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Romania
Citizenship:
Ph.D. degree award:
Ioan Andrei
Dascalu
-
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"
Researcher
10
years
Personal public profile link.
Expertise & keywords
gene and drug delivery
Fullerenes
Cyclodextrin
Organic synthesis
Metal-Organic frameworks
Organic synthesis
Projects
Publications & Patents
Entrepreneurship
Reviewer section
New coordinated porous polymers with variable sized organic ligands for gas storage
Call name:
2016
-
2020
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"
Project partners:
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" ()
Affiliation:
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" ()
Project website:
http://pocpolig.icmpp.ro/
Abstract:
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Functional DNA nanostructures-gold nanoparticles for targeted gene therapy purposes
Call name:
Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-1444
2015
-
2017
Role in this project:
Coordinating institution:
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"
Project partners:
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)
Affiliation:
Project website:
http://rotarualexandru.wix.com/dnananogold
Abstract:
The new and emerging field of DNA nanotechnology centres around the unique self-assembly properties of DNA and other nucleotide derivatives to form nanoscale structures with predictable geometry and/or function. It includes studies of the basic self-assembly properties of single bases to large assemblies of hundreds of DNA strands. Chemical synthesis of short DNA sequences makes it possible to insert non-natural chemical modifications at specific positions in DNA strands. Such modifications include fluorophores, biotin and in particular reactive chemical linkers that in turn make it possible to covalently attach other molecules or nano-objects to DNA. In consequence, DNA Nanotechnology has the potential to solve one of the major challenges of Nanotechnology - the precise assembly of nano-scale materials for different applications. In this regard, DNAnanoGold project proposes to explore the potential of precisely assembled DNA nanostructures to be decorated with functionalized gold nanoparticles with the ultimate goal of creating functionalized nano-carrier for targeted gene therapy. The proposed system possesses biocompatibility and a very precise shape and size control. It takes advantage over other functionalized nanostructures by multiple active and recognition sites and by controlled fluorescent labeling. Besides the scientific value of the proposal, DNAnanoGold intends to create a unique young interdisciplinary research team in the emerging field of DNA Nanotechnology.
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Biologically inspired systems for engineered structural and functional entities
Call name:
Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0028
2012
-
2016
Role in this project:
Coordinating institution:
"Petru Poni" Institute of Macromolecular Chemistry
Project partners:
"Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "N. Simionescu" Institute of Cellular Biology and Pathology (RO); " Gheorghe Asachi" Technical University of Iasi (RO); " Costin D. Nenitescu" Institute of Organic Chemistry (RO)
Affiliation:
Project website:
http://www.intelcentru.ro/Biomimetics_PCCE
Abstract:
The project aims to study, to develop and to preliminary test biomimetic structural and functional entities, able to act as gene transfection vehicles of non-viral type, and having a DNA packaging capacity of about 2 5 kilobases. The main features of these entities are: (i) the general structure of a polyplex, (ii) the functionality of a cargo-complex that chemomimic the histones, morphomimic the nucleosome and biomimic a virus like gene vector, (iii) the ability to include or to reversibly bind and transport (bio)chemical species necessary to assist the DNA vehiculation and trafficking, (iv) are based on fullerene-rich polymers and / or dendrimers, (v) the capacity to associate to artificial extracellular matrices, in order to generate gene delivery systems with transfection ability, for ex vivo applications. The developed entities will represent effective tools in genetic and tissue engineering, useful in health restoration, life quality enhancement, and to cure tissue and human organism deficiencies. The envisioned engineering strategy to build biomimetic entities may sustain a spin-off type transfer of knowledge towards hi-tech application areas, with a clear echo in clinics and, finally, in human health. The project involves seven complementary teams hosted by four research and academic institutions. In equilibrated ratios, senior, young and junior researchers will collaborate inside the project frame.
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Bionanoconjugates formation by laser ablation in liquid
Call name:
Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0174
2011
-
2014
Role in this project:
Coordinating institution:
Institutul de Chimie Macromoleculara "Petru Poni" Iasi
Project partners:
Institutul de Chimie Macromoleculara "Petru Poni" Iasi (RO)
Affiliation:
Project website:
http://www.intelcentru.ro/BioNP/index.html
Abstract:
The object of this proposal is the formation of metallic or metal oxide bionanoconjugates. Bionanoconjugates are functionalized nanoparticles, attached to biomolecules. The formation method we propose is based on laser ablation of the metal or metal oxide immersed in an appropriate liquid medium (solution). The biomolecules (or other species that will subsequently react with the biomolecules) are present in the solution and will act as capping agent, preventing the agglomeration of the formed nanoparticles and stabilizing the obtained colloid. The bionanoconjugates thus formed suitable for biological applications.
We will produce and characterize cysteine – gold nanoconjugates in aqueous solution and oleic acid coated magnetite (Fe3O4) nanoconjugates that will be used afterwards to form bionanoconjugates of interest.
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Synthesis and in vitro/in vivo assessmnet of new conjugates with antimicrobial activity
Call name:
P 3 - SP 3.1 - Proiecte de mobilități, România-Moldova (bilaterale)
PN-III-P3-3.1-PM-RO-MD-2016-0110
2016
-
Role in this project:
Coordinating institution:
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"
Project partners:
INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); Institutul de Chimie al Academiei de Științe a Moldovei (MD)
Affiliation:
Project website:
Abstract:
Propunerea de proiect se axeaza pe o cercetare interdisciplinara prioritara a nanomedicinei: nanosisteme de transport cu eliberare controlata de medicamente, incadrandu-se in prioritatile tematice ale programelor PN III si Orizont 2020. Obiectivul strategic al acestui proiect este de a dezvolta o colaborare stiintifica intre parteneri din diferite tari cu competente complementare, care sa creeze premisele recunoasterii si integrarii colectivelor in proiecte internationale. Proiectul isi propune instruirea si perfectionarea tinerilor cercetatori, eficientizarea schimbului de experienta intre parteneri, cresterea transparentei si credibilitatii in fata partenerilor internationali prin implicare in propunerile de proiecte europene. Prezentul proiect are trei obiective stiintifice majore: (i) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo de noi compusi mic moleculari cu activitate antimicrobiana (derivaţi ai oxindolului, oxadiazolului, triazolului, tiazolidinelor); (ii) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo a complecsilor de incluziune pe baza de ciclodextrine adecvat functionalizate si compusi mic moleculari sinteti in cadrul obiectivului (i), pentru a obtine sisteme de transport si eliberare controlata de medicamente; (iii) valorificarea rezultatelor prin prezentarea la manifestari stiintifice,vpublicarea in reviste cotate ISI si pregatirea de proiecte stiintifice pentru competitii lansate in Programul Orizont 2020.
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FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
[T: 0.3912, O: 180]