BrainMap

Leau Sorina-Alexandra

Scientific Research Assistant - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Other affiliations

PhD student - UNIVERSITATEA NAȚIONALĂ DE ȘTIINȚĂ ȘI TEHNOLOGIE POLITEHNICA BUCUREȘTI (Romania)

Researcher | PhD student

Web of Science ResearcherID: https://publons.com/researcher/AAY-8457-2021/

Curriculum Vitae (03/04/2025)

Expertise & keywords

Electrochemical platforms based on nanocomposite materials for the detection of biologically active compounds Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-3693 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: https://www.icf.ro/pr_2022/MATSENSBIO/MATSENSBIO.html

Abstract:

The project MATSENSBIO is aiming to develop sensitive and selective electrochemical sensing platforms based on nanocomposites materials for the analysis of relevant biologically active compounds like neurotransmitters and antioxidants. The monitoring of neurotransmitters and antioxidants is of paramount importance in the early diagnosis and the management of various diseases. Therefore, the main objective of the project is aiming to address these societal needs related to the development of electrochemical sensors for health monitoring. The electrochemical sensors are developed by the modification of conventional electrode substrates, glassy carbon, screen printed and metal electrodes (Pt, Au) with nanocomposites materials consisting of conducting polymers (CP) and metal/inorganic nanoparticles (MeNPs). The CPs-MeNPs materials combine two or more characteristic properties featured by the components, namely good electrochemical stability, favorable immobilization matrix and microenvironment brought by the CPs like poly(3,4-ethylenedioxythiophene), poly(3,4-ethylenedioxypyrrole), with high electrocatalytic activity of MeNPs (Au, Pt, Ag) and inorganic ones like Prussian blue. The CPs-MeNPs materials will be prepared via in situ electrodeposition onto electrode substrates by using innovative procedures based on sinusoidal currents and voltages. The electrochemical sensors will be tested and validated in laboratory environment toward the detection of benchmark neurotransmitters, epinephrine and serotonin, and relevant antioxidants, lipoic acid and quercetin. The CPs-MeNPs materials preparation procedures (methods) and the electrochemical sensors (products) are the main outcomes of the project. The use of commercially available electrode substrates (GC, Pt, Au, ITO), including SPEs for single-use sensors, is intended to provide the basic supports upon which the nanocomposite materials will be deposited to develop the envisaged products – the electrochemical sensors.

SOFT INTERACTIONS IN POLYMER AND HYBRID HYDROGELS INVESTIGATED BY ELECTRON PARAMAGNETIC RESONANCE SPECTROSCOPY Call name: P 4 - Proiecte de Cercetare Exploratorie
PN-III-P4-ID-PCE-2016-0734 2017 - 2019

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2017/CTR_86-2017/index.html

Abstract:

The project aim is to approach structural aspects of polysaccharide hydrogels with self-healing properties or represented by interpenetrating polymer networks (IPN) using electron paramagnetic resonance (EPR) spectroscopy. This is a physico-chemical method that provides highly specific local information on the environment around the paramagnetic species in a range of several nanometers. As polysaccharides are diamagnetic, spin labelling will be a necessary step in studying these hydrogels by EPR, in order to obtain information that can be further exploited in tailoring the properties of a particular hydrogel.

The major goals of this project are: 1) to get insight into the formation of hydrogels resulted through noncovalent assembly of polysaccharides, and 2) to analyse gel properties and some processes, taking place inside the hydrogel network, which can generate hybrid materials, all these in connection with their possible applications. The goals will be pursued by following five research objectives:

O1. Design of spin labelled self-healing hydrogels based on host-guest interactions

O2. Design of interpenetrating polymer network (IPN) hydrogels involving polysaccharides and the study of their behaviour by EPR spectroscopy

O3. Exploration of mesh size using EPR measurements and distribution of spin probes in the non-homogeneous systems represented by polysaccharide hydrogels

O4. Obtaining hybrid materials represented by self-healing and IPN polysaccharide hydrogels and inorganic nanoparticles

O5. Investigation of processes occurring in alginate/hyaluronic acid hydrogels embedded with riboflavin and irradiated with UVA light

Although the main technique will be EPR spectroscopy, the research will involve additional investigations and characterization by other techniques like porosimetry, electron microscopy, thermal analysis, rheology, fluorescence and IR spectroscopy, all readily available in our institute.

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List of research grants as project coordinator or partner team leader
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