BrainMap

Mr. Mircea Bogdan Matei

MD, PhD

- UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA"

Researcher

Curriculum Vitae (10/02/2024)

Expertise & keywords

NEW METHODS OF DIAGNOSIS AND TREATMENT: CURRENT CHALLENGES AND TECHNOLOGIC SOLUTIONS BASED ON NANOMATERIALS AND BIOMATERIALS Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0062 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE IN DOMENIUL PATOLOGIEI SI STIINTELOR BIOMEDICALE "VICTOR BABES" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE "GRIGORE T. POPA" DIN IAŞI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE CHIMICO - FARMACEUTICA - I.C.C.F. BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA TRANSILVANIA BRASOV (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" (RO)

Project website: http://infim.ro/en/project/sanomat/

Abstract:

The project will develop novel conceptual and functional solutions of biomedical devices for treatment, reinforcement/repair/replacement (of human tissues) and diagnosis based on nanostructured and/or biocompatible materials, with high attractivity and certain potential for technology transfer to industry. The experience of the interdisciplinary consortium will allow a passage from concepts of nanomaterials and biomaterials with extended and/or complementary functional features to implementation to new biomedical applications of great interest: (i) antitumoral therapeutic systems (by localized magnetic hyperthermia, photodynamic therapy and drug delivery); (ii) biocompatible compounds with enhanced antimicrobial efficacy; (iii) stent or vein/arterial filters implants based on ferromagnetic shape-memory alloys (with the advantage of repositioning without the need of new invasive interventions); (iv) personalized bone regenerative implants (i.e. porous ceramic scaffolds for bone tissue engineering; dental implants with rapid osseointegration); (v) (bio)sensors for monitoring the bioavailability of pharmaceutical compounds and detecting the reactive oxygen species and their biologic effect; and (vi) correlation of physico-chemical properties with clinical investigations for two types of aerosols (salt particles and essential oils), and their prospective coupling with possible synergistic effects. The synergic development of the institutional capacity of the project partners will be achieved by: creating new jobs and purchasing new equipment and software, providing technical/scientific assistance to the emerging institutions, initiating and fostering collaborations with partners from industry in view of technology transfer, and increasing the international visibility of the involved institutions by capitalizing on the obtained research results. The project will create the core of the first national cluster in the field of healthcare technologies.

Transfer de cunoștințe în aplicații clinice ale biogenomicii în oncologie și domenii conexe” BIOGENONCO, ID P_40_318, cod MySMIS 105774 Call name:
D P_40_318, cod MySMIS 105774 2014 - 2020

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO); INSTITUTUL ONCOLOGIC PROF.DR.I.CHIRICUTA CLUJ-NAPOCA (RO)

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Project website:

Abstract:

Concentrations of lead, mercury, arsenic, cadmium, manganese, and aluminum in blood of Romanian children suspected of having autism spectrum disorder Call name:
HSC-GEN-15-0844 2015 - 2018

Role in this project: Partner team leader

Coordinating institution: Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA

Project partners: Biostatistics/Epidemiology/Research Design (BERD) core, Center for Clinical and Translational Sciences (CCTS), The University of Texas Health Science Center at Houston, Houston, TX 77030, USA (); UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" ()

Affiliation: UNIVERSITATEA DE MEDICINA SI FARMACIE "CAROL DAVILA" ()

Project website:

Abstract:

Environmental exposure to lead (Pb), mercury (Hg), arsenic (As), cadmium (Cd), manganese

(Mn), and aluminum (Al) has been associated with neurodevelopmental disorders including autism

spectrum disorder (ASD). We conducted a pilot study during May 2015–May 2107 to estimate blood

concentrations of six metals (Pb, Hg, As, Cd, Mn, and Al) and identify their associated factors for

children with ASD or suspected of having ASD in Romania. Sixty children, age 2–8 years, were

administered versions of ADOS or ADI-R translated from English to Romanian. After assessment,

2–3 mL of blood was obtained and analyzed for the concentrations of the six metals. The mean age of

children was 51.9 months and about 90% were male. More than half (65%) of the children were born

in Bucharest. Over 90% of concentrations of As and Cd were below limits of detection. Geometric

mean concentrations of Pb, Mn, Al, and Hg were 1.14 µg/dL, 10.84 µg/L, 14.44 µg/L, and 0.35 µg/L,

respectively. Multivariable linear regression analysis revealed that children who were female, had

less educated parents, exhibited pica, and ate cold breakfast (e.g., cereal), watermelon, and lamb had

significantly higher concentrations of Pb compared to their respective referent categories (all p
except for eating lamb, which was marginally significant, p = 0.053). Although this is the first study

that provides data on concentrations of the six metals for Romanian children with ASD, the findings

from this study could be useful for designing future epidemiologic studies for investigating the role

of these six metals in ASD in Romanian children.

The role of microparticles in the pathogenetic mechanisms of vascular complications in patients with chronic myeloproliferative neoplasms Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1315 2017 - 2018

Role in this project:

Coordinating institution: SPITALUL CLINIC "COLENTINA" BUCURESTI

Project partners: SPITALUL CLINIC "COLENTINA" BUCURESTI (RO); UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Affiliation: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO)

Project website: http://www.spitalulcolentina.ro/proiecte/ped141/index.html

Abstract:

Patients with chronic myeloproliferative neoplasms MPNs presents frequently thrombotic complications. Associated with high platelet counts, the risk of thrombosis is also due to defective function of platelets and the presence of thrombophilia status; recent studies showed also the presence in circulation of derived platelet microparticles (MPs). Their production involves the formation of vesicles in the platelet membrane as a result of changes in cell cytoskeleton and membrane phospholipid properties. The degree of expression of these MPs is considered a marker for diagnosis and prognosis in some proliferative pathologies.

In this project we aim to correlate the presence of MPs with MPNs patients increased risk for thrombotic complications. Early identification of patients at high risk for thrombotic events is very important in the cytoreduction treatment decision.

We will exploit an ensemble of molecular techniques and biophysical methods to evaluate the activity of platelets, their membrane properties, the presence and properties of MPs from blood of MPNs patients. These data will be correlated to the thrombotic risk score as determined by standard hematological evaluation schemes.

The existence of such correlations may provide a new molecular predictive marker for thrombotic risk at patients with MPNs.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects