BrainMap

Mrs. Madalina Tudose

senior researcher

researcher - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher

I have extensive research experience, particularly in organic chemistry, focusing on the synthesis of molecules with predetermined properties such as acid-base, redox, fluorescence, or unpaired electrons (free radicals). I also have strong expertise in materials science, including nanoparticles of gold, silver, silica, and graphene oxide. This is reflected in numerous papers published in high-impact journals, where I emphasize methods for labeling and functionalizing such materials to develop innovative applications in medicine, catalysis, and beyond. I am highly experienced in spectral and chemical analysis, utilizing techniques such as chromatographic methods (TLC, RP-TLC), nuclear magnetic resonance (¹H-NMR and ¹³C-NMR), as well as infrared and ultraviolet spectrometry (FTIR and UV-Vis). My research activities include 34 ISI-indexed articles, 4 national patents, 317 citations (excluding self-citations), and a Hirsch index of 12.

Web of Science ResearcherID: 23111367000

Curriculum Vitae (02/04/2025)

Expertise & keywords

Biomedical applications of hybrid materials based on graphene oxide and fluorescent structures Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0288 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: https://www.icf.ro/pr_2022/BIOGOM.ppt

Abstract:

In this project, we present a simple method for the preparation of new fluorescent hybrid systems, based on amino-coumarin and nitro-benzofurazan derivatives that attach covalently or non-covalently to graphene oxide (GO). In the first stage, our method aims to increase the number of carboxyl groups required for functionalization with amino-coumarin derivatives. To achieve this, the hydroxyl groups can be converted by derivatization with chloroacetic acid into carboxylic groups, transforming GO into GO-COOH material. Activation of carboxylic groups is an important step in improving its reactivity to nucleophilic reagents, and this is done using the carbodiimide-promoted reaction. In the second stage, the amidation reaction with the amino group of the coumarin compounds will take place. We will also synthesize, from lipoic acid and two nitro-benzofurazan derivatives, new multifunctional molecules with enhanced biological properties, which we will attach non-covalently to GO to preserve their fluorescent properties. The obtained materials will be evaluated by numerous characterization techniques, and their fluorescence will be highlighted by live-cell imaging. Their antimicrobial activity will be tested on Mycobacterium tuberculosis, as well as on bacteria and fungi in planktonic and biofilm growth states. Biocompatibility of the compounds will be assayed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide and lactate dehydrogenase tests.

Holistic design of fuel cell electrocatalysts for the least power applications Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET-M.-CATALEAST-1 2019 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Budapest, Hungary (HU)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2018/CATALEAST/index.html

Abstract:

Due to their low operation temperature/pressure requirement and high energy density, Polymer Electrolyte Membrane Fuel Cells (PEMFCs) comprise the most important type of fuel cell for different applications, like automobiles, stationary, and small-scale portable electricity generation. One of the key constituents of PEMFCs responsible for the longevity, performance and price is the electrocatalyst. The best available catalysts consist of activated carbon, so called support, and platinum, as active phase, which are known to suffer from degradation, which can only be compensated with extremely high platinum loading, keeping the price of the cells high. Our aim is the development of new types of corrosion resistant catalysts with improved stability and decreased or completely eliminated Pt content. The project proposes integration of novel catalytic system into Membrane Electrode Assemblies (MEAs) and building of fuel cells for laboratory tests and application in new portable, hydrogen powered, devices. Finally, the project aims to scale-up the preparation of the best compositions to industrially relevant amounts. The novel generation of electrocatalysts and the completed small PEMFCs with MEAs built on these catalysts as the outcomes of the proposed work will contribute to the deployment of hydrogen fuel cells, one of the key technologies towards a sustainable, decarbonised and more efficient energy system. Therefore, a foreseeable result of the proposed work at the economy level is a contribution to the European innovation chain of Fuel Cell and Hydrogen technologies.

Silver nanoparticles- the effect of chemical surface modification on their chemical and biological reactivity Call name: Postdoctoral Research Projects - PD-2012 call
PN-II-RU-PD-2012-3-0090 2013 - 2015

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/PD/PD90/MT_2015.pdf

Abstract:

The objective of the project is to obtain and evaluate, from a physical, chemical and biological point of view, hybrid (multilayer) nanoparticles, meaning silver nanoparticles embedded into a silica matrix, to which organic compounds (such are antibiotics- like penicillins and isoniazid) are covalently attached. The surface chemical modification and the influence on the (bio)chemical reactivity of the nanoparticles will be followed throughout the whole project. To accomplish this aim, silver nanoparticles will be obtained and evaluated first (for example, for anti- or pro-oxidant behavior); coverage with silica will lead to the formation of hybrid metallic-inorganic nanoparticles, and finally, organic compounds of interest will be bonded to the silica surface, thus organic functionalizing the whole assembly. This will lead to the acquisition of nanomaterials with remarkable multifunctional properties. The simple or multilayer hybrid nanoparticles will be characterized by different general measurements (UV-Vis, IR, SEM, TEM, etc.) and also by particular measurements (as function of the organic compound linked to the surface, such fluorescence, DLS, XRD, etc.). The properties of the new hybrid multilayer nanoparticles will be studied involving them in different physical, chemical or biological processes. Antibacterial evaluation of all these nanoparticles will be also measured.

Obtaining strategies for ceramic ecofriendly pygments by clean methods Call name:
32-146/01.10.2008 2008 - 2011

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website:

Abstract:

(Para)magnetic multifunctional materials: from molecules with tuned properties to supramolecular architectures of nanometric size Call name:
2005 - 2008

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects