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Romania
Citizenship:
Romania
Ph.D. degree award:
2011
Mrs.
Dana
Iancu
MD. PhD
Habilitat professor, Associate professor
-
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Other affiliations
General surgeon
-
INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR CLUJ-NAPOCA
(
Romania
)
Researcher | Teaching staff | Scientific reviewer
>20
years
Web of Science ResearcherID:
https://publons.com/researcher/3145758/dana-bartos/
Personal public profile link.
Expertise & keywords
Laparoscopic surgery
Oncologic surgery
HIPEC procedure
Hibrid approach of surgeries
Nano materials in medicine
Projects
Publications & Patents
Entrepreneurship
Reviewer section
European Network on Pseudomyxoma Peritonei
Call name:
COST CA17101
2018
-
2022
Role in this project:
Partner team leader
Coordinating institution:
Oslo University Hospital
Project partners:
Oslo University Hospital ()
Affiliation:
Oslo University Hospital ()
Project website:
https://www.cost.eu/actions/CA17101/#tabs|Name:management-committee
Abstract:
Pseudomyxoma peritonei (PMP) is a rare abdominal cancer originating in the appendix, causing extensive tumour growth in the peritoneal cavity. Although rare, PMP still dramatically affects the lives of almost 4,000 new persons in Europe every year, posing a huge financial and logistical challenge for health-care providers. If complete surgical removal cannot be accomplished at expert centres, prognosis is very poor, and no other effective treatments are currently available.
Because it is a rare disease, research into the pathogenesis, classification, molecular composition and treatment of PMP has been fragmented and challenging. The EuroPMP Action aims to sculpt a new, collaborative landscape within PMP research through the creation of a strong and capable network of experts from many fields, including surgeons, pathologists, oncologists, radiologists, molecular biologists, bioinformaticians and allied health care professionals. The Action will work towards a cure for PMP through the facilitation of collaborative research projects, the sharing and dissemination of knowledge, and the improvement of standards of care for the thousands of patients afflicted with PMP.
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Photothermal nanotherapeutics for selective eradication of Methicillin- resistant Staphylococcus aureus (MRSA) with biofunctionalized gold nanoparticles.
Call name:
Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1289
2012
-
2016
Role in this project:
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO); INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR CLUJ-NAPOCA (RO); ASOCIATIA AAMIRA APPLIED MATHEMATICS AND INFORMATICS IN RESEARCH AREA JUDETUL CLUJ (RO)
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)
Project website:
http://www.nmn.ro/nanostaft.htm
Abstract:
Antibiotic resistance is a growing and increasingly serious public health problem. Infectious diseases caused by MRSA and other bacteria are responsible for millions of deaths each year, and much of this mortality is due to the rise of antibiotic resistant organisms. MRSA has emerged as a major nosocomial pathogen in the last decade. Treatment for MRSA infections is difficult as vancomycin, the only responsive treatment, is partially effective, has considerable toxicity and it is poorly absorbed by body tissues Newer antibiotics may help to offset the onward march of MRSA resistance but new technologies for rapid detection of MRSA carriage and treatment are needed to help reduce the threat in the future. From a clinical perspective, attractive alternative approaches for treating such MRSA resistant strains would be using agents that cause physical damage to the bacteria.
The long term objective of this project is to develop new anti-infectives that are highly effective and refractory to antibiotic resistance exhibited by MRSA using specific antibodies conjugated to gold nanoparticles as NIR responsive photothermal contrast agents. Thus, we plan to obtain a very efficacious pulse laser mode treatment of individual MRSA agents with minimal effects on the surrounding cells, providing highly localized killing effects for the Ab-GnP targeted bacteria only. In addition, we intend to identify the optimal dose and schedule of administration of this selective nanophotothermal treatment that will cure people with MRSA infections without causing the emergence of resistance.
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Selective near-infrared plasmonic photothermal terapy (PPTT) of human liver cancer mediated by biofunctionalized gold nanoparticles.
Call name:
Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1551
2012
-
2016
Role in this project:
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR CLUJ-NAPOCA (RO)
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO)
Project website:
http://nmn.ro/nanoliv.htm
Abstract:
The general goal of this project is to develop a novel therapy for hepatocellular carcinoma (HCC) based on a combination of a treatment strategy that involves gold nanoparticles bound to antibodies and laser irradiation. The strategy involves selective tumor ablation obtained by irradiation of gold nanoparticles that will be targeted to the liver cancer cells by antibodies conjugated to them. Furthermore these nanobiosystems will be tested using in vitro, in vivo and ex vivobiological platforms.
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Nanomediated colon cancer prophylaxis in mice using a MUC-1-conjugated GoldNPs/ dendritic cells synergic vaccine.
Call name:
Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1586
2012
-
2016
Role in this project:
Coordinating institution:
INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR CLUJ-NAPOCA
Project partners:
INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR CLUJ-NAPOCA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE (U.M.F) Cluj-Napoca (RO); UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA (RO)
Affiliation:
INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR CLUJ-NAPOCA (RO)
Project website:
http://www.nmn.ro/vaccinan.htm
Abstract:
Colon cancer is a major cause of deaths worldwide, and it is expected to rise in the coming years. Importantly, in adults younger than 50 years, CC incidence rates have been increasing by about 1.6% per year since 1998 in men and women. Up to date therapeutic management in colon cancer treatment include surgical resection of the primary tumor, chemotherapeutic agents and radiotherapy. Despite advances in surgical techniques and adjuvant therapy, there has been only a limitted improvement in survival for patients who present advanced neoplasms.
In order to achieve a distinct colon cancer vaccine model, present project aims to develop a new method of immunization through combined administration of functionalized Gold NPs and dendritic stem cells suspensions. The key aim of the project would be to conjugate MUC1 antigen to Gold NPs in order to promote major histocompatibility complex mediated (MHC) antigen presentation by dendrite cells. We hypothesize that the moiety would then contribute to an optimal combined Gold NPs+dendrite cells colon cancer prophylaxy effect. As a result to VACCINAN project, CC patients will have the chance to benefit from improved survival by being offered innovative, improved treatment solutions to be further applied in the near future.
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Nanotherapeutics for the selective treatment of pancreatic cancer
Call name:
Exploratory Research Projects - PCE-2012 call
PN-II-ID-PCE-2012-4-0241
2013
-
2016
Role in this project:
Coordinating institution:
INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR
Project partners:
INSTITUTUL REGIONAL DE GASTROENTEROLOGIE - HEPATOLOGIE PROF. DR. OCTAVIAN FODOR (RO)
Affiliation:
Project website:
http://nmn.ro/nanocap.htm
Abstract:
Pancreatic cancer (PC) represents the fourth leading cause of cancer death worldwide.An exciting and new approach to PC treatment is represented by the targeted therapeutics systems.Recent developments in the field of plasmonics offer new opportunities for both primary and multimodal photothermal therapy strategies using nanoparticles.The general goal of this project is to develop a novel nanophotothermolysis system for pancreatic cancer based on a treatment strategy that involves biocompatible laser active nanoparticles bound to novel specific antibodies combined with laser irradiation. We propose an innovative approach for obtaining a high degree of selectivity on pancreatic cancer cells. Furthermore the developed nanobiosystems will be tested using in vitro, in vivo and ex vivo biological platforms.
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prevention of colo-rectal carcinoma through generation, testing and modulation of undifferentiated stem cells-based vaccines
Call name:
PN II Parteneriate, nr. 42111/01.10.2008
2008
-
2011
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (); UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA CLUJ-NAPOCA ()
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" ()
Project website:
Abstract:
Read more
Selective photothermal nanotherapy of hepatocarcinoma by intracellular internalization and laser activation mechanism of bio-ligand functionalizated carbon nanotube
Call name:
PNCDI II- 42-115
2008
-
2011
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" ()
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" ()
Project website:
http://ro.itim-cj.ro/cercetare/proiecte/pncdi-ii-parteneriate-in-domeniile-prioritare-competitia-2007/
Abstract:
Read more
Prophylaxis of colorectal cancer through the generation, testing and modulation of vaccines based on undifferentiated stem cells.
Call name:
2008
-
2011
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" ()
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" ()
Project website:
Abstract:
Read more
Molecular targeted therapy of pancreatic neoplasm by optic excitation laser resonance of chemically functionalized and cellular internalized carbon nanotubes
Call name:
PNCDI II 41-009
2007
-
2010
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"
Project partners:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" ()
Affiliation:
UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" ()
Project website:
https://www.itim-cj.ro/index.php?menu=2&submenu=361
Abstract:
Read more
FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.6813, O: 248]