BrainMap

MIHAI ANASTASESCU

Dr.

CS1 (Senior Researcher 1st Degree) - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher | Scientific reviewer

Senior researcher, >25 years in Surfaces and Interfaces Research experience: High vacuum techniques, Electrochemistry techniques, Spectroscopic Ellipsometry on thin films in air and films / solution interface; Photoluminescence, Scanning Tunneling Microscopy, Atomic Force Microscopy; Image analysis. Research area: Optical, electrical and microstructural properties of multifunctional nanostructured materials. Number of Published papers: >100, >2200 citations. Special Award: "I. G. Murgulescu" Romanian Academy Award (2010) for the group of papers “Optical and structural characterization of nanostructured oxide thin films”.

Web of Science ResearcherID: I-5031-2016

Curriculum Vitae (18/10/2017)

Expertise & keywords

3D laser printed absorbable scaffolds with a prolonged biomechanical stability in human body fluids. Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-0992 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: https://www.icf.ro/pr_2020/PCE-234-2021/index.html

Abstract:

Novel biomaterials for temporary orthopedic implants are one of the most challenging areas of exploratory research in advanced materials. Third generation biomaterials are designed to be both resorbable and bioactive, that is, the implant will be temporary, and once implanted, it will help the body heal itself. The aim of this project is to progress toward a novel absorbable scaffold biomaterial for temporary orthopedic implants, through hierarchically structured surfaces that protect the scaffold, effective to convey higher corrosion tolerance and increased scaffold strength retention for extended periods in body fluids while at the same time capable to stimulate human osteoblast cell proliferation behavior. Specific objectives are (i) the design and fabrication of 3D printed scaffold structures with biocompatible elements by rapid solidification from melt through laser additive manufacturing-3D printing; (ii) the development of original cost-effective surface modification procedures for surface protected scaffolds (SPS) with enhanced corrosion tolerance and bioactivity; (iii) the determination of bare and SPS corrosion rates and corrosion mechanisms in human physiological fluids of pH and chloride concentrations reproducing the most exigent conditions for implant use; and (iv) the assessment of the scaffold-cell constructs to initiate tissue repair processes and osteogenesis; contributing to Romanian research with: 1 patent, 4 scientific articles, 6 conference presentations

Micro-nanotechnologies for monitoring of greenhouse gases Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-2073 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2019/TECH4GREEN/index.html

Abstract:

The main purpose is the monitoring of greenhouse gases which are directly linked with the human activities. To this scope the project will develop a new technology for the fabrication of smart, miniaturized sensor array for greenhouse gases monitoring. A microsensors array based on alumina transducers and MOx (metal oxides) and polymer materials will be developed. The targeted gases considered as main contributors to the greenhouse effect, are methane, ozone, carbon dioxide and water vapors. The microtransducers are made up of alumina µ-chips with interdigitated gold electrodes on top (front side of the transducer) and platinum microheater on the backside. The microsensors array will contain undoped and doped MOx sensitive films (SnO2, ZnO, SnO2-ZnO, CuO) and polymers deposited by safe and low-cost chemical routes (sol-gel and hydrothermal method).

The novelty of the project consists of: a) the significant improvement of properties of the proposed materials by controlling the nanometer-level architecture oxide (nanowires) and by utilizing the multilayered mixed structure containing MOx and polymeric films; b) new technology for microsensors fabrication on thin alumina with very low power consumption. A laboratory platform and a mobile apparatus for gas detection will be tested. In Romania a project focused on monitoring of greenhouse gases, comprising detection, correlated with geographical and environmental conditions, data acquisition and interpretation is new. The two years duration will allow to optimize and to demonstrate the technology up to TRL 4, to fabricate the sensors (TRL 4), to start the data acquisition and interpretation. All these developments will allow a long-term prediction algorithm for pollution evolution, geographical mapping of areas with the highest pollution, prediction of local and global warming, under different RCP scenarios (Representative Concentration Pathways), monitoring of local evolution of these gases.

Smart Portable System for VOCs detection Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERANET-M.-VOC-DETECT 2019 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); NANOM MEMS SRL (RO); Institute for Technical Physics and Materials Science (MFA), Centre for Energy Research, Hungarian Academy of Sciences (HU)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: https://www.imt.ro/voc-detect

Abstract:

Most human environments are characterised by the presence of a large number of chemical substances which mainly belong to the group of volatile organic compounds (VOC). Numerous studies revealed the toxic and carcinogenic effects of these VOCs which usually can be found in indoor air, but the tools for the detection of VOCs are still not very precise and too expensive.

The project will develop new sensors based on nano MOX and CNT materials for VOC detection, integrated into a smart portable system providing quantitative information about the concentration of Formaldehyde and Benzene in indoor air.

The results will be:

- Technology demonstrator and Smart, portable system prototype and new formaldehyde and benzene sensors;

- Technology for thin sensitive films deposition and integration in the microtechnology steps flow for sensors fabrication on silicon – Demonstration;

- E-Nose system, including sensor array, data processing algorithms and software for VOCs accurate detection.

Sensors and Integrated Electronic and Photonic Systems for people and Infrastructures Security Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0419 2018 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA PITESTI (RO); Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.sensis-ict.ro

Abstract:

The Complex Project “Sensors and Integrated Electronic and Photonic Systems for people and Infrastructures Security” aims to develop new sensors, new integrated electronic and photonic systems for detection of explosives used in terrorist attacks or accidentally released in military bases or industrial sites.

The Complex Project is developed through four distinct projects, called “components” which are converging to the Project goals by detection of explosive substances and increasing the security of people and infrastructures, as follows:

1) Design and development of a portable microsystem, based on TF BAR sensors arrays, for multiple detection of explosives (TATP, HMTD, TNT, RDX, NG, EGDN) used in terrorist attacks; 2) SiC-based hydrocarbons sensors for measuring the hydrogen and hydrocarbons in hostile industrial environments; 3) Infrared sensors for dangerous gases detection, such as explosive gases (methane) or pollutants (carbon dioxide / monoxide); 4) Design and development of a piezoelectric energy micro-harvester, able to generate electric power in the 100µW range, used for powering up sensors and portable microsystems used in explosive gases and substances detection.

The complex project description includes the novelty elements, detailed activities description, the working procedures within the consortium, expected results and deliverables. The deliverables has an average TRL 5, which means all four component projects will have a high technological level and the result’s maturity will reach at least successful laboratory testing.

The project will deliver the sensors and integrated systems along with the energy micro-harvester as physical objects and technologies, functional and laboratory- and real conditions tested, scientific papers and patents. The project’s high impact on the participants and also the social impact are detailed.

Advanced theranostic approach in cancer combining photodynamic therapy and NPs Call name: P 3 - SP 3.2 - Proiecte ERA.NET
M.ERANET-3055-NANOTHER-3 2016 - 2019

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/Research/reg_proiecte.html

Abstract:

Theranostic is an emerging medical concept, combining imagistic diagnosis and therapy for personalized medicine. Considering the need for highly targeted therapy in cancer, the main objectives of the project are: 1) to develop new tools for one step imaging and therapy directed towards tumors (theranostic approach). Taking advantage of the huge biomedical potential and versatility of nanoparticles (NPs) and of fluorescent porphyrins as photosensitizers (PSs), we will bring improved joint power by designing, producing and characterizing porphyrin/biopolymer-coated iron oxide NPs, exhibiting superior imaging and photodynamic properties in solid tumors; 2) to test the hypothesis that inhibition of the antioxidant response of targeted tumors for developing a co-therapy can increases the efficacy of nanoPDT. Secondary objectives: 1) to build a multidisciplinary network in the field of nanotheranostics; 2) to train and sustain career development for young researchers; 3) obtain scientific and economic advantages for partner institutions, both academia and SMEs. The project is in line with the M-era.Net topic “Tailoring of bioactive material surfaces for health applications” by developing a new/improved (nano)solution with multi-functional properties for theranostics in cancer. It will be demonstrated at preclinical level (in vitro and in animal models), addressing both therapeutic efficacy and toxicological issues. We will start the project at TLR 1 – basic principles observed, advancing through TRL 2 – technology concept formulated, and TRL 3 – experimental proof of concept, towards TRL 4 – technology validated in lab, at the end of the project. The project is proposed by a multidisciplinary consortium composed of 3 universities, 2 research institutes and 2 SMEs from Portugal, Spain, Turkey and Romania. Partners will benefit from high level joint research and will share state-of-the-art technologies and know-how. Activities will be organized in 8 WPs: WP1-Porphyrins, WP2-Nanoparticles and nanosystems, WP3Structural characterization of nanosystems, WP4 Photochemical characterization of nanosystems, WP5Preclinical study, WP6-Mechanistic study, WP7-Dissemination and technology transfer, WP8Management. Main deliverables: 1) Porphyrinic compounds and biocompatible functionalized nanosystems with antitumor activity and acceptable side-effects, comprehensively characterized from the physicochemical, photophysical and preclinical points of view; 2) therapeutic targets for improving photodynamic therapy by modulating the antioxidant response; 3) technical specifications and procedures for all the investigated compounds / nanostructures; 4) study-specific biobank, that will further allow the consortium to continue research beyond the project’s frame; 5) improved protocols for preclinical investigation of nanostructures; 6) patent request documentation; 7) documentation for pre-registering of at least 2 porphyrinic compounds at the European Chemicals Agency; 8) publications in high impact journals (at least 6) and result communication at relevant international congresses (at least 10); 9) training and exchange of young scientists in the field of nanotechnology and experimental medicine (at least 8); 10) organization of at least 2 workshops (industry showcase). The market strategy is to patent at least 1 nanosystem and to promote the patent to the pharmaceutical/nanotechnology industries after project completion. The new nanosystems and technologies which will be generated represent the premise for a future large scale project joining industry and academic research. Additionally, this project represents a good opportunity for young researchers to get specialized and to grow in a competitive research area. The success of the project is supported by the recognized expertise of the participating scientists, their previous fruitful cooperation and the commitment to apply material science for developing biomedical applications.

Sustainable autonomous system for nitrites/nitrates and heavy metals monitoring of natural water sources Call name: P 3 - SP 3.2 - Proiecte ERA.NET
M-ERA.NET-WaterSofe 2016 - 2018

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); NANOM MEMS SRL (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2016/WaterSafe/index.html

Abstract:

The project sets to develop a new energy autonomous system based on (photo)electrochemical sensors for detection of different ionic species in natural water sources and ultra-thin solar cells (UTSC). It focuses on three directions: high efficiency, new materials in solar energy harvesting and fabrication of small UTSC and the power stabilizing device able to supply the needed voltage to the sensors and electronic module; new microsensors for detection of nitrites/nitrates and heavy metals in water; low cost autonomous energy system integration and fabrication.

The harvester will include a UTSC, a dedicated storage and a power stabilizing device. SnO2, TiO2, ZnO materials will be optimised for sensors and (TiO2, ZnO,CuxS)or(CZTS, CuxS, TiO2) for the solar cells. Bacterial flagellar filaments will be investigated and engineered as sensitive biolayer for heavy metal detection. The project will provide a technology demonstrator and water monitoring system prototype.

Piezoelectric MEMS for efficient energy harvesting Call name: P 3 - SP 3.2 - Proiecte ERA.NET
ERA-M-PiezoMEMS 2015 - 2018

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); ROMELGEN S.R.L. (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.imt.ro/piezomems

Abstract:

The project proposes to develop a new piezoelectric harvester based on micro-electro-mechanical system (MEMS) devices and piezoelectric materials together with storage module and power circuitry. It focuses on small-scale power energy harvesting techniques (1-100µW) for autonomous operation of portable or embedded micro devices and systems. The harvester will include a MEMS device based on 10÷20 micrometric structures, covered with a piezoelectric thin film (ZnO/doped ZnO or KNN), connected together for increasing the power density.

Expected results: New technology and Prototype of a piezoMEMS harvester for powering portable biomedical devices or sensor networks, tested in real environment applications. Potential benefits: Green and cheap energy, reduction of CO2 emissions, improving quality of life. The project will impact the field of MEMS and piezomaterials manufacture, portable medical devices, sensors networks and green energy production.

Novel hybrid structures based on enzymes/1D oxide nanostructures for soil fertility increasing via accelerating bio-degradation rate Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1395 2017 - 2018

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL DE BIOLOGIE (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2017/BIONANOTUBENZ/index.html

Abstract:

The project aim is to obtain hybrid materials in form of enzymes/1D oxide nanostructures for enhancement of biodegradation process rates, leading to increased soil fertility. In order to achieve this scope, SiO2 (SiO2_NT) and sodium titanate nanotubes (TiNTs) will be functionalized with extracellular proteases, lipases and amylases of halophilic/halotolerant microorganisms isolated from Romanian saline environments, i.e. saline soils and lakes. Exoenzymes will be isolated, purified, biochemically characterized and immobilized on inorganic support (SiO2_NT and TiNTs). The efficiency of the hybrid materials will be tested for their biologically activity in native enzymatic form. The ability of the novel hybrid structures to contribute at the accelerating rate of biodegradation in experimental soil models will be also evaluated. The project is looking for obtaining reproducible data regarding the enhancement of enzymatic activity obtained by immobilization of extracellular protease, amylase, and lipase on tubular matrix of SiO2 and TiNTs. These results are meant to be a useful support for the biofertilization of intensively exploited or salted soils. Our project proposal is focusing on: (a) optimization of the textural properties of inorganic matrices (SiO2_NT and TiNTs) with respect to the further enzymatic immobilization; (b) modification of tubular surfaces with chemical active species in order to improve the enzymatic immobilization; (c) isolation of halophilic strains for targeted exoenzymes extraction; (d) tests regarding the adherence/adsorption of enzymes; (e) enzymatic tests with application in soils biofertilization.

Improving oral and systemic health using dental works from modified alloys Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0869 2014 - 2017

Role in this project:

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA BUCURESTI (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); DENTAL ART GROUP SRL (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://cercetare-umf.ro/proiecte_parteneriate

Abstract:

The project proposal entitled “Improving oral and systemic health using dental restorations from modified alloys” is addressed to the priority field 4 Health and has as goal the improvement of oral and systemic health of the population through implementing new methods of prevention and intervention at national level having capacity of international expansion. Having the central objective the improvement of the health level mainly through the offer of medical services of prevention, the project will contribute to the reduction of costs in the field of health. The offer is elaborated under the competent and representative direction of the University of Medicine and Pharmacy “Carol Davila”, the Faculty of Dental Medicine, another 2 Universities, 1 Institute of research of the Romanian Academy and 2 co-financing SMEs. This consortium is by definition inter- and pluri-disciplinary and exhibits synergy and complementarity due to the contribution of Medicine, Chemistry and Biology to the achievement of the central objective and it shall benefit of the un-financed support of an European partner (Universita’ del Piemonte Orientale “Amedeo Avogadro”) well known in the field of oral pathology, partner which shall participate to the activity of research and dissemination of results. This partner with experience and tradition will enhance the chances of the project both at level of the choice of the best methods of prevention and intervention in oral health and also at the level growing the visibility of the research. As derived objectives to achieve the central goal, the project takes into consideration the formation of target groups of patients according to the following criteria of selection: the detection of lichenoid reactions, of a metallic pigmentary lesions; the existence of dental alloys (CoCr, CoCrMo, etc. used at mass level) which favoured the release of ions and the absorption due to materials imperfections. The project will also form proof-lots including in the study a high number of patients comprising also patients who did not use dental alloys, fact which will allow the set out of the cause of the diseases and of the most appropriate treatments for all the studied cases. Both the scientific background and the expertise of the 6 partners as well as the richness of human and material resources represent a warranty that it is possible to overlap the knowledge about the creation of an improved alloy (CoCrZr or Nb) capable to reduce the potential for serious diseases such as Lichen Planus. The project analyses the sick tissue and the amount of ions released chemically and biologically and to compare the behaviour of the existing materials with that of our new alloy. The improvement of the dental alloy will aim at both the composition as well as the surface state at micro- and nano- level. The trial of these materials will be performed in simulating conditions respecting the corresponding regulations form the European space of operation including the norms of bio-ethics and bio-security and the informed agreement of the patient. The results of the project will be disseminated and exploited both at level of health services as well as at level of co-financing partners who will develop technology and innovating dental works from improved alloys at reduced costs, fact that emphasizes the co-relation between the thematic of the project and the strategy of development of the SMEs partners. Obtaining a patent and publishing 5 research works in international publications of high impact is a prognosis of result indicators that complete the process indicators. The benefits of implementing the project and its exploitation after ending will grow the quality of life through precocious detection of diseases and their treatment and also through the proposal of a new less dangerous and less toxic alloy. The co-financing SMEs will develop as well the commercialisation capacity subsequent to the production of materials with high market potential.

Improvement of biomedical implant properties by surface nano-architecturing and antibacterial protection Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0855 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE CANTACUZINO (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); TEHNOMED IMPEX CO S.A. (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2014/PN-II-PT-PCCA-2013-4-0855/SursaDeFinantare.html

Abstract:

This project proposes the obtaining of a novel, advanced, biocompatible Ti-Ta-Ag bioalloy for orthopaedic and maxillofacial implants with complete innovative composition and properties. Two Research Institutes, one University and two SMEs will resolve in synergetic, multi and inter-disciplinary way the following main scientific objectives: a) elaboration of a novel, original ternary Ti-Ta-Ag bioalloy that contains only non-toxic and non-allergenic elements (Ti and Ta) and an antibacterial element (Ag), assuring increased corrosion resistance, very low ion release, high bioactivity and bacteriostatic activity to avoid adverse reactions in the human body; b) the functionalisation of the alloy surface by introduction of antibacterial nano-particles to increase the antibacterial properties; c) nano-architecturing of the alloy surface with nano /-tubes, /-channels, /-fibres which will stimulate the implant direct attachment and rapid bone healing; d) assessment of the alloy chemical composition and structural characteristics by high level techniques; e) determination of the alloy mechanical properties by static and dynamic tests; f) alloy long-term electrochemical behaviour and corrosion resistance in artificial human biofluids simulating the severe functional conditions of an implant, using modern electrochemical methods; g) monitoring of the quantity of ions (specially Ag+ ions) released into biofluids by high level techniques to know the release rate of Ag+ ions from the bulk alloy; h) establishment of the nano-architecture with the most optimal properties of the stability, roughness, porosity by world level techniques; i) determination of the bacteriostatic capacity of the new alloy before and after its surface functionalisation and nano-architecturing; j) evaluation of the alloy biocompatibility in as-cast, functionalised and nano-architectured state by in vitro and in vivo studies. The project technological objectives are: a) laboratory technology of the alloy synthesis by the modern melting method in vacuum levitation furnace with cold crucible; b) laboratory technology for the surface functionalisation with antibacterial nano-particles having suitable properties of the stability and antibacterial ability; c) laboratory technology for the surface nano-architecturing by the application of nano /-tubes, /-channels, /-fibres; e) two technologies for the orthopaedic and maxillofacial implants obtaining; d) fabrication of the orthopaedic and maxillofacial implants – demonstrator products. The original and innovative contributions of the project are: a) novel, biocompatible ternary Ti-Ta-Ag alloy; b) a new, complex functionalisation and nano-architecturing of the alloy surface; c) elaboration of the original mechanisms of electrochemical behaviour for the as-cast, functionalised and nano-architectured alloy in simulated physiological solutions; d) scientific novelties concerning the modelling of the physical processes at the interface between new bioalloy and simulated biofluids; e) monitoring of the bacteriostatic activity by the modern techniques; f) prime novelty determination of the bare and structured alloy biocompatibility by in vitro and in vivo tests; g) original data bank regarding physico-mechanical, electrochemical, anticorrosive, surface, biocompatible, antibacterial characteristics of the novel bioalloy. The obtained orthopaedic and maxillofacial implants will fulfill the multiple, complete functions and properties of a good implant, actually non-existing on market.

New generation of photocatalytic self-cleaning systems for functionalization of technical textiles and architectural coatings Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0864 2014 - 2017

Role in this project: Partner team leader

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); CHIMCOLOR S.R.L. (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.cleanphotocoat.roit.ro

Abstract:

Pollution and its side effects on health, structural damage of materials, costs for maintenance, cleaning and replacement of damaged materials is one of the most important causes of severe human diseases and of great economic losses all over the world. The project is focused on the development of new photocatalytic coating materials for technical textiles and architectural finishing systems that can be used to decompose pollutants in the air and on the coated surfaces in order to maintain a clean and healthy environment and avoid economic loses. The objective of the project is to obtain stable, adherent, efficient and durable daylight photocatalytic self cleaning coatings for different types of substrates, such as flexible technical textiles and rigid construction structures. To accomplish the objective, issues that require skills in various fields are to be addressed, in view of: scientific research for designing new photocatalysts, innovation activity for the improvement of their efficiency by extending absorption in the visible range of the spectrum, and technological development in order to obtain photocatalytic coatings dedicated to a particular type of substrate. All these issues will be solved due to a multidisciplinary partnership formed of high rank specialists in materials physics, laser physics, physical-chemistry, polymer chemistry, dyestuffs chemistry, and chemistry of textile materials, constantly having in mind obtaining safety products and technologies and achieving economic advantages from the production stage up to the application by the end-users.The method used for the synthesis of semiconductor materials is a key factor that determines their efficiency, the main reason for developing comparative studies regarding the most important oxide type photocatalysts used in practice (TiO2 and ZnO) that could be obtained and doped by wet methods (hydrothermal,sol-gel) or by laser pyrolysis route. Investigations developed in the project comprise also sensitizing the photocatalysts at the surface or by obtaining composites in order to use more efficient visible light in the photocatalytic decomposition of pollutants. Thus, we aim to develop new and optimized photocatalytically materials exhibiting activity upon visible light with surface characteristics of improved performance and of the high chemical and physical stability, crucial for broader scale utilization of photocatalytic systems in commercial application. However, another important challenge will be to obtain film building materials containing photocatalysts specially designed for coating technical textiles or for architectural coatings. Technologies regarding photocatalytic coatings developed in the project present several barriers that can be lifted by carrying out this project. The photocatalytic coatings that will be obtained will be compatible with the substrates, protect them to self-degradation and maintain their initial physical-mechanical characteristics, presenting high photocatalytic efficiency in visible light and durability. The newly developed photocatalytic coatings during the project will decompose air pollutants and other contaminants in outdoor and indoor applications using sunlight or artificial light, especially after expanding widespread use of LEDs for interior or exterior lighting of buildings, tunnels, advertising materials, thus making possible an enhancement of the photocatalytic effect and thus providing significant benefits for the environment and human health. Photocatalytic materials obtained in project together with the development of technically applicable photocatalytic coating systems adaptable to different types of substrates will represent a step change in this field particularly regarding the economic viability of a range of potential processes.

Electronic Nose for detection of low concentration pollutant and explosive gases Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1487 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); ROMELGEN S.R.L. (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2014/PN-II-PT-PCCA-2013-4-1487/

Abstract:

The aim of the project is the realization of an „electronic nose” for detection of very low concentration of pollutants and explosive gases. To obtain such a device, a microsensor array will be fabricated using integrated and miniaturized silicon based microtransducers. The microtransducers containing a microheater and interdigitated electrodes on top are built on a thin Si3N4 membrane suspended on four arms. The microsensor array will contain metallic-oxide based sensors, namely TiO2, ZnO and HfO2 nanostructured materials with special morphologies, with large surface areas, patterned on top of the interdigitated electrodes. These are one order of magnitude more sensitive than „normal materials” and able to detect very small quantity of gases. The novelty of the project consists: a) the significant improvement of properties of the proposed materials by controlling the nanometer-level architecture oxide (nanostructures) by forming ordered nanoporous structures, nanorods, nanotubes, spheres, and thin films with controlled morphology and porosity; b) new technology for microsensors fabrication with very low power consumption; c) using HfO2 nanotubes obtained by chemical methods for sensor application. The microsensor array based on TiO2, ZnO and HfO2 nanostructured materials will be tested as sensors for 7 gases: H2, CO, propane, NOx, NH3, CH4, H2S. The microsensor arrays will be encapsulated and coupled with an electronic module which will allow interfacing with a computer. A laboratory platform and a mobile apparatus for gas detection will be elaborated and tested especially for interior microclimates. The use of the microsensors together with information technology will improve these microclimates and will reduce their energy consumption.

Molecular control over single-crystalline GaAs(hkl) surface electronic properties by using bio-thiols Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0304 2012 - 2016

Role in this project:

Coordinating institution: Institutul de Chimie Fizica Ilie Murgulescu al Academiei Romane

Project partners: Institutul de Chimie Fizica Ilie Murgulescu al Academiei Romane (RO)

Affiliation:

Project website: http://www.icf.ro/pr_2011/PN-II-ID-PCE-2011-3-0304.pps

Abstract:

The project aims to explore the control exerted by the adsorbed cysteine over the electronic properties of the GaAs (hkl) surfaces. Beside the thiol group that binds to substrate with high affinity, this small highly polar molecule owns carboxyl and amino functional groups whose intramolecular and intermolecular interactions with themselves or other ions present in its environment play a key role in determining adsorbate conformation and overlayer structure. The complexity of the interfacial phenomena accompanying its binding to GaAs (hkl) requires an interdisciplinary approach. This is mainly achieved by correlating the information concerning the interplay of the semiconductor surface states- and field-effects supplied by electrochemical impedance spectroscopy with that referring to the changes in the surface chemistry furnished by XPS and surface morphology provided by the fractal analysis of the AFM / STM images. UV-VIS-NIR and IR spectroellipsometry investigations on the surface morphology are also considered. Special attention will be focused on pH and doping effects as well as on the influence exerted by the metal cations (e.g. Ca2+/Mg+/ Ni2+), anions (e.g. Cl-) and redox probes (e.g. Fe(CN)63-/4- on the electrochemical properties of the self-assembled monolayer of cysteine on GaAs(hkl) electrodes. Electrochemical response of the cysteine-modified GaAs (hkl) electrodes in the presence of two important neurotransmitters (dopamine / epinephrine) will be also examined.

Rapid, innovative, soft-solution advanced processing of a new bioalloy surface for the improvement of its interactions with human fluids Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0510 2011 - 2016

Role in this project:

Coordinating institution: Institutul de Chimie Fizica "Ilie Murgulescu"

Project partners: Institutul de Chimie Fizica "Ilie Murgulescu" (RO)

Affiliation: Institutul de Chimie Fizica "Ilie Murgulescu" (RO)

Project website: http://www.icf.ro/pr_2011/JC/Index.html

Abstract:

Project theme is the elaboration of an innovative procedure for the controlled surface processing of a new bioalloy by combining for the first time of the chemical, electrochemical and bacteriostatic methods. This project represents a scientific novelty and enlarges the interdisciplinary research areas concerning the surface science, physical chemistry and electrochemistry in accordance with the international trends of increased bioactivity of bioalloy surfaces. Main objectives are: obtaining of nanoporous, controlled surface structures for the increase of the bioactivity, antibacterial action and life time of the implants (innovative procedures); complex and complete characterization (scientific novelties) of the new nanostructured surfaces by modern world-level techniques; modelling for the first time of the interfaces: structured metallic surface/human fluids by electrochemical methods (internationally competitive) demonstrating the improved bioactivity of new processed surfaces; analysis of the bioactivity and bacteriostatic properties on new functionalized surfaces (progress in the field); increase of Romanian research capacity and performance by: patent (1), scientific papers (6). Long term objectives are: improvement of the life quality and health state of the patients by the utilisation of the new implant biomaterial with nanostructured surfaces; an efficient utilisation of the natural resources by the increase of the „service life” of the processed surfaces.

Improved TCO materials for the next generation transparent electronics and their complex investigation by wide range ellipsometry from UV to Mid IR Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0446 2011 - 2016

Role in this project: Key expert

Coordinating institution: Institutul de Chimie Fizica Ilie Murgulescu al Academiei Romane

Project partners: Institutul de Chimie Fizica Ilie Murgulescu al Academiei Romane (RO)

Affiliation: Institutul de Chimie Fizica Ilie Murgulescu al Academiei Romane (RO)

Project website: http://www.icf.ro/pr_2011/MG/index.html

Abstract:

Transparent conductive oxides (TCO) are materials that exhibit electrical conductivity and high optical transparency together with a wide band-gap. The traditional applications of these materials are flat-panel displays, light-emitting diodes, solar cells, and imaging sensors.

The aim of this project is the preparation by low-cost sol-gel methods of improved TCO (ITO, ZnO) and of new generation of TCO (Nb or V doped TiO2, SrCu2O2) n and p type films with various morphologies on different substrates (silicon, glass and plastics), having a very stable surface. A complete optical and microstructural characterization of the TCO samples will be performed by ellipsometry in a wide spectral range, from UV to Mid-IR (our IR ellipsometer being the only one available in Romania) and the results will be corroborated with those obtained by complementary methods (UV-VIS, IR and Raman spectroscopy, XRD, XPS, AFM, SEM, TEM, electrical measurements).

A database for optical constants of the TCO investigated materials in the IR range (2-33 microns), which for the moment is lacking in the literature, will be provided.

In the frame of this project the best films obtained will be used in specific tests for solar-cell application.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator
List of research grants as partner team leader
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects