BrainMap

Mrs. Mirela Enache

Ph.D.

Researcher - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher

Education and training: 2005-2006, Postdoctoral fellow-Institute of Nuclear Chemistry and Technology, Warsaw, Poland 1998-2004, PhD. Chemistry, University of Bucharest, Faculty of Chemistry 1997-1998, Master degree, University of Bucharest, Faculty of Chemistry 1992-1997, License, University of Bucharest, Faculty of Chemistry Research interests: - physico-chemical characterization of antitumor drug–surfactant, micelles, aggregates, DNA interactions; - redox activation study of some antitumor drugs; - interfacial electrochemistry

Curriculum Vitae (15/09/2021)

Expertise & keywords

Molecular control over single-crystalline GaAs(hkl) surface electronic properties by using bio-thiols Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0304 2012 - 2016

Role in this project:

Coordinating institution: Institutul de Chimie Fizica Ilie Murgulescu al Academiei Romane

Project partners: Institutul de Chimie Fizica Ilie Murgulescu al Academiei Romane (RO)

Affiliation:

Project website: http://www.icf.ro/pr_2011/PN-II-ID-PCE-2011-3-0304.pps

Abstract:

The project aims to explore the control exerted by the adsorbed cysteine over the electronic properties of the GaAs (hkl) surfaces. Beside the thiol group that binds to substrate with high affinity, this small highly polar molecule owns carboxyl and amino functional groups whose intramolecular and intermolecular interactions with themselves or other ions present in its environment play a key role in determining adsorbate conformation and overlayer structure. The complexity of the interfacial phenomena accompanying its binding to GaAs (hkl) requires an interdisciplinary approach. This is mainly achieved by correlating the information concerning the interplay of the semiconductor surface states- and field-effects supplied by electrochemical impedance spectroscopy with that referring to the changes in the surface chemistry furnished by XPS and surface morphology provided by the fractal analysis of the AFM / STM images. UV-VIS-NIR and IR spectroellipsometry investigations on the surface morphology are also considered. Special attention will be focused on pH and doping effects as well as on the influence exerted by the metal cations (e.g. Ca2+/Mg+/ Ni2+), anions (e.g. Cl-) and redox probes (e.g. Fe(CN)63-/4- on the electrochemical properties of the self-assembled monolayer of cysteine on GaAs(hkl) electrodes. Electrochemical response of the cysteine-modified GaAs (hkl) electrodes in the presence of two important neurotransmitters (dopamine / epinephrine) will be also examined.

DNA INTERACTION AND CARDIOTOXICITY OF SOME ANTITUMOR DRUGS: PHYSICO-CHEMICAL AND BIOCHEMICAL STUDIE Call name:
PN-II-ID-PCE-2008-2 2009 - 2011

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website:

Abstract:

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List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects