLE EXPLOITATION IN BIO-INDUSTRIES AND CONSERVATION OF ECOSYSTEM FUNCTIONS Call name:
PN-III-1927 2019 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Project website: http://www.incdsb.ro/en/proiecte/proiect-nucleu/

Abstract:

Obiectiv 1: CARACTERIZAREA SUBSTANTELOR SI PROCESELOR DE BAZA ALE SISTEMELOR BIOLOGICE SI A INTERELATIILOR LA NIVEL MOLECULAR SI/SAU CELULAR SI VALORIFICARII ACESTORA

19270101: Solutii integrate-versatile pentru concentrarea, caracterizarea si valorificarea fitocompusilor proveniti din (bio)resurse autohtone cu asigurarea principiilor dezvoltarii durabile (acronim BIO-AUP):

Extractia, caracterizarea si valorificarea unor fitoproduse cu valoare farmaceutica si cosmetica din clasa saponinelor prin procedee inovative.

Sistem bioanalitic multiparametru pentru determinarea compusilor cu structura fenolica cu activitate antioxidanta/antiinflamatorie si discriminarea celor cu activitate estrogenica/ antiestrogenica.

19270102: Tehnologii avansate de obtinere a unor noi biomateriale polimerice 3D pentru regenerarea tisulara, prin valorificarea subproduselor de origine animala si vegetala (acronim 3D-BIOMAT):

Obtinerea si caracterizarea fizico-chimica si biologica a unor biomateriale compozite si selectarea variantelor optime biomimetice matricei extracelulare dermice.

Caracterizarea biologica in vitro a biomaterialelor polimerice compozite prin teste pe celule specifice tesutului dermic.

19270103: Impactul schimbarilor climatice asupra microorganismelor si asupra organismului uman – Delta Dunarii in corelatie cu medii extreme: abordari practice si teoretice (ISC-MUD):

Analiza culturilor de microorganisme din habitatele studiate; analiza seturilor de probe de sânge prin citometrie în flux; studiul algoritmic al evoluţiei genomului ȋn relaţie cu aspecte cu diferite masuri.

Plant-derived products with putative use in onychomycosis: combinatorial and nano-based strategies Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1894 2020 - 2022

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO)

Project website: https://plantsynan.grant.umfiasi.ro/

Abstract:

Onychomycosis are fungal infections of the finger or toenails, mainly caused by fungi of genera Trichophyton, with T. rubrum being the main etiological agent in 60-70 % of the cases. Onychomycosis is among the most common nail disorders in adults, accounting for 15–40% of all nail diseases and the incidence increases for elderly patients and those with comorbid medical conditions. Onychomycosis is often intractable, and relapses occur frequently after cessation of the antifungal therapy due to poor adherence to long-term treatment regimens and to development of antifungal resistance mechanisms. Current available therapies consist of oral and topical allylamines, azoles, benzoxaboroles, ciclopirox, and amorolfine. Among them, terbinafine is a synthetic allylamine derivative that is widely used, both orally and topically. However, oral use of terbinafine is hampered by several side effects such as gastrointestinal complaints, headache, hepatotoxicity, and cutaneous allergic reactions (rash and itching). Nail solutions and sprays with terbinafine have been also investigated as topical agents in onychomycosis, but showed poor nail penetration and low efficacy. The project aims at identifying natural products which could improve the antidermatophytic activity of terbinafine when administered in combination, with putative use in the treatment of onychomycosis. Combinatory effects of terbinafine and essential oils of selected spices (cumin, clove, cinnamon, laurel, black pepper and their main constituents: carvone, eugenole, cinnamaldehyde, β-pinene, limonene) on viability of Tricophyton rubrum (standard strains and clinical isolates) will be assessed. Putative synergistic antifungal effects will be determined; further, enhancement of terbinafine as topical antifungal will be done by development of nanoformulations which include its synergistic combinations (either with essential oils or their main constituents) with potential use in topical therapy of onychomycosis.

Advanced and emergent technologies to obtain vegetal extracts used in innovator food supplements Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1604 2017 - 2018

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://tevisped.webs.com

Abstract:

This proposal, having as an aim to obtain innovator formulas of food supplements with an action to sustain the hepatic function, will capitalize two autochthonous medicinal species (Scirpoides holoschoenus and Helichrysum arenarium), the first used in traditional medicine, the second in modern medicine (in some European countries, highlighted by EMA). For the first species, we aim the experimental field cultivation to preserve the biodiversity and to assure the vegetal raw material, by multiplication techniques and the establishing of technological parameters. The plants from culture and wild flora will be phytochemically evaluated. Both vegetal species will be capitalized in an innovator mood so that there will be achieved comparative studies for extraction using classical (static and dynamic) and non-conventional (SPE, ultrasounds, supercritical fluids etc.) methods. The best method will be selected. The extracts will be phytochemically characterized (TLC, HPTLC, densitometry, HPLC, GC-MS, UV/VIS spectrophotometry, etc.), and tested biologically (to demonstrate the action of sustaining the hepatic function) and phytobiologically (cytogenicity, cytotoxicity). The compounds with the action of sustaining hepatic function, are easily to be assimilated and non-toxic and contribute to the good functioning of the organism. Finally, an extraction technique will be elaborated (laboratory stage), for obtaining selective plant extracts with a rich content in bioactive compounds of interest and some original bio-complexes of plant extracts will be obtained as vectors for new food supplements. Innovator conditioning formulas (encapsulation) will be realized (laboratory stage), based on plant extracts obtained in experimental test conditions, establishing testing methods for qualitative and quantitative evaluation. This form of conditioning has the advantage of a good and easy administration of the dose pre-established by bio-components, with the protecting of the phytocomplex.

Capitalization of the natural potential of several medicinal and aromatic species in the Artemisia genus with economic and ecological value in Moldova Call name:
No. IZ73Z0_152265 2014 - 2017

Role in this project: Partner team leader

Coordinating institution: Mediplant, Swiss Research Institute for Aromatic and Medicinal Plants

Project partners: Mediplant, Swiss Research Institute for Aromatic and Medicinal Plants (); Botanical Garden (Institute) of ASM (); INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT ()

Affiliation: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT ()

Project website:

Abstract:

Development of a functional model for sustainable capitalization of genetic and phytochemical diversity of Arnica montana L. wild populations in the Northern area of the Romanian Eastern Carpathians Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0791 2014 - 2017

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); UNIVERSITATEA "ŞTEFAN CEL MARE" DIN SUCEAVA (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://ccb-stejarul.ro/2014/ARMOREC.html

Abstract:

The ARMOREC project has as the general aim the optimizing the capitalization of the Arnica montana L. natural populations from the north of the Eastern Carpathians by developing a new innovative model for the sustainable production of raw material (collecting, cultivation, conditioning) and of some eco-efficient processing methods of the vegetal material.

In this respect, it is necessary to develop inter- and transdisciplinary studies in the fields of biology, ecology, geomorphology, biotechnology and phytochemistry, grouped in 3 major components: the environment componen with connex aspects, the phytochemical and economical component – the capitalization by the industrial partner (SME).

The members of the concortium, by their expertise and experience in the project domain has the competences necesary to the development of the researches with a high degree of complexity and interdisciplinarity.

To attain the general objective of the project, we will process a series of activities grouped in 5 work packages corresponding the specific objectives:

1. Evaluating the bioproductive potential in the natural populations of A. montana from the north of thr Eastern Carpathians, on the basis of the quantitative and qualitative determinations onthe biomass yield, as well as the content of biologically active principles.

2. Evaluating the preservation status of the A. montana species in the target area, correlated to the main pressure factots.

3. Elaboration of a model of developing a coplimentary source of raw material by conventional and biotechnological methods.

4. The development of some eco-efficient methods of extraction and phytochemical anaysis for the main biologically avtive compounds – sequiterpen-lactons, flavonoids and phenolic acids, essential oil.

5. The development of an experimental model for the sustainable capitalization of A. montana (natural populations and experimenta cultures) by obtaining and characvterizing the specific phytocomplexes with multiple uses.

The originality of the project resides both in selecting the study and analysis methods and in the holistic approach of the problem that aim the whole capiatlizing chain of the principles of sustainable growth. It is the first time when an interdisciplinary approached is proposed to model the effect of the abiotic fators on the distribution of A.montana on the basis of a spacial analysis model.

Reaching the aims will promote the sustainable capitalization of the species in the north of the Eastern Carpathians, that will have complex , interdisciplinary stadie at the basis (with economic and scientific importance) and will generate added value over the whole chain of capitalization and will also assure the biodiversity conservation.

Although for A. montana he interst kept itsel at a high international level, in România, the species is slightly capitalized, both economically and scientifically. Thus, thorough studies are scrace, integrated in the present state of the species in the natural populations, in the preservation and capitalizing and promoting of autochthonous products. The majority of the studies achieved in Romania refer to the Apuseni Mountains, in the Eastern Carpathians, the species being only mentioned in some floristic studies.

By developing this project, we aim the sustainable capitalization of the species at local and regional level, in relation to the peculiarities of the species, and of its status as a rare and vulnerable species and the demands of the market.

Approaching a species that has already for long been studied worldwide, represents a reason to elaborate a capitalization plan of the species, this being in the same time a very good model to capitalize other medicinal, aromatic and food species of the mountain zone. In the time, this model of sustainable capitalization may be adapted and extrapolated to all the Romanian areals of this species.

Evaluation and characterisation of genetic resources of Lamiaceae species with antiinflamatory properties, for in situ and ex situ conservation Call name:
PNCDI-II-694-2013 2013 - 2015

Role in this project: Key expert

Coordinating institution: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT

Project partners: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT (); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI ()

Affiliation: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT ()

Project website:

Abstract:

Analysis of the intraspecific genetic polymorphism for the elaboration of molecular markers of chemotypes of medicinal and aromatic plants Call name:
PN-II-695/24.04.2013 2013 - 2014

Role in this project: Key expert

Coordinating institution: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT

Project partners: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT (); Universitatea Academiei de Ştiinţe a Moldovei ()

Affiliation: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT ()

Project website:

Abstract:

Technological transfer and assistance for the implementation of micropropagation technology on selected bioforms of lavender Call name:
PN-II-IN-CI-2012-1-0251 2012 - 2013

Role in this project: Key expert

Coordinating institution: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT

Project partners: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT (); SNAILBOX SRL ()

Affiliation: INCDSB BUCURESTI SUCURSALA CENTRUL DE CERCETARI BIOLOGICE '' STEJARUL'' PIATRA NEAMT ()

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader	Download (70.14 kb) 08/01/2019
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects	Download (31.98 kb) 27/10/2017