BrainMap

Mrs. Florina Teodorescu

scientific researcher II

Scientific Researcher II - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher | Scientific reviewer

Dr. Florina Teodorescu is scientific researcher II at Institute of Physical Chemistry ‘Ilie Murgulescu’ of the Romanian Academy, Laboratory of Chemical Thermodynamics. During 2014-2016 she held a postdoctoral position at Institute of Electronics, Microelectronics and Nanotechnology (IEMN)- University of Lille 1, France in the Nanobiointerfaces Group with the topic Nanocomposite materials based on graphene – Synthesis, characterisation and applications. She received PhD in Chemistry domain since 2013 at University of Bucharest in the topic of chemically modified electrodes with improved electrocatalytical properties. Her main research interests are: synthesis and characterisation of nanomaterials for biomedical applications, optical and electrochemical sensors, drug delivery, interaction of nanomaterials with proteins.

Curriculum Vitae (17/04/2025)

Expertise & keywords

CARBON SUPPORTED METAL OXIDES PRODUCED BY SUPERCRITICAL WATER IMPREGNATION METHOD Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1241 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: http://www.icf.ro/pr_2020/APASUPER.pptx

Abstract:

The APASUPER project deals with preparation, characterization and testing supported metal oxides to be used as sorbent materials in separation processes carried out under supercritical water (scH2O) conditions. The one-step preparation method (continuous scH2O impregnation of metal oxides on carbon) is here presented as novelty. It will be developed by combining the available knowledge with the very recent information on the coexistence of gas- and liquid-like phases, observable when scH2O interacts with porous carbon (Maxim et al. Nat. Comms. 2019). The project has both an exploratory and an inter-disciplinary character and aims to be the first step towards long-term collaboration between the Institute of Physical Chemistry, Romania (host) and Paul Scherrer Institute, Switzerland (main partner). During the research stages at the Swiss partner, cutting-edge research will be performed at PSI’s large-scale facilities using neutron/synchrotron radiation. In this way, the project will contribute to spread the excellence within Europe by bringing the scH2O science to the attention of the Romanian research community. The materials prepared, characterized and tested during this project might contribute to the implementation at large-scale of the promising scH2O technologies, which can in turn help to achieve the 6th (clean water and sanitation) and the 7th (affordable and clean energy) Sustainable Development Goals on UN’s new 2030 agenda.

TARGETED MULTIFUNCTIONAL NANOEMULSIONS TO INTERRUPT METASTATIC PROGRESSION Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-ERANET EURONANOMED 3-METASTARG 2019 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); Consorcio Centro de Investigación Biomédica en Red, M.P. (ES); Aptus Biotech S.L. (ES); Internattional Iberian Nanotechnology Laboratory (PT); Fondazione IRCCS Istituto Nazionale dei Tumori (INT) (IT); Stanipharm (FR)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2019/METASTARG/index.html

Abstract:

Metastases are the major cause of death in cancer patients with solid tumors. In Non-Small Cell Lung Cancer (NSCLC), highly metastatic locally and in distal organs, the 5-year mean survival is lower than 5% in the metastatic setting. Occult micrometastases (OM) are, by definition, small clusters of metastatic cells, and can only be detected by highly invasive molecular methods, remaining largely untreated and eventually leading to the formation of metastases. Early detection of OM and treatment can interrupt progression to macroscopic metastasis, and ultimately improve survival.

METASTARG is an innovative solution relying on nanotechnology for the early detection and treatment of OM to cause a direct impact in the survival of the disease, quality of life, and health-economics. METASTARG Nanoemulsions are developed to identify OM by novel characteristic targets found in metastatic cells and Interrupt Metastasis Progression (NIMPs). This unique patient-driven approach has the potential to become a gold standard in the treatment and monitoring of NSCLC cancer.

We have developed sphingomyelin nanoemulsions (SN) that are easy to manufacture, stable, non-toxic, and can incorporate active ingredients and radionuclides. We have surface-decorated them with ligands to mediate a specific interaction with the biomarker Taste receptor type 1 member 3 (TAS1R3), identified by molecular analysis of metastatic cancer cells isolated from the blood of patients with NSCLC (Circulating Tumor Cells, CTCs). In this project, we address a multidisciplinary and translational research to i) optimize the technology to develop NIMPs with the ultimate aim of improving patient survival, ii) understand the biophysics of targeting metastasis to improve NIMPs interaction with OM, iii) generate the proof-of-concept for NIMPS activity in relevant in vitro and in vivo models representative of the micrometastatic situation in NSCLC, and iv) advance in the translation of NIMPs to a clinical setting.

Mobilitate cercetător Florina Teodorescu Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori, 2019
PN-III-P1-1.1-MC-2019-2382 2019 - 2020

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website:

Abstract:

Research of the bone substitution with biocomposite materials processed by powder metallurgy specific techniques Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-2094 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA DIN CRAIOVA

Project partners: UNIVERSITATEA DIN CRAIOVA (RO); TEHNOMED IMPEX CO S.A. (RO); SPITALUL CLINIC DE URGENTA " BAGDASAR-ARSENI " (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://mecanica.ucv.ro/Cercetare/BONY/index.html

Abstract:

The research proposal is entitled “Research of the bone substitution with biocomposite materials processed by powder metallurgy specific techniques”, acronym BONY. Its general objective is to obtain advanced biocomposite materials, based on hydroxyapatite (HAP) matrix reinforced by Ti-based powder particles. The osseointegration process is accelerated by the natural organic esters of Bor, as a component of the biocomposite powders mixture. The applications aim the bone substitution by small-sized reconstructions for skull and vertebrae body.

BONY project matches the priority domain 7 (Materials, innovative processes and products), research area 7.1 (Advanced materials), research topic 7.1.6 (Advanced materials and biomaterials for life quality improvement (health, sport, education etc.)).

The project relevancy is underlined by the necessity to elaborate bone implants for skull and vertebrae by advanced biocomposites, with improved osseointegration capacity to the adjacent native bone tissue. Also, the technical and economical savings are important as far as the processing technologies concern.

The BONY project results are:

1. the innovative biocomposite material as bulk product for vertebral implant processed by micro-injection moulding technique;

2. the innovative biocomposite material as coating for skull implant processed by MAPLE technique on Titanium substrate;

3. the innovative material and method to accelerate the osseointegration process of the bone implants.

The innovative/original aspects of the BONY project are represented by:

- the innovative combination of metallic and ceramic powders, micrometric and nanometric sized. The advanced sintering techniques as well as the coating ones provide hybrid structured biocomposites that assure improved physical, mechanical, technological and biochemical properties relative to the native bone.

- using, for the first time, of the micro-injection moulding technique, to process complex shaped and small sized bone implants;

- the original an innovative application of MAPLE coating technique to process hybrid biocomposite coatings on Ti substratewith similar properties to the bulk biocomposites type.

- the original method to accelerate the osseointegration process by using special additives, Bor natural organic esters, in special technological procedures.

The BONY implant biocomposites provide the following advantages as follow: resorbability, geometrical stability, improved lifetime, micro-machinability for final geometrical adjustments, able to be processed as complex shapes and small dimensions, improved osseointegration.

The impact of the project results may be evaluated from the following points of view: scientifical (innovative biocomposite materials), technological (suitable processing technologies to the implants shape and size), research human resources training (young Ph.D. students or graduated, members of consortium), economical and social (improving the patient’s life quality).

The quality, expertise and research, innovative and entrepreneur skills of the BONY partners assure the successful fulfilment of the project objectives. The BONY consortium is represented by: CO – University of Craiova (UCV); P1 - S. C. Tehnomed Impex Co S.A., Bucuresti (IMM); P2 – The Emergency Clinic Hospital „Bagdasar-Arseni”, Bucharest; P3 – The National Institute for Laser, Plasma & Radiation Physics (INFLPR), Bucharest ; P4 – « Ilie Murgulescu » Institute of Physical Chemistry of the Romanian Academy (IPC), Bucharest ; P5 – Politehnica University of Bucharest (UPB).

nanoPerovskites in one-dimension: synthesis, structure, properties Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0160 2012 - 2015

Role in this project:

Coordinating institution: Institutul de Chimie Fizica Ilie Murgulescu

Project partners: Institutul de Chimie Fizica Ilie Murgulescu (RO)

Affiliation:

Project website: http://www.icf.ro/pr_2011/1DnanoPEROVSKITES.htm

Abstract:

Modern technology demands nanostructures. Recently, one-dimensional (1D) nanostructures, including nanowires, nanotubes and nanorods, have been considered as the most promising building blocks for nanoscale electronic and optoelectronic devices. Worldwide efforts in both the theory and the experimental investigation of growth, characterization and applications of 1D nanostructures have resulted in a mature, multidisciplinary field. Within this context, the main aim of this project is to elucidate the correlations between dimensionality and properties of some 1D nanostructured complex oxides with perovskite structure obtained by bottom-up chemical methods. The synthesis of some ferroelectric and multiferroic perovskites type nanomaterilas will receive a special focus and the process optimization will be guaranteed by exhaustive characterization based on electron microscopy techniques. The electrical (ferroelectric, multiferroic) and thermodynamic properties of the resulted 1D nanomaterials will be investigated in order to establish the size-shape-properties connection to further applications.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects