BrainMap

Mr. Marian Miculescu

Professor

- UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI

Researcher | Teaching staff | Scientific reviewer | PhD supervisor

Expertise & keywords

Novel technology for implants manufacturing from 3D printable reinforced composite filaments for guided bone regeneration Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1650 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation:

Project website: http://www.florinmiculescu.ro/bonegapfill/

Abstract:

Compared to the limited market of products destined for bone reconstructive surgery and the high-patient-risks of current approaches, this project is a necessity to solve the absence of 3D products with optimal geometry, internal architecture and mechanical properties for customized compatibility with natural bone and a rapid repair of defects with variable dimensions. The overall goal of the project is to develop and promote a new reproducible and sustainable manufacturing technology for the products fabrication by 3D printing, using as platform the previously implemented technology for the synthesis of hydroxyapatite derived from bovine bone biogenic resources and the project team`s experience in the field. Composite filaments with printable features will be obtained based on natural hydroxyapatite and two polymers, one of which will be of natural origin. Also, superior and adaptable mechanical characteristics will be ensured by reinforcing the ceramic matrix with multi-layer graphene-based materials. Further, the filaments will be used for 3D printing of products with regular and random internal architecture (based on a new STL file developed within the project). Afterwards, the products will be tested as to evaluate their performance as potential bone replacements. In this regard, a patent application will be filed. The proposed topic is new and challenging for the project team, but all the premises are fulfilled through the team`s synergy and previous research experience. The concept and experimental testing of the possibility of embedding naturally derived ceramic particles into a polymer matrix of natural origin were also demonstrated and reported by the team members as viable for achieving the project objectives.

Meta-structures made by composite coatings on biodegradable Mg-Ca implants for bone regeneration Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2591 2021 - 2023

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA NAŢIONALĂ DE ŞTIINŢĂ ŞI TEHNOLOGIE POLITEHNICA BUCUREŞTI (RO)

Affiliation:

Project website: http://www.smmmf.pub.ro/magicbone/

Abstract:

Main objective of the project is the development of one composite coatings with polymer-based (cellulose acetate, collagen, polylactic acid or chitosan) reinforced with Mg and Mg-substituted hydroxyapatite particles, for biodegradable implants made by Mg-Ca alloy, followed by in vitro cell based tests for evaluating biocompatibility and osseointegration activity. Obtained coated implants will be characterized not just from structural and morphological point of view, but also for mechanical properties and surface properties. Several specific tests for evaluation of the osseointegration will be performed, like study of coating hydrolysis at physiological pH, degradation compounds, flows and proteins retention. After the chosen of best coating material for osseointegration, a commission constituted by independent experts will validate the proposed experimental model. The project objectives are totally feasible, due to the previous experience and results obtained by the project leader and his research team, as well as the equipment available for synthesis, characterization and testing. The project results will be innovative and relevant in relation to the national and international state of the art because the final composite coatings is a new solution from materials point of view, and new coated biodegradable implant will have a better osseointegration, controlled biodegradability and proper mechanical properties during degradation process, like a magic bone (MAGICBONE).

Nanoencapsulated eugenol advanced compounds with addressability in dental medicine Call name: P 2 - SP 2.1 - Transfer de cunoaștere la agentul economic „Bridge Grant”
PN-III-P2-2.1-BG-2016-0455 2016 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE " VICTOR BABEŞ " TIMISOARA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); TITUS & SONS SRL (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.umft.ro/pniiip221bg20160455_519

Abstract:

The aim of the present project proposal is to increase the performance and competitivity of S.C TITUS&SONS S.R.L using the expertise and technology existent in the University of Medicine and Pharmacy Victor Babes Timisoara and Politehnica University of Bucharest. The success of the present project proposal is guaranteed by the team who is comprised by members with national and international research expertise. They will be involved in the research activities, as well in the data analysis, validation, and improvement of the S.C TITUS&SONS S.R.L products, the final endpoint being the increase of their competitivity and quality. The specific objectives of the project are: 1. The manufacture of new compounds starting from the original formula of the company product with the addition of nanoencapsulated eugenol. 2. Evaluation of the in vitro effects of these novel compounds on primary normal human oral keratinocytes - NHOK and tumor line cells of oral squamous cancer - SCC-4. 3. Evaluation of bioenergetic profile of normal and tumor cells treated with these compounds. 4. Evaluation of the in vivo effects on SKH-1 animal models of these novel compounds with histopathologic analysis. 5. The assessment of physical-chemical parameters. 6. Interconnection of informations from chemical, biological, physical, and informatics point of view

New technology for the synthesis and manufacturing of biomimetic implants derived from biogenic resources used for bone reconstruction surgery Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0892 2017 - 2018

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO)

Affiliation: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Project website: http://www.florinmiculescu.ro/bioimms/

Abstract:

The overall goal of this project is to develop and implement a new complex and reproducible synthesis technology of biomimetic ceramic materials (hydroxyapatite and tricalcium phosphate, in different proportions) derived from marble and seashell precursors and their performance assessment as potential bone substitutes in restorative and reconstructive surgery. This project proposes the synthesis of a mineral phase presenting mechanical properties at least similar to those found at bone structural arrangement level. Once the biomechanical requirements are met, the biomimetic products will be tested through in vitro standardized methods to assess their biological performance. The ultimate goal of this project is to achieve biomimetic implants (compact and porous products) with custom features related to the mechanical requirements for an optimal biofunctionalization. In this regard, one patent application will be submitted, but it will not be funded through this project.

This project aims to develop, implement and promote a ceramic biomaterial known as biogenic hydroxyapatite. This is expected to lead to a new concept of biomimetic implant with improved features, for a rapid and complete resolution of all sizes bone defects.

The proposed subject is new and challenging for the project members, but all premises (for congent result achievement) are met through the sinergy and extended collaboration of both teams. The initial TRL level 2 was gradually established through the expertise of the project team. The project starts from conceptual approaches adopted from some studies and applied to the selected precursors. Experimental testing of research hypothesis will lead to an improved synthesis route. The appropiate manufacturing methods will be assessed for both types of biomimetic products (TRL level 3). Once the best experimental route is established, a comission constituted by independent experts will validate the proposed empirical model (TRL level 4).

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects