BrainMap

Mrs. Erzsébet-Eleonóra Kapronczai

Assist. Prof. Dr. Eng.

- UNIVERSITATEA BABES BOLYAI

Researcher | Teaching staff

Web of Science ResearcherID: M-3422-2016

Expertise & keywords

Tailoring Organochalcogen (Se, Te) Based Compounds with Potential as Antitumor Agents. Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1028 2021 - 2023

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation:

Project website: http://www.chem.ubbcluj.ro/~ccsoom/organometallic/pce1028.html

Abstract:

The goal of this proposal is to obtain new organochalcogen compounds and metal complexes which can act as efficient antitumor and chemopriventive agents. Our objectives are: (i) to design organochalcogen derivatives of type R2E2, RR'E, R2E (E = Se,Te; R,R' = organic groups with donor atoms capable for intra- or intermolecular interactions) and their metal (Au,Ag,Zn,Sn,Bi) complexes, with potential as antioxidant, antitumor and chemopreventive agents, (ii) to study their solution behavior and solid state structure, (iii) to assay their antitumor activity against commercial tumor cell lines, (iv) to find an optimized strategy, based on experimental evidence and theoretical approach (DFT, QSAR) for highly active species with low toxicity, (v) to investigate the relation structure-antioxidant activity-antitumor properties for selected classes of compounds and (vi) to identify the interaction mechanism at cell level. The proposed organochalcogen compounds are flexible, potential tridentate systems, containing, besides Se or Te, other functionalities (pyrazole (pz), phenylthiazole (Phtz), amino, imino, COOH, OH) which share with the central chalcogen or the metal their donation ability and the own biological properties. The chosen ligands and their metal complexes are very attractive both for fundamental research and as promising active antitumor agents. The project combines research excellence and complementarity and is essentially based on inter- and multidisciplinary studies.

Development of efficient luminescent compounds based on imidazolone and chalcogen-related scaffolds with potential biological activity Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1342 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://www.chem.ubbcluj.ro/~ccsoom/organometallic/te1342.html?fbclid=IwAR1aBSSWuczzpu-IxG2yE1Giw18Xhz_2Gulxv-1ZeZnl3TxyE12wqe_vSEw

Abstract:

The aim of the present project proposal is the synthesis, structural characterization and investigation of the optical properties (luminescence) of some new 4-arylidene-5(4H)- imidazolones, -oxazolones, -thiazolones, -selenazolones and their late d metal complexes (Ru, Ir, Pd, Pt, Ag, Au). The biological (antioxidant and antibacterial) properties of selected new compounds will be also investigated.

Our studies envisage appropriate methods for controlling the molecular structure of the respective species and to promote a fine tuning of the metal-ligand interactions by changing the electronic environment about the chalcogen and/or the metal centre. We intend to find solutions for optimizing the conditions for a better molecular structure / biological activity relation.

All the new compounds will be investigated by spectroscopic methods: multinuclear NMR spectroscopy, electronic spectroscopy, mass spectrometry, single-crystal X-ray diffraction, IR, UV-VIS spectroscopy and luminescent measurements.

Functionalized hierachical structures on graphene exhibiting magnetic, adsorption and catalytic properties Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0088 2018 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: https://www.chimie.unibuc.ro/cercetare/anorganica/PN-III-P4-ID-PCCF-2016-0088/PCCF_M%20Andruh_2022.pdf

Abstract:

The present research proposal aims to develop a series of directions which are less or non-explored to date in the chemistry of graphene. Its objectives rely on the experience of the four participants in organic synthesis, organometallic chemistry, molecular magnetism and catalysis. The project will stimulate not only the enhancement of the value of previously synthesized compounds by the partners, but also the development of an original chemistry. The hierarchical organization of organometallic – classical transition metal complexes on graphene surface is a step forward in materials science. The design of 3-D frameworks incorporating graphene is original and opens interesting perspectives for applications. The grafting of magnetic and luminescent complexes on graphene could bring an important added value in molecular magnetism. The catalytic processes to be investigated are carefully selected, in order to address important problems in organic synthesis, environmental protection and energy. The project will focus on the following major objectives: (i) design of networks by covalent connections between the decorated graphene sheets; (ii) design of graphene-based hybrid materials with appropriate organometallic/metalloid units as ligands for transition metals; (iii) single molecule magnets and luminescent molecules grafted on graphene; (iv) functionalization of graphene with macrocycles, cryptands and rotaxanes for organocatalytic reactions; (v) development of multifunctional catalysts for controlled cascade reactions; (v) applications in catalysis (the valorization of the CO2 emissions; the hydrogenation of nitro-alkenes and mixtures of acetylene-ethylene; C-C and C-N coupling reactions) and gas sorption. A special attention in these studies will be addressed to the investigation of the catalytic mechanisms.

The improvement of the manufacturing technology of lead-acid batteries to be used for start-and-stop automobiles Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1226 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA BABES BOLYAI (RO); ROMBAT S.A. (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://www.itim-cj.ro/PNCDI/rombss/

Abstract:

We propose a methodology for the improvement of fabrication technology for the positive electrodes used as components in the lead-acid batteries produced at sc rombat sa . The final goal of our consortium is to improve the current technology used by industrial partner for fabrication of the batteries to be used for start-and-stop automobiles (i.e . To satisfy the j240 – sae and en 50342-6 quality tests) . The proposed approach is designed for the optimization of the scientific and technological steps involved in the fabrication of positive electrodes . It integrates the fundamental knowledge obtained from ab initio calculations, synthesis of new chemical compounds, fabrication of new alloys and structural characterization of the materials used to fabricate the electrode, at both nanoscopic and mesoscopic scale . The key element for the integration of all these activities is the fabrication and characterization of functional prototypes by the industrial partner.

The main problem to be solved is to control the corrosion of the positive electrode during the charge-discharge cycles, imposed by the requests of the start-and-stop technology . The solutions proposed by our consortium are: (i) fabrication of new alloys to be used for the production of the metallic grid that support for the active mass of the electrode (ii) improving the fabrication technology of the metallic grid (iii) improving the electrochemical properties of the active mass by new fabrication technology and by the use of new additives to the active mass. We note here that for the negative electrode as well as for the electrolyte the standard products fabricated by sc rombat sa will be used . The project’s goal will be achieved by using a feed-back loop: the design of materials and the fabrication steps involved by each prototype will be refined by successive fabrication of the prototypes that will gradually incorporate the information produced by each partner . At each step of our methodology the full characterization of the electrochemical and structural properties of the materials and prototypes already fabricated will be used as starting point for further refinement of the fabrication technology . A continuous exchange of data between the research Institutes and the industrial partner is foreseen for the whole duration of the project . This will allow us to tune the results obtained in the laboratory with those produced in industrial conditions . At project’s term we will discuss the technological steps needed for the implementation of the results by using the infrastructure available at sc rombat sa.

New complexes with metal-chalcogen bonds as potential precursors for electronic materials Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0659 2012 - 2016

Role in this project:

Coordinating institution: Universitatea Babes-Bolyai din Cluj-Napoca

Project partners: Universitatea Babes-Bolyai din Cluj-Napoca (RO)

Affiliation:

Project website: http://www.chem.ubbcluj.ro/~ccsoom/organometallic/id659.html

Abstract:

The proposed research project refers to some new classes of metal complexes which can act as precursors for new materials, either thin films or nanopowders. Thermal decomposition and CVD technics are envisaged. The main goal is to obtain new complexes with metal-chalcogen bonds, mainly with monomeric structure and good volatility, suitable as precursors for materials used in electronics. In order to avoid intermolecular associations, we decided to combine the stabilization effect of organic groups with pendant arms and donor atoms capable for intramolecular coordination in organochalcogen (Se, Te) ligands with the high flexibility of a new class of dichalcogenolato organophosphorus(V) ligands, i. e. [(EPR2)(O2SR)N]H. We will follow different synthesis routes, starting from metal halides. Taking in account their specific electronic, optical and magnetic properties,our interests are focused on several species containing d- or main group metals (Fe, Co, Ni, Cu, Ag, Zn, Cd, Sn, Sb), which can act as precursors either for nanopowders or thin films. Structural characterization of the new chemical species, both in solution and in solid state, will be performed by using different spectroscopic methods: multinuclear (1H, 13C, 31P, 77Se, 125Te), 2D and dynamic NMR, IR, RAMAN, mass spectrometry, single-crystal and powder X-ray diffraction, ESR for paramagnetic species. Thin films and nanopowders will be characterized by specific methods;SEM,TEM, EDS, EXAFS.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects