BrainMap

Mr. Florin Miculescu

Dr.Habil.Eng.Bsc.

Professor - UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI

Researcher | Teaching staff | Scientific reviewer | Manager | PhD supervisor

Florin Miculescu is Full Professor at the Materials Science and Engineering Faculty from University Politehnica of Bucharest, Romania. He leads a research group working on advanced methods for materials, biomaterials and nanomaterials obtaining, processing and characterization and he coordinates two research laboratories. He has participated in five postdoctoral stages in Europe and USA and applied his expertise in various research projects related to materials science, engineering and technology. His research activities are presented in few papers indexed in Web of Science Clarivate Analytics, books and book chapters, edited books and patents. He is an Editorial Board Member and Guest Editor of some WOS indexed journals. He is the President of the Materials Engineering and Science Committee from CNATDCU. He received more than 100 awards for his contribution in science (for published papers, presentations and patents).

Web of Science ResearcherID: A-4524 -2011

Curriculum Vitae (04/10/2023)

Expertise & keywords

Novel technology for implants manufacturing from 3D printable reinforced composite filaments for guided bone regeneration Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1650 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: http://www.florinmiculescu.ro/bonegapfill/

Abstract:

Compared to the limited market of products destined for bone reconstructive surgery and the high-patient-risks of current approaches, this project is a necessity to solve the absence of 3D products with optimal geometry, internal architecture and mechanical properties for customized compatibility with natural bone and a rapid repair of defects with variable dimensions. The overall goal of the project is to develop and promote a new reproducible and sustainable manufacturing technology for the products fabrication by 3D printing, using as platform the previously implemented technology for the synthesis of hydroxyapatite derived from bovine bone biogenic resources and the project team`s experience in the field. Composite filaments with printable features will be obtained based on natural hydroxyapatite and two polymers, one of which will be of natural origin. Also, superior and adaptable mechanical characteristics will be ensured by reinforcing the ceramic matrix with multi-layer graphene-based materials. Further, the filaments will be used for 3D printing of products with regular and random internal architecture (based on a new STL file developed within the project). Afterwards, the products will be tested as to evaluate their performance as potential bone replacements. In this regard, a patent application will be filed. The proposed topic is new and challenging for the project team, but all the premises are fulfilled through the team`s synergy and previous research experience. The concept and experimental testing of the possibility of embedding naturally derived ceramic particles into a polymer matrix of natural origin were also demonstrated and reported by the team members as viable for achieving the project objectives.

Hemodialysis combined with stimuli responsive drug delivery - a new generation of polymeric membranes for advanced biomedical applications Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1154 2021 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: https://hemdelstim.wixsite.com/hemdelstim/research

Abstract:

The HemDelStim project sets as its main scientific goal the development of a new approach and a new scientific direction for the treatment of patients with chronic kidney dysfunction and liver cancer. Unlike the therapeutic approach so far, which involves performing hemodialysis (to replace kidney function) in parallel with chemotherapy, the project aims to combine these two processes, in an intelligent way, with a minimal impact on the body. The drug used to treat liver cancer – doxorubicin, will be encapsulated in supramolecular or polymeric architectures, the release being made strictly on the basis of a stimulus - alpha-fetoprotein, the tumor marker for this type of cancer. For this intelligent release, the concept of “stimuli responsive drug delivery” will be used. The supramolecular or polymeric architectures containing doxorubicin will also include a monoclonal antibody for alpha-fetoprotein. The presence of alpha-fetoprotein in the blood subjected to dialysis will cause the encapsulation to break down and release doxorubicin in a controlled manner. The supramolecular or polymeric architectures containing alpha-fetoprotein monoclonal antibody on the surface and encapsulated doxorubicin will be immobilized on polysulfone hemodialysis membranes (membranes containing anticoagulants on the surface). The combination of these two therapeutic procedures, hemodialysis and stimuli responsive drug delivery, is the main novelty of the project.

Meta-structures made by composite coatings on biodegradable Mg-Ca implants for bone regeneration Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2591 2021 - 2023

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: http://www.smmmf.pub.ro/magicbone/

Abstract:

Main objective of the project is the development of one composite coatings with polymer-based (cellulose acetate, collagen, polylactic acid or chitosan) reinforced with Mg and Mg-substituted hydroxyapatite particles, for biodegradable implants made by Mg-Ca alloy, followed by in vitro cell based tests for evaluating biocompatibility and osseointegration activity. Obtained coated implants will be characterized not just from structural and morphological point of view, but also for mechanical properties and surface properties. Several specific tests for evaluation of the osseointegration will be performed, like study of coating hydrolysis at physiological pH, degradation compounds, flows and proteins retention. After the chosen of best coating material for osseointegration, a commission constituted by independent experts will validate the proposed experimental model. The project objectives are totally feasible, due to the previous experience and results obtained by the project leader and his research team, as well as the equipment available for synthesis, characterization and testing. The project results will be innovative and relevant in relation to the national and international state of the art because the final composite coatings is a new solution from materials point of view, and new coated biodegradable implant will have a better osseointegration, controlled biodegradability and proper mechanical properties during degradation process, like a magic bone (MAGICBONE).

Synthesis, Characterization and Testing of Hydrogen Permeation Barriers (HPBs) applied as a safety measure for future fusion reactors Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2019-0745 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://scthpb.inflpr.ro/

Abstract:

The fusion reactors are proposed as green solution for producing large amounts of energy with a minimal environmental impact. Tritium inventory is the most major issue that the research community has to resolve in order to guarantee the environmentally and economically acceptable operation of a fusion power plant. The tritium inventory can lead to major consequences, starting from the hydrogen isotope accumulation in the plasma facing components. This could slowly determine hydrogen embrittlement, permeation through the entire facility, environmental emissions and worker dose. Most of the candidate materials that will be integrated in future fusion reactors (ITER, DEMO) are metals that have a relatively high permeability for the hydrogen isotopes.

Hydrogen permeation barriers (HPB) are currently considered a valid solution for controlling the tritium inventory in the fusion reactors. HPB layers have to fulfill various physical and mechanical properties as lowering the tritium retention, permeation and increasing the thermal conductivity for heat displacement.

The SCTHPB project will follow the application of plasma-based synthetization techniques that where not previously applied for HPB layer synthesis. The proposed methods are the Thermoionic Vacuum Arc (TVA), the Combined Magnetron Scattering with Ion Implantation (CMSII) and the Atmospheric-Pressure (AP) Plasma Jet methods. Different multilayer configurations based on metallic layers, oxides and Metal reinforced Matrix Composites (MMC) will be synthesized in order to develop HPB layers with an improved permeation property. A complex characterization of the synthesized HPB will be achieved in relation to the structure, morphology, purity, composition and layer adhesion to the substrate interface. Also, correlations between the thermal conductivity, thermal stress and permeation yield in relation to the internal structure of the deposited HPB candidates will be conducted.

Advanced biodegradable materials based on MgB2 resistant to microbial colonization Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-M-ERA.NET II-BIOMB 2017 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://infim.ro/project/biomb/

Abstract:

The innovation of this project consists in the evaluation for the first time of the MgB2 potential for biomedical applications, although it is currently produced for superconductivity devices. Expectations are to generate new MgB2-based composite multifunctional biomaterials with antimicrobial/antifouling properties, and an increased biocompatibility at interfaces between the material and the biological media.

The MgB2 powders, coatings and bulks could be used in biodegradable implants or drug delivery systems, handles and surgical tools, catheters, wound dressings and so on. The mechanical and physico-chemical properties of the proposed materials will be investigated by a comprehensive approach, and bioevaluation will include in vitro and in vivo assays. The MgB2 materials are viewed as solutions for space and time- scale controlled variation of the functional properties required for different bio-applications.

OBTAINING AND EXPERTISE OF NEW BIOCOMPATIBLE MATERIALS FOR MEDICAL APPLICATIONS Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0239 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); UNIVERSITATEA PENTRU STIINŢELE VIEŢII "ION IONESCU DE LA BRAD" DIN IAŞI (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ”GEORGE EMIL PALADE” DIN TARGU MURES (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU FIZICA TEHNICA-IFT IASI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.medicalmetmat.tuiasi.ro/

Abstract:

The Complex Project "OBTAINING AND EXPERTISE OF NEW BIOCOMPATIBLE MATERIALS FOR MEDICAL APPLICATIONS" - MedicalMetMat, is proposed by a consortium of 10 partners, coordinated by Technical Univ."Gh. Asachi" of Iasi. It is a complementary and interdisciplinary scientific consortium of specialists from 2 technical universities (TUIASI and UPBucharest), 2 medicine universities (UMF Iasi, UMF Tg Mures), a veterinary medicine university (USAMV Iaşi), UAIC Iasi and UDJG Galati universities and as well 3 R&D institutes with possibilities for economic recovery (IFT Iasi, INOE Magurele and ICPE-CA). The consortium proposes the realization of 5 research projects, 4 focusing on the production and expertise of metallic biomaterials for various medical applications (biodegradable materials for orthopedics-Pr1-ORTOMAG, biomaterials for medical prosthesis-Pr2-BioTIT, biomaterials for dental applications-Pr3-BIODENTRUT and biocompatible alloys with high entropy for medical applications-Pr4-HEAMED). These projects provided production stages, structural/physico-chemical/mechanical analyses performed by specialists from technical universities and research institutes; In vitro cell viability tests, conducted by specialists from the medicine universities and in vivo determinations (veterinary specialists) by osseointegration study and the resorption rate by animal experimental model, which will conduct to the expertise and approval of these metallic materials for the manufacturing of medical applications. Project Pr5-SOLION presents methods for increasing biocompatibility for the obtained biomaterials in the previous 4 projects, through specific coatings and aerosols systems.

Results dissemination of the Complex Project is aimed to patenting and recommending for the approval of optimal compositions, for implementation in the economic/medical environment and preparation of technology transfer to producers and beneficiaries in the field of production and distribution of medical devices.

SOL-2020-2 5. The development of innovative decontamination solutions against SARS-CoV-2 virus (surfaces, equipments, close and open spaces) Call name: P 2 - SP 2.1 - Soluţii - 2020 - 2
PN-III-P2-2.1-SOL-2020-2-0399 2020 - 2020

Role in this project:

Coordinating institution: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie

Project partners: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNITATEA MILITARA 02433 BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); SPITALUL UNIVERSITAR DE URGENTA BUCURESTI (RO); STIMPEX S.A. (RO)

Affiliation:

Project website: https://www.nbce.ro/?page_id=895

Abstract:

The project's scope consist in the development of an innovative decontamination solution, with antimicrobial and antiviruses effects, using a mixture of quaternary ammonium salts and gold or silver nanoparticles as active compounds, and also the development of a complex system for solution dispersion.

Composite scaffolds with biological functions for bone tissue engineering Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-China (bilaterale)
PN-III-P3-3.1-PM-RO-CN-2018-0201 2018 - 2019

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); National Engineering Research Center for Biomaterials (CN)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.biobone.srb.ro

Abstract:

BIOBONE aims the development of bioinspired and bioresorbable scaffolds, composed by biodegradable magnesium alloys as substrate combined with bioceramic coating granted biological functions, as building blocks for the production of advanced scaffolds towards bone regeneration, promoting innovation in health sector, mainly on orthopaedic therapies. It is pretended to establish a sustainable and eco-friendly raw materials pipeline, including the production of a novel biological scaffolds, which specific formulations mimics bone tissue composition. Advanced biomaterials and technologies will be further used to develop functional scaffolds, based in real clinical cases, recapitulating the complexity of bone structures obtained through a reverse engineering approach. A simple and standardized procedure from acquisition of imaging data to the production of patient case-specific biomaterials by 3D printing will be established, with potential to be successfully translated into clinics.

New technology for the synthesis and manufacturing of biomimetic implants derived from biogenic resources used for bone reconstruction surgery Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0892 2017 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.florinmiculescu.ro/bioimms/

Abstract:

The overall goal of this project is to develop and implement a new complex and reproducible synthesis technology of biomimetic ceramic materials (hydroxyapatite and tricalcium phosphate, in different proportions) derived from marble and seashell precursors and their performance assessment as potential bone substitutes in restorative and reconstructive surgery. This project proposes the synthesis of a mineral phase presenting mechanical properties at least similar to those found at bone structural arrangement level. Once the biomechanical requirements are met, the biomimetic products will be tested through in vitro standardized methods to assess their biological performance. The ultimate goal of this project is to achieve biomimetic implants (compact and porous products) with custom features related to the mechanical requirements for an optimal biofunctionalization. In this regard, one patent application will be submitted, but it will not be funded through this project.

This project aims to develop, implement and promote a ceramic biomaterial known as biogenic hydroxyapatite. This is expected to lead to a new concept of biomimetic implant with improved features, for a rapid and complete resolution of all sizes bone defects.

The proposed subject is new and challenging for the project members, but all premises (for congent result achievement) are met through the sinergy and extended collaboration of both teams. The initial TRL level 2 was gradually established through the expertise of the project team. The project starts from conceptual approaches adopted from some studies and applied to the selected precursors. Experimental testing of research hypothesis will lead to an improved synthesis route. The appropiate manufacturing methods will be assessed for both types of biomimetic products (TRL level 3). Once the best experimental route is established, a comission constituted by independent experts will validate the proposed empirical model (TRL level 4).

Nanostructured membrane reactors for derivatization and doping of carbon nanotubes and graphenes Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0292 2015 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://nanomemreact.blogspot.ro/

Abstract:

Derivatization, functionalization and doping of carbon nanotubes and graphenes in solution raises the question of uniformity and reproducibility of the chemical methods due to their high degree of aggregation in solution. "Nanostructured membrane reactors for derivatization and doping of carbon nanotubes and graphenes (NANOMEMREACT)" project aims as main scientific objective, the opening of a new approach and a new scientific direction for both derivatization and doping reactions of carbon nanotubes and graphenes and for obtaining composite membrane materials with such chemical species with high added value for applications in sensors, biomedicine or decontamination techniques. Unlike classical derivatization and doping reactions reported so far in literature, the project aims to achieve these reactions by using composite membranes with nanoparticles, membrane playing the role of membrane reactor, this being the main novelty element of the project.

Integrated technology for custom-made biomimetic implants development used for major bone defects reconstruction Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0590 2015 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.florinmiculescu.ro/biomimbone

Abstract:

This project aims to develop and promote an integrated technology solution of a new custom made biomimetic implant concept used for bone substitution and dedicated to the rapid and complete surgical solving of large scale bone defects. The theme finds its need in clinical considerations related to the market lack of such products. We are focused on the development of custom made implanting biomaterials capable of simulating the most efficient the bone reconstruction mechanism. The biomimetic biomaterials will be obtained from natural origin materials (combinations of HA and TCP) in a massive form, 3D processed, used for surgical solving of large bone defects according to each patient case. Another project objective involves the significantly improvement of the healing process, miming the implantation bone structure, for a more rapid integration and an enhanced functionality. The implants mechanical characteristics will be similar to the tissues they are implanted in. The project implementation stages are: synthesis and processes developing for superior materials obtaining; bone tissue 3D defect detection; 3D texture development for the model of the reconstruction structure implants; implant topology development and optimization based on mechanic aspects and the rapid fusion of the reconstruction implant with the adjoining bone.

MgB2 based superconducting tapes Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1065 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); R & D SPECIAL ALLOYS SRL (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://infim.ro/projects/mgb2-based-superconducting-tapes-benzisupra

Abstract:

Nano structured composites in the form of powder-in-tube tapes, based on MgB2 with different additions and targeting improved critical functional parameters such as critical current density and irreversibility fields will be prepared. Innovative solutions are proposed and explored based on processing-properties relationships and vortex pinning details (from advanced relaxation magnetometry measurements). Expectations are to provide a model tape for further implementation and commercialization.

Therapeutic strategies for enhancing bone healing response by using bioactive coatings for bioabsorbable magnesium-based implants Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-2119 2014 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); TEHNOMED IMPEX CO S.A. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.unibuc.ro/prof/cimpean_a/pcca-195-2014/

Abstract:

During last decade, orthopedic implants have attracted an increasing interest for research and clinical applications but still can be said that they are far from being optimal. Current metallic implanted biomaterials remain permanent in the body and the long-term exposure of these non-degradable implants significantly increases the risk of complications such as chronic inflammation and associated foreign body reaction. The implant encapsulation represents one of the major drawbacks of these implants. Besides, several implantable devices are used to achieve a temporary function and a second procedure to remove them is often difficult. The current research is focused on investigating the application of bioresorbable metals, which are expected to support the healing process of the damaged tissue and to degrade further as the functional regenerated tissue is formed. Magnesium (Mg)- based alloys represents o novel class of biodegradable biomaterials with high specific strength and biocompatibility able to achieve a temporary function making possible the avoidance of the costly second replacement. However, the side effects such as hydrogen gas bubbles formed around the implant and a localized pH change, generated by extremely high degradation rate of magnesium in body fluids, can negatively impact on its host-tissue integration.

In this context, the aim of this project is to develop a new biotechnological strategy to overcome the issues previously mentioned and improve the osseointegration capacity of magnesium-based implants. Therefore, a novel coated alloy based on MgCaMnZr system will be developed and investigated by innovative technologies and techniques to obtain a controlled dissolution rate and to reduce the hydrogen gas production.

This material will be thermomechanically processed to allow its structural adjustment and to meet the expected properties. Moreover, the coatings based on cellulose will be functionalized with resveratrol or sericin, two biomolecules recently characterized for their beneficial effects on bone regeneration. We are expecting that the selected novel Mg-based alloy along with the developed coatings will protect the alloy slowing down its rate of degradation, providing the implant with the desired strength in the initial period of healing process and avoiding side effects associated to its rapid degradation. Furthermore, the functionalization of these coatings is expected to accelerate the healing process and the osseointegration of the implant. The project approaches an experimental multidisciplinary research seeking significant advancement in more than one field of science (i.e., biotechnology, material science, medicine etc), involving a qualified research team with specific skills and expertise. Thus, complex in vitro biological investigations consisting of interface studies will be performed in order to select the most suitable alloy formula for the targeted application and further to establish its in vivo biological performance on experimental animal models. The selected samples will be implanted as prototypes in Wistar rats and small domestic animals for in vivo monitoring of host tissue response and defect repair. The developed material and the demonstrator product will be also investigated to evaluate the physico-chemical properties. All the data obtained will be integrated in order to identify the best material’s features for targeted application. The original and innovative biotechnological approach of this project is expected to have an important impact on health related life standard and contribute to increasing life expectancy. We also hope into a positive impact of the project on the health care-associated costs, educational system and human resources.

Biodegradable Implants from Magnesium Alloys used in Foot and Ankle Surgery Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-2267 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); MEDICAL ORTOVIT S.R.L. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.biomagia.eu

Abstract:

The field of medical materials is very important into the general frame of materials science. The advanced technologies from engineering and medicine developed in the last years, associated with the society demand related to the better daily life conditions and returning to work after some trauma followed by the bone fracture make this field to be a dynamic one. As a consequence, many new materials and implantable medical devices were developed recently and the tendency is to continue those efforts using an interdisciplinary approach based on the knowledge and skill from different field like materials science, physics, biology and medicine.

Also, there is a need in healthcare for cost-efficient treatments, including those for implantable devices for orthopaedic surgery. Foot & ankle surgery is an emerging direction of the orthopaedic surgery and the number of patients who need this kind of surgical intervention is higher. At this moment, is clearly an intensive trend in orthopaedic surgery to use the bioresorbable implants for trauma surgery, but for the foot & ankle surgery the resorbable trauma implants made by polymeric (PLLA) or composite materials (PLLA reinforced with TCP or Hap) didn’t show the clinical advantage because the implants didn’t have a necessary mechanical properties and their degradation rate is much faster than the healing of bone fracture. Magnesium alloys are strong candidates for obtaining biodegradable implants who require better mechanical properties, biocompatibility and slow degradation rates. The consortium that made the BIOMAGIA project proposal is interdisciplinary and comprises a university, two research institutes and two companies. The partners are one of the best research groups in their field (UPB-materials science/biomaterials; INOE200-physics/coatings; IBPC-biology/biocompatibility testing; R&D-materials industry/casting, processing metallic materials; MOV-medical devices industry/medicine, instruments and implants for orthopaedic surgery), with strong skills, capacities, and who were involved in many national and international projects. BIOMAGIA will contribute to the major demand for intelligent biomaterials and smart implants in orthopaedic surgery which are resorbed by the body upon remodelling the bone tissue by the development of new aluminium free magnesium implant materials with tailored properties specific for a biodegradable implant used in foot and ankle surgery. To reach this goal, carefully selected materials and processing routes will be combined with a comprehensive research to elucidate the correlation between magnesium alloys chemical composition, microstructural aspects and processing techniques, surface modifications, related to the corrosion processes in vitro and in vivo who modulate the degradation rate, hydrogen release, and implant resorbtion. The project members are confident that based on their skills and previous results will be able to pass the current barriers like the absence of specific commercial magnesium alloys tailored for orthopaedics applications, the manufacturing technology and the lacking scientific knowledge about the degradation rate based on the corrosion mechanism, hydrogen release and toxicity. The ultimate goal of the project will be a prototype implant for foot & ankle surgery with a new design based on the achievements in this consortium, which brings together leading scientists from various research fields: material scientists and mechanical engineers, physician and experts in surface engineering, biologist and medical scientists. BIOMAGIA collectively covers basically all aspects, the instrumental techniques and approaches necessary to tackle successfully the challenge to understand, and ultimately control, interactions at the material-bone interface. The full achievements of this research are gained because we cover the full value chain from fundamental engineering research towards hospitals and in vivo studies and implant production.

Multifunctional coatings for load bearing implants made of a novel titanium-based alloy Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1958 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); TEHNOMED IMPEX CO S.A. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.osseopromote.inoe.ro./

Abstract:

The actual challenge in the orthopaedic surgery is to obtain orthopaedic implants with good mechanical, physical, chemical and surface compatibility with the bone. But the difficulties are remarkable, because these characteristics fail in time and, in general, it is difficult for a single material to have all the required properties.

The main goal of the present project is to give innovative solutions to increase the service life of load bearing implants by:

- Preparation in a levitation melting furnace of a novel type of alloy consisting of only biocompatible elements (Ti, Zr, Nb), in order to replace Ti6Al4V, the most popular alloy in the present, but which consists of elements (Al, V) causing cytotoxic and allergic reactions. The novel alloy is I nsystem Ti-Zr-Nb. It is expected that an optimum Nb content in the alloy composition will be found, for achieving a Young’s modulus close to that of the bone, which was an important target for the researchers in the last two decades.

- Preparation of novel types of osteoconductive coatings, by magnetron sputtering method, as follows:

• osteoconductive coatings in mono (type 1) and bilayer (type 2) structures, in order to enhance the osteoconductive capability of the TiZr30Nbx alloy:

˗ type 1: MeC+IA (Me-metal, C-carbon, IA-inorganic additive), by addition in the MeC film composition (Me = Ti, Zr, Nb) of small amounts of various IA (Ca3(PO4)2, TiSi);

˗ type 2: MeC/(IA + TiO2), where IA is Ca3(PO4)2 and MeC is the bottom layer and (IA+TiO2) is the top layer. It is expected that such structures will reveal an optimum combination of the coating microhardness, adhesion, residual stress, toughness, friction, corrosion-wear resistance, osteoconduction and biocompatibility. The MeC films are produced to enhance the adhesion of the osteoconductive coatings to metallic substrates, because the films consist of elements which are found in the bioalloy composition.

• use of a complex magnetron set-up, containing a high vacuum system and equipped with 5 different cathodes made of pure metallic or alloyed targets, able to work simultaneously or alternatively.

Magnetic biomimetic scaffods as alternative strategy for bone tissue repair and engineering Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-2287 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "GR. TH. POPA"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "GR. TH. POPA" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA "ION IONESCU DE LA BRAD" (RO); VODIMEDICOR S.R.L. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.umfiasi.ro/Cercetare/sr/Projects/Pages/132.aspx

Abstract:

Strategies for developing of new alternative therapies are necessary due to the complications and limitations associated with the current bone grafts substitutes. The using of biodegradable scaffolds in tissue engineering is constantly increasing since such biomaterials have become fundamental tools to help the body rebuild damaged or diseased tissues. The benefit of using a biodegradable scaffold consists in the capacity of the tissue to completely heal itself without remaining foreign entities. In some cases, the drug pre-loading techniques reduce the delivery of localized, controllable and long-term biochemical stimuli, thus impairing the tissue regeneration potential in the scaffold. Additional, in some diseases with degeneration risk (bone tumours) after bone tumour resection, only few available bone reconstruction and substitution material can be used as chemotherapeutics carriers. Therefore, it is impetuous to find multifunctional bone reconstructive scaffolds for bone tumour therapy. In this context the main concept of the project is to develop magnetic scaffolds via biomimetic methods as alternative for actual regenerative medicine for bone repair. The new therapy involves the use of magnetic scaffolds as guiding matrix for circulator magnetic nanoparticles which are functionalized with growth factors, drugs or other bio-agents. Once in the magnetic scaffold, the magnetic carriers successively release the bio-agents that they are transporting, so that the bio-agents can be taken up by the tissue during the regeneration process. The released bio-agents have indisputable roles in the facilitation of osteoblast proliferation, differentiation and subsequent bone formation and regulation. Additional, chemotherapeutical drugs can be loaded and targeted to the magnetic scaffold via magnetic field.The general objectives of the project are: (G1) Development of high added value in bone scaffolding (magnetic biomimetic composites as guiding matrix for osteoiductive bio-actives and chemical agents, with natural bone – like morphology and properties) (scientific impact); (G2) Promoting of a manufacturing technology for a magnetic osteoinductive scaffold that will be subsequently used as bone substitute (technological impact); (G3) Increasing the competitiveness and creativeness by stimulation of the young researchers in conceptual thought and their training in methods of scientific and technological research (long-term educational impact); (G4)The development of new therapy based on solutions that integrate materials engineering and biological processes and medical approach (economical impact); (G5) Increasing the qualification of human resources by stimulation of professional training on the new advanced therapies, bio-inspired technologies, bio-characterization, biomaterials processing and analysis of new advanced medical devices (social impact).

The MAGBIOTISS consortium comprises 5 partners from 3 different domains (academic, university, 1 partner from industry medium) which have agreed to launch in this project. Furthermore, the partnership reflects a combination of fundamental and applicative research as practiced in academia and of pragmatic engineering technology and new therapy development as represented by the industrial partner. Since MAGBIOTISS is strongly connected to health – new therapies - regenerative medicine and novel therapies based on medical devices (new magnetic guiding scaffolds), it is anticipated that MAGBIOTISS will contribute to growth in modern therapies by direct or indirect effects via developing the following activities: - Methods and protocols for testing of new magnetic biomimetic scaffolds and scientific data to support this methodology. - Strategies for new therapeutic applications and prototypes/examples of guiding scaffolds for the safe regeneration of the bone. - Development and safe production of the new bioactive-loaded magnetic scaffolds.

New high entopy alloys/composites with superior mechanical and corrosion resistance characteristics, for high temperature applications Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1048 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU METALE NEFEROASE SI RARE - IMNR (RO); UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); RANCON S.R.L. (RO); CENTRUL DE CERCETARE PROIECTARE SI PRODUCTIE REFRACTARE S.A. (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.headurcor.pub.ro

Abstract:

This project aims to develop metals plastic deformation tools (rolls and bearings mill) processed from an innovative metallic material, high entropy alloys(HEA) and composites. The project is included in the priority research field 7 thematic 7.1.4 Advanced materials for competitive products export.

The project proposes a new approach to the manufacture of plastic deformation tools by replacing steels and superalloys conventional materials with HEA alloys and composites with superior technological characteristics. The raw materials for HEA processing consist in metallic metals and wastes.

The project meets the objectives of the program as follows:

1. The consortium constitution (two prestigious universities, a National Institute for R-D and two SMEs in the materials field) and the joint research activities addressing the Stimulation of research - development activities conducted in partnership objective.

2. By realize tools with enhanced features, processed from metallic materials using new and advanced technologies, the project is part of the Applied research joining requirements to economical environment demands by developing original products, advanced technologies, competitive and with major socio-economic impact objective.

3. Co-financing significant research expenses (16.67%) and active involvement of SMEs contribute to Stimulating private sector expenditure growth in R & D objective.

4. Acquisition of advanced equipment and integration of PhD students in research teams, contribute to Development of infrastructure and human resource skills objective.

Scientific and technical objectives of the project are:

i. Processing of high entropy alloys (HEA) and composites with superior physical and mechanical properties by induction melting/casting, respectively by mechanical alloying/ pressing/ sintering; ii. Obtaining og rolls and bearings mills from HEA alloys/composites; iii. Obtaining technologies for HEA alloys/composites; iv. Demonstrating and verifing the technologies and tool prototypes at pilot level.

The novelty and originality of the project are: a. new metallic materials for plastic deformation tools developing; b. alloys/ composite systems selection with preset technological features.

The main results of the project are: 1. Innovative technologies for obtaining HEA alloys/composites with predefined characteristics; 2. Mill rolls and bearings - prototype tools with superior technological characteristics; 3. Patent applications for products/ technologies; 4. Dissemination: articles in ISI journals, conferences, workshops, seminars.

Project impact/potential benefits: i. strengthening the cooperation between research units and companies; ii. development of research infrastructure and increase capacity of the partners to participate in R&D national and international projects; iii. increasing the competitiveness of SMEs through the tools manufacturing from new materials with high added value (alloys/composites), increased turnover by 5-10%. iv. patents exploitation; v. social impact by increasing the quality of life (reducing the amount of metallic waste containing potentially toxic metals, increasing labor productivity and safety of plastic deformation sections), creation of new working places; vi. environmental impact: metallic waste exploitation, green technology for obtaining alloys / composites, a waste decrease from recycling used tools.

Complex systems with deformable structure for ballistic protection of armored vehicles involved in asymmetric conflicts Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1296 2014 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); R & D SPECIAL ALLOYS SRL (RO); Academia Tehnica Militara (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.upb-armprot.webs.com

Abstract:

The recrudescence of terrorist attacks typical of asymmetrical war during the past years has compelled the accelerated development of protection structures and systems destined for both light vehicles and individual equipments. The aim of the project is the accomplishment of multifunctional complex materials with deformable structure and controlled characteristics for special applications, by using advanced techniques allowing structural molding and projecting the properties of the material (in concordance with the theme areas 4.2, 4.3 and 4.4 of FP 7) as well as the integration of the classical processing technologies with the non-classical ones which led to the occurrence of integrated and flexible technological processes for industrial applications – sectorial and intersectorial – thus favoritizing the development of new technologies, processing techniques and production processes in the field of the defense industry.

The main objective of the research project consists of establishing the optimal technology for attaining a complex system with deformable structure type „sandwich”: Ti72Si28 alloy-Maraging steel foam-Ti82Si18 alloy,destined for ballistic protection.The ARMPROT project is carried on by means of highly complex research and technological development activities including industrial and technological development research as well technology transfer activities and certification of investigated products which are carried on by collaboration within a consortium that is representative at a national level for the specific field of top technologies. As far as the technical measurable objectives go the aim is to establish the processing conditions and to elaborate the optimal technology for the achievement of a complex system with deformable structure type ”sandwich”: Ti72Si28 alloy-Maraging steel foam-Ti82Si18 alloy, for ballistic protection with small or medium caliber weaponry, with the following framing of the values of the properties:-Maraging steel foam with a high elastic limit (1800MPa, hardness of around 320 HB, density of 3.9-4.4g/cm3, porosity higher than 50%,low tendency of hardening when deformed N≈ 0,02 and a high capacity of absorbing kinetic energy able to ensure its dissipation in a high volume of material;extra-hard plates made out of Ti72Si28 alloy and Ti82Si18 alloy respectively (density of the TiSi system:4.2-5.3g/cm3,hardness 1300-1700 HV30, depending of the majoritary intermetallic compound which forms:Ti5Si3 or Ti3Si respectively) which are formed directly on the sides of the foam strip from precipitation hardening of Maraging stainless made by SHS.

The application of innovative technologies–SHS and Horizontal Continuous Casting of metal foams in the form of a steel strips of Maraging precipitation hardening steels-which will allow the accomplishment of the stratified material with deformable structure type Ti72Si28 alloy-Maraging steel foam-Ti82Si18 alloy, represents a nationally premiere.The estimated results of the project shall consist of:-the realization of the multilayered complex system with deformable structure destined for ballistic protection, in which the exterior extrahard layers shall be attained by means of the SHS technique applied to powdery Ti72Si28 and Ti82Si18 alloys, and the interior layer(deformable layer)shall be realized with Maraging steel foam (with modified composition–for the increase of stability at warmth) by an innovative procedure of „foamy continuous casting”. The project shall be completed with:-realization of experimental model of hybrid material with deformable structure for ballistic protection;-realization of prototype batch of the complex system with„sandwich” type structure:Ti72Si28 alloy-Maraging steel foam-Ti82Si18 alloy;-elaboration of technical-economical documentation for the prototype batch;-optimized technologyof the prototype batch;-elaboration of final technical documentation;-patenting of technology/experimental model;-dissemination.

Biocompatible coatings for enhanced bond strength of ceramic to metal in dental restorations Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1240 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU OPTOELECTRONICA INOE 2000 INCD (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GR. TH. POPA" (RO); DIPADENT GROUP SRL (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.coat4dent.eu

Abstract:

The main scientific objective of this project is to obtain a new variety of high bond nanostructured coatings, based on nc-MeN/a-Si3N4 and nc-MeON/a-Si3N4 nanocomposites (nc-nanocrystalline, a-amorphous, Me – metal (Ti, Zr, Cr or Al), N – nitrogen, O - oxygen), in mono, multilayered and graded structures, with good hardness, high adhesion to metallic and ceramic substrates, low internal stress, high resistance against wear, corrosion and oxidation, high fracture toughness, good biocompatibility to tooth and to oral environment.

In the present project we propose to enhance bond strength of ceramic to metal in dental restorations by inserting novel biocompatible nanocomposite coatings between the metal and ceramics, by means of the cathodic arc technique:

- nanocomposite single layer coatings (nc – MeSiN or nc – MeSiON), where Me is Ti, Zr, Cr or Al,

- nanocomposite mutilayer coatings (nc – MeSiN/MeN and nc – MeSiON /MeN),

- nanocomposite graded MeN/MeSiN/MeSiON coatings.

The scientific expectation is that such coatings enhance the adhesion of ceramic to metallic substrates (NiCr or CoCr alloys), leading to longer service life of the dental restoration. Also, the proposed coatings would effectively prevent the adverse oxidation of NiCr and CoCr alloys and would ensure good biocompatibility in oral environment, having colours close to natural teeth. The great challenges of the project are to obtain a high bond of ceramic to metal and dental restorations with color closed to natural teeth.

COMBINED METHODS FOR EVALUTION OF THE HEAVY METALS CONTAMINATION OF HUMAN BEINGS CORELATED WITH HUMAN HARD TISSUES METABOLISM Call name: Projects for Young Research Teams - TE-2010 call
PN-II-RU-TE-2010-0144 2010 - 2013

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.biomat.ro/laborator

Abstract:

General population contamination with heavy metals and occupational people exposure from diffuses sources (autovehicles emissions, imissios, ecc.) or localized (plants, offices, etc.) is a dangerous phenomenon which is not correct assessed due to the lack of methods and proper measurement technics.

The project addresses specific researches about how to develop a methodology for heavy metals contamination and also for heavy metals acumulation assessment in heavy human tissues.

Our main aim is to find an assessment methodology for heavy metals stored in heavy human tissues correlated with their metabolism for the assessment of human health state and also for an objective valuation for contamination sources. We estimate a sinergistic link between elemental analyses method at bulk level with local ones, at microscopical level (localized and mapped). The research group, based on the whole adequate experience, has established that edpxrf (energy dispersive polarized x-ray fluorescence spectrometry) and esem-eds(environmental scanning electron microscopy-energy dispersive spectrometry) can be used together for Pb, Hg, Cd, Sr, etc. contents, but also for constitutive elements, too.

The project has the following main research directions:

- determination of physical-chemichal spectrometry analitical programs;

- modelling and quantifing of heavy metals contamination processes;

- modelling and quantifing of heavy metals methabolism;

- to prove scientifically the uncertainty budgets for EDPXRF and ESEM-EDS.

- the substantiation, development and practice of some statistic methods for transfer uncertainty assesment of heavy metals in biological processes.

In this way, the group is formed by national experts for ESEM-EDS, EDPXRF and stomatology, quality assurance and methods validation, physiology, statistics and ecology.

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List of research grants as project coordinator or partner team leader	Download (33.94 kb) 17/01/2019
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects