BrainMap

Ocsana-Ileana OPRIŞ

Established Researcher (R3)

Established Researcher (R3) - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Researcher

Web of Science ResearcherID: I-7805-2016

Expertise & keywords

Developing innovative solution for mitigation of drought effects Call name: PNCDI IV, P 5.8 - SP 5.8.1 - COFUND-2023
COFUND-WATER4ALL-DIME 2024 - 2027

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITY OF CUKUROVA (TR); Zuckerberg Institute for Water Research - ZIWR, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer Campus, 8499000, ISRAEL (IL); Technical University of Moldova (MD); RAIT88 srl (IT)

Affiliation:

Project website: https://www.itim-cj.ro/dime/

Abstract:

The scarcity of water resources is expanding worldwide due to the continuous growth of the imbalance between the availability and utilization of freshwater. This motivates researchers to find new water-saving methodologies and water management tools responding to future demands. The general objective of this project consists of the development of novel and low-cost material based on alginate and biochar functionalized with metal oxides and its application for the treatment of contaminated water, to support the implementation of strategies for mitigation of hydro-climatic extreme events, especially droughts in the catchment of different sources of irrigation water. Also, the material will be investigated for water saving and soil fertilization. The influence of this new material on bean crops will be studied, bean being widely used food due to their high protein content and vitamins. The specific objectives of the research are: Preparation and characterization of cost-effective new superabsorbent materials based on alginate and biochar functionalized with metal oxides. Assessment of the efficiency of recycling and reusing the superabsorbent material. Evaluation of the removal efficiency of organic pollutants from polluted water using the superabsorbent material. Testing the attenuation of antibiotic resistance genes and bacteria by the new adsorbent from greywater effluents using established molecular methods (qPCR and c sequencing); Assessment of the impact of the superabsorbent material on the physical, chemical, and biological properties of soil and its effects on growth-development, yield, and crop quality in agricultural plants under current and predicted climate change scenarios. The current project is pertinent to the work program topic, contributing to the management of water resources by adaptation and mitigation to hydroclimatic extreme events and management tools by preparation of new materials that will be used for water decontamination thus increasing the water reserve that can be used for irrigation. Also, these superabsorbent materials can be used to store and gradually release water during droughts. The project, by its objectives, fits the following topics of the call: Topic 1. Resilience, adaptation, and mitigation to hydroclimatic extreme events – by developing a mitigation strategy to cope with hydro-climatic extreme events, especially drought. Topic 2. Tools for water management - in the context of hydroclimatic extreme events – by developing tools (e.g. superabsorbent material, multi-risk approach) to support the design and implementation of strategies for mitigating droughts in a catchment to sea perspective. In addition, following the influence of the superabsorbent materials prepared in the project on bean cultivation under current and future climate change conditions of temperature and CO2 concentration in the atmosphere will provide knowledge on how the proposed solution will perform today and in the foreseeable future. (This is also addressed in Topic 2). Because the countries involved in the project (Romania, Italy, Moldova, Turkey, India) have different climates, it can also fit with Topic 3: Improved water governance in the context of hydroclimatic extreme events and international contexts - Addressing and encouraging international cooperation in the field of water, including management of transboundary water resources and contribution to Water Diplomacy. The novelty of the project: i) the material prepared; ii) 3 simultaneous applications of the same material: pollutants removal, swelling, and drought stress mitigation under current and predicted climate change scenarios for crop cultivation as model plant bean crop and soil improvement; iii) the application of the material prepared for solar desalination and the elimination of ARGs and ARBs.

Ketoconazole: from fundamentals to new antifungal formulations based on PAMAM dendrimers with improved biodisponibility Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0244 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation:

Project website: https://www.itim-cj.ro/PNCDI/ket-in-pamam/

Abstract:

The goal of the proposed project is to create a young, multidisciplinary research team capable to promote new solid forms/formulations of active pharmaceutical ingredient (API) Ketoconazole with market potential. My research experience in APIs new solid forms development will be expanded with the knowledge about API-dendrimer encapsulation, antifungal activity and biocompatibility studies. The team consist of five young researcher (project leader - chemical engineer, 2 chemists, 1 biotehnologist, 1 dermatologist), one SR dermatologist and one postdoc.

Finding new solid forms/formulations of Ketoconazole with enhanced solubility and bioavailability can be the basis of a better product in order to maximize its therapeutic efficacy. For two new co-crystals, KTZ-Adipic Acid and KTZ-Sorbic Acid, with 100 and 40-fold increased solubility compared to commercial KTZ and for an KTZ-PAMAM complex, as APIs in optimized antifungal products with oral/topical administration, the research team will strengthen their market potential.

For the co-crystals we will complete the preliminary preformulation information with specific studies/assessment: compatibility with pharmaceutical excipients, in vitro and in vivo biocompatibility tests, a protocol for co-crystallization process at grams scale necessary in pharmaceutical industry for developing a successful industrial co-crystallization process.

Increasing technological and knowledge transfer capacity of INCDTIM Cluj in the field of bioeconomics Call name:
POC 18/2016 2016 - 2021

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/poc/ttc/

Abstract:

Assessing the influence of nonsteroidal anti-inflammatory drugs on physiological characteristics and secondary metabolites in autochthonous vegetables Call name: P 1 - SP 1.1 - Proiecte de cercetare Postdoctorală
PN-III-P1-1.1-PD-2016-0484 2018 - 2020

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru12/index.html

Abstract:

In the recent years, the presence of pharmaceutical products (emerging contaminants) in environment represents the most important environmental concern at world level. Among these environmental contaminants are included the nonsteroidal anti-inflammatory drugs – NSAIDs, the most relevant therapeutic classes for their analgesic, antipyretic and anti-inflammatory properties. The influence of environmental stress factors on both crop and wild plants of nutritional value represents a very important research topic, and understanding the effects of NSAIDs on plant physiological activity and structural modification is limited, especially at environmentally relevant concentrations. Thus, to gain insight into influences of different NSAIDs on plant performance and identify the most promising traits for fast assessment of toxicity, in the present project it is aimed to study the impact of different NSAIDs on performance of the autochthonous green leafy vegetables in the context of monitoring both certain vegetables leaf parameters and the accumulation/contamination level. The proposed objectives of the present project will be achieved by investigating the influence of different NSAIDs on foliage photosynthetic characteristics, monitoring the emission of volatile organic compounds, evaluation of the vegetables leaf anatomy, quantitative evaluation of the photosynthetic pigments, polyphenolic compounds, vitamin C, determination of the antioxidant capacity, and determination of the NSAIDs content accumulated in the vegetables, and soil respectively. Thus, the present project will contribute with information for a better understanding of the adverse effects of these drugs on the environment and awareness a responsible consumption of drugs.

Methodological guide for monitoring antibiotic residues and antimicrobial resistance in the environment as a supporting instrument for an enhanced quality management of surface waters and groundwater. Call name:
EEA Grants 3499/2015 -

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CERCETARI BIOLOGICE CLUJ FILIALA A INCDSB BUCURESTI

Project partners:

Affiliation:

Project website: http://Http://enviroamr.ro

Abstract:

The EnviroAMR project rose awareness on the fact that antibiotics and antimicrobial resistant microorganisms are considered novel classes of pollutants in the environment with major consequences on the health of humans, animals and plants. The EnviroAMR project has proposed a methodological guide for a standardized monitorization of antibiotics and antibiotic resistance in the environment through a chemical and biological (phenotypic, genotypic, metagenomic) approach together with techniques of antibiotics/antibiotic resistance mitigation in wastewaters.

Effects of microwave fields on essential oils and secondary metabolites of some indigene plants Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0283 2011 - 2014

Role in this project: Key expert

Coordinating institution: Institutul National de Cercetare - Dezvoltare pentru Tehnologii Izotopice si Moleculare, Cluj-Napoca

Project partners: Institutul National de Cercetare - Dezvoltare pentru Tehnologii Izotopice si Moleculare, Cluj-Napoca (RO)

Affiliation: Institutul National de Cercetare - Dezvoltare pentru Tehnologii Izotopice si Moleculare, Cluj-Napoca (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru76/index.html

Abstract:

The seasoning plants (spices) are ingredients that, added to food and drinks give the flavor, taste and color, without having nutritional value. Due to their uses in medicine and cosmetics, it is important to know their composition and how it is affected by external factors (electromagnetic radiation, drought, and other types of stress). Among these plants, we selected three for our study: Anethum graveolens, Petroselinum crispum and Apium graveolens, rich in volatile oils and antioxidants (especially vitamin C).

The general objective of the project is the effects determination of microwave fields on volatile oils, vitamin C and secondary metabolites of some indigene plants. Within this objective will consider the following specific objectives: 1. Preparation of system for microwave irradiation of the plants considered for the study; 2. Selection of extraction methods for bioactive compounds analyzed from the seasoning plants considered for the study; 3. Monitoring changes of vitamin C amount from the irradiated plants compared to the reference plants; 4. Monitoring of the essential oils composition changes, from the irradiated plants compared to the reference plants; 5. Tracking BVOC variation in microwave stressed plants with different frequencies and powers; 6. Monitoring changes occurred in BVOC from the irradiated plants compared to the reference plants; 7. Concluding of the chemical and structural changes from irradiated plants.

The substitution of the synthetic food additives with bioactive components extracted from natural renewable resources Call name: P 3 - SP 3.1 - Proiecte de mobilități, România-Moldova (bilaterale)
PN-III-P3-3.1-PM-RO-MD-2016-0133 2016 -

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); Universitatea Tehnică a Moldovei (MD); UNIVERSITATEA DE STIINTE AGRICOLE SI MEDICINA VETERINARA "ION IONESCU DE LA BRAD" (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website:

Abstract:

Problema alimentelor funcţionale cu componente bioactive de origine naturală este mai mult decât actuală pentru industria alimentară. Activitatea antiradicalică şi antimicrobiană a extractelor vegetale, bogate în polifenoli, reprezintă o sursă promiţătoare de soluţii alternative pentru utilizarea lor în scopul substituirii anumitor conservanţi alimentari de origine sintetică. Prezenţa antioxidanţilor naturali poate preveni apariţia unor boli legate de stresul oxidativ, prezentând efecte generale de protecţie şi ameliorare a sănătăţii. Obiectivul general al prezentului proiect constã în valorificarea complexă a resurselor şi deşeurilor agricole în scopul realizării unor produse sanogene, îmbogăţite cu antioxidanţi, substanţe cu molecule sensibile al cãror efect biologic poate fi afectat atât de condiţiile de fabricaţie şi păstrare a alimentelor, cât şi de cele din tractul gastro-intestinal. Rezultatele cercetărilor vor contribui la producerea unor alimente funcţionale, capabile sã diminueze impactul stresului oxidativ şi alergiilor nutriţionale, contribuind la integrarea conceptului de alimentaţie sanogenă şi la sporirea competitivităţii întreprinderilor locale. Proiectul înglobează şi importante aspecte educaţionale. Astfel, cercetătorii şi doctoranzii implicaţi în realizarea prezentului proiect, îşi vor antrena şi perfecţiona aptitudinile şi competenţele profesionale, proiectul propus vizând şi îmbunătăţirea calitãţii ştiinţifice a resursei umane.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects