BrainMap

Mrs. Irina Rosca

PhD

Researcher - INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Researcher

Web of Science ResearcherID: AAA-6788-2019

Curriculum Vitae (08/10/2019)

Expertise & keywords

BIOMAT4CAST - PETRU PONI INSTITUTE OF MACROMOLECULAR CHEMISTRY MULTI-SCALE IN SILICO LABORATORY FOR COMPLEX AND SMART BIOMATERIALS Call name: P 5.8 - SP 5.8.1 - Premiere Orizont Europa - Instituții - Competiția 2023
PN-IV-P8-8.1-PRE-HE-ORG-2023-0048 2023 - 2027

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://icmpp.ro/projects/l1/about.php?id=69

Abstract:

The aim of the BioMAt4CAST - Support project is to strengthen the institutional capacity of ICMPP, through the institutional award given to organizations that successfully apply and implement projects financed by the European Commission's Innovation Research Framework Program. The funding allocated through the BioMAt4CAST – Support project supports the project signed with the European Commission, BioMat4CAST (GA 101086667), by creating new support activities. The funding obtained through the European project is mainly focused on the molecular modeling and simulation team and less on the experimental team. For this reason, BioMat4CAST - Support will be directed to the priority financing of experimental research activities that are not provided in the already signed project with the European Commission, procurement activities for the development of the research infrastructure and those for disseminating the results. Thus, the proposed activities will lead to the strengthening of the institutional capacity to sustainably participate in new competitions organized in the Innovation Research Framework Program of the European Commission.

Innovative multifunctional, bioactive topical formulation for the management of malignant wounds Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2193 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); SANIMED INTERNATIONAL IMPEX S.R.L. (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://bios.unibuc.ro/Proiecte/proiect-pn-iii-p2-2-1-ped-2021-2193.html

Abstract:

Malignant fungating wounds (MFW) are incurable, severe, and debilitating conditions normally occurring in the last (six) months of oncologic patient’ life, affecting the overall quality of life and requiring appropriate palliative care to alleviate pain and suffering. MFW’s microbiome may influence the development and severity of wound symptoms, causing foul odors, peri-wound skin damage, inflammation, and ultimately, delays in the healing proliferative phase. ARGOS project is implemented by a consortium of two research institutions and one company with previous experience in developing collagen-based pharmaco-cosmeceutic products and is aiming to develop an innovative multi-purpose, bioactive topical formulation to assist the physical management of malignant fungating wounds, by addressing the microbiome-related symptoms such as pain, odor, and exudate. The proposed solution is based on collagen and inorganic - gold, silver and magnetic – nanoparticles functionalized with plant-derived bioactive compounds (such as polyphenols contained in Chelidonium majus L. and Tamarix gallica extracts, with previously demonstrated antioxidant, antimicrobial, antiproliferative, antiviral and immunomodulatory activity). Therefore, the main novelty of the proposed solution is that it provides not only a wide antimicrobial effect, but also anti-cancer activity and pro-healing properties on the site of malignant wounds. The physico-chemical, mechanical and biological properties of the collagen-based optimized product will be validated by standard protocols and the technological scaling documentation and argumentation of the investments required for in vivo tests will be elaborated (TRL4).

Improved technologies for the development of electrospun polysulfone membranes integrated in an extracorporeal device applicable in renal failure Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2700 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA POLITEHNICA TIMIŞOARA (RO)

Affiliation:

Project website: https://icmpp.ro/techmembreid/

Abstract:

Renal failure is one of the major health issues faced by many people worldwide, having a negative economic impact on health systems, due to the increasing prevalence of the disease. This shortcoming highlights the urgent need for innovations on to dialysis therapies, by development of new approaches/strategies and dialysis therapeutic modalities that are cost-effective, accessible and offer improved patient outcomes. As a result, one of the challenges of the project is to catalyze the fundamental redesign of dialysis, supported by a series of innovations in biomaterials field used for hemodialysis and to develop a novel technology able to overcome the disadvantages of conventional dialysis technologies and to offer numerous advantages. Thus, in order to achieve these improvements, the innovation of this project consists in the design and development of new bioactive functionalized hollow membranes - fibrous functionalized bioactive membranes based on quaternized polysulfones - with improved characteristics (modeled and controlled morphology, biocompatibility, hydrophilic/hydrophobic balance), which will be used as medium separations in an extracorporeal innovative device which will be tested and validated at the laboratory-scale. Consequently, the project will provide a new high-performance technology, tested and validated at the laboratory-scale, which will ensure an advanced hemodialysis treatment, contributing significantly to the quality and efficiency of the systems that address human and by thematic approach being connected to international directions on research-medical development namely the main fields Eco-nanotechnologies and Advanced Materials, Life Sciences – Biotechnology.

Metal oxide nanoparticles as new and effective alternatives for duodenoscope reprocessing Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0739 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://icmpp.ro/projects/l1/about.php?id=45

Abstract:

NanoClean aims to identify a new efficient, cost-effective solution to one of the most provocative challenges of the gastroenterology field represented by dodenoscope reprocessing. Within this framework it is evaluated for the first time the disinfectant activity of metal oxide nanoparticles (MeO-NPs), in an attempt to improve the quality of medical care and the quality of patient’s life. There will be synthetized, characterized and tested different classes of MeO-NPs represented by simple and mixed metal oxides with antimicrobial properties. The additive or synergistic interactions resulting from the loading of nanoparticles with active substances will be studied. Through the products developed and tested, the project explores the possibility of obtaining disinfectants that have a different mechanism of action than the classic substances, with applications against resistant pathogens. To evaluate the disinfection efficacy and the required time of contact MeO-NPs will be tested in vitro in biomimetic conditions on multidrug-resistant organisms (MDRO) producing biofilms on duodenoscope. Subsequently there will be tested also the MeO-NPs compatibility with duodenoscope polymer coatings, internal channels and elevator. This project constitutes a new direction in finding new classes of efficient disinfectants to fight against microbial resistance, emphasizing MeO-NPs as a promising alternative which meets the requirements to be used in duodenoscope reprocessing.

Hybrid bio-systems enriched with biotechnological extracted oils and applicability in skin tissue engineering Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-2229 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation:

Project website: https://hytechskin.wordpress.com/

Abstract:

Infections are a common problem associated with dermal wounds, contributing to tissue degeneration and, in extreme cases, leading to death. In this context, hydrogels with antimicrobial activity become indispensable for covering the surfaces of implants or for direct treatment of wounds to prevent or even inhibit existing infections. The main goal of the project is the development of a new strategy for the preparation of a hybrid gel biostructure based on a natural / synthetic polymer matrix enriched with active antibacterial ingredients extracted from aromatic plants. The new gels will be the main component of a new patch improved with antibacterial compounds obtained from bio-extracts. The project will bring clear results in the field of biotechnology supporting the use of new components with therapeutic activity extracted from plants.

Versatile molecular vectors with tailored carrying and actuating abilities, dedicated to gene and drug delivery in fight against cancer Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1523 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://www.intelcentru.ro/tm-vector/index.php

Abstract:

Gene therapy represents nowadays one of the most challenging promises for the cure of cancer, rare, and severe diseases. The speed of the steps toward it strongly depends on the efficacy and reliability of the molecular tools involved in the manipulation (isolation, reconfiguration, multiplication) and vehiculation (native state preservation, dense packaging, targeted and “stealth” delivery, local protection) of the nucleic acids.

The main objective of TM-Vector project is to develop a highly reproducible macromolecular edifice capable to function as a cooperative carrier for nucleic acids, characterized by the ability to be post-decorated with biochemical and / or pharmacologic active molecules, by virtue of dynamic processes of selective affinity of host-guest type. The particular architecture of the carrying vector will offer three unique functional properties, representing our original contribution to the practice of nucleic acid vectorization: (i) the ability to target various cell receptors; (ii) the possibility to concomitantly vectorize several types of active molecules (e.g. nucleic acid molecules and pro-drug molecules); (iii) the capacity to selectively attach molecules having neat different volumes and conformations.

TM-Vector project could have societal impact, contributing to the improvement of the quality of life of sufferers. The applied research directions could also contribute to the technology of gene and drugs carriers produced at biopharmaceutical scale.

Eco-nanomaterials based on chitosan for applications of contemporary interest Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2717 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://icmpp.ro/projects/l3/about.php?id=39

Abstract:

The goal of the project is to develop new ecological sustainable chitosan based nanofibers by ecological electrospinning method in view of application in healthcare and environment protection. The central idea is to use quaternary salts of chitosan as co-spinning agent of chitosan to prepare a library of chitosan/quaternary salts of chitosan nanofibers (C/Q-NF). This will be further developed by embedding various fillers towards composite nanofibers and by imination towards dynamic imino derivatives, targeting to amplify properties for certain applications. The project proposal implies a systematic investigation of the new ecological nanomaterials, by laborious laboratory work and a solid knowledge of the state of the art, to produce a database comprising manufacture conditions/products/properties. Thus, the novelty of the proposed nanomaterials, the well documented premises behind their design, and the well-organized form of presentation of the project findings will contribute substantially to facilitate the transfer of the research to application towards the society benefit.

Zwitterionic porous microparticles containing zein and betaine moieties, with antimicrobial activity and drug delivery capabilities Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-1541 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://icmpp.ro/projects/l4/about.php?id=33

Abstract:

The necessity to increase the treatment efficiency in medical and pharmaceutical fields has led to the improvement of the already existing drug carriers and to new methods for the development of drug delivery systems with various sizes, morphologies and properties. The ZwitterZein project objective is to design novel macromolecular supports based on zwitterionic porous microparticles containing zein and betaine moieties in order to obtain efficient drug delivery systems for both hydrophobic and hydrophilic drugs as well as novel antimicrobial materials with possible medical applications. The Zwitterzein project specific objectives are the development, characterization and testing of zwitterionic microparticles containing zein and betaine moieties, as complex drug vehicles for targeted delivery: (OS1) synthesis of porous crosslinked microparticles based on glycidyl methacrylate, N-vinylimidazole and various crosslinking monomers, (OS2) preparation of novel zwitterionic porous microparticles containing zein and betaine moieties, (OS3) core/shell composite construction by in-situ CaCO3 crystallization on porous microparticles, (OS4) complex characterization of all obtained materials, (OS5) study of zwitterionic porous microparticles antimicrobial activity and their drug loading/release capabilities. Project dissemination: 6 articles in ISI ranked journals, participation at 6 international conferences, 3 technical-financial reports, 1 website.

Resorbable bandage with "on demand" norfloxacin release for the healing of burn wounds Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-5071 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: https://www.icmpp.ro/projects/l3/about.php?id=28

Abstract:

The present project proposal is the result of the cumulated experience of two teams, which intend to further bring together researchers with diverse and complementary skills and expertise in chemistry, materials science, and pharmacology to provide a marketable product for burn wound healing. The proposal is made considering the critical socio-economic impact of burns, especially in low- and middle-income countries, such as Romania.

The product is designed in the form of a non-woven fiber bandage made of biodegradable chitosan, and is expected to promote the scar-free healing, without trauma.

To reach this goal, the original approach of the project is to produce nanoporous chitosan fibers, which are able (i) to encapsulate a broad-spectrum antibiotic (norfloxacin) inside the interconnected nanopores created in the fibres mats, (ii) to ensure a high swelling degree of the fibers, necessary to allow the exudate drainage while maintaining a moist environment for healing, and (iii) to obtain tiny chitosan surfaces, facilitating biodegradation over the healing period. The fibers will be sealed by iminoboronate units, which also exhibit a strong antimicrobial activity.

Therefore, the final product is expected to ensure the exudate drainage and to act as a barrier against bacterial and fungal infections. In addition, the product is biodegradable, which avoids the traumatic debridement process characteristic of traditional dressings. The product is designed to respond “on demand” to the infections threatening healing, circumventing the need for cleaning and redressing, which allows the body to do work on its own.

The behaviour of new multicomponent polymeric systems in simulated environmental conditions for flame retardant coating materials Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-0604 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: https://www.icmpp.ro/epoxyphosdeg/

Abstract:

Polymeric materials are continuously replacing traditional ones. These materials easily ignite and rapidly spread flames, releasing highly toxic and corrosive gases. Ten to twenty persons per million inhabitants die each year from fires occurring in industrialized countries. Along greenhouse effect gases, many other toxic gases and compounds are generated during uncontrolled fire spread, such as carbon monoxide, hydrogen cyanide, dioxins, furans and corrosive gases: sulfur dioxide, nitrogen oxides, hydrochloric acid and aldehydes. Reducing fire risk leads to a significant decrease of toxic emissions. Volatile phosphorylated compounds are among the most effective combustion inhibitors, since phosphorus-based radicals are five times more effective than bromine, ten times more effective than chlorine radicals, and far less toxic than both. Since 2006, when the European Union restricted hazardous compounds, the need of developing halogen free fire-resistant materials emerged. The originality and innovation of the project objectives consist in the synthesis of new flame retardant semi-interpenetrating polymer networks based on a cross-linked epoxy network with three different curing agents and phosphorus containing aromatic polyester, as potential coating materials, correlation of their different thermal and UV accelerated aging decomposition mechanisms with the materials flame retardant capacity for outdoor exposure (on which no literature was found) and the forming of a group in new interdisciplinary approach for developing a future subdomain in characterizing flame retardants. The project relevance reflects on fundamental and applicative knowledge, educational area, by creating new international interdisciplinary research collaboration opportunities, technological research area, by generating guidelines for material design, and economic domain, by providing fundamental and experimental know-how for possible future sustainment of technological transfer to companies.

Mimicking living matter mechanisms by five-dimensional chemistry approaches Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0050 2018 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); CENTRUL DE CHIMIE ORGANICA AL ACADEMIEI ROMANE "C.D.NENITESCU" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.intelcentru.ro/5D-nanoP/

Abstract:

Mimicking the living matter mechanism of cooperation by complementarity represents one of the most challenging tasks of supramolecular chemistry. For now the solution consists in using particularly designed molecular unimers, endowed with the necessary amount of chemical information.

The 5D-nanoP project is dedicated to interfacing the fundamental research area of constitutional dynamic chemistry with the practical approaches of medicinal chemistry and biomedical applications. In the spirit of a metaphor of Jean-Marie Lehn (Nobel Prize in Chemistry, 1987), the project aims to materialize the concept of 5D chemistry in designing, synthesizing, characterizing, and using molecules with conditional affinity, to build versatile supramolecular nanoplatforms able to vectorize compounds of pharmaceutical or biochemical relevance, and genetic actuators, all of them involved in physiologic and pathologic processes at cell- and tissue-level.

The project will add the layer of 5D chemistry over the backgrounds of molecular assembling line techniques to produce particulate nanoplatforms, self-assemblable in the virtue of the chemical information stored by the designed unimer molecules. Two modern techniques of building dynamic chemical structures will be considered: (i) the use of self-immolative linkers, and (ii) the space stepwise and time phased (microfluidic) assisted synthesis. To prove the applicability of the produced nanoplatforms, an ex vivo cell cultivation system will be developed to emulate tissue/tumor niches.

Eight teams will be involved in the 5D-nanoP project to cover the main addressed research areas: (i) the in silico molecular design, (ii) the development of a unimers chemical library, (iii) the development of a molecular assembling line, (iv) the conjugation of the developed platforms with chemical species of biomedical interest, (v) the build of ex vivo emulating niches, and (vi) the bio-oriented assessment of nanoconstructs efficacy.

Smart Wound monitoring Restorative Dressings Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0138 2021 - 2021

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation:

Project website: https://icmpp.ro/projects/l3/about.php?id=38

Abstract:

The project aims to prepare non-woven mats based on chitosan and two aldehydes, in order to be used for chronic wound healing. This objective will be reached at the level of eight activities, mainly targeting (i) the preparation of the chitosan based nanofibers by electrospinning, (ii) their functionalized with two aldehydes with complementary activity: one with antimicrobial activity and another one with potential to improve its permeability towards the bacteria membrane, and (iii) their characterization from structural, supramolecular and morphological point of view, and biodegradation and antimicrobial properties as well.

Intelligent therapies for non-communicable diseases based on controlled release of pharmacological compounds from encapsulated engineered cells and targeted bionanoparticles Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0697 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU''

Project partners: INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA ,,NICOLAE SIMIONESCU'' (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/intera.html

Abstract:

Non-communicable diseases (atherosclerosis, diabetes, obesity), a major cause of mortality, are characterized by associated inflammatory processes. The complex project INTERA aims to develop innovative therapeutic methods to ameliorate the pathological progression by reducing the inflammatory process. The multidisciplinary studies proposed by INTERA can create and define new nano- or micro-medical devices usable for smart and innovative anti-inflammatory therapies. INTERA includes 4 projects: (1) Encapsulation of genetically manipulated eukaryotic cells for controlled release of pharmacologically active products; (2) Development of a 3D platform designed for pre-clinical drug testing composed of cells incorporated into three-dimensional bio-matrices; (3) Intelligent nanobioparticles designed for bioactive compounds vectoring to pathological sites for vascular inflammation targeting. (4) Polymeric conjugates for efficiently inducing the expression of genes of interest with applicability in cellular therapy. The consortium consists of 4 partner research units - two institutes of the Romanian Academy (IBPCNS, ICMP), a university (UPB) and a national CD Institute (INCDFM) with good territorial coverage (Bucharest-Ilfov-Iasi). Predicted Indicators: 10 new R & D jobs, 8 ISI articles, 4 patent applications, 8 new technologies, 7 new service offers posted on the ERRIS platform. Institutional development: the new competences and the improvement of existing ones in partner units will attract the attention of the economic environment towards a better correlation of scientific and economic interests and better valorization in the field of drug science. From a social point of view, institutional development will lead to lowering the cost of these pathologies through new therapeutic approaches, more accessible to the population and hence, improving the quality of life.

ANTITUMORAL THERANOSTIC PLATFORMS BASED ON CARBON DOTS AND POLYMER MATRICES Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0083 2018 - 2021

Role in this project:

Coordinating institution: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI

Project partners: UNIVERSITATEA TEHNICĂ "GHEORGHE ASACHI" IAŞI (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); INSTITUTUL REGIONAL DE ONCOLOGIE IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU FIZICA TEHNICA-IFT IASI (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.cercetare.icpm.tuiasi.ro/proiecte/TERADOT/

Abstract:

The TERADOT consortium will implement this project with the aim of reaching its strategic objective: the consolidation of the consortium scientific and technical competencies (in particular those of the P3 partner with relaunch potential) in the field of econanotechnologies and advanced materials by supporting / developing the existing research competences and the transferability of its research results. The TERADOT Consortium is an alliance that will devote its efforts to capitalize the potential of nanotechnologies by creating new teranostic platforms based on Carbon Dots (CDs) in order to radically change the proceedings to diagnose and treat cancer. Building on the significant preliminary results obtained by the project's members, the consortium represents a systematized initiative, comprising four public sector institutions, having the potential to be expanded with private-sector entities, designed to accelerate the application of these new concepts of cancer diagnosis / treatment. The project consists of three distinct subprojects aiming at: 1. Obtaining and testing of some CDs-type nanostructures starting from imidic precursors, suitable as teranostic investigation / anti-tumor treatment platforms; 2. Obtaining and testing of polymeric biocomposites containing imidic CDs, suitable as teranostic investigation / anti-tumor treatment platforms; and 3. Developing a pilot-scale process for synthesizing CD-type nanosciences for medical applications. The TERADOT project proposes to achieve these objectives by accomplishing several specific output indicators, of which the most important are: the employment of eight young researchers, obtaining 4 new products, 1 new technology for CDs preparation, minimum 8 articles in high impact journals, 5 patent requests (4 national and 1 international) which will further facilitate the collaboration with economic entities as potential beneficiaries.

SupraChem Lab - Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems - ERA Chair initiative Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2016-0011 2016 - 2020

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://www.intelcentru.ro/suprachem_lab/PNIII/

Abstract:

The SupraChem Lab - Support Project aaims to complements the European funding for the WIDESPREAD 2-2014 project: ERA CHAIR, no. 667387: SupraChem Lab - Laboratory of Supramolecular Chemistry for Adaptive Delivery Systems ERA Chair initiative Project.

The Orizont 2020 project started in July 2015 and aims to create a team to conduct advanced research on supramolecular chemistry. The SupraChem Lab project benefits from the scientific support of several high-level chemists, including Nobel Prize-winning Professor Jean-Marie Lehn in 1987 and is considered the founder of the global supramolecular chemistry school.

Wood and derivatives protection by novel bio-coating solutions Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET-ERA IB 2 -ProWood 2017 - 2019

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://intelcentru.ro/prowood/index.php

Abstract:

The European Union (EU27) woodworking industry consists today of more than 380,000 companies and employs more than 2.1 million

workers. The European industrial interest on wood decay processes is both to accelerate (biorefinery) and to prevent wood degradation

(decay). While, the hydrolytic degradation processes are extensively studied and improved for biofuels production, the prevention of wood

degradation has received less attention, even though, the preservation of wood structures against decomposition is an old challenge. The

effect on wood of environmental factors (sun, water, chemicals or fire) and, due to its natural origin, low resistance against biotic agents

(moulds, bacteria and insects) cause a progressive diminution of its mechanical properties and biodeterioration. Although, there are

products for wood protection available on the market they do not meet the expectations in terms of efficiency, price and long term activity,

whereas some of them release toxic substances.

The project ProWood (Protection of Wood) is an interdisciplinary 6-members Consortium of molecular biologists, (bio)chemical engineers

and industrial partners selected for their know-how in biotechnology, bio-coating development, wood handling and validation processes.

ProWood aims the development of novel solution(s) for wood decay protection under the light of the previous and successful developments

and knowledge of the Partners. Thus, the combination of bio-based coating solutions with biological decay antagonists guarantees an

industrial-relevant solution. The workplan of ProWood consists of four Research and Analysis workpackages (WP) and one of Management

ERA-IB 7th Call ProWood - ID: ERA-IB-16-040 5 of 33

and Dissemination. These WPs cover the process from the initial definition of coating precursors (chemistry) and the biological antagonists

(biotechnology) to the combined coating demonstration and validation (industry) and the industrial use (market). Thus, ProWood walks

along the entire value chain of wood protection.

Mobilitate cercetător Irina Rosca Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori, 2019
PN-III-P1-1.1-MC-2019-1059 2019 - 2019

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website:

Abstract:

INNOVATIVE BIOPOLYMER-BASED HYDROPHILIC MATRICES WITH TAILORED PROPERTIES FOR MEDICAL APPLICATION Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0558 2015 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website: http://dciolacu02.wix.com/start-from-scratch-n

Abstract:

This project aims to develop innovative hydrogels based on biopolymers with properties designed for high-values medical applications. The extraordinary versatility of these materials has its origins in the diversity of the constituent biopolymers, ranging from vegetable polysaccharides (cellulose and its various allomorphic forms) to the bacterial polysaccharides (alginate, xanthan, etc.), coupled with the presence of materials reinforcement of high-tech, such as cellulose nanoparticles (CNs). The purpose is not only the assembly of biopolymers in hydrophilic matrices by chemical cross-linking, but also the biosynthesis of new exopolysaccharides (EPS) with well-defined chemical and structural characteristics. The new series of EPS will be biosynthesized by lactic acid bacteria (Lactobacillus spp., Weisella sp., Pediococcus sp.) in order to provide a controlled compositions, degrees of branching and molecular weights. Moreover, the isolation of CNs by novel methods for a low environmental impact (enzymatic hydrolysis with specific cellulases together with molecular fragmentation at low temperatures or chemical modifications) emphasizes the complexity of the project. Its originality is given also by the isolation of cellulose CNs from the corresponding allomorphic forms. Finally, the biocompatibility of new hydrogels in order to determine their uses, either as systems for controlled release of active principals or as scaffolds in tissue engineering, will be tested.

Biologically inspired systems for engineered structural and functional entities Call name: Complex Exploratory Research Projects - PCCE-2011 call
PN-II-ID-PCCE-2011-2-0028 2012 - 2016

Role in this project: Key expert

Coordinating institution: "Petru Poni" Institute of Macromolecular Chemistry

Project partners: "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "Petru Poni" Institute of Macromolecular Chemistry (RO); "N. Simionescu" Institute of Cellular Biology and Pathology (RO); " Gheorghe Asachi" Technical University of Iasi (RO); " Costin D. Nenitescu" Institute of Organic Chemistry (RO)

Affiliation: "Petru Poni" Institute of Macromolecular Chemistry (RO)

Project website: http://www.intelcentru.ro/Biomimetics_PCCE

Abstract:

The project aims to study, to develop and to preliminary test biomimetic structural and functional entities, able to act as gene transfection vehicles of non-viral type, and having a DNA packaging capacity of about 2  5 kilobases. The main features of these entities are: (i) the general structure of a polyplex, (ii) the functionality of a cargo-complex that chemomimic the histones, morphomimic the nucleosome and biomimic a virus like gene vector, (iii) the ability to include or to reversibly bind and transport (bio)chemical species necessary to assist the DNA vehiculation and trafficking, (iv) are based on fullerene-rich polymers and / or dendrimers, (v) the capacity to associate to artificial extracellular matrices, in order to generate gene delivery systems with transfection ability, for ex vivo applications. The developed entities will represent effective tools in genetic and tissue engineering, useful in health restoration, life quality enhancement, and to cure tissue and human organism deficiencies. The envisioned engineering strategy to build biomimetic entities may sustain a spin-off type transfer of knowledge towards hi-tech application areas, with a clear echo in clinics and, finally, in human health. The project involves seven complementary teams hosted by four research and academic institutions. In equilibrated ratios, senior, young and junior researchers will collaborate inside the project frame.

project title Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2018-0726 2018 -

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website:

Abstract:

4th Annual Meeting SFNano 2017, Bordeaux, France Call name: P 1 - SP 1.1 - Proiecte de mobilitate pentru cercetatori
PN-III-P1-1.1-MC-2017-2094 2017 -

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website:

Abstract:

BIOBASED AERO- AND CRYOGELS AS VERSATILE MATERIALS FOR MEDICAL APPLICATIONS Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Franța (bilaterale)
PN-III-P3-3.1-PM-RO-FR-2016-0022 2016 -

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); Mines ParisTech, Centre de Mise en Forme des Materiaux (FR)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website:

Abstract:

In ultimii ani, s-a înregistrat o concentrare importantă a interesului mediului academic și industrial asupra utilizării biopolimerilor în realizarea de materiale bioactive. Datorită unor proprietăți precum biodegradabilitatea, biocompatibilitatea, abundența naturală, structura și proprietățile fizico-chimice specifice, biopolimerii s-au bucurat de-o atenție sporită în dezvoltarea de materiale versatile, precum aero- si criogelurile. Proiectul BIOGELS își propune atât obtinerea unor astfel de aero- și criogeluri cu proprietăți adaptate pentru aplicații medicale, cât și dezvoltarea unei colaborări deja stabilite între institutul român ICMPP și cel francez, CEMEF. Pentru realizarea obiectivelor proiectului au fost selectate două polizaharide, celuloza și pectina, care vor fi utilizate la prepararea a două tipuri de matrici poroase realizate prin căi diferite de uscare. In acest sens, se dorește evaluarea influenței stării inițiale de sol/gel a polizaharidului utilizat și a metodei de uscare (liofilizare sau uscare supercritică cu CO2) asupra morfologiei finale și a porozității matricilor. Tipul rețelei tri-dimensionale obținute va permite orientarea către o aplicație medicală țintită, cum ar fi sistemele de eliberare controlată a medicamentelor sau matrici pentru ingineria tisulară. Evaluarea in vitro a matricilor tri-dimensionale va fi realizată prin determinarea citotoxicității, a activității antimicrobiene și a cineticii de eliberare controlată a agentului farmaceutic.

Synthesis and in vitro/in vivo assessmnet of new conjugates with antimicrobial activity Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Moldova (bilaterale)
PN-III-P3-3.1-PM-RO-MD-2016-0110 2016 -

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI"

Project partners: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); Institutul de Chimie al Academiei de Științe a Moldovei (MD)

Affiliation: INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO)

Project website:

Abstract:

Propunerea de proiect se axeaza pe o cercetare interdisciplinara prioritara a nanomedicinei: nanosisteme de transport cu eliberare controlata de medicamente, incadrandu-se in prioritatile tematice ale programelor PN III si Orizont 2020. Obiectivul strategic al acestui proiect este de a dezvolta o colaborare stiintifica intre parteneri din diferite tari cu competente complementare, care sa creeze premisele recunoasterii si integrarii colectivelor in proiecte internationale. Proiectul isi propune instruirea si perfectionarea tinerilor cercetatori, eficientizarea schimbului de experienta intre parteneri, cresterea transparentei si credibilitatii in fata partenerilor internationali prin implicare in propunerile de proiecte europene. Prezentul proiect are trei obiective stiintifice majore: (i) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo de noi compusi mic moleculari cu activitate antimicrobiana (derivaţi ai oxindolului, oxadiazolului, triazolului, tiazolidinelor); (ii) sinteza, caracterizarea fizico-chimica si testarea in vitro si in vivo a complecsilor de incluziune pe baza de ciclodextrine adecvat functionalizate si compusi mic moleculari sinteti in cadrul obiectivului (i), pentru a obtine sisteme de transport si eliberare controlata de medicamente; (iii) valorificarea rezultatelor prin prezentarea la manifestari stiintifice,vpublicarea in reviste cotate ISI si pregatirea de proiecte stiintifice pentru competitii lansate in Programul Orizont 2020.

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List of research grants as project coordinator or partner team leader	Download (14.19 kb) 08/10/2019
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects