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Romania
Citizenship:
Romania
Ph.D. degree award:
2009
Mrs.
Marcela-Elisabeta
Barbinta-Patrascu
Associate Professor
Associate Professor
-
UNIVERSITATEA BUCURESTI
Researcher | Teaching staff | Scientific reviewer
Main research interests: (Bio)Eco-NanoTechnology; BioPesticides; Green inhibitors of urease; Biomimetics/Bioinspiration; Green Nanotechnology; Valorization of natural resources for development of valuable Materials; Materials Science & Engineering; Nanosciences; “Green” Design of Bio-Multifunctional Materials; “Green” Metal/Metal oxide/Metal chloride–based Materials; BioPhysics; BioPlastics; Green and Sustainable Chemistry; (Bio)Chemistry; Bioenergetics; Drug Delivery Systems; Molecular Genetics; Oxidative stress studies; Photosynthesis; Chlorophyll; Optical microscopy of biological structures. The first initiator of multifunctional chlorophyll a ‒ labelled phytosomes (containing curcumin, chitosan and folic acid-functionalized silver nanoparticles). The first initiator of “Green Nanotechnology” methods and of Multifunctional Biohybrids based on Artificial cell membranes, at the Faculty of Physics, University of Bucharest.
>20
years
Web of Science ResearcherID:
B-2582-2013
Personal public profile link.
Curriculum Vitae (21/02/2024)
Expertise & keywords
Econanotehnologii şi materiale avansate
nanohybrids
Nanomaterials,Nanotechnologies,Nanobiotechnology,Health,Safety
nanometals
Biomimetics
biocomposite materials
Biocompatible materials
phytochemistry, biochemistry, phytocomplexes, antioxidants, extraction
Bionanomaterials
ecomaterials
Biopesticides
Green chemistry
green synthesis
Phytochemicals
Natural plant extracts
Projects
Publications & Patents
Entrepreneurship
Reviewer section
New protein hybrid nanostructures for specific targeting in colon tumor cells
Call name:
P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1323
2022
-
2024
Role in this project:
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO)
Affiliation:
Project website:
http://fpce7.fizica.unibuc.ro/biomol/1323.htm
Abstract:
The project proposes an interdisciplinary collaboration between research teams from the University of Bucharest, the Faculty of Physics (UB, CO), the Transilvania University of Brașov, the Faculty of Medicine and the Research-Development Institute (UT, P1), and the National Institute of Materials Physics Magurele, Romania (NIMP, P2).
One way to facilitate the entry into cells of protein hybrid nanostructures, which encapsulate or are coated with drugs or other structures of medical interest, is the use of folic acid (FA) as a molecule that specifically targets tumor cells receptors.
The main goal of this project is to synthesize and characterize a new type of hybrid nanoparticles (NPs), consisting of serum proteins (albumin, transferrin), functionalized with FA and loaded with the flavonoid rutin (Ru). These hybrid NPs are stable, reproducible, highly effective, and specifically, target HT-29 colon cancer cells.
The objectives of the project will be achieved by: 1) the use of synthesis methods involving nanoprecipitation, desolvation, and stabilization of new nanoparticles of serum proteins loaded with Ru, functionalized with FA, 2) characterization of the morphology and properties of new NPs by structural (SEM, AFM, DLS), spectroscopic (UV-Vis, FT-IR, SPR) and electrochemical (EIS) methods and 3) application of synthesized nanohybrid on HT-29 cells.
The new hybrid nanostructures have not been the subject of other studies published in the literature, and the effect of these nanohybrids on the viability and proliferative capacity of HT-29 cells is not reported in the literature. In the future, the results of this project may be clinically useful in the design and use of nanoparticles in the treatment of cancer.
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Structural investigation of bioactive materials containing “intelligent” biomolecules (DNA), “green” metallic nanoparticles, and artificial cell membranes
Call name:
Project IUCN No.68 (IUCN ORDER no.365/11.05.2021)
2021
-
2021
Role in this project:
Project coordinator
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); UNIVERSITATEA BUCURESTI (); Joint Institute for Nuclear Research (JINR) - Dubna ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
OBJECTIVES:
- the eco-design and complex characterization of innovative biohybrids with multifunctionality
Read more
Development of the laboratory infrastructure for structural investigation of nanomaterials and biopolymers
Call name:
Grant IUCN No.19 (IUCN ORDER no.367/11.05.2021)
2021
-
2021
Role in this project:
Project coordinator
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); UNIVERSITATEA BUCURESTI (); Joint Institute for Nuclear Research ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
The main results expected from this investigation are:
• preparation of biohybrid materials, by “green” methods
• complex characterization of bionanocomposites
• evaluation of bio-activities of the obtained materials ( antioxidant activity,
antimicrobial activity)
Read more
Applications of Neutron diffraction and Small angle scattering in modern investigation of bio-based (advanced multifunctional bionanosystems) and inorganic (Romanian rocks) materials
Call name:
Project IUCN No.38 (IUCN ORDER no.365/11.05.2021)
2021
-
2021
Role in this project:
Project coordinator
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); UNIVERSITATEA BUCURESTI (); Joint Institute for Nuclear Research ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
OBJECTIVES:
- the implementation and development of innovative strategies of applications of neutron small
angle scattering and neutron diffraction to investigate the advanced multifunctional bionanosystems, and the inorganic
materials.
Read more
Obtaining and investigations of the new biocomposite materials with bio-medical applications by means of neutron scattering and complementary methods
Call name:
Project IUCN No.43 (IUCN ORDER no.365/11.05.2021)
2021
-
2021
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (); UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
The aim of this proposal is to obtain and characterize (by means of neutron scattering and complementary
methods) multifunctional biocomposite materials (based on "green" ZnONPs and AgNPs) with bio-medical
generated by using vegetal raws.
Read more
Development of the infrastructure laboratory for investigating the structure of complex biomolecules
Call name:
Grant IUCN No. 17 (IUCN ORDER no. 267 / 20.05.2020)
2020
-
2020
Role in this project:
Project coordinator
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
http://fpce7.fizica.unibuc.ro/biomol/Docs/Proiect_17.pdf
Abstract:
implementation and development of innovative “green” nanotechnological strategies in order
to develop novel hybrid bionanocomposites as Drug Delivery Systems (DDS) to transport
active therapeutics into the living systems.
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Structural investigation of drug delivery systems consisting of biohybrids based on DNA, biomimetic membranes, “green” nanometals and therapeutic agents,
Call name:
Project IUCN No. 75 (IUCN ORDER no. 269 /20.05.2020)
2020
-
2020
Role in this project:
Project coordinator
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); UNIVERSITATEA BUCURESTI ()
Affiliation:
INSTITUTUL DE FIZICA ATOMICA ()
Project website:
http://fpce7.fizica.unibuc.ro/biomol/Docs/Proiect_75.pdf
Abstract:
OBJECTIVES:
- the eco-design and complex characterization of innovative biohybrids with multifunctionality
ESTIMATED RESULTS:
The main results expected from this investigation are:
• “green” preparation of biohybrids based on DNA, liposomes and metallic nanoparticles
• spectral, structural and morphological characterization
• evaluation of biological performances of obtained materials (antioxidant capacity,
antimicrobial action, haemolytic activity, antiproliferative activity)
Read more
Obtaining and investigations of the new biocomposite materials with bio-medical applications by means of neutron scattering and complementary methods,
Call name:
Project No. 33/2020 (IUCN ORDER no. 269/20.05.2020) of JINR–Roma
2020
-
2020
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA
Project partners:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (); UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
The aim of this proposal is to obtain and characterize (by means of neutron scattering and complementary
methods) multifunctional biocomposite materials (based on "green" Ag/ZnONPs ) with bio-medical
generated by vegetal wastes.
Read more
Neutron diffraction and Small angle scattering applications in geosciences (Romanian garnet peridotites, Foltea, Sebeshel formation) and biosciences (supramolecular bio-based nanostructures)
Call name:
Project IUCN No.48 (IUCN ORDER no. 269 / 20.05.2020)
2020
-
2020
Role in this project:
Project coordinator
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI (); JINR, Dubna ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
http://fpce7.fizica.unibuc.ro/biomol/Docs/Proiect_48.pdf
Abstract:
Objective: the implementation and development of innovative strategies of applications of neutron small
angle scattering and neutron diffraction to investigate the bio-based and the inorganic
materials.
Read more
The use of neutron diffraction and small angle scattering in geosciences (strong deformed gneisses and granites) and biology (hybrid bio-nano entities), Project IUCN No. 40 (IUCN ORDER no. 397 / 27.05.2019), Theme No. 04-4-1121-2015/2020 (2019, Project Leader)
Call name:
Project IUCN No. 40 (IUCN ORDER no. 397 / 27.05.2019)
2019
-
2019
Role in this project:
Project coordinator
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); UNIVERSITATEA BUCURESTI (); Joint Institute for Nuclear Research (JINR) - Dubna ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
http://fpce7.fizica.unibuc.ro/biomol/04-4-1121/index.htm
Abstract:
OBJECTIVES:
- the implementation and development of innovative strategies of applications of neutron small angle scattering and neutron diffraction to investigate the bio-based and the inorganic materials.
ESTIMATED RESULTS:
The main results expected from this investigation are:
preparation of multifunctional bio-based materials, by “green” methods, and their spectral and morphological characterization
evaluation of biological performances of the obtained hybrid bio-nanoentities (haemolytic activity, antioxidant capacity, antimicrobial activity, evaluation of the cytotoxic effects in normal and cancer cell lines)
selection and analysis by modern physical methods, of some specimens of gneisses from the Romanian Mountains and two specimens of volcanic rocks.
Read more
Investigations of biocomposite materials with bio-medical applications by means of neutron scattering and complementary methods, Project IUCN No. 44/ 2019 (IUCN ORDER no. 397/ 27.05.2019), Theme No. 04-4-1121-2015/2020
Call name:
Project IUCN No. 44/ 2019 (IUCN ORDER no. 397/ 27.05.2019), Them
2019
-
2019
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (); UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
The aim of this proposal is to obtain and characterize (by means of neutron scattering and complementary methods) multifunctional biocomposite materials (based on "green" ZnONPs and AgNPs) with bio-medical applications by using vegetal raws.
Read more
Green bio-design of 3D hybrid bioarchitectures with applications in biomedical field, Project IUCN No. 48/ JINR Order No. 322/21.05.2018, Theme No. 04-4-1121-2015/2020
Call name:
Project IUCN No. 48/ JINR Order No. 322/21.05.2018
2018
-
2018
Role in this project:
Partner team leader
Coordinating institution:
INSTITUTUL DE FIZICA ATOMICA
Project partners:
INSTITUTUL DE FIZICA ATOMICA (); UNIVERSITATEA BUCURESTI (); Joint Institute for Nuclear Research (JINR) - Dubna ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
http://fpce7.fizica.unibuc.ro/biomol/04-4.htm
Abstract:
OBJECTIVES:
- the eco-design and complex characterization of biohybrid nanomaterials with multifunctionality
ESTIMATED RESULTS:
The main results expected from this investigation are:
preparation of biohybrid materials, by “green” methods
spectral and morphological characterization
evaluation of biological performances of obtained materials (haemolytic activity, antioxidant capacity, antimicrobial activity, evaluation of the cytotoxic effects in normal and cancer cell lines)
Read more
Synthesis, screening and controlled release of some novel thiazole, bithiazole and thiazolidin-4-one compounds with antioxidant, antiproliferative and antimicrobial activity
Call name:
PN-II-PT-PCCA-2013-4-2075
2014
-
2017
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEHNOLOGII CRIOGENICE SI IZOTOPICE - I.C.S.I. RAMNICU VALCEA
Project partners:
INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE PENTRU TEHNOLOGII CRIOGENICE SI IZOTOPICE - I.C.S.I. RAMNICU VALCEA (); UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
http://www.icsi.ro/synthiazo/#Summary
Abstract:
The project is a multidisciplinary approach with some important interdisciplinary valences aiming to bring its contribution in the solving of generic problems identified within the framework of Research Domain No. 6. BIOTECHNOLOGIES, with specific fit in the Research direction 6.1 Biotechnologies: 6.1.1 Design and development of new drugs with maximal efficiency and minimal secondary effects.
The final aim of the SYNTHIAZO project is to develop new thiazole, bithiazole and thiazolidin-4-one compounds with controlled delivery and antioxidant/antiproliferative effects and/or specific antitumoral activity, and antimicrobial properties in order to respond at two recurring problems in clinical medicine:
multiple drug resistance (MDR) of infectious agents;
the proliferation and metastasis of drug-resistant tumor cell lines, combined with an insufficient specificity of current anticancer drugs.
In the challenging process of new drug discovery, the partners tasked themselves not only with solving a whole range of difficult scientific and technical problems but even dissemination of project’s without affecting the allocation of intellectual property rights. Therefore, partners will work together and the outcomes of the project will be promoted at national and EU level.
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BIO-ACTIVE LIPID NANOCARRIERS FOR CO-ENCAPSULATION OF SELECTIVE VEGETAL EXTRACTS WITH ENHANCED PHARMACO-COSMETIC PERFORMANCE
Call name:
Exploratory Research Projects - PCE-2012 call
PN-II-ID-PCE-2012-4-0111
2013
-
2016
Role in this project:
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)
Project website:
http://www.chfiz.pub.ro/idei2
Abstract:
The project aims at developing two innovative aspects based on using soft nanotechnology techniques to prepare novel formulations with a coupled pharmacologic and cosmetic activity. First is related to completely replacing of synthetic chemicals by natural sources from selective plant extracts; this supposes to use phytochemicals not only as bioactive principles encapsulated at nano-scale, but also as main components of the lipid nanocarriers, thus developing new bio-active lipid nanocarriers. The second innovative aspect, which highly increases the complexity of the problem, is to co-encapsulate multiple bio-active compounds from two selected vegetal extracts (ivy leaves extract and willow bark extract) thus taking advantage of their synergistic and/or complementary therapeutic effects. Some natural oils (e.g. raspberries seed oil, grape seed oil, pomegranate seed oils and rice brain oil) have been chosen for bio-active nanocarriers synthesis. Free and loaded bioactive lipid nanocarriers have been characterized for their structure and morphology by adequate techniques (UV-VIS, FT-IR, GC-MS, HPLC, DSC, HR-TEM), photoprotective properties and photostability, and sustained-release behavior of bio-active principles. The new topical formulations have been tested for both cosmetic efficacy (antioxidant and anti-UV properties) and pharmacology activity (anti-microbial, anti-inflamatory and skin healing properties) in order to demonstrate their amplified therapeutic performance.
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"Biophysical studies on hybrid systems composed of carbon nanotubes and artificial lipid membranes"
Call name:
UB project Nr. 1120/06.06.2012
2012
-
2013
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
Biophysical studies on different hybrid systems composed of carbon nanotubes and artificial lipid membranes (liposomes labelled with chlorophyll)
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Biomaterials for applications in human therapy based on self-assembled lipids in presence of carbon nanotubes and conducting polymers
Call name:
PNII-62-081
2009
-
2011
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA
Project partners:
INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (); UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
http://lab40.infim.ro/Projects%20lab%2040/2008/Parteneriate/PNII-62-081/index.html
Abstract:
he project developes new biomaterials based on self-assembled lipids in the presence of carbon nanotubes (CNs) and conducting polymers (CPs) for applications in human therapy area. Taking into account that the main applications of the liposomes in the health and medicine field have as priority the tumour treatments, genetic therapy, gene delivery and cosmetic treatments, these biomaterials are tempted to be used as: i) drug transporters or ii) component of certain drugs (exemple: vaccines). The goal followed in this project is: i) the synthesis of new bio-composites based on liposomes, CNs and CPs in order to use them as efficient drugs transporters at the target requiring therapeutic treatment, ii) increasing the stability of liposome based on CNs and CPs in the presence of various vitamins and chlorophyll, iii) increasing the circulating time of liposome by using various poly-ethylene glycol (PEG) derivatives and iv) increasing the liposome interaction capacity with the target cell.
Read more
Fluorescent nanostructures based on complex combinations linked to DNA for optoelectronic devices
Call name:
CEEX, ET 1.3
2006
-
2007
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI ()
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI ()
Project website:
Abstract:
Read more
Preparation of supported lipid membranes with liposomes using chlorophyll; studies for biotechnological applications
Call name:
CNCSIS Nr. 34699/2004
2004
-
2006
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
Read more
Testing the UV protection capacity of some compositions and products based on natural plant extracts
Call name:
CNCSIS AT, Code 50
2003
-
2005
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
Testing the UV protection capacity of some compositions and products based on natural plant extracts
Read more
Structural and functional changes of immune system induced by gamma irradiation components
Call name:
CERES Nr.3-100/2003
2003
-
2005
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA BUCURESTI
Project partners:
UNIVERSITATEA BUCURESTI ()
Affiliation:
UNIVERSITATEA BUCURESTI ()
Project website:
Abstract:
Structural and functional changes of immune system induced by gamma irradiation components
Read more
Implementation of Molecular Techniques in Sunflower Breeding to Improve Oil Quality and Diseases Resistance
Call name:
IAEA ROM /5/007/D2
1995
-
1998
Role in this project:
Key expert
Coordinating institution:
INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE AGRICOLĂ-FUNDULEA
Project partners:
INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE AGRICOLĂ-FUNDULEA ()
Affiliation:
INSTITUTUL NAŢIONAL DE CERCETARE-DEZVOLTARE AGRICOLĂ-FUNDULEA ()
Project website:
Abstract:
Implementation of Molecular Techniques in Sunflower Breeding to Improve Oil Quality and Diseases Resistance
Read more
Modern spectral methods of characterization and investigation of the structure of DNA extracted from plants and some cellular biosystems
Call name:
C376+381/B10/1997
1995
-
1998
Role in this project:
Key expert
Coordinating institution:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI
Project partners:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI ()
Affiliation:
UNIVERSITATEA POLITEHNICA DIN BUCURESTI ()
Project website:
Abstract:
Modern spectral methods of characterization and investigation of the structure of DNA extracted from plants and some cellular biosystems
Read more
FILE DESCRIPTION
DOCUMENT
List of research grants as project coordinator or partner team leader
Download (203.02 kb) 22/09/2021
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects
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