BrainMap

Mr. Claudiu Filip

Dr

General Director - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Curriculum Vitae (08/04/2016)

Expertise & keywords

National Platform for Semiconductor Technologies Call name:
PCIDIF/123/PCIDIF_P1/OP1/RSO1.1/PCIDIF_A2/304244 2024 - 2029

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (); BEIA CERCETARE S.R.L. ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD ()

Project website:

Abstract:

The National Platform for Semiconductor Technologies (PNTS) represents the materialization of an initiative to support and strengthen Romania's capacity in the strategic field of semiconductor technologies, respectively microelectronics. This field - recognized worldwide as an essential engine for the development of advanced technologies and the successful implementation of EU industrial policies - represents at the same time a key element in supporting the digitization and green transition processes. From the analysis of the current state of this field in Romania, we have identified the following needs:

• The development of state-of-the-art pilot lines and the necessary experimental capabilities to ensure adequate technological coverage of the semiconductor value chain (LVS) at the level required for the development of innovative processes and products, with relevance for the real economy. • Bringing the results obtained in CDI to a level of technological maturity appropriate to ensure both the efficiency of technological transfer and the continuity of collaboration with relevant partners in the high-tech industry. • Support and sustainable development of the national high-tech industry by ensuring easy access to experimental and prototyping capabilities, with direct support from specialists in the field. • Ensuring a solid foundation for reaching a sustainable critical mass in the future - capabilities, expertise, qualified personnel - in the field of semiconductor technologies.

• Increasing the attractiveness of the ecosystem for future investments (public, private) and international collaborations. In the last 20 years, public R&D organizations - research institutes and universities - have benefited from important funding from public funds, obtained competitively (national calls for projects and/or structural funding actions) which led including to the development of high-tech infrastructure. The major impact of these funding schemes has been the continued increase in international visibility and collaborative successes, enabling expanded participation in European and international research programmes. The development was, however, limited in terms of achieving a sufficiently high TRL of the results to allow their transfer to industrial partners in the high-tech area. This situation affected the process of collaboration with the industry and, in general, the credibility of the work carried out. According to the National Strategy for Research, Innovation and Specialization (SNCSI 2022-2027), there are two main limiting factors: (i) the fragmented landscape of advanced research and innovation infrastructures (reduced and niche capacities, uneven access conditions); (ii) the low levels of visibility and credibility of this type of technological ecosystem vis-à-vis the business sector (resulting in recurrent reluctance to fully and effectively use these available resources). Therefore, Romania needs to invest in high-tech in a consolidated manner, along the entire value chain, taking into account - and building on - the existing advanced infrastructures and the expertise accumulated in a number of judiciously selected organizations. To become beneficial, such an investment must aim at pooling the most advanced national resources in the field of the project, with the main focus on human resources/know-how, and the quality and operational status of logistics resources.

Bio-inspired interfaces for the development of next generation degradable multi-phase materials Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-M-ERANET-3-InsBIOration 2022 - 2024

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); Leibniz Institut für Polymerforschung Dresden e.V. (DE); CNRS Institut Charles Sadron (FR); National Institute of Chemistry (SI); University of Turku (FI); Kunststofftechnik Bernt GmbH (DE)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/insbioration/

Abstract:

Societal needs demand substitution of processes with high energy consumption or using hazardous substances and reduction of waste by use of fully recyclable or biodegradable materials. The project addresses this by proposing a universal platform for bio-inspired surface and interface design basing on dopamine, a substructure of adhesive mussel proteins. A multidisciplinary consortium of researchers and industry aims at developing a portfolio of upscalable technologies for the “green” manufacturing of materials for selected applications (antipathogenic coatings, biodegradable energy sources and polymer-metal hybrids as examples for a broad application range) and their recycling or biodegradation and transferring them to mass production. The project outcome will enable European manufacturers to create sustainable production processes and a circular economy of the materials.

Unveiling the mystery behind the strong polydopamine adhesion: an original approach by introducing local isotopic markers Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1463 2021 - 2023

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/izopda/

Abstract:

Polydopamine (PDA) was discovered in 2007 as a biomimetic solution for the underwater strong adhesion of mussels. Since then, the interest in using PDA as an intermediate layer for developing functional surfaces has grown exponentially, due to many favorable properties: simple deposition process, strong adhesion to virtually any substrate, biocompatibility, and chemical reactivity. Despite the growing number of PDA applications, the exact mechanism by which it adheres so strongly to virtually any substrate is a fundamental challenge remained unsolved in the field. Conventional analytical techniques, including solid-state NMR applied on natural abundance samples, can give only global information, with no selectivity to the interactions between substrate and PDA molecular sites. In this context, the solution we propose here is to introduce local markers in PDA that can “report” about their interaction with the atoms at the substrate’s surface. The idea is implemented by 2H/13C/15N isotopic labeling of each distinct chemical site in dopamine monomer (selective labeling): the selectively labelled monomers will be used to synthesize multiple PDA@substrate samples, of which investigation by ss-NMR will give information with atomic resolution. The proposed scheme is original, representing the first proposed experimental approach that can address the problem of PDA adhesion at the atomic level in a realistic way, thus going well beyond the current state of the art in the field.

Increasing technological and knowledge transfer capacity of INCDTIM Cluj in the field of bioeconomics Call name:
POC 18/2016 2016 - 2021

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/poc/ttc/

Abstract:

Increasing institutional capacity of INCDTIM' Call name:
PNIII-PDI-PFE 2018 - 2020

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website: https://www.itim-cj.ro/PNCDI/cresc-itim/index.htm

Abstract:

Open School for Academic Self-Improvement. Research, Academic Writing and Career Management Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0682 2012 - 2016

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.econ.ubbcluj.ro/~rodica.lung/openres

Abstract:

Research management, research career development and academic writing have become in later days prerequisites for successful academic track records and/or research careers. Formal and informal support programs are already in place in many of the top universities worldwide. Nevertheless, in Romania, such an approach has not been yet prospected and tested. The project proposes to build and expand the research capacity at both undergraduate and graduate level, helping students and researchers not only to improve their research skills but also their capacity to manage and communicate research (through research management, career management and academic writing).An interdisciplinary group will be created at the end of the project implementation, which will have a comprehensive set of tested instruments, competencies and the necessary know-how for carrying out a Complex Research Competencies training program. Once developed and tested the open training program may become a cornerstone in the future academic and research career development of researchers, weather at the beginning of their career or more advanced ones. While keeping the open school concept, the project team will promote and propose that the program becomes a permanent offer for the academic community and to be included as a transversal skills development program for the various faculties within the Babes-Bolyai University. The partner in the project, INCDTIM Cluj, will continue to provide expertise in the hard sciences component of the program. If such decision is reached, the CRC training program will contribute to the creation, development and further advancement of the Romanian academic community, especially those at the beginning of their research career. This will create, on a long run, a pool of better prepared and trained candidates for research positions within the structures of the two partners.

Rational design and generation of synthetic, short antimicrobial peptides. Linking structure to function Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0595 2012 - 2016

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI

Project partners: UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.science.research.uaic.ro/biopep/

Abstract:

Antimicrobial peptides (AMPs) are an integral part of the immune system and protect a host from invading pathogenic bacteria. To overcome the problem of antimicrobial resistance, AMPs are being considered as potential alternatives for antibiotics. Although over 1000 AMPs have been isolated and characterized from various hosts, only limited successes have so far been achieved in clinical trials. The major hurdles for converting them into drugs lie in the high cost of production, toxicity to host cells, and susceptibility to proteolytic degradation. Therefore, a better understanding of the structure–activity relationships of AMPs is required to facilitate the design of novel antimicrobial agents. Herein we plan to focus our effort on designing and optimizing novel short, cationic amphiphilic peptides. We will undertake rational design, synthesis, and extensive testing of a series of short cationic peptides, we envision proteolityc and salt resistant. They will be made of a limited set of L- and D-aminoacids based on an elementary amphipathic templates of up to to 11 aminoacids, searching for the minimum number of aminoacids and optimal architecture able to confer the peptide optimal lytic activity and specificity against various pathogens. In order to enhance antimicrobial activity with no additional hemolytic activity, peptide synthesis will be considered by using non-natural amino acid analogs that will substitute hydrophobic residues leucine, isoleucine and phenylalanine. This group of peptides will be designed and synthesized with shorter sequence and simpler molecular structure and could be easily modified upon a particular requirement. The structural simplicity also offer technological advantages for mass production and purification.

Modern approaches for solid forms screening of active pharmaceutical ingredients and structural characterization on powders Call name: Postdoctoral Research Projects - PD-2011 call
PN-II-RU-PD-2011-3-0021 2011 - 2013

Role in this project: Project coordinator

Coordinating institution: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare Cluj-Napoca

Project partners: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare Cluj-Napoca (RO)

Affiliation: Institutul National de Cercetare Dezvoltare pentru Tehnologii Izotopice si Moleculare Cluj-Napoca (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru53/

Abstract:

Through the present project we propose the obtaining by parallel crystallization methods of new solid forms (polymorphs, solvates/hydrates, salts) of Acyclovir, Ciprofloxacin, and Efavirenz pharmaceutical compounds, their identification and structural characterization by adequate combination of modern analytical techniques – i.e. powder X-ray diffraction, solid-state NMR and molecular modeling. The systematic study of the solid state is essential for pharmaceutical compounds since the understanding of their crystallization general behavior provides important contributions in defining the structure-biological activity relationships, and also, allows the selection of those new solid forms with improved therapeutic properties. The estimated results are also important from a theoretical point of view, because they lead to: (i) improvement of the general methodology of searching new solid forms, and (ii) characterization of the crystal packing modes and the responsible intra- and intermolecular interactions. The project novelty degree consists of: (i) implementation of parallel crystallization technology, which allows the parallel screening of hundreds crystallization conditions with the objective of rapid discovery of new solid forms, and (ii) development of alternative methods to identify the molecular and crystalline structure directly from powders by combining complementary techniques (X-ray powder diffraction, SS-NMR and molecular modelling).

Advanced ss-NMR methods for investigating structure and non-covalent interactions in supramolecular chemistry Call name:
PN-II-ID-PCE-2008-872 2009 - 2012

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website:

Abstract:

NEW TECHNIQUES IN SOLID STATE NUCLEAR MAGNETIC RESONANCE: METHODOLOGICAL DEVELOPMENTS AND APPLICATIONS Call name:
CEEX-05-1638 2005 - 2008

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website:

Abstract:

A new theoretical tool, called SD-CAS (Spin Dynamics Computer Algebra System), will be developed in the present project for analyzing spin dynamics in solid-state nuclear magnetic resonance (SS-NMR); its practical applicability will be effectively demonstrated in the process of SS-NMR methodological development – the main focus will be on spectroscopic applications aimed at investigating the structure and dynamics of complex biomolecular systems (polypeptides), but specific problems of spin dynamics in NMR emerging techniques like MRFM (Magnetic Resonance Force Microscopy), and NMR-QIP (Quantum Information Processing), will be treated as well. SD-CAS represents a novel approach to studying the dynamics of strongly dipolar coupled nuclear spins, which requires the implementation of the spin ½ algebra in a symbolic programming language, and it is designed in such a way that it removes major deficiencies of classical methods based on the average Hamiltonian theory, and pure numerical simulations. A systematic strategy will be employed for the SS-NMR methodological development process, where the intensive use of SD-CAS will result in a substantial reduction in the research duration and costs. This because the emphasis will be put on theoretical simulations, while the practical performances of the new methods will be experimentally demonstrated only at the end, on uniformly 13C and 15N labeled polypeptides. Using this strategy, new practical solutions for improving 1H-1H homonuclear decoupling, 1H-13C polarization (coherences) transfer, and selective multiple quantum (MQ) excitation techniques (which are key elements in SS-NMR applications on complex biomolecular systems). The SD-CAS applications in SS-NMR emerging techniques will be centered on elaborating models of spin dynamics for decoherence processes in NMR-QIP, and for the MRFM detection of the signals produced by strongly dipolar coupled nuclear spins. The project is multidisciplinary, and proposes novel solutions for a range of high-level applications in basic sciences: quantum mechanics (spin dynamics, quantum information processing, quantum measurement theory), symbolic programming, computational physics, and biochemistry. It will be executed within a consortium made of four R&D institutions, and will benefit from the direct cooperation with a prestigious SS-NMR center in Great Britain

Spin decoupling in solid-state Nuclear Magnetic Resonance spectroscopy. Methodological advances and applications in biotechnology Call name:
CERES 2003 - 2006

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website:

Abstract:

Multi-spin effects in high-resolution solid-state NMR spectroscopy. Applications to the spatial structural investigation on proteins. Call name:
GAR 19/2004 2004 - 2005

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website:

Abstract:

Novel approaches for studying spin dynamics in 1H solid-state NMR Call name:
International Incoming Short Visits - 2004/R6 (Royal Society) 2004 - 2004

Role in this project: Partner team leader

Coordinating institution: University of Warwick

Project partners: University of Warwick (); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M ()

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator	Download (199.37 kb) 08/09/2017
List of research grants as partner team leader	Download (199.37 kb) 22/08/2017
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects