BrainMap

Mrs. GEORGIANA-ILEANA BADEA

PhD

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Researcher

Analytical chemist with experience in instrumental analysis, method development, and validation, focused on the analysis of chemical compounds in complex matrices. My work involves sample preparation, extraction techniques, and formulation-related studies, as well as qualitative and quantitative analysis using chromatographic and spectrometric methods (HPLC, LC–MS, GC–MS). I have a strong experimental background and practical laboratory experience, with attention to method robustness, accuracy, and reproducibility. My professional interests include analytical method optimization, extraction processes, and the characterization of active compounds for research and applied laboratory settings.

Web of Science ResearcherID: J-2512-2014

Curriculum Vitae (19/02/2026)

Expertise & keywords

Novel 3D bioprinted composites based on extracelular matrix components and bioactive antimicrobial compounds encapsulated in chitosan nanostructures for diabetic wound healing Call name: PNCDI IV, SP 5.7.1 - Proiect experimental demonstrativ
PN-IV-P7-7.1-PED-2024-1044 2025 - 2027

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); APEL LASER S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://proiecte.incdsb.ro/hemibiocomp/

Abstract:

The project proposal aims the development of an innovative strategy for diabetic wound healing by creating novel 3D bioprinted composites based on extracellular matrix components (gelatin and hyaluronic acid), algal antimicrobial peptides and trigger flavonoid (naringin) encapsulated in chitosan nanoparticles. The novelty of proposal consists of the following key aspects: synergistic effect of the antimicrobial activity of peptides obtained from green algae and trigger flavonoid (naringin); encapsulation of antimicrobial bioactive compounds in chitosan nanostructures and obtaining of novel 3D bioprinted composites. The physico-chemical and structural analyses of 3D bioprinted composites will be realized by SEM-EDX, X-ray diffractometry, FTIR and Raman spectroscopy. Functionality and effectiveness of 3D bioprinted composites will be validated by analysis of genotoxicity, anti-inflamatory and antimicrobial activity, cell migration and wound healing, in normal and diabetic in vitro conditions, and in vivo angiogenesis by spectrometry techniques, fluorescence/confocal microscopy, flow cytometry, ELISA and RT-PCR. The original results regarding the product and lab technology will be patented in view of transfer to the partner SME. The interdisciplinary public-private partnership will ease the development of new products that will bring benefits in wound healing and improving the life`s quality for people with diabetes.

Integrated analytical approach for identification of tropane alkaloids-producing plants and assessing their contamination level in herbal teas Call name: P 5.2 - SP 5.2.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - Competiția 2023
PN-IV-P2-2.1-TE-2023-0162 2025 - 2026

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation:

Project website: https://sites.google.com/view/contral21te/home

Abstract:

ConTrAl builds on numerous data and studies reporting that commercial herbal teas are highly susceptible to contamination with toxic tropane alkaloids (TAs), which in turn raise serious quality and public health safety concerns. The body of evidence shows an urgent need for more tailored methods to be developed and routinely applied to identify TAs contamination. Severe toxic effects occur in case of TAs overdosage. The most widespread source of unintentional ingestion of TAs is through the consumption of foodstuffs, mainly crops such as herbal teas, that have been contaminated or cross-contaminated as a result of co-harvested TAs-containing weeds. ConTrAl aims to develop, test, and apply innovative analytical solutions to detect plant species containing TAs and to obtain analytical data about the TAs that occur as contaminants in commercially available herbal teas. Specifically, DNA sequence-based assays using Barcode DNA-High Resolution Melting (Bar-HRM) will be developed, and the resulting data integrated with chromatography-based determinations for comprehensive evaluation of herbal teas quality with respect to TAs contamination. ConTrAl will provide the first (public) set of substantial data on the TAs occurrence in herbal teas commercially available on the Romanian market that will allow a better exposure assessment and characterization of the risks to human health associated with the intake of contaminated herbal teas.

Bioeconomy Excellence Alliance For StiMulating Innovative And Inclusive Green Transition Call name: PNCDI IV, P 5.8 - SP 5.8.1 - Orizont Europa - Premiere Instituții - Competiție 2024
PN-IV-P8-8.1-PRE-HE-ORG-2024-0190 2024 - 2025

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://proiecte.incdsb.ro/73-phe-2024/

Abstract:

The National Research and Development Institute for Biological Sciences, NIRDBS, has defined three main research directions that fit the strategic objectives of HORIZON EUROPE: (I) Biomedicine/Health, (II) Agriculture, Nutrition and Food Safety and (III) Environment and Biodiversity. The performance of the INCDSB research teams in these areas will be supported by the complementary areas in which the Institute has demonstrated its expertise at national and international level, namely: bioanalysis, bioinformatics, applied biotechnologies and research in extreme environments. Strengthening the institutional capacity to ensure continuous participation in competitions organised under the European Commission's Research Innovation Framework Programmes is one of the main objectives for the institutional development of NIRDBS. Therefore, the activities proposed in this project aim to improve knowledge sharing, strengthen innovation capacity and disseminate research results on a broad scale, based on the strengths in the areas of interest defined in the Bioeconomy Excellence Alliance For Stimulating Innovative And Inclusive Green Transition (BEAMING) project: Bioeconomy Research expertise, Open Science practises, Knowledge Valorisation and Inclusive Innovation Culture, which are in line with NIRDBS development and activity areas.

The development of an innovative product based on increasing the therapeutic potential of some extracts obtained within CROMATEC PLUS SRL Call name:
Proiect tehnologic inovativ - Apel 202, MySmis 156316 2023 - 2023

Role in this project: Key expert

Coordinating institution: CROMATEC PLUS SRL

Project partners: CROMATEC PLUS SRL (); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Project website:

Abstract:

Development of New PHYTo-formulations with enhanced BIOACTive potential based on polyphenols complexes from plants and vegetal by-products Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-3945 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA BUCURESTI (RO); CENTRUL DE CERCETARE SI PRELUCRARE A PLANTELOR MEDICINALE PLANTAVOREL SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://www.incdsb.ro/p/nphytbioact/Rezultate.html

Abstract:

NPHYTBIOACT project intends to demonstrate the feasibility of using innovative technologies to improve natural resources (plants and vegetal by-products) use and to increase the efficiency of phyto-products formulation. The core objective of the project: to settle a complete solution for development and lab-scale validation of new phyto-formulations with enhanced bioactivity. Achieving the NPHYTBIOACT major goal implies the following technological downstream: 1.Validation of the innovative technologies of extraction existing at the consortium level (TRL 3) for silymarin extraction from milk thistle and polyphenols/flavonoids extraction from rosehip; 2.Development and characterization of phytosomes (phyto-phospholipids complexes) based on complexes “active compound –phospholipids” to be further used in phyto-products formulation. In our case active compound are silymarin, respectively polyphenols/flavonoids while phospholipids are phosphatidylcholine, phosphatidylethanolamine phosphatidylserine; 3. Lab-scale new phyto-formulations based on the developed phytosomes & validation of the new-formulations

At the project completion the following outcomes will be provided: two validated extraction technologies (microwave assisted extraction), for silymarin from milk thistle (plant, by products) and polyphenols/flavonoids from rosehip (plant, young branches, by-products) and selective concentration and standardization in rutin, quercitrin and kaempherol will be performed; lab-scale validated procedures for phytosomes synthesis, silymarin-phytosomes, respectively flavonoids-phytosomes; validated formula for new highly bioactive phyto-products including synthesized phytosomes.

NPHYTBIOACT, aims to perform a step forward from the results existing at the consortium level, targeting to improve the existing know-how in order to obtain new phyto-products with enhanced bioactivity and increased solubility characteristics in physiological relevant fluids.

Metode inovative de valorificare a resurselor naturale si de imbunatatire a eficientei nutritionale a fito-produselor - contributii la cresterea competitivitatii micilor intreprinderi Call name:
2016 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Project website: http://www.incdsb.ro/p/FITOCOMP/index.html

Abstract:

Innovative methods for natural resources high valorisation and improving the nutritional efficiency of phyto products – knowledge support to increase the competitiveness of small enterprises

Buget 9015935 RON (1930607 Eur)

EU share (%) 83.72 %

Implemenmtation period (years): 2016-2021 (5 years)

Implementer (type): Public institution

Type of investment: Public and private

Operational objective Operational Program Competitiveness, axis: Research, Technological Development and Innovation (RDI) to support the economic competitiveness and business development

Expected direct results:

a.Knowledge transfer results

a1.Innovative solutions for phyto-products/phyto-drugs technologies; technological process innovation ensuring higher exploitation of natural resources (plants, fruits, biomass);

a2. Knowledge transfer portofolio including:

18 methods of characterisarion, efficiency assessement and quality control of vegetal material and formulated phyto-drugs;

3 new extraction technologies applicable to raw materials and by-products;

6 new customized instruments for fast analisys & quality control of agro-food/phyto-pharmaceutical products;

a3.Knowledge transfer online platform FITO-PLAT connecting experts, industrial end-users, technology brokers, regulatory organisations;

b.Human resources results

b1. 2 new available positions for specialists in knowledge transfer; technology brokers, innovation management;

b2. Increased professional capabilities of the implementation team by widening industrial experience and technology transfer experience as results of two instruments, professional formation and direct assistance in technology implementation at facilities of SME partners;

c.Increased number of direct contracts with SME providing direct servicies (45 new contracts), new implemented technologies (3 new contracts with SME’s from phyto-pharmaceutical industry, nutritional suplements industry and food/beverages industry) and food/beverages industry)

Expected outputs / deliverables:

The use of new technologies by the SMEs as recipient of the knowledge transfer will determine the optimization of the natural resources use by the beneficiary SME eliminating their dependence on the optimal harvesting periods and ensuring the continuity of the technological process line, accordingly contributing to the realization of a new value chain.

Direct assistance to increase the competitivness of at least 3 SME from Romanian agro-food industry, producing and promoting nutritional supplements, beverages and phyto-drugs, as recipients of knowledge transfer

Reducing the direct production pressure for existing technological lines at recipient SMEs by implementation of new control instrumenst and new valorisation technologies (for by-products)

Fast analysis method of aspartame from foods using an amperometric enzymatic biosensor Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0503 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/Aspsense/PED-180-ASPSENSE.htm

Abstract:

This demonstrative project aims to develop and validate in laboratory a fast analytical method for detection of aspartame from food samples based on a combination of an amperometric enzymatic biosensor and a Low-noise potentiostat. The growing use of aspartame in the food industry requires the development of rapid and effective methods for its determination. The project aims to provide a cost effective and easy to use analytical method of aspartame. The detection principle of the biosensor is based on enzymatic oxidation of aspartame catalyzed by carboxyl esterase (CaE) and alcohol oxidize (AOX), with the production of hydrogen peroxide that is electrochemically quantified. The developed potentiostat used for the quantification of the biosensors’ amperometric signals has two building blocks: (i) a potentiostat circuit that provides constant continuous voltage and (ii) current sensing circuit to quantify the current solution ICELL related with the concentration of aspartame. Low-pass filter will be added to the current sensing circuit’s feedback loop to diminish the induced electromagnetic noise effects. The consortium combines the vast experience in the field of biosensors and enzymology of National Institute of R&D for Biological Sciences with the know-how in electronic potentiostat design of the University Politehnica of Bucharest.

Pencil˗based sensor array for naringenin like compounds analysis from beverages Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0477 2017 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.chimie.unibuc.ro/cercetare/analitica/PED_2017_David_Iulia.pdf

Abstract:

The health benefits of phenolic antioxidants from food and beverages is well known. At present, there are no specific legislative or regulatory requirements with respect to antioxidant capacity of a compound nor a standard method for naringenine (NG) and derivatives quantification. Flavonoid antioxidants of NG and derivatives type exist in different concentrations in largely consumed beverages (beer, juice, tea) worldwide. Therefore, there is a great demand on cheap and non-polluting methods for rapid, routine determination of the composition of complex samples with implications on human health. The aim of the present project is the development and validation of a method for NG and derivatives determination and of a dual sensors array based on disposable pencil graphite electrode (PGE) which has good electrode characteristics, is non-toxic, cheap, easy to procure, being largely commercially available. The device intended to be developed and validated consists of a bare PGE for the content and a DPPH-modified –PGE for the antioxidant efficacy assessment of NG and derivatives from beverages, using methods already developed by project team members (coordinator-UB has experience in voltammetric methods development based on PGE; partner P1- NIRDBS has expertise in methods and sensors development pot the assessment of antioxidant efficacy of compounds from different matrixes). According to the existing team members’ publications, this proposal starts from TRL2 and reaches TRL4 after the development and validation of the dual sensors array. The proposed device could be used as a reliable and rapid tool for beverages process control in order to replace tedious and time-consuming analysis, if yes/no decisions should be taken.

High Valorisation of Press Cake Resulted in Processing of Milk Thistle Oil by Cold Pressing Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0119 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); HOFIGAL EXPORT IMPORT SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: https://www.chimie.unibuc.ro/cercetare/analitica/VALSUSA.pdf/

Abstract:

The project is targeting two main objectives: a) development of efficient extraction technologies to support the higher valorisation of byproduct resulted from milk thistle processing to obtain oil; b) strenghtening the collaboration between academic research and industrial end-users and enhancing the human resource expertize. Achieving the first objective involves the following subsidiary objectives: characterization of by-product from the production of oil thistle in terms of profile composition and initial efficacy; development and optimization of extraction technologies; formulation and characterization of extracts with high content of sylimarin; demonstration/testing/validation of realised extraction technologies for the trader. At the end the obtained product have to have a silymarin concentration of at least 50%. The second objective consists of training internships of master students at the trader facilities, to enhance their entrepreneurial capabilities, and the training of specialized HOFIGAL staff in academic laboratories.

The assessment of composition profile will be performed by HPLC – DAD- MS, capillary electrophoresis, fluorimetric methods, chemiluminescent method etc. Silymarin extraction will be accomplished using: ethyl alcohol, methyl alcohol, ethyl acetate, dioxane, water or various mixtures solvent/water. It will be performed the study of the temperature influence and the influence of the extraction technique used: percolation / maceration, Soxhlet, and accelerated extraction based on the use of cavitation phenomena (ultrasound or microwave assisted) on sylimarin extraction yield. The aim is to settled extraction technologies based on the use of non-flammable solvent (or with reduced flammability) and mild working conditions, as technology agreed by trader. The extracts antioxidant capacity and their antitumoral effects will be assessed. The obtained silymarin concentrate will be used by HOFIGAL in phyto-drugs formulation and food supplements.

Integrated system for monitoring and bioremediation of metal/radionuclides - contaminated area Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0608 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO); CP MED LABORATORY SRL (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU METALE SI RESURSE RADIOACTIVE - I.C.P.M.R.R. BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/Imonbio/Proiect.html

Abstract:

The core objective of the proposal consists in the development of new integrated system for monitoring and bioremediation of metal/radionuclides from contaminated areas, this meaning the complex approach of the subject from the following points: development of new analytical methods/devices applicable to fast assessment/monitoring of heavy metals and radionuclides from contaminated areas; development of a bio-remediation strategy based on micro-organisms effective against the two classes of contaminants. The project proposes as monitoring devices an array of electrochemical (enzymatic and micro-organism based) biosensors, selective and sensitive for heavy metals and radionuclides. Envisaged heavy metals are copper, lead, mercury, cadmium, zinc, while envisaged radionuclides are uranium, radon, and thorium.

The following subsidiary objectives are envisaged:

 Design of a microorganisms based bio-remediation strategy and development of the experimental model on lab-scale;

 The versatile use of Pseudomonas and Clostridium strains, both in bio-remediation strategy (as biocatalysts) and in biosensors construction (as pollutants bio-recognition element).

 Design, construction and validation of the new analytical device: biosensor platform based on microorganisms and enzymes immobilization.

 Design of a demonstrator model to support the bio-remediation strategy

Sustained dissemination actions (ISI papers, Conferences) and patent request are also planned.

Higher Valorisation of Vegetal By-Products and Wastes to Support Sustainable Use of Natural Resources Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0361 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website: http://www.incdsb.ro/p/HIVEGRES/index_ro.html

Abstract:

The project Higher Valorisation of Vegetal By-Products and Wastes to Support Sustainable Use of Natural Resources - HIVEGRES- proposes, in general terms, new technologies able to improve the natural resources use (wastes and by-products) and to increase the efficiency of bio-products formulation in terms of process control and formulation technology. The project frames in the general field of Industrial Green Technology aiming to acquire, by safe methods, an enhanced content of high quality natural nutraceutics to be used as supplements and additives in obtaining efficient functional phyto-products.

HIVEGRES project aims to provide industrial innovative solutions (sustained by a strong scientific basis) to cover the industrial activities which are supporting the base for launching new healthy products, conforming to EU regulations and claims, with lower processing and production costs while enhancing the natural resources sustainable use; the project is focusing mainly on the phyto-pharmaceutical products sector.

In the frame of present project the practical addressed issues are:

1) Improved, sustainable use of natural resources by recycling vegetal wastes and by-products, improving the production yields and, consequently saving material from disposal while improving the whole process

2) Introducing new tools to control and monitor the production process and to assess the products quality: nano-sized biosensors array and flow injection analysis (FIA) methods and device

3) To create new opportunities for functional phyto-products diversification and opening new prospects in the market segment for the involved Small and Medium Enterprises (SMEs).

To achieve the main goals of the project within the proposed 24 months project, the following main active principles are envisaged: the most efficient xanthophylls (Lutein and Zeaxanthin), carotenoids and anthocyanins from vegetal by-products, respectively wastes. For each active principle a specific vegetal source will be addressed, accordingly to the existing by-products and wastes and to the expected content of compounds occurring in each source.

Targeted vegetal materials are: by-products resulted from Vaccinium vitis-idaea, (cowberry), Myrtilli fructus and leaves (bilberry), Cynosbati fructus and leaves (rosehip), Hippopheas fructus (sea-buckthorns) and leaves (wild and cultivated in Romania, mainly Northern part) and vegetables wastes resulted from cultivars (all over the country) of tomatoes, carrots and egg plants.

Two important innovative approaches are proposed by HIVEGRES: in the products quality control (raw material and final products) by introducing nano-sized sensors able to provide information which comply to EU claims, and in natural resources processing technology, by proposing an improved extraction technology able to lead to higher extraction yield of active principles.

Elaboration and implementation of a new diagnosis algorithm in malign pathology of the genital system and mammary gland, based on the correlation of clinical and preclinical factors with genetic and epigenetic ones Call name:
PNII: Program 4 Parteneriate: 62086/2008-11 2008 - 2011

Role in this project: Key expert

Coordinating institution: SPITALUL CLINIC CF NR.2 BUCURESTI

Project partners: SPITALUL CLINIC CF NR.2 BUCURESTI (); UNIVERSITATEA BUCURESTI ()

Affiliation: SPITALUL CLINIC CF NR.2 BUCURESTI ()

Project website:

Abstract:

Cercetarile intreprinse in domeniul oncologiei clinice si experimentale din ultimele aproximativ trei decade au condus la conturarea unor concepte fundamentale privind originea si evolutia bolii canceroase bazate pe etiologia multifactoriala, dezvoltarea secventiala, rolul mediului, al reprogramarii genetice si implicarea deopotriva a factorilor epigenetici. Aceste realizari din domeniul cercetarii fundamentale au contribuit intr-o masura substantiala la dezvolatarea strategiilor actuale de diagnostic si terapie anticancer. Experienta acumulata in practica strategiilor mentionate, nu a dovedit totusi eficienta scontata initial, mai ales in ceea ce priveste boala metastatica, aspectele de susceptibilitate individuale si de borderline.

Modelul de studiu ales in cadrul proiectului este complexul de cancere ale aparatului genital si al glandei mamare, motivele alegerii fiind corelate cu incidenta crescuta a acestor maladii in lume si in tara noastra, cat si cu posibilitatea abordarii comparative mai facile a acestei forme de cancer pe model animal, (tumori spontane canide), care inregistreaza, de asemenea, o cazuistica numeroasa si forme histologice similare cu cele intilnite la femeie. Obiectivul major al cercetarii propuse este integrarea in cadrul bilantului clinic si paraclinic a unor informatii furnizate de metodele moleculare genetice si epigenetice de analiza care sa permita o mai buna caracterizare a stadiului bolii si sa reprezinte un punct de plecare in individualizarea terapiei si a urmaririi bolii postterapie, inclusiv in surpinderea si caracterizarea metastazelor.

Proiectul vizeaza dezvoltarea cunostintelor stiintifice in domeniu, definirea unor noi markeri biologici cu relevanta in aprecierea gradului de severitate al bolii pe baza selectiei fenotipurilor moleculare specifice. Definirea algoritmului de criterii moleculare va implica, in faza iniziala, un studiu genetic (mutatii) si epigenetic (modificari covalente la nivelul componentelor cromatinice ADN si histone) al unor seturi de gene critice pentru toate tipurile de cancer (gene care controleaza ciclul celular, procesele de reparare ADN si adeziunea celulara). Fazele urmatoare vor viza particularizarea seturilor de gene candidat pentru cele trei tipuri de cancer ginecologic si ale glandei mamare (cancer mamar, de endometru si ovarian), numitorul comun al acestora fiind considerat setul de gene implicate in activitatea receptorilor de hormoni. Proiectul vizeaza in final stabilirea genelor candidat definitorii pentru fiecare tip de cancer luat in studiu. Totodata, se are in vedere considerearea factorilor de risc familial (asociat cu gena de risc BRCA1), cat si de susceptibilitate individuala pentru cele trei tipuri de cancere, asociata cu genele BRCA1 si BRCA2.

In cadrul markerilor biologici sunt propusi de asemenea metabolitii (S-adenozilmetionina, S-adenozilhomocisteina si homocisteina) implicati in caile metabolice ale grupei metil (recuperarea donorilor de metil in procesele de metilare ADN si histone), acestia avand un rol critic in intretinerea stabilitatii genomice si fiind considerati indicatori de risc in anumite boli metabolice (diabet, cardiovasculare), cancer si boli asociate imbatranirii.Metabolitii vor fi monitorizati astfel in sangele periferic al indivizilor selectati pe baza criteriilor clinice si paraclinice si confirmati genetic si epigenetic. Acestia vor fi corelati intr-o abordare metabolomica, implicand si un studiu al polimorfismului genei critice mthfr (metilentetrahidrofolatreductaza), in scopul conturarii unui tablou al elementelor de preventie prin stil de viata si dieta.

Modelul de studiu propus este interdisciplinar; el este in conformitate cu obiectivele si prioritatile programului national de cercetare si antreneaza participarea unui numar mare de specialisti in diverse domenii (medicina, biologia dezvoltarii, biochimie analitica, genetica moleculara, epigenetica), a caror experienta in aplicarea diagnosticului clinic si paraclinic cat si a tehnicilor de bioanaliza, bazate pe o diversitate de metode moderne moleculare si modelare matematica, face posibila obtinerea unui tablou complex al mecanismelor moleculare de cancerogeneza, cu accent pe factorii epigenetici.

Prestige and Power. Romanian Museums’ Antique Items of Trade. Non-metallic adornments, with an archaeometrical study regarding the origin of amber beads Call name:
91-019/2007, 2007 - 2010

Role in this project: Key expert

Coordinating institution: MUZEUL NATIONAL DE ISTORIE A ROMANIEI

Project partners: MUZEUL NATIONAL DE ISTORIE A ROMANIEI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: MUZEUL NATIONAL DE ISTORIE A ROMANIEI (RO)

Project website: http://http//www.romanit.ro

Abstract:

FAST METHODS FOR TOXINS MONITORING DURING FOOD PROCESSING TECHNOLOGIES FOR SAFETY IMPROVEMENT Call name:
61-030 / 2007 2007 - 2010

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Project website: http://www.icechim.ro/biotehnologie/proiecte/safefood/indexen.php

Abstract:

New biocompatible nanostructured materials with guided properties and biomedical applications Call name:
129/2006 2006 - 2008

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (); UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (); UNIVERSITATEA BUCURESTI (); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (); ASOCIATIA "CENTRUL DE BIOTEHNOLOGII MICROBIENE" - BIOTEHGEN ()

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE ()

Project website:

Abstract:

Mobilitate cercetător GEORGIANA-ILEANA BADEA Call name: PNCDI IV, SP 5.2.2 - Proiecte de mobilitate pentru cercetatori, MC-2024
PN-IV-P2-2.2-MC-2024-0668 2024 -

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website:

Abstract:

3th International Conference and Innovation in Art Research and Technology Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2017-2093 2017 -

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects