BrainMap

Mrs. Lucia Pirvu

Senior researcher, Doctor in chemistry

senior researcher - INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI

Researcher

Senior researcher Lucia Camelia Pirvu graduated the Faculty of Biology, Specialization Biochemistry (1994); she completed Master studies in Molecular Biology (1995) and PhD studies in Chemistry (2003). She has 28 years of work and experience in the field of design and development of natural, vegetal pharmacological active products for human, animal and agricultural use. The major achievements are: project coordinator of 12 interdisciplinary research studies amounting about 5 million€ attracted in innovative natural products and technologies; project director of POC-G-SMIS-105542 through which 12 profile companies benefited from the know-how developed at ICCF Bucharest;(co)author of 15 Patents and over 100 scientific works in the field of plant derived products; 37 plant species studied within the research projects developed; author of a new concept of activating the antioxidant power of the plant products and extracts through irradiation with monochrome laser radiation in visible.

Web of Science ResearcherID: 1044

Curriculum Vitae (29/01/2024)

Expertise & keywords

INNOVATIVE THERAPEUTICAL FORMULA FOR OSTEO-ARTICULAR INFLAMMATIONS Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-2125 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO)

Project website: https://hivegartic.squarespace.com

Abstract:

The proposal aims to develop an innovative pharmaceutical product with increased bioavailability based on a combination of hyaluronic acid and plant extracts intended for parenteral (intra-articular) administration, that will restore the viscoelastic properties of the synovial fluid and also will provide effective and prolonged antiinflammatory and antioxidant effect. This goal will be achieved by turning to account a herbal product with already proved biological activity in a previous project and patented and by raising hyaluronic acid (HA) and extracts value by designing an innovative formulation. Development of therapeutic products based on renewable resources represents a key point from bioeconomical point of view, in accordance to smart specializations domains. The application of this innovative combination in inflammatory arthropathies will be demonstrated by: a) preparation of the innovative pharmaceutical injectable formulation of selective extracts with antiinflammatory activity and hyaluronic acid; b) assessment of safety and quality of formulation c) in vitro and in vivo pharmacological studies; c) technology validation..

The project starts at TRL 3: experimental proof of concept which includes laboratory-scale studies (technological, analytical and preclinical pharmacological) of a patented herbal preparation. Components of the technology are validated, antiinflammatory and antioxidant properties are confirmed, but there is no attempt to integrate the components into a complete system (pharmaceutical formulation with HA for IA administration). At the end of project, we will reach TRL 4: technology validated in lab. The basic technological components are integrated to establish that the pieces will work together in the proposed combinations, that is, the active extracts for antiinflammatory purposes are tested preclinically, to confirm their quality, safety and efficacy.

Technological transfer for development of innovative natural therapies for the veterinary sector Call name: P 2 - SP 2.1 - Proiect de transfer la operatorul economic
PN-III-P2-2.1-PTE-2019-0363 2020 - 2022

Role in this project:

Coordinating institution: DACIA PLANT S.R.L.

Project partners: DACIA PLANT S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); ASOCIATIA "CENTRUL DE BIOTEHNOLOGII MICROBIENE" - BIOTEHGEN (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO)

Project website: https://herbavet.ro/about-us/

Abstract:

The general purpose of HERBAVET is to transfer the technologies validated and patented by ICCF Bucharest in order to expand the portfolio of innovative veterinary products of SC Dacia Plant.

The specific objectives consist of: a) development of two products based on plant extracts for a combined and sustainable therapy of endometritis in cows - product "A" for local use with antimicrobial and anti-inflammatory effects and product "B" for oral use with antimicrobial and antispasmodic effects, b) stimulation of innovation by providing solutions to practical problems of farmers, in accordance with the principles of ecological farming, to produce "for man in harmony with nature", promoting the increase of productivity and animal health, c) valorization of indigenous plant species with medicinal properties, their ecological cultivation ensuring a high quality raw material c) exploiting a market opportunity that can lead to a competitive advantage for SMEs.

The project is based on the procedures for obtaining the two phytotherapeutic products validated at the laboratory level by ICCF (TLR4) and it aims the design, realization, testing, validation in industrial environment of the existing technologies in the laboratory (TLR5) and demonstration and validation the functionality of the model by implementing a complex program of preclinical and clinical experiments (TLR6). The project is in agreement with the National Strategies for Competitiveness and RDI for transforming the innovative potential of research into economic results that form a solid and sustainable basis, for competitive advantages in bioeconomy. The need for efficient natural products, without adverse effects and adapted for veterinary use, as well as the willingness of the private sector to take over the research results, are intelligent approaches to sustainable development by using the concepts related to eco-bio-economy, innovation and quality.

ADVANCED RESEARCH ON THE DEVELOPMENT OF SOME PHYTO-IMMUNOMODULATORS FOR VETERINARY USE LINKED UP WITH INDUSTRIAL DEVELOPMENT FOR TECHNOLOGIES AND PRODUCTS Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-1496 2012 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA

Project partners: UNIVERSITATEA DE STIINTE AGRONOMICE SI MEDICINA VETERINARA (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); ASOCIATIA "CENTRUL DE BIOTEHNOLOGII MICROBIENE" - BIOTEHGEN (RO); DACIA PLANT S.R.L. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO)

Project website: http://www.phytoimmuvet.ro

Abstract:

The discoveries that are awarded the 2011 Nobel Prize have provided novel insights into the activation and regulation of the immune system demonstrating that immunology domain is of great actuality and still a source of discovery. Moreover, the motto of the EU animal health strategy for 2007-2013 is "Prevention is better than cure" and aims to ensure a high standard of public health and food safety, to promote animal health by preventing/ reducing the incidence of diseases supporting thereby the rural economy. Immunomodulation using medicinal plants can provide an alternative to conventional chemotherapy for a variety of diseases.

The main objective of PHYTOIMMUVET is to design an innovative herbal-based immunomodulatory product targeted for veterinary use, with parenteral administration, efficient for the prophylaxis but also for curative purpose, subscribing to the improvment of the human and animal health, safety and quality of alimentation.

PHYTOIMMUVET presents an interdisciplinary character based on the consortium high expertise in scientific research, high education and manufacture of herbal-based products, complexity of the investigation methods- from laboratory technologies and assays to industrial scale application, launching a long-term public private partnership to support industry-oriented technological development. In order to accelerate the development, implementation and operation of experimental models, PHYTOIMMUVET consortium was specially created to cover aspects like: agriculture-farming (ecological cultures), lab- and pilot-scale technology, chemical analysis (standardization), microbiological control, preclinical testing (pharmacotoxicology and pharmacodynamics in vitro and in vivo), clinical testing (on five animal species-companion or farm animals) using a complex methodology on an enhanced research infrastructure and focus on quality and efficiency, according to European and national standards for veterinary products.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects