BrainMap

Mrs. Gabriela Marinescu

Ph.D.

Researcher - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher

Curriculum Vitae (02/04/2025)

Expertise & keywords

Design of new antenna ligands for obtaining lanthanide based luminescent materials Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1345 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: https://chimie.unibuc.ro/cercetare/anorganica/LanLumiMat/LanLumiMat.pdf

Abstract:

The present project will focus on the synthesis and characterization of new lanthanide metal-organic frameworks for luminescent sensing and light-emitting applications. The molecular systems are based on pre-formed lanthanide-phenanthroline derivatives precursors and organic spacers or lanthanide metalloligands using the molecular approach. This strategy relies on the acting of phenanthroline derivatives as C3 ligands and will be used for the first time in lanthanide chemistry. Two synthetic strategies will be used to achieve the envisaged extended networks: (i) the self-assembly process involving homonuclear 2D networks and 4,4’-bipyridine N,N’-dioxide as pillar-like connector (ii) as a follow up to the self-assembly route, in order to synthesizes 4f-4f’ networks, the spacer will be a stable Weakley-type lanthanide-containing POMs ([EuW10]9- or [TbW10]9-). The structural features, which influence the desired properties of the new systems, will be controlled by designing special organic ligands and, consequently, by choosing the appropriate lanthanide units derived from them. The same organic ligands can be used for both purposes (oligonuclear structures or coordination polymers), the final structure being determined by the coordination algorithm of the assembling cations.

NEW DIAGNOSIS AND TREATMENT TECHNOLOGIES FOR THE CONSERVATION AND REVITALIZATION OF ARCHAEOLOGICAL COMPONENTS FROM NATIONAL CULTURAL HERITAGE Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0476 2018 - 2021

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA OVIDIUS (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA "VALAHIA" TARGOVISTE (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: https://icechim.ro/project/tehnologii-noi-de-diagnoza-si-tratament-pentru-conservarea-si-revitalizarea-componentelor-arheologice-ale-patrimoniului-cultural-national-arheocons/

Abstract:

The cultural heritage, as a source of national historical and cultural authenticity, is subjected to deterioration, and for stopping it, some specific procedures are required: cleaning, replacement of old materials and application of new protective materials compatible with the original, and advanced monitoring with sustainability assessment. The consortium of the present project has a unique expertise in Romania, recognised in Europe, through the many published papers, essential projects in Romania (Basarabi Churches, Potlogi Palace, etc.), OSIM and EPO patents, technology transfer, nanomaterials in chemical and biological preservation for cultural heritage objects and objectives; the partner institutions complement each other on a regional basis in the working plan of the whole project.

The overall objective of the project is to develop new materials, new methods and technologies that obey the principles of authenticity, reversibility and value, with a strong impact on immobile cultural heritage objects (fresco, basreliefs and mosaic) and mobile (decorative artefacts from ceramics, glass, metal, bone, objects of art and archaeology). Specific objectives: Developing innovative technologies for protecting national cultural heritage, multidisciplinary cross-sectoral approach, encouraging young professionals as leaders in heritage preservation, exploitation of research results for new jobs, promoting heritage education, professional expertise among all factors involved in the patrimony protection system.

The project, with a high degree of innovation and originality, applies unique technologies in Romania based on new materials compatible with the original materials and develops new techniques practical applied to: Roman Mosaic and Hypogeum Tomb, Constanta, Adamclisi Museum (basreliefs), Constanta County, Corvin’s Castle (Fresca Loggia Mathia) and Archaeology Museum, Hunedoara.

New versatile dicyanidometallate precursors [MIII(L)(CN)2]- for designing heterometallic molecular magnetic materials Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0321 2017 - 2019

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2017/Contract_88-2017-eng.pdf

Abstract:

The present project develops a systematic study on the design and synthesis of new versatile dicyanidometallate [MIII(L)(CN)2]- precursors (MIII = Cr, Ru and Os, L = compartmental ligands of Schiff base type, derived from condensation reaction between salicylaldehyde or o-vanillin with various diamines, including chiral amines) and the investigation of the possibility to use them as tectons for the construction of cyanido-bridged heterometallic complexes with novel topologies, structural diversity, and predictable magnetic properties.

The synthetic approach towards heteropolymetallic systems consists in self-assembly processes between the [MIII(L)(CN)2]- tectons and solvated metal ions, partially blocked complexes (e.g. mononuclear 3d complexes or binuclear 3d-3d’, 3d-4f complexes) or alkoxo bridged homo- and heterometallic cationic clusters. The binuclear complexes 3d–3d’, 3d–4f with compartmental ligands, due to their versatility and structural flexibility, efficiently act as tectons in designing heterotrimetallic systems with relevance in molecular magnetism. A special emphasis will be given to the synthesis of 3d-3d’, 3d-4(5)d, 3d-4f, 4(5)d-4f or 3d-4f-4(5)d, 3d-4f-3d’ heterometallic systems. In order to obtain systems with improved single-molecule magnets (SMM) or single-chain magnets (SCM) behavior, the metal ions with large magnetic anisotropy (Mn3+, Co2+, Ni2+, Tb3+, Dy3+, Ho3+) will be used. Another important objective of the project is focused on the use of chiral multidentate ligands for the obtaining of magneto-chiral systems, very interesting in the field of materials science.

From the fundamental point of view, our project will enrich the still poor coordination chemistry based on RuIII-, OsIII- and CrIII- cyanido tectons with novel examples. Besides aesthetic and structural diversity, the systems that will be obtained in this project are very important for understanding and interpreting their properties.

INNOVATIVE MATERIALS AND PROCESSES FOR SELECTIVE HEAVY METALS REMOVAL FROM WASTEWATER Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0418 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU INGINERIE ELECTRICA ICPE - CA BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); KEMCRISTAL SRL (RO); INSTITUTUL DE STUDII SI PROIECTARI ENERGETICE S.A. (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://hapchitmag.chimie.upb.ro

Abstract:

The project entitled Innovative Materials and Processes for Selective Removal of Heavy Metals from Wastewater is included in the global concerns of humanity to have access to drinking water resources in the conditions in which water sources are becoming increasingly polluted. The most important anthropogenic sources of heavy metals are wastewater from various industries such as: electroplating, leather industry, textile industry, dyes industry, mining industry. Due to the fact that heavy metals are not biodegradable and they can be bio(accumulated) in living tissues, they can enter directly or through the food chain in human bodies, most of them being toxic, thus their removal from wastewater is currently imposed by legislative rules. Technologies to remove heavy metals from wastewater include precipitation, ion exchange, electrodeposition, membrane processes, sorption, sequestration by cementation. All these technologies have advantages and disadvantages (high operating costs, and for some of them obtaining sludges with heavy metals that will be stored and thus will determine soil pollution, or they will require further processing).

The project’s aim is to develop novel materials (nano- and micro-scale) with high selectivity for removal/retaining heavy metals from wastewater by solid phase synthesis, precipitation from aqueous solutions, and non conventional techniques such as sol-gel and microwave-assisted synthesis. The products obtained will be also as powder, beads, micro/nanospheres (hydroxyapatite, magnetite and chitosan), and compounds with complex structures like chitosan composites, chitosan cross-linked with glutaraldehyde, magnetite nanoparticles functionalized with organosilane and chitosan. The main purpose is to increase the selectivity, sorption capacity, durability and stability in acid environments, specific to wastewater.

Materials obtained will be tested in heavy metals (Pb(II), Cu(II), Ni(II) si Zn(II)) removal/retaining processes from synthetic solutions and industrial wastewater in order to identify the material with high selectivity and sorption capacity. There will be performed batch and continuous tests to establish the influence of factors (contact time, stirring speed, pH, size of adsorbent particles, height of adsorbent bed, metal ion concentration in the initial solution/wastewater, competition with other metal ions) on the sorption process. The kinetic and thermodynamic studies will be performed to establish the mechanisms involved in sorption process for industrial technology development.

Some of residual products resulted can be used in different industrial sectors such as: ceramics industry, building materials industry, and the others can be recovered by desorption processes and reused in other sorption processes. Materials and technologies proposed can be considered as main components of sustainable development of society due to the fact that they improve population health, protect the environment, reuse and integrate wastewater in natural and industrial cycles, create new jobs for young researchers, but also for people in urban areas, especially those affected by industrial pollution. The results obtained by the work performed in this project will be disseminated. The most relevant results will be used to apply for a patent proposal and for their industrial implementation. Research and development works will be based on moral and ethical principles according the deontology (Law 206/2004) endorsed by all partners in the consortium.

New complex combinations of some lanthanides with antitumoral properties and their use in design and development of new drugs Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-0913 2012 - 2016

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://ncpri.ro/proiecte/antineomed/index.php sau antineomed.ncpri.ro

Abstract:

Cancer, considered to be the “century scourge”, is one of the diseases with the highest death rates around the world.

One of the major concerns of researchers in pharmaceutical and medical field is to discover new molecules and new drugs to fight cancer more effectively than existing.

The latest approach to developing antitumor drugs, at an international level, focuses on enriching the studies on the metallic compounds of the therapeutically active organic structures. Those compounds should have a better pharmacological activity due to the synergic effect of the ligand and the metallic ion or due to the complex’s self-included activity.

Being in agreement with the general world-wide interest, this partnership project sets sights on making the most of the acknowledged antitumor potential of the lanthanides by designing new therapeutically active molecules that have never been recorded in any pharmacological databases. Thus, the objective is to obtain new complex combinations of simple and mixed ligands - benzothiazine-carboxamides (oxicams) or polihydroxyflavones (flavonols) – that would further be used to conceive and develop new drugs. Oxicams are especially recognized for their anti-inflammatory activity, as well as anitumoral, while flavonols – which are natural compounds – are known for their powerful antioxidant, antibacterial and antitumor properties. It is expected that the new complex combinations, as well as the resulting original drugs, would comprise the cumulative antitumor/antiinflammator/antioxidant potentials of the reactants, thus creating new mechanisms of action with increased efficiency in antitumor therapy.

This project sets out to conceive and then fully develop original drugs, starting from the chemical synthesis of new pharmaceutically-active substances that have never been cited in any databases, to the including into pharmaceutical doses and the elaboration of all the documentation required for setting a product out on the market.

Molecular and Supramolecular Heterotrimetallic Systems: towards a new generation of molecular magnetic materials Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0126 2011 - 2014

Role in this project:

Coordinating institution: Academia Romana, Institutul de Chimie Fizica Ilie Murgulescu Bucuresti

Project partners: Academia Romana, Institutul de Chimie Fizica Ilie Murgulescu Bucuresti (RO)

Affiliation:

Project website: http://www.icf.ro/pr_2011/Visnescu_TE_english_version.ppt

Abstract:

The present proposal focuses on designing of a new generation of (supra)molecular heterotrimetallic magnetic materials. The main objectives of the project are:(i)obtaining of new heterotrimetallic molecular-based materials with modulated magneto-optical properties; (ii)achieving new physical properties which are intermediate between molecules and nanomaterials: these materials mark a crucial transition between molecular and nano-level;(iii) obtaining revolutionary multifunctional heterotrimetallic materials;(iv)developing of new theoretical models for understanding the magnetic properties of the obtained heterotrimetallic systems.The general method for the synthesis of complexes carrying three different metal ions is the self-assembly process between of pre-formed 3d-3d' and 3d-4f heterobimetallic units and suitable diamagnetic or paramagnetic metalloligands. The obtained compounds will be characterized by means of X-ray diffraction techniques on single-crystal and powder,magnetic measurements,various spectroscopic techniques according to their properties(FTIR, NIR-UV-Vis, fluorescence and circular dichroism) and elemental analysis.The project could be almost completely carried out in Romania due to the existent infrastructure.

Metallo-complexes with functionalised tripodal ligands as molecular recognition devices Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0252 2011 - 2014

Role in this project:

Coordinating institution: Universitatea din Bucuresti

Project partners: Universitatea din Bucuresti (RO)

Affiliation:

Project website: http://www.chimie.unibuc.ro/cercetare/anorganica/te0252/

Abstract:

The current proposal is devoted to:

- the design, synthesis and investigation of chemical and physical properties of complexes of 3d metal ions and/or lanthanides(III)with tripodal ligands bearing functional groups (amino, carboxylato, -OH) or biological residues, such as amino-acids, oligopeptides, urea or guanidinium fragments;

- the investigation of the luminescent and magnetic properties of the metallocomplexes;

- the investigation of the ability of the metallocomplexes with one or two functionalised tripodal coordination sites in molecular recognition of different chemical species (anions, cations, small biological molecules);

- the synthesis and structural characterization of “molecular tweezers” based on bicompartmental ligands derived from o-vanillin, for specific recognition by hydrogen bonding of complexes with octahedral stereochemistry and two water or two ammonia ligands coordinated in trans position.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects