BrainMap

Mariana Voicescu

Dr. Habil.

Senior Researcher - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher | Scientific reviewer | PhD supervisor

Senior Researcher at Institute of Physical - Chemistry ,,Ilie Murgulescu,, of the Romanian Academy, Bucharest, Romania. PhD in Chemistry in 2004 at University POLITEHNICA of Bucharest, Faculty of Industrial Chemistry. Marie Curie Fellowship (Feb. 2002 – Jan. 2003) at CEA, Saclay, France. Postdoctoral Fellowship (Oct. 2004 – Oct. 2005) at Paris-Sud University, Orsay, France. CNRS Research Stage (Dec. 2007 – Dec. 2010) at Louis Pasteur University, Strasbourg, France. The Romanian Academy Award in Chemistry “Ilie Murgulescu”, 2014. Habilitation in Chemistry in 2023 at School of Advanced Studies of the Romanian Academy (SCOSAAR). Research interests cover the field of Spectroscopy and Chemiluminescence on systems of biological interest, with emphasis on Fluorescence Spectroscopy in Protein analysis. Research, Synthesis and Design of Flavin – based BioNanoSystems for Biomedical Applications.

Web of Science ResearcherID: C-5588-2012

Curriculum Vitae (29/03/2025)

Expertise & keywords

Functionalized mesoporous bioglass based 3D scaffolds for hard tissue regeneration Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-0598 2020 - 2022

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU STIINTE BIOLOGICE (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2019/BIOSCAFTIS/index.html

Abstract:

The project proposal “Functionalized mesoporous bioglass based 3D scaffolds for hard tissue regeneration“, aims to improve the well-being of people by treating them with new biomaterials. The objective of the project is to restore and improve the function of hard tissue by using functional bioactive scaffolds. These scaffolds will provide good mechanical properties in a suitable environment for tissue regeneration and repair. Sodium free mesoporous bioglasses (MBGs) doped with cerium will be used for scaffold manufacture using a combination of structure-directing agents and a polymer foam replication method. The BIOSCAFTIS project is based on our early results demonstrating that MBGs doped with cerium have good bioactivity and biocompatibility properties. In order to improve the growth and remodelling of bone tissue the surface of the scaffold will be functionalized with vitamin D3. The properties of the scaffolds e.g. bioactivity, mechanical strength, antimicrobial activity and drug delivery profile will be evaluated using adequate characterization techniques. The performance integration of 3D scaffolds to native tissues will be investigated using in vitro experimental models mimicking interaction with osteoblast cells. As a result of the research the project aims to disrupt the area of biomaterials by developing a new class of materials for medical applications.

Flavone-Protein Systems Involved in Oxidative Stress Probed by Advanced Spectroscopic Methods Call name: Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0055 2013 - 2016

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2012/MVoicescu.pdf

Abstract:

The oxidative stress appeared as a necessity to express the bio-unbalance regarding the ratio between the antioxidant and oxidant chemical species, one of the major causes leading to organisms being taken ill. Based on previous experience and on the obtained results connected to the pro and anti oxidant activity of some molecules of biological interest, the main goal of this project is to develop quantitative methods to study biochemical aspects of some flavone-protein systems, in different media and partnership conditions (biommimetic and nanostructured systems), using Fluorescence, Raman, FTIR and EPR spectroscopies. The used systems are chosen in order to assure superior ways of organizing biological species. One follows/thinks of a detailed study regarding the spectrophotometric properties of flavonols and isoflavones in emulsion/micellar media and in lipidic bi-layers of lecithin on nanoparticles support. Monitoring and generating free radicals in the studied systems based on luminol-hydrogen peroxide are considered. The study is relevant for clearing up the antioxidant activity of different flavones classes and flavone-protein interactions in different media and partnerships conditions especially when associated with nanoparticles. These aspects lead to new insights on the oxidative stress process in the living organism, redox regulation and consequently, a priority in biochemical and biomedical domains.

Mobilitate cercetător Mariana Voicescu Call name: PNCDI IV, SP 5.2.2 - Proiecte de mobilitate pentru cercetatori, MC-2024
PN-IV-P2-2.2-MC-2024-0792 2024 -

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website:

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects