BrainMap

Mr. Lucian Barbu

Senior Researcher II, Associate Professor, PhD

Associate Professor - UNIVERSITATEA BABES BOLYAI

Other affiliations

Senior Researcher II, EM Lab. Manager - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (Romania)

Researcher | Teaching staff | Manager

ResearcherID: B-7352-2011

Curriculum Vitae (08/01/2019)

Expertise & keywords

Characterization of the sub-cellular effects of functionalised magnetic nanoparticles in targeted anti-tumor therapy Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0608 2015 - 2017

Role in this project: Project coordinator

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://poravpaul.wix.com/cellspion

Abstract:

Having unique magnetic properties, super-paramagnetic nanoparticles (SPIONs) are an efficient vector for anti-tumor targeted therapy, non-viral gene therapy, magnetic resonance imaging contrast agent, and thus personalized medicine. SPIONs are cheap and easy to synthesize, have determined dimensions, can be functionalized and loaded with various substances, and they can transport a certain drug to a certain area of the body in a targeted way, being conducted by magnet. They can be, this way, monitored in real time and at the area of interest SPIONs combine the chemical effect of the drug with the physical effect of the magnetic fluids induced hyperthermia, which generates selectively local overheating through an external magnetic field. In spite of all this promising features, there is still a certain holdback for using SPIONs as a nanotherapy method. This happens mostly because of the fact that nanomedicine is a new domain and because of the lack of coherence in all studies involving NPs in medical applications. Through our project we intend to integrate all aspects regarding cell-NPs interactions and to eliminate all dissonances that shows when passing from a certain study system to another (in vitro-2D-3D-in vivo), finally leading us to obtain coherent data. This is why this study is needed, a complete, integrating and complex study, which starts from NPs synthesis, bioavailability, cytostatic loading, fluorescent loading, in vitro and then in vivo, up to clearance.

Modeling and simulation of the dynamics of thymocyte populations and cells of the thymus medulla under normal and pathological situations Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0571 2012 - 2016

Role in this project: Key expert

Coordinating institution: Universitatea de Medicina si Farmacie "Victor Babes" Timisoara

Project partners: Universitatea de Medicina si Farmacie "Victor Babes" Timisoara (RO)

Affiliation: Universitatea de Medicina si Farmacie "Victor Babes" Timisoara (RO)

Project website: http://simtim.umft.ro

Abstract:

Thymus is the organ in which the positive and negative selection of thymocytes occurs, resulting in the production of mature T-cells that populate the peripheral tissues. In mouse thymocytes can be divided into four populations, based on the expression of CD and CD8 (developing in this sequence): CD4-CD8- double-negative, immature double-positive CD4+CD8+ and mature single-positive CD4+ and CD8+. From a mathematical standpoint these four thymocyte populations could be considered as four separate compartments connected with a one way flow of cells, with thymocytes from each compartment undergoing proliferation, cell death and inter-compartment transfer. We aim at developing a full mathematical model of the mouse thymus, based on a system of differential equations that would include all thymocyte populations, the medulla and the stromal component of the thymus with the purpose of describing the dynamics of thymocyte populations and the thymocyte-medulla interactions in normal and pathological situations. By investigating the the proliferation and death of each thymocyte population we aim at obtaining a precise expression of the proliferation, death and transfer rates during the investigation in order to optimize the mathematical model. Pathological conditions influence thymocyte dynamics by altering their death and proliferation. In a disease like diabetes that influences the proliferation and death of thymocytes we would like to be able to predict the evolution of the organ.

NANOPHOSPHORS BASED ON YTTRIUM SILICATE FOR OPTOELECTRONICS Call name: Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0360 2013 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation:

Project website: http://nanoluminofori.granturi.ubbcluj.ro

Abstract:

The project theme is in the domain of the nanomaterials and aims to synthesis and characterizes rare earth doped yttrium silicate based phosphors with predetermined properties with applications in optoelectronics. By its scientific objectives the project contribute to: the formation of young researchers in luminescent materials field; *develop the specific knowledge in domain; *open new research direction, *increase the national /international visibility. The specific objectives are related to: ● preparation of rare earth doped yttrium silicate based micro and nano-phosphors ● optimisation of the synthesis methods in order to improve performances of phosphors and to control the morphology, structure and luminescence characteristics. ●Resolving some aspects concerning the energy transfer between rare earth in silicates.
The methodology is specific for materials science and implies: sample design; synthesis of phosphors; characterization of materials; interpretation of the original results and dissemination of the original results. The preparation of phosphor powders is made by wet chemical methods by simultaneous adition of reagents and combustion method. The characterization will be performed by: chemical analysis, FT-IR spectroscopy, XRD, SEM/TEM, photo-luminescent spectroscopy and surface area investigations. The original results will be patented and disseminated by publication in journals and communication at scientific events.

Roman versus barbarian identity – the phenomenology of acculturation. The case of Roman Dacia and the adjacent barbarian world Call name: Exploratory Research Projects - PCE-2012 call
PN-II-ID-PCE-2012-4-0210 2013 - 2016

Role in this project: Key expert

Coordinating institution: ACADEMIA ROMANA FILIALA CLUJ

Project partners: ACADEMIA ROMANA FILIALA CLUJ (RO)

Affiliation: ACADEMIA ROMANA FILIALA CLUJ (RO)

Project website: http://www.romanversusbarbarianidentity.ro

Abstract:

The present research project is focused on the phenomenology of acculturation on two main entities that at the first sight may look in a complete opposition to each other: The Roman Empire and the barbarians beyond the Roman borders.
In the light of new technologies in the field or archaeology and informational devices and programs nowadays the acculturation phenomenology is one of the most requested disciplines in order to understand what actually has happened with the transformation of various historical and ethnical entities from Prehistory to present times.
If for the other areas of the former Roman Europe such a topic is under full research approaches (Germany, Great Britain, France) in Romania this project will be a premiere as nobody else has tried, so far to look deeper at the details revealed by archaeological evidence and different categories of artefacts coming from sites placed on the both sides of the Roman frontier of Dacia (2nd -3rd centuries AD).
The fortunate situation of Romania, to have a part of its territory in the Roman Empire and the other part left to be inhabited by various ethnical groups is an extreme advantage for this project to establish general and specific patterns of acculturation phenomenology not only in regards for the border of Roman Dacia but also to compare with other similar situations in Roman Europe.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader	Download (42.49 kb) 15/11/2019
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects