BrainMap

Mrs. Mihaela Filipescu

Scientific researcher I

Researcher - INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Researcher | Scientific reviewer

The scientific research of Dr. Mihaela Filipescu has a strong interdisciplinary character, involving different fields of physics: lasers and plasma physics, solid-state physics, highlighting on semiconductors, insulators and polymers physics. Relevant works on simple and complex oxides thin films and nanostructures obtaining and characterization, organic material processing for different applications, are just a few examples. During 19 years of research activity, she achieved skills for different processing techniques: pulsed laser deposition (PLD), radio-frequency assisted PLD (RF-PLD), matrix-assisted pulsed laser evaporation (MAPLE), laser-induced forward transfer (LIFT) and for investigation techniques like Atomic Force Microscopy (AFM), Raman spectroscopy, profilometry, and UV-VIS spectroscopy.

Curriculum Vitae (04/02/2024)

Expertise & keywords

Integrated aerial system for intelligent monitoring and precision agricultural applications for horticulture crops Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-3678 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA TRANSILVANIA BRASOV

Project partners: UNIVERSITATEA TRANSILVANIA BRASOV (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA LUCIAN BLAGA (RO)

Affiliation:

Project website: https://iasimpah.webnode.ro/

Abstract:

The project intitled Integrated aerial system for intelligent monitoring and precision agricultural applications for horticulture crops (IASIMPAH) adresses the problem of integration at operational level of technological aerial- based capabilities adapted for precision horticulture.

The aim is to capitalize on the results obtained with the help of multispectral sensors used in precision agriculture by transforming them into data used by fertilization systems installed on scalable and modular systems of aerial platforms. This innovative technology allows farmers to carry out efficient treatments in agricultural crops in the shortest time, including in those times of the year when soil moisture does not allow access to traditional agricultural machinery.

IASIMPAH technology provides a tool to the farmer through which from identifying problems in real time (using multispectral technology), its precise location in the culture (using digital maps), can intervene aerially (using fertilizing drones), subsequently performing the re-evaluation of the results (using multispectral technology), and making corrections.

The implementation of sensors for monitoring the quality of treatment solutions at the level of aerial fertilization systems, as well as at the soil level, as well as by applying treatments only in problem areas will reduce the impact on the environment.

The identification of problem areas and the application of treatments with strict control of the quality of the substances used will lead to a reduced impact on the environment and an economy of forces and means to the economic agent. Data collected from multispectral sensors are analyzed by deep learning algorithms and transferred to the aerial treatment application platforms as missions to be performed.

The IASIMPAH consortium acccumulates a consistent mass of technology at TRL 2 level offering through experience of participation in previous projects real acceleration capabilities to a TRL 4 level system.

Tungsten oxide/polymer composites for sensor applications Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0219 2022 - 2024

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://mihaelafilipescu.wixsite.com/co-polysens

Abstract:

Permanent, rigorous and efficient monitoring of the environmental pollution involves the use of efficient devices, namely highly sensitive and reproducible sensors that work at room temperature. The most important part of such a sensor is the active membrane that detects these pollutants, based on chemical or physical phenomena. In the case of chemoresistive sensors, the use of new composite material obtained by mixing organic and inorganic compounds appears to be a promising alternative. Materials used in this project are: WO3, polyaniline and polypyrrole. The project aims to use alternative technologies based on laser deposition for obtaining nanostructured composites (WO3/polymer) with high sensitivity to ammonia and low working temperature. Nanostructures are obtained by pulsed laser deposition and matrix assisted pulsed laser evaporation. Following detailed parametric studies, the first part of the project is based on identifying the optimal method for processing WO3/polymer composites as thin films having high specific area, good adhesion to the substrate and high conductivity. The second part will be dedicated to sensors based on the optimized nanostructures: design, processing and testing.

Magnetic sensors based on ecofriendly piezoelectric thin films Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2921 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation:

Project website: https://pocproiecte.wixsite.com/ms-ecop

Abstract:

The magnetoelectric effect is temperature dependent and is currently a very important subject due to the need to know the physical phenomena involved and implicitly to be able to develop magnetic devices capable of working in various environments.

All types of electronic devices are subject to the limitation imposed primarily by the constituent materials. In the case of magnetic sensors, in order to obtain a high and stable ME effect in temperature, different piezoelectric or magnetostrictive materials can be used. For all these materials it is imperative to know the temperature variation of the electrical or magnetic properties. In our proposal we chose for the studio and to develop a magnetic sensor, ecological materials based on barium titanate doped with calcium and zirconium (BCZT) and magnetostrictive materials (Terfenol-D). A parametric study on temperature dependence for BCZT- Terphenol-D structures will be made and based on these studies the best configuration will be chosen for the development of a magnetic sensor capable of working in the temperature range between -190C 300C

Breast implants silicon outshell bioinstructive engineering for preventing microbial and fibrosis development Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-2375 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation:

Project website: https://ancabonciuub.wixsite.com/breaslife

Abstract:

Breast cancer is a significant public health issue for women and it is currently targeted by the national strategies for health outcomes. Considering both physical and psychological impacts on health-related quality of life, a large percentage of women with a mastectomy will choose breast reconstruction by implants. One inevitable consequence of silicone breast implantation and foreign body response is the capsular contracture, which often leads to health complications, need for revision surgery, etc. Hence, the main objective of the BreasLIfe project is to design, develop, and obtain new silicone out shell bioinstructive interfaces of breast implant with specific modulated characteristics (in terms of surface topography, chemistry,wear-resistant) for a final antibacterial and low inflammatory response that could lead to a reduced capsular contracture.

The approached innovative bioengineering solutions for achieving this objective refers to:

1)multi-architectural 2 and the 3-dimensional surface texturing of silicone for reducing the wear and friction of implant biointerfaces surface, inhibiting bacteria and fibrosis;

2)surface chemistry by using the synergetic effect of zwitterionic polymers, antifibrotic and anti-inflammatory compounds ( i.e., pirfenidone, Lactoferricin);

3)surface multiple specific functionalizations by laser techniques for the embedding of bioactive synergetic compounds(antifibrotic and anti-inflammatory)in a biodegradable zwitterionic polymer coating.

Laser transfer of graphene sheets for the fabrication of sensors: process optimization via time-resolved imaging Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1093 2021 - 2023

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://alexandrapalla.wixsite.com/lasting

Abstract:

In recent years there has been a growing interest for two-dimensional nanomaterials such as graphene, for applications in the electronic and optoelectronic industries. Graphene has many advantages; however, its main disadvantage for application in devices remains the need to use special growth / synthesis and handling conditions.

In the field of sensors, most of the research work is focused on reducing the size of the sensors and identifying and quantifying several species. Also, fast response, minimum hardware requirement, good reversibility, sensitivity and selectivity are also qualities of an excellent sensor. The main problem related to the new generation of miniaturized sensors is the complexity of the manufacturing processes, i.e. the integration of many functions on the same device through a single manufacturing process.

Thus, the LASTING project “Laser transfer of graphene sheets for the fabrication of sensors: process optimization via time-resolved imaging” has as main objective the optimization of the laser induced forward transfer process (LIFT) by imaging techniques (shadowgraphy) that allows the deposition of two-dimensional atomic layers of graphene with high spatial resolution for the subsequent realization of sensors.

Integrated sensors platform based on eco-friendly materials for smart city environmental monitoring Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-4734 2020 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://valentinion2015.wixsite.com/spsmcity

Abstract:

The "Integrated sensors platform based on eco-friendly materials for smart city environmental monitoring" (SPSMCITY) project proposal aims are to develop new integrated sensors architecture for the city air pollution monitoring. A major human health problem comes from intense car traffic which release toxic gasses such as NOX, CO, O3 and the nowdays sentence „Don’t breathe deep – the air may be killing you” is a true fact. We propose a way to monitoring in real time the amount of toxic gas concentration in town cross street by using a smart integrated sensor platform. The sensors platform will be composed by four modules linked together: gas sensor working in GHz regime, RH sensor for humidity monitoring, a communication and a digital processing signal modules. The gas sensor architecture is based on a concept working in GHz regime and will use eco-friendly piezoelectric material covered with polymers. For the RH sensor oxidized carbon nanohorns will be used. The final sensor platform will be tested and validated according with TRL 4 requirements.

Air-Water Innovative System for Environment Monitoring Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-1480 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA "DUNAREA DE JOS"

Project partners: UNIVERSITATEA "DUNAREA DE JOS" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://awisem.ugal.ro

Abstract:

AWISEM project propose a versatile and innovative system for monitoring the environment, either aerial or aquatic. It will be composed by two major parts: a) an aerial and aquatic monitoring platform, having the intrinsic ability to fly and also to float in an aquatic environment, characterized by the potential to carry a larger payload than the usual rotary-wing drones (helicopters and multi-copters), b) two sets of sensors (for either aerial or aquatic monitoring of the contaminants) mounted on-board of the platform according the environment monitored. Overall, AWISEM system has to be an advanced type of drone, a sort of a computerized drone system, to be used for monitoring the environment, looking for contaminants, either aerial or on the surface of the water.

Selective extremozyme-based platform for aldehydes detection in air in a wide temperature range Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-2746 2020 - 2022

Role in this project:

Coordinating institution: CENTRUL INTERNATIONAL DE BIODINAMICA

Project partners: CENTRUL INTERNATIONAL DE BIODINAMICA (RO); INSTITUTUL DE BIOLOGIE (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); EPI-SISTEM S.R.L. (RO)

Affiliation:

Project website: https://www.biodyn.ro/PROJECTS/ALDSENS/aldsens.html

Abstract:

The project aims to develop an innovative biosensor-based analytical platform for the detection of aldehydes in air addressing various applications such as the evaluation of the freshness of cold-stored food, air quality assessment and breath analysis as non-invasive screening of different medical conditions. The proposed analytical platform will be small, portable, easy to use and will enable reproducible measurements in the 4-40°C temperature range. The experimental prototype will selectively detect acetaldehyde in mixtures with other volatile organic compounds. The platform consists in a set of biosensors made from electrodes modified with laser-deposited enzyme layers. The device includes as main elements: (i) 3 recombinant psychrophilic aldehyde dehydrogenases with high specific activity for acetaldehyde, stable and active from 4 to 40° C as biosensor components; (ii) electrodes covered with biocatalytic enzyme layers; (iii) a sensor array including sensors with the 3 enzymes; (iv) chemometric analysis of signals measured with the biosensors array. Temperature and humidity sensors added to the biosensor array will allow to compensate for variations in these parameters and enable accurate measurements. The array will be characterized at 4, 25 and 40° C and will be tested for 3 applications, namely(1) measuring the freshness of cold stored food; (2) evaluating the quality of indoor air and (3) breath analysis. The project unites 4 partners (3 research centers and a SME) with expertise in microbiology and extremophiles, laser deposition methods, biosensors development and manufacturing of measurement and control system. System will start at TRL2 will reach TRL 4 corresponding to the validation of the analytical platform at lab level. The project will have a strong economic, scientific and social impact thanks to the innovative elements proposed and the targeted applications

Antiadhesive Bionic Combs for Handling of Nanofibers Call name: P 3 - SP 3.6 - Premierea participării în Orizont 2020
PN-III-P3-3.6-H2020-2020-0156 2021 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation:

Project website: https://alexandrapalla.wixsite.com/biocombs4nanofibers

Abstract:

The BioCombs4Nanofibers project aims to create and test nanostructured surfaces for handling and controlling the adhesion of nanofiber structures (including those with nanofiber terminations - cells and microorganisms). The project is organized in 5 work packages (WP): one deals with the management of the project (WP1), one with dissemination, exploitation and communication (WP5) and three with scientific activity. WP2 is dedicated to the theoretical and experimental study of the calamist, a special organ ("comb" type) found in the composition of the screened spider web and which facilitates the manipulation of nanofibers. WP3 is dedicated to the creation and characterization of periodic nanostructures by laser techniques, nanostructures with dimensions and geometries similar to those of the calamist.

The techniques used are direct writing by photopolymerization with two photons and induction of structures by repeated irradiation of metal surfaces. WP4 is intended for testing the structures obtained in WP3 with both nanofibers and cells and microorganisms.

INFLPR is responsible for the work package no. 3 (WP3) and contributes to the realization of the work packages WP1, WP4 and WP5.

The most important activities that INFLPR carries out consist in: i) the realization of bionic hierarchical structures by photopolymerization with two photons using lasers operating in femtosecond regime in an experimental system of "nanoscribe" type; ii) characterization of structures (SEM, AFM, adhesion, etc.); iii) realization of controlled coatings with functional properties by pulsed laser deposition, laser assisted evaporation of the matrix and treatments in radiofrequency plasma jet, their characterization; iv) testing the behavior of cells in relation to bionic structures and those with functional coatings.

Surface acoustic wave biosensor based on functionalized graphene with monoclonal anti-alpha-fetoprotein antibody for hepatic cancer diagnostic Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2019-1603 2020 - 2022

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://sawsenseproject.wixsite.com/sawsense

Abstract:

The objective of the project “Surface acoustic wave biosensor based on functionalized graphene with monoclonal anti-alpha-fetoprotein antibody for hepatic cancer diagnostic (SAWSENSE)” is to develop a biosensor with surface acoustic waves (SAW) for the detection of alpha-fetoprotein (AFP) used as tumor marker for hepatic cancer diagnosis. The sensor is based on the chemical selectivity of the matrix, which is crossed by acoustic waves. When the selective matrix interacts with the species to be detected, the mass of the sensitive matrix is loaded and the wave’s amplitude changes, this phenomena representing the detection principle. The project proposes the development of a sensor based on this principle, the selectivity for AFP arousing form the immobilization of antibody on graphene. The project aims the synthesis of a sensitive matrix (graphene functionalized with monoclonal Anti-α-Fetoprotein antibody), the deposition of the sensitive matrix on the sensor’s surface using laser induced forward transfer (LIFT) technique, sensor’s calibration and signal validation. In order to fulfill these objectives, the execution consortium is composed of researchers from University Politehnica of Bucharest (UPB) and National Institute for Laser, Plasma and Radiation Physics (INFLPR). The project aims the transition from TRL 2 (concept of SAW sensors with sensitive matrix based on functionalized carbon nanotubes for gas detection) to TRL 3 (laboratory product - SAW biosensor for AFP detection) and TRL 4 (small scale prototype validated in a laboratory environment for a SAW biosensor for AFP detection). The obtained results will be disseminated through the publication of three ISI articles, at least four communications at relevant international presentations and submission of a patent application - SAW biosensor for AFP detection.

Advanced nanoelectronic devices based on graphene/ferroelectric heterostructures (GRAPHENEFERRO) Call name: P 4 - Proiecte Complexe de Cercetare de Frontieră
PN-III-P4-ID-PCCF-2016-0033 2018 - 2022

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD

Project partners: INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://www.imt.ro/grapheneferro/

Abstract:

Applications such as high-frequency and neuromorphic circuits, optoelectronic/plasmonic detection of biomolecules or thermo-opto-electronics energy harvesting, require tunable and reconfigurable functionalities. Graphene is suitable for these applications because of electrostatic doping, its optical constants being tuned via gate voltages. However, oxide substrates limit the mobility in graphene to few thousands cm2/V•s. On the contrary, the mobility in graphene/ferroelectric (G/F) heterostructures is 2-3 orders of magnitude larger. The groundbreaking nature of the project is based on the possibility of significantly enhancing the functionality of graphene-based transistors/devices by using crystalline ferroelectric substrates instead of common oxides or SiC substrates. The G/F heterostructures allow: (i) the achievement of very high mobilities in G/F field effect transistors (FETs), which push the transistor gain in the 0.3-1 THz range, far above 70 GHz at which the maximum gain is attained nowadays, (ii) the fabrication of uncooled tunable detectors working in the THz and IR, (iii) the exploitation of the hysteretic resistance behaviour, essential for neuromorphic applications such as artificial synapses, (iv) the fabrication of reconfigurable microwave circuits, and (v) of tunable thermoelectronic devices, since graphene displays a giant thermoelectric effect. The project will consist of the design, fabrication and testing of groundbreaking, innovative nanoelectronic devices, in particular ultrafast electronic devices, neuromorphic circuits for computation, reconfigurable and harvesting devices, all based on the outstanding physical properties of G/F heterostructures. All fabrication techniques for growing graphene-ferroelectric heterostructures in this project should be scalable at wafer scale. The project is implemented by a consortium of 3 national R&D institutes and the leading Romanian university, which have the necessary advanced infrastructure.

Multiagent intelligent systems platform for the monitoring of water quality on the Romanian sector of the Danube and Danube Delta Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0637 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); Academia Fortelor Aeriene "Henri Coanda" Brasov (RO); Ministerul Apărării Naționale prin Centrul de Cercetare și Inovare pentru Apărare CBRN și Ecologie (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE MECANICA SOLIDELOR (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://multimond.wixsite.com/multimond

Abstract:

The MultiMonD2 project proposes the development of a multi-agent platform consisting of micro-laboratories specialized in the monitoring the water quality of the Danube and Danube Delata and the testing of its decontamination capabilities. To this end, robotic vectors will be realized which will integrate systems for the investigation of Danube's water quality and dynamics. The acquired data will be collected and interpreted by a dedicated software system, operated from a control center. The robotic vectors will be equipped with sensors systems and devices for diagnostics organized as micro-labs for the monitoring of water quality, management of floods and sediments. The project (MultiMonD2) is made of 4 interdisciplinary and complementary projects, interconnected through specific objectives aimed at achieving the general objective: development of the MultiMonD2 multifunctional platform. Therefore, the aerial and surface water vectors will be used used as carrier systems for the sensor based detection equipment (developed in project 1). Project 2 proposes the development of a technical solution that allows the optimizing of communication from the different types of sensors mounted on the robotic vectors and includes software modules that will interact with the Control and Command Center developed in project 3. Project 4 constitutes a 'proof-of-concept', which proposes, based on the results obtained and processed in the other projects, a solution for local decontamination. The consortium is made of 5 partner institutions. The institutional consolidation of the partners is achieved by: i) ensuring new positions for young people in the field of research, ii) development of novel/improved technologies and iii) the providing of research and technological services with impact in the economy.

Integrated development project for advanced medical treatment technologies Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0728 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE-DEZVOLTARE MEDICO-MILITARA „CANTACUZINO” (RO); INSTITUTUL DE BIOCHIMIE (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA PITESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://teramed.inflpr.ro/

Abstract:

In order to increase community’s quality of life, the aim of the project proposal entitled “Integrated development project for advanced medical treatment technologies” (TERAMED) is to develop novel technologies with respect to the treatment of osseous and cutaneous conditions and oncological disorders. Given our experience in healthcare research and the current requirements of multidisciplinary and interinstitutional collaboration towards the personalized treatment purpose, the TERAMED project aims genuine synthesis and processing of biomaterials, but also functional and therapeutic evaluation relevant for clinical trials. The main objectives of the “Medical devices functionalized by laser technologies and alternatives for enhanced osseous integration and regeneration” subproject are to design and produce inorganic, composite or hybrid coatings for superior osteoconductive and osteoinductive performances of titanium-based implants. Smart wound patches and polymeric gels functionalized with antimicrobial and wound healing biomolecules incorporated within micro- and nanoparticles constitute the purpose of the “Medical devices (patches and gels) based on composite biomaterials obtained by laser, plasma and radiation technologies and alternatives for enhanced healing of cutaneous injuries” subproject. The “Technologies based on magnetic triggered nanostructures for oncological therapy: early diagnosis and targeted treatment” subproject aims the development of multifunctional medical devices for specific and selective diagnosis and treatment of breast cancer and melanoma. The general impact of the TERAMED project ensues from the beneficial conjunction of the clinical potential of the proposed medical devices, the feasible technological transfer and the economic advantages of interinstitutional collaboration.

Emerging technologies for the industrial capitalization of 2D structures (graphene and nongraphenic) Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0387 2018 - 2021

Role in this project:

Coordinating institution: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti

Project partners: Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA DIN CRAIOVA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://icechim-rezultate.ro/proiect.php?id=49

Abstract:

EMERG2Ind is a complex solution that responds to the needs of Romanian research on one side through a institutional management and development mechanism, but at the same time it is a complex interface tool for the Romanian automotive industry as a development engine and integrator for the horizontal and vertical integration of the Romanian economic resources. International expertise is available in an attempt to develop concrete solutions in the country. Emerging technologies are being developed up to TRL4 and TRL5, through complementary harmonization of three strategic subprojects. The complex project approach is regional and institutional with cumulative indicators that fully meet the requirements and seeks to maximize the use of the funding instrument.

Advanced materials and laser / plasma processing technologies for energy and depollution: increasing the applicative potential and scientific interconnection in the field of eco-nanotechnologies Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0755 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA PITESTI (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://malasent46.wixsite.com/malasent

Abstract:

The MALASENT project proposes the development of research competencies of the consortium members in the field of advanced materials and their novel processing technologies, as well as a potential transfer towards industrial beneficiaries, for the energy production and complex decontamination of water and air. The scientific objectives associated this project proposal are the following:

- development of catalytic systems based on advanced materials processed by laser techniques and plasma, for complex processes of decontamination of residual waters and reduction of toxic exhaust gases emitted by internal combustion engines.

- development of heterostructures of advanced materials obtained by laser techniques and plasma for the production of energy through photolytic dissociation of the water molecule or photovoltaic.

- integration of the advanced materials through laser/plasma techniques in photocatalytic and photovoltaic applications at the industrial level.

The project proposal aims to consolidate, numerically and professionally, the human resources of the consortium, especially for the partner institution with recovery possibilities. Moreover, the project pursues an increase in the service providing capabilities for research services and in the establishment of consolidated collaborations with industrial beneficiaries, as well as in the visibility at the national and international level of the consortium members.

Fabrication, calibration, and testing of advanced integrated sensor systems aiming at applications in societal security Call name: P 1 - SP 1.2 - Proiecte complexe realizate in consorții CDI
PN-III-P1-1.2-PCCDI-2017-0172 2018 - 2021

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NAŢIONAL DE CERCETARE - DEZVOLTARE PENTRU SECURITATE MINIERĂ ŞI PROTECŢIE ANTIEXPLOZIVĂ - INSEMEX PETROŞANI (RO); UNIVERSITATEA DIN CRAIOVA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://alexandrapalla.wixsite.com/testes

Abstract:

The TESTES project is divided into four independent projects, each of these projects contributing on a long term to the accomplishment of the priorities established in the Innovation, Development, and Research Strategy 2014-2020, TIC, Space and Security.

D1. Demonstration and validation of a chemorezistive sensor matrix based on nanomaterials (functionalized carbon nanotubes and carbon nanowalls) aiming at the detection of volatile explosives compounds (military and homemade).

D2. Demonstration of a surface acoustic wave sensor with nanowires and porous thin films for the detection of explosives showing sensitivities below the ppb range.

D3. Development of a mobile pressure sensor based on an environmentally friendly ceramic piezoelectric structure or a ceramic-polymer heterostructure for monitoring explosive blasts.

D4. Technological development of a new class of active membranes for gas detectors based on tungsten thin films doped with iron or WO3/MnO2 structures.

These projects correspond to the fabrication of sensors and sensor matrices with exceptional performances, in terms of sensitivity and selectivity, capable of detecting the analytes of interest. With this, we aim at strengthening the national capability to fabricate, entirely in Romania, portable and cheap platforms to detect volatile explosive compounds aiming at applications in societal security. Actually, this is a strategic motivation for us and an important characteristic of this project, as detection systems for explosives are not only important for monitoring in airports, but also for safety of people and places.

Smart flexible biosensor via laser transfer for body fluids monitoring Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2016-1417 2018 - 2020

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://alexandrapalla.wixsite.com/iflex

Abstract:

Electrochemical sensors play a leading role in point-of-care diagnostics owing to their portability, low cost, simplicity, and high performance, being ideally suited for on-body physiological monitoring. The iFLEX project aims at the fabrication of an original, flexible, wearable, and low cost biosensor based on nanocomposite materials (polymers and graphene) fabricated by a laser-induced forward method. The electrochemical biosensors will have all laser printed electrodes and shall be used for the detection of heavy metals in human body fluids. The iFLEX project aims two specific objectives: i) Design and development of the electrochemical biosensors based on LIFT of nanocomposite materials i.e. conductive polymers and graphene; and ii) System testing of the electrochemical biosensors for detection of heavy metals.

iFLEX is a multidisciplinary project which involves different specialties such as laser physics, electrochemistry, sensor fabrication, and engineering. As the whole field of electrochemical sensors prepared by laser based methods is very young, a comprehensive picture of the state-of-the-art in the EU in terms of research activities and probable future developments is still under preparation. In order to provide alternatives to this expanding market, the qualifications of the team members together with the proposed approach are more than matching.

ADDING ANTIMICROBIAL PROPERTIES TO HERNIA-REPAIR MESHES BY PLASMA AND LASER PROCESSING Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1715 2017 - 2018

Role in this project:

Coordinating institution: SPITALUL CLINIC COLTEA

Project partners: SPITALUL CLINIC COLTEA (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://alexandrapalla.wixsite.com/hermesh

Abstract:

Currently, the meshes are the most used prosthetic objects, millions being implanted annually worldwide. Their use for the treatment of parietal defects is everywhere accepted as standard treatment due to the decrease of recidivism rate from about 44% to 15%. Numerous techniques and synthetic or biological biomaterials have been developed with the aim of creating a scaffold that allows cells to colonize and integrate the foreign material in the local anatomy in a mechanically stable and biocompatible configuration. Although the use of meshes has gradually increased in recent years, the local integration and healing remains a subject for debate. It is still difficult to obtain an optimum inflammatory response at the interface with the host tissue, thus avoiding a chronic reaction to the foreign body. The clinical challenges in this area focus on long term integration in the body without risk of microbial infections. We propose a research aiming to elaborate yet biocompatible, but antimicrobial hernia-repair meshes. The approach uses last moment laser and plasma techniques capable to add to conventional meshes layers with controlled release of antibiotic and antimicrobial agent, even without a direct contact with them. The expertise in hernia surgery and mesh usage in clinical environment (evaluation of body behavior and long term evolution after intervention) of a medical team from Coltea Hospital (coordinator of the project) and the expertise of a physicists team (partner, National Institute for Laser, Plasma and Radiation Physics) are gathered, providing at the end of project laboratory samples of antimicrobial meshes and a laboratory technology for producing coatings with controlled release of the antibiotics and antimicrobial agent.

New sensors based on active composite materials obtained by laser assisted evaporation by a matrix for organophosphorus compounds detection Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0880 2017 - 2018

Role in this project:

Coordinating institution: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie

Project partners: Ministerul Apararii Nationale prin Centrul de Cercetare Stiintifica pentru Aparare CBRN si Ecologie (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://www.nbce.ro/sensdetect.html

Abstract:

Nowadays, the endowment with performant detection devices, with simple and safe operation, reduced sizes, miniaturised, easy to handle and no complex training represents a requirement for army and authorized institutions of the defense system.

Within this context, the aim of SENSDETECT project is to develop a series of sensors with enhanced sensitivity and selectivity for organophosphorous compounds detection that could be used both for chemical weapons agents detection and also for toxic industrial chemicals (TIC). The project specific objective is the developing of a multifunctional, accurate, reliable, reusable sensor matrix for real-time monitoring of toxic volatile chemicals (e.g., phosporous compounds. ) using active layers deposited by laser based technique Matrix Assisted Pulsed Laser Evaporation (MAPLE).

The strategy used will be based on multiple active layers deposited and integrated into a matrix device for improved selectivity response of the sensor. This will be done by using hybrid or composite “active membranes” onto SAW transducers as compared with sensitivity of single active polymeric materials (polyisobutylene, polyepichlorhydrine and polyethyleneimine). The composites active membranes will be obtained by laser immobilisation of carboxylesterase (i.e. enzymes acetylcholinesterase (ACHE, AChE or acetylhydrolase)) within the polymeric matrix (layered and encapsulated structures) by using sequential MAPLE. The envisaged sensitivity is related to enzyme characteristics, AChE being used as primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.

This project will tackle the challenges of optimization of sensing materials with good sensitivity and robust selectivity to the substances to be detected, ongoing from TRL2 to TRL 3/4 namely the fabrication of a real-time monitoring of toxic volatile phosphorous compounds sensor device through the integration of the hybrid active layers into a SAW transducer.

Pyroelectric sensing device based on structurally tunable ferroelectric lead-free layers Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-1472 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: https://andreeaandrei4.wixsite.com/profile-project

Abstract:

The aim of this proposal to develop an environmentally friendly pyroelectric sensing device working at room temperature through integrations of structurally tunable NBT-xBT thin films obtained by pulsed laser deposition (PLD) into a pyroelectric test heterostructure. The necessary scientific and technological steps to obtain lead free thin films of sodium bismuth titanate doped with barium titanate – Na0.5Bi0.5TiO3-xBaTiO3 with functional properties have been already developed, as can be seen from our previous research projects, articles or book chapters. The main reason for this is related with the latest trends in environmental protection laws and regulations both national and international, concerning the use of toxic chemical elements. Ferroelectric perovskites based on NBT are considered the most promising lead-free candidate materials to substitute Pb(Zr1-xTix)O3 (PZT) in devices designed to respect standards and environmental laws. Taking into account the toxicity of lead-based systems, there is an urgent need to develop environmental friendly materials and numerous lead-free piezoelectric materials are under investigation worldwide for replacing PZT in future devices. Thin-film pyroelectric sensors have many advantages, such as facile integration with on-chip circuitry, uncooled detection, lower system costs, portability and a wide spectral response with high sensitivity. We will develop lead free thin films of sodium bismuth titanate doped with barium titanate – Na0.5Bi0.5TiO3-xBaTiO3 with different structural, dielectric properties and compositions at and near morphotropic phase boundary (6% BT) were functional features critically depend on the substrate temperature, as already demonstrated. We will design and build a test pyroelectric sensing device working at room temperature, based on the best pyroelectric NBT-xBT active layers sandwiched between top and bottom electrodes built on thermally isolated structures or substrates to reduce heat loss.

Integrated Platform for OFET Design Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2016-0221 2017 - 2018

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); SITEX 45 SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://andreeapurice.wixsite.com/ipod-project

Abstract:

The aim of the project is to study and produce an OFET – organic field emission transistor, polymer based device, for green and flexible electronics. The design will consist in a standard geometry, with the gate at the bottom and the source and drain electrodes on top. We will obtain thin layers of semiconductor/ dielectric/ electrodes made of organic and environment friendly materials. The substrate will also be an organic support.

The project addresses 4. ECO-NANO-TECHNOLOGY AND ADVANCED MATERIALS area of research, both from the point of view of technology and materials science. IPOD project will start from TRL 2 (well defined materials with great potential of being deposited as thin layers), TRL 3 will be completed by tests and analysis of the interest separate components (individual layers) and TRL 4 will be achieved, by the integration of all necessary layers and pixels. The OFET final system will be design, produced, tested and the capabilities will be defined with respect to Si / inorganic transistor technologies or other organic transistor technologies.

Organic thin films/ pixels will be produced by clean, laser techniques (matrix assisted pulsed laser evaporation - MAPLE and/ or laser induced forward transfer - LIFT). Exhaustive characterization will be performed in order to identify and optimize the critical elements which influence the films / pixels from the point of view of the chemical composition, surface morphology and electrical output. Important advantages arising from our approach using laser based techniques are the low cost, low processing temperature and scalability.

All the materials processed in IPOD project are environmentally friendly, specially conceived for green, flexible electronics.

Multiscale bone-like intelligent interfaces engineering using laser methods for mesenchymal stem cells enhanced osteoinduction Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-2434 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/TE_24/biosintel_ro.htm

Abstract:

BIosINTEL project aim is engineering smart bio-interfaces with multiple and synergetic functionalities for effective controlled regulation of stem cell differentiation and low inflammatory response for enhanced osseointegration. The innovative strategy within the project proposed is:

-Smart surface design: Bone like multiscaled microstructured surfaces(concave pits with various curvatures,depths, diameters and pits density on the surface) obtained by grey level masks assisted excimer laser processing technique

-Innovative hierarchical nanostructuring of the bone like microstructured surfaces by tailoring the self assembling of elastomeric polypeptides and biodegradable Poly-caprolactone copolymers spherulites formation

-Specific laser based functionalization by i)tethering active factors (elastin) within the biodegradable smart copolymer matrix (by single step matrix assisted pulsed laser evaporation) and ii)selective patterning of 2d and 3d bio-clusters as nucleation centers for mineralization (by laser induced forward transfer)

-Effective use of hierarchically patterned topography for tuning biointerface characteristics to i) stem cell differentiation, ii) modulate fibrous tissue formation/ tissue encapsulation, iii) extending the designed bone like topography toward implants (Ti and Zr alloy)

The design model based on tailored topographical and chemical cues for quantifying the steering of stem cell has impact in basic cell researches and tissue engineering application.

Fabrication of flexible electronic micro-device networks via direct laser writing aiming at real-time pressure measurements Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-2311 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/TE_25/flexsens_ro.htm

Abstract:

This project deals with the application of a laser-based technique, i.e. laser-induced forward transfer (LIFT) for the fabrication of different electronic components onto flexible substrates.

The project FlexSens aims three specific objectives: i) to demonstrate the feasibility of LIFT for the fabrication of thin film transistors (TFT); ii) to demonstrate the feasibility of LIFT for the fabrication of an organic light emitting diode (OLED) array; and iii) to direct-write distinct electronic components (TFT, OLED, and pressure sensors (PSR)) onto flexible substrates.

This corresponds to the developments of a fully operational miniaturized electronic device that provides a visual response (OLEDs turn on) to the applied pressure (different intensities correspond to different magnitudes of pressure applied).

With this, we also aim to contribute to the consolidation of the micro-device fabrication industry in Romania, i.e. systems-on-plastic for general purposes. In fact, this is a strategic motivation for us and an important characteristic of this project, since systems-on-plastic are important not just for environmental monitoring and control, but also for medicine, health monitoring.

Detection system for harmful food additive: monosodium glutamate Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0976 2015 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/TE_270/desyre_en.htm

Abstract:

Nowadays, a strong research effort is devoted to avoid eating food with harmful additives and to inform people about the side effects of these additives used in food industry. Consumers should be aware about what they buy and they should feel safe about the food they eat.

There is a continuous and increasing need of simple detection systems, new solutions and active materials in order to identify the harmful elements or elements exceeding the limit amount in food and beverages.

The aim of the Desyre project is to develop a detection system with high sensitivity and low detection limit for the harmful additives. Selected additive for testing is monosodium glutamate MSG (additive number 621). The device developed by Desyre project will be based on voltammetric sensing. The working electrode will be layered double hydroxides thin films prepared by laser techniques grown on platinum coated isolator.

The project will investigate the possibility and the costs for making the device a portable system. The main goal of the project is to grow crystalline layered double hydroxides as thin films, using laser based deposition. Desyre project comes to fulfil the miniaturization tendency by finding alternative methods to fabricate the active sensing material of the detector.

Application of laser techniqes for the fabrication of biosensors based on microfluidic real-timp detection systems Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1992 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); OPTOELECTRONICA - 2001 S.A. (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU MICROBIOLOGIE SI IMUNOLOGIE "CANTACUZINO" (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/SOLE.htm

Abstract:

The project SOLE deals with the design, fabrication and characterization of a microfluidic “Lab-on-Chip” system to perform DNA analysis and to detect pathogenic microorganisms such as Escherichia coli and Staphylococcus aureus. The DNA analysis is based on the Real Time Polymerase Chain Reaction (RT-PCR) to amplify the DNA of interest and on the measurement of fluorescence emitted by fluorogenic compounds intercalated in the amplified DNA.

Therefore, the SOLE project aims 3 specific objectives: (1) design, fabricate and characterize a microfluidic PCR device, which allows the amplification of the DNA of interest i.e. from Escherichia coli and Staphylococcus aureus; (2) Implement, characterize and calibrate an electro-optical setup for optical measurement of fluorescence signal emitted by amplified DNA and (3) to integrate in a "Lab-on-a-Chip" system, the electro-optical detection setup to the PCR amplification device.

This corresponds to the development of a fully operational miniaturized Real-Time PCR system, able to perform quantitative detection of the DNA of interest and consequently, a state of the art development in terms of biosensors.

With this, we also aim to contribute to the consolidation of a national capability to develop, entirely in Romania, portable and cost effective diagnostic system for general purposes. In fact, this is a strategic motivation for us and an important characteristic of this project, since diagnostic system are important not just for environmental monitoring and control (our target here), but also for medicine, public health, and biology.

Wastewaters treatment through flocculation- oxidation processes mediated by red mud derived flocculants and catalysts Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0177 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA BUCURESTI

Project partners: UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU METALE NEFEROASE SI RARE - IMNR (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); EDAS-EXIM SRL (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://www.unibuc.ro/depts/chimie/chimie_organica_biochimie_si_cataliza/PROIECTE-DE-CERCETARE/pn-ii-pt-pccaPN-II-PT-PCCA-2013-4-0177-2013-4-01770/

Abstract:

The project aims the development of an innovative technology for the treatment of wastewaters with high organic loading which may occur from different sources such as: food processing, stock farming, tanneries, oil pumping stations, engine cleaning stations.

The ground principle for the new technology is fighting pollution by valorizing the useful components from pollutants, or briefly ”Pollutants fighting pollution”. In this way the benefic impact on the environment is practically doubled. On one hand the volume of industrial wastes polluting the soil and waters is diminished, and on the other hand after the treatment clean water is obtained while decreasing the consumption of chemical grade reagents utilized in water treatment, as well as the costs related to the consumption of energy, raw and auxiliary materials needed for their manufacture avoiding also the emissions of other pollutants.

The industrial waste which is going to be valorized for this purpose is the red mud which is yielded in huge quantities from alumina manufacturing by Bayer process. Red mud is a highly alkaline residue (pH >11,5) with high concentration of iron oxides (40-50%) along with other oxides such as Al2O3, SiO2, TiO2, Na2O, CaO. It has elevated sodium concentration (>30 g/kg), and soluble alkalinity (≈30 g/kg as equivalent CaCO3). Due to its alkalinity and high content of fine-grained particles (>90% have sizes
Taking into account the high concentration of iron oxides in red mud waste, this project aims the utilization of red mud as iron source in order to replace partially the chemical reagents (generally synthesis grade Fe(III) salts) used in the obtaining of coagulation-flocculation-oxidation agents and advanced oxidation catalysts used in wastewaters treatment, laying the grounds for a sustainable green technology for the treatment of high organic loaded wastewaters.

The following original aspects that were not investigated up to now will be addressed:

a) the utilization of red mud suspensions for the generation of ferrate anions (FeO42-) which are the most powerful oxidation agents that may be used in water treatment (as it may be seen from the variation of the redox potentials: FeO42- (2,2eV) > O3 (2,03 eV) >H2O2 (1,78 eV) > MnO42- (1,68 eV) > Cl2 (1,36 eV) > O2 (solved) (1,23 eV) > ClO2 (0,95 eV)). The ferrate anions are considered to be a „green oxidant” since after the ferrate (VI) treatment there are no toxic by-products and following the redox cycle Fe(VI) is reduced to Fe(III) which is a very good coagulant/flocculant. Subsequently, in the stage following the oxidation it may serve as coagulant/flocculant able to remove the non-degradable impurities.

b) the obtaining of red-mud derived ceramic foams by gel-casting method - water treatment advanced oxidation catalysts

c) the obtaining of nanostructured amphiphilic magnetic materials - carbon nanofibers/red mud ceramic foams by chemical vapor deposition (CVD) method – efficient adsorbents of hazardous organic contaminants in wastewaters.

d) integration of the above mentioned obtained materials in the technology for the treatment of wastewaters with high organic loading.

The project enables the partnership between public and private areas in the priority domain 3- Environment. The partnership includes 5 participants: an university, 3 national research-development institutes, a private company EDAX EXIM SRL provider of equipments and specific tasks in the domain of wastewaters and water treatments which co-finances the project. The participation of the co-financer has the role to create the mechanisms for implementing the technologies developed by this project.

Next generation of orthopaedic implants based on new Ti bioalloy functionalized with hybrid biomimetic coatings Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1994 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA BUCURESTI (RO); INSTITUTUL DE BIOCHIMIE (RO); TEHNOMED IMPEX CO S.A. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/ORTHOBIOMIM.htm

Abstract:

The main objective of ORTHO-BIOMIM project is to obtain competitive and original products, namely advanced orthopaedic implants based on a new Ti-Ta-Nb alloy, which are functionalized by laser based technique (Matrix Assisted Pulsed Laser Evaporation) with complex hybrid biomimetic coatings (Lactofferin, Hydroxyapatite, Polyethilenglycol-Polycaprolactone synthetic copolymer functionalized with methyl ether group, Lf_HA_PEG-PCL-Me). The proposed approach relies on applied experimental research involving strongly interdisciplinary domains (i.e. material science, mechanics, laser physics, chemistry, microbiology, biomedicine), combined with industrial research activities, development.

The strategic key points for obtaining orthopaedic implant with enhanced characteristics within ORTHOBIOMIM project are:

• New and highly biocompatible Titanium (Ti)–based alloy containing non-toxic components (Ti-Ta-Nb) obtained by levitation technique with enhanced properties (low corrosion, mechanical resistance, elastic modulus etc.) working as implant body;

• Improved mechanical characteristics of the alloy obtained by its thermo-mechanical processing;

• Alloy biofunctionalization with complex hybrid coatings having multiple functionalities (biodegradable, bioresorbable, increased capacity osteogenic, osteoconductive and osteoinductive, anti-inflammatory ) by laser methods (MAPLE).To mimic the process of osseointegration, these coatings will be composed of natural biodegradable compounds, namely lactoferrin (Lf) and hydroxyapatite (HA), and a antifouling synthetic copolymer functionalized with methyl ether PEG-PCL-Me);

• Highly flexible methods for obtaining alloy processing and functionalization, allowing control defined composition, chemistry and surface topography when both alloy and the coating / film hybrid biomimetic functional.

The implications anticipated within ORTHOBIOMIM project development are related to major scientific benefits by increasing national competitiveness and visibility in research, development and innovation, but also to social and economic benefits . In the social context, in addition to the involvement of a large number of youth in the project and creating jobs, a very important benefit provided by this project is given by the envisaged faster osseointegration and long lifespan of the implant. This might be of crucial importance for those patients whose health status and life will be enhanced through the use of new medical implants by reducing risks of infection and thus reduce costs for medication or those necessary to replace a failed implant.

By the proposed objectives and approach, the project is aligned with the main points defined Partner Program, which promotes the applied inter and trans-disciplinary research in micro and nanostructured advanced materials for applications in medical field.

Orthopaedic implants obtained from multifunctional "Gum" alloys Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1643 2014 - 2017

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA BUCURESTI (RO); TEHNOMED IMPEX CO S.A. (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://www.mdef.pub.ro/research/IMPLANTGUM/ro/index.html

Abstract:

The use of more sophisticated and more expansive biomaterials for medical devices (as will be ours) practically does not affect the implantation expenditure, because the total involved cost is essentially determined by the surgery and patient’s treatment after implantation. Moreover, the faster osseointegration, less stress shielding avoiding bone atrophy, guarantee implantation success making longer the implant life (over 20 years instead of actually 10 years), improving the patient comfort and also reducing the costs for drugs and reimplantation. The project objective is to obtain orthopedic implants from a new biomaterial, with advanced properties, able to eliminate as many possible causes that lead to surgical intervention.

A group of special beta Ti alloys with unique physical-mechanical properties and large range of possibilities to be used in medical and other applications are “Gum” alloys. From 2003, the development of these alloys acquired a large scientifically and technical interest, because of their special properties. Their composition belongs to beta-type Ti alloys and is basically expressed as Ti (Ta, Nb, V) + (Zr, Hf, O). “Gum” alloys exhibit excellent mechanical multi functionality at room temperature: an ultra-low Young’s modulus (Young’s modulus 60-70 GPa) and a non-linear elastic behaviour, an extended elastic limit, ultra high strength (> 1 GPa), superplastic-like deformability, Invar-like thermal expansion, and Elinvar-like thermal dependence of the elastic modulus. The mechanical properties of the alloy investigated in the present project, a “Gum” alloy type, superior to other materials on the market, make possible to obtain medical devices with considerably increased lifetime, which will lead benefit regarding the patient's life quality and economic advantages.

The enhanced characteristics of the proposed implant biomaterial are: (1) high biochemical compatibility, demonstrated through SBF corrosion and citotoxicity tests of both bioalloy (containing only non-toxic elements); (2) high biomechanical compatibility, demonstrated through the obtained special advanced properties of the “Gum” alloy (improved mechanical properties: tensile strength >1000 MPa; super-elasticity; superplasticity permitting cold plastic working close to technical limit of 99.9 % with no work hardening at room temperature; near zero linear expansion coefficient; a low, constant elastic modulus, close to those of human bone 30–40 GPa).

The needs in biomaterials/implants, at the world level, do not stop growing. The load-bearing implants market (representing 20-25% form implantable devices market) including a significant part of orthopedic and dental prosthetics, dental crowns, implants for maxillofacial surgery, artificial limbs, fixtures, is a large one, estimated at a few billions €. This situation creates favourable conditions for the application of research results at industrial level.

The project has high success chances because its outcomes are two new products necessary on the market and their manufacturing technologies that can be implemented at two industrial agents in Romania that have technical and technological capacity to achieve these products.

Antireflection coatings for ultra-short high power lasers Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-1870 2014 - 2017

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA MATERIALELOR BUCURESTI RA (RO); INSTITUTUL NATIONAL DE CERCETARE- DEZVOLTARE PENTRU MICROTEHNOLOGIE - IMT BUCURESTI INCD (RO); PRO OPTICA SA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/arcolas.htm

Abstract:

The ARCOLAS project addresses an important topic fitted with specific thematic area of New Photonic Materials, namely design and testing as demonstrator of durable advanced antireflection (AR) coatings for plasma mirrors working in ultra-short TW/PW lasers systems.

It is intimate related to the existing high level technological ultra-short pulses lasers network facility in NILPRP (CO) and, with the aim and goal to upscale the obtained optical components for the unique ELI-NP facility to be built in the Magurele research area and where NILPRP is involved as partner.

The project answers to the demand for optical components used to ultra-short high power lasers systems because the number of these facilities is increasing and there are only two suppliers in the world.

The project will be developed in precise steps, following the concept in its theoretical and practical aspects.

First, the composition/combination of the dielectric materials with different refractive indices to be used as thin film(s) and/or heterostructures with antireflection properties will be studied.

The different layers will be obtained by pulsed laser deposition (PLD) and PLD assisted by a Radio-Frequency discharge (RF-PLD).

The experimental parameters for obtaining of each layer and of layers combination will be established after their careful characterization by specific techniques as AFM, XRD, spectroellipsometry, SIMS, SEM, HR-TEM, with high performance equipments belonging to the involved partners.

Then, optical components – demonstrators with controlled antireflection characteristics will be obtained based on dielectric layers with optimized properties and deposition architecture with the objective to be compatible with generation of plasma mirrors capable to withstand high energies ultra-short laser pulses.

Simultaneously, computer simulation studies regarding the phenomena that rise when a high energy ultra-short laser beam hits a material will be performed using Particle in Cell-Finite Difference Time Domain method.

Of a paramount importance in the project will be the components-demonstrator for plasma mirror testing in ultra-short high intensity laser field, in relativistic regime (intensities of 1018 W/cm2 - 1020 W/cm2). This will be made at INFLPR, where there is already established a complete and unique power-chain laser system: GIWALAS – GW, TEWALAS – TW and CETAL – 1 PW. The possibility of the direct access to these facilities will allow a rapid feedback regarding the AR coating behavior in the plasma mirror regime.

An important aspect is related to the prospective to use the demonstrator for the future 10 PW ELI-NP facility, where ultra-relativistic regime (1023 - 1024 W/cm2) are expected to be generated.

The industrial partner has the ability to design and produce the supports for optical components capable of withstanding high power ultra-short laser pulses.

The generated results will be the subject of patents first, as the topic is of vanguard, and of publications in high impact journal.

Nanostructrures based on new organometallic compounds for electronic applications Call name: Joint Applied Research Projects - PCCA-2011 call, Type 2
PN-II-PT-PCCA-2011-3.2-0394 2012 - 2016

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/nanocea_ro.htm

Abstract:

In the last few decades, the continuous development of human society has led to exceptional scientific and technological accomplishments, but a vast number of classical materials and devices tend to reach physical limitations concerning their performances. The proposed NANOCEA project approaches two important directions: the high speed processing needed for integrated circuits and the miniaturization demands.

The current state-of-the-art electronics implies transistors (the metal semiconductor field effect transistors MESFETs and high-electron-mobility transistors HEMTs) designed for microwave applications. Materials that exhibit ultrafast response to the incoming light signal in picosecond to nanosecond time scale are of current interest in optical sensors, optoelectronics and nonlinear optics due to their potential application in ultrafast optical switching and passive optical device applications. The projects aims to develop new organometallic compounds based on azo derivatives, ferrocenes and acridines that can be integrated in high speed optical switching devices.

Hybrid materials synthesized by sol-gel method and thin films /pixels/ heterostructures processed by alternative lasers technologies for further device building and testing are the challenges of the NANOCEA project.

The novelty of the project, that requires both theoretical and experimental future research, relies not only on the new organometallic based composite materials but also on the methods and technologies involved in acquiring the project objectives. The optical properties of the most promising materials will be investigated in greater depth in the research institutes and the applications of these lab synthesized materials lie in the optoelectronic sector. The innovative aspects and complexity of the project is consolidated by the highly complementary partnership between the research institutions and the SME unit involved in this project

Developing new graphene-polymer composites biomaterials for scaffold fabrication with applicability in bone repair by coupling multiscale molecular modelling and experiments Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1538 2012 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA DE VEST "VASILE GOLDIŞ" ARAD (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://www.tsocm.pub.ro/cercetare/POLYGRAPH/

Abstract:

The main aims of this project are interdisciplinary efforts using complex computational tools of materials modelling and advanced experimental techniques for the knowledge-based design of novel, improved biopolymer-graphene scaffolds for bone repair. The key functionality of these materials is both physical and chemical cues to direct cells organization, growth, and differentiation in the process of forming functional tissue. The aim is pursued by developing and extensive application of multiscale computer-aided molecular design complemented with computer-assisted evaluation of the end-use performance of the materials in question. The resulting outputs will constitute the doorstep toward the fabrication of the biopolymer-graphene biomaterials of potential commercial values. This goal is achieved by the development of a complex protocol based on advanced experimental techniques. A method for graphene synthesis and modification by plasma treatment in order to introduce different chemical groups on the surface and graft peptides or proteins capable to facilitated cells adhesion, growth, and tissue remodelling will be establish. The end-use performance of these materials depends on several crucial factors such as graphene surface properties, polymer nature, and the methods used for biomaterial synthesis. On the frame of the experimental activity the research will be focus on modulating synthesis parameters in order to obtain a material suitable for bone repair scaffold. Extensive characterisation of biomaterials surface and bulk by physical-chemical techniques will be employed. The ultimate aim of present project should be the in vitro assessment of biocompatibility in terms of cellular morphology, adhesion, viability and proliferation, and the evaluation of differentiation potential of the new elaborated scaffolds. These studies will be complemented with in vivo assay regarding bone reconstruction with biopolymer-graphene scaffolds.

Hybrid inorganic-organic nanocomposites films of layered double hydroxides with hydrophobic/protective coating surfaces Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1462 2012 - 2016

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA BUCURESTI (RO); Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie - ICECHIM Bucuresti (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/PCCA_137_ro.htm

Abstract:

The aim of the project is to produce and study layered double hydroxides (LDHs) thin films modified with organic compounds in order to obtain hydrophobic surface acting as protective coatings. The LDH component will be Zn-Al LDH and Mg-Al LDH prepared at different Me(2+)/Me(3+) ratios. LDH will play either a host material role, to accommodate organic molecule such as fatty acids and macromolecules as a vinyl acetate copolymer or, a guest role, to produce hybrid nanocomposites of LDH/polymers. Laser techniques, pulsed laser deposition (PLD) and matrix assisted pulsed laser evaporation (MAPLE) will be used for the deposition of LDH –based thin films. It is a novel application of laser techniques for the fabrication of complex nano-structures. Extensive characterization will be performed in order to evidence the critical elements which influence the chemical composition and surface topography of the films, the two main elements governing the wettability properties of surfaces. The host matrix composition, the compatibility between the organic and the inorganic component, deposition conditions, protocols of preparation will be correlated with the hydrophobic properties of the as-prepared films. All the materials used for HYLAYHY project, the inorganic LDH component and the organic compounds are environmentally friendly.

Electrically stimulated scaffolds for tissue engineering Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1187 2012 - 2016

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO); INSTITUTUL DE CHIMIE MACROMOLECULARA "PETRU PONI" (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO)

Project website: http://ppam.inflpr.ro/elitiss_ro.htm

Abstract:

The project relies on an innovative, sound and unique combination of clean, environmental friendly and spatiotemporally accurate laser techniques for producing biofunctionalized conducting tridimensional scaffolds for tissue engineering. The project addresses the synergistic combination of major pillars of science and technology (Micro-Nano-Bio-Info), in the framework of Convergent Technologies for Improving Human Performance: (a) nano-micro science and technology-by using laser processing techniques for scaffolds fabrication; (b) biotechnology and biomedicine-by scaffolds biofunctionalization with biologically active agents and by analyzing the cells cultured within the scaffolds. (c) information technology-by developing advanced computing and application codes for tridimensional scaffolds fabrication and for monitoring the cells cultured within them. The laser techniques will be integrated in a three-step protocol, comprising scaffolds fabrication, biofunctionalization and testing. Rigid (titanium) and flexible organic-inorganic hybrid polymeric scaffolds will be obtained. Each of them will be biofunctionalized with polypyrrole-based conducting polymers combined with biologically active agents e.g. growth factors, drugs. Electrical stimulation of the scaffolds will trigger a spatiotemporally localized control of cell growth and the delivery of biologically active agents. The process occurs outside the body i.e. non invasive, ex vivo tissue engineering. This will lead to a new generation of biofunctionalized conducting tridimensional scaffolds with potential for bone/cartilage replacements, skin grafts and nerve regeneration. In all, the integrated platform proposed by the project will emerge as a new tissue engineering approach for modulating cell growth, proliferation and organization into functional tissues. The proposed methods based on clean, environmental friendly laser techniques will improve the therapeutic effects of tissue engineering technologies.

Laser printing of hybrid nanocomposited for chemiresistive sensors Call name:
SCIEX 13.251 -

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA

Project partners:

Affiliation:

Project website:

Abstract:

The aim of NANO-SENS (“Laser printing of hybrid nanocomposite chemiresistors”) project is the application of a laser based method, i.e. dynamic release layer–laser induced forward transfer DRL-LIFT for the deposition of hybrid nanocomposites, such as SWCNT doped with SnO2 nanoparticles on a specifc area of chemiresistors. DRL-LIFT is a fast and flexible process, offering high spatial resolution (a few micrometers) which will enable to fabricate low-cost improved chemiresistor sensors.

This project aims at three specific objectives: (1) Design of chemiresistor sensors based on hybrid nanocomposites. (2) The fabrication of sensors by DRL-LIFT onto flexible substrates and, (3) characterization of the chemiresistor sensors based on the hybrid nanocomposites which should exhibit a high sensitivity and selectivity with a very low response time.

This corresponds to the development of a highly sensitive and selective chemiresistor sensor, i.e. a future generation state of the art sensor.

The NANO-SENS project aims at integrating the expertise in laser physics of the Fellow with the material aspects of hybrid nanoscomposites and one-step direct writing process of LIFT.

By its multidisciplinary nature, NANO-SENS will broaden the knowledge of the Fellow by contributing to the development of chemiresistor sensors.

The NANO-SENS project is a unique opportunity for the Fellow to invest her effort in a coordinated program designed to explore the proposed objectives.

TRANSDERMAL PATCH DEVELOPED BY LASER BASED METHODS FOR HYPERTENSIVE HEART DISEASE Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0267 2011 - 2014

Role in this project:

Coordinating institution: Institutul Natinal de Cercetare Dezvoltare pentru Fizica Laserilor, Plasmei si Radiatiei

Project partners: Institutul Natinal de Cercetare Dezvoltare pentru Fizica Laserilor, Plasmei si Radiatiei (RO)

Affiliation:

Project website: http://ppam.inflpr.ro/TE_41_ro.htm

Abstract:

The new trend in the era we live, i.e. tobacco use, a dietary customs, and physical inactivity is responsible for the major killers worldwide - the hypertensive heart diseases. This lead to the development of new pharmaceutical forms with improved bioavailability and stable dosage by using clean technologies. Among these, transdermal patches gained popularity, being nowadays developed for everything, i.e. from contraception to Parkinson's disease. Although significant advances have been directed towards the fabrication of transdermal patches for hypertensive heart diseases, so far the already available transdermal patches present a large series of limitations. This is due to the large number of requirements they have to fulfil: the fabrication of a drug delivery system that meets all the stringent needs specific to the drug molecule, they have to be comfortable and cosmetically appealing, scale-up and manufacturability, and most important, economical. This project, through its team of six young researchers and one senior scientist, aims at using an alternative technology, MAPLE, to prepare in a quick and one-step procedure a new generation transdermal patches with Captopril as active compound, for hypertensive heart diseases, in order to overcome its side effects by oral application. Such developments of an improved state-of-the-art transdermal patch by means of MAPLE promise to be a breakthrough in the field of medicine, biotechnology and polymer science.

Antimicrobial and degradable biohybrid substrates with controlled surface architecture combining localized bio activation with antifouling properties Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0289 2011 - 2014

Role in this project:

Coordinating institution: Institutul National de Cercetare Dezvoltare pentru Fizica Laserilor Plasmei si Radiatiei (INFLPR)

Project partners: Institutul National de Cercetare Dezvoltare pentru Fizica Laserilor Plasmei si Radiatiei (INFLPR) (RO)

Affiliation: Institutul National de Cercetare Dezvoltare pentru Fizica Laserilor Plasmei si Radiatiei (INFLPR) (RO)

Project website: http://ppam.inflpr.ro/TE_43_en.htm

Abstract:

The choice of polymeric materials as platform for cell regeneration and the patterning methods are the key point in realizing hybrid complex supports with superior properties targeting the adhesion and cell manipulation activity.

Within this context, the project objective is the realization of antimicrobial, biocompatible and degradable bio-hybrid scaffolds/substrates with controlled designed surface architecture and chemistry. The project novelty relies on combining the advantages offered by specific properties of naturally derived and synthetic polymers (i.e controlled degradability, specific activation) with the ones offered by laser based methods (i.e. localized transfer, flexibility, clean techniques, no prior pretreatment of materials). A team of six young researchers and one senior researcher will work on addressing the afore mentioned issues by: i) processing of bio-hybrid structures by spin coating and Matrix Assisted Pulsed Laser Evaporation; ii) substrates controlled laser structuring and patterning by laser ablation and Laser Induced Forward Transfer; iii) enhancing the scaffold functionality by embedding naturally derived polymers (i.e. chitosan, collagen, laminin) as antimicrobial, antifouling and bio activation factors into biocompatible and degradable synthetic polymers (polyethylene glycol, polycaprolactone) and iv) evaluating of texturing and disposition of specific “architecture” substrate effect on the cellular metabolic response and proliferation.

Sensors based on tungsten oxides cluster-assembled structures obtained by laser and plasma methods for nitrogen oxides detection Call name: Postdoctoral Research Projects - PD-2011 call
PN-II-RU-PD-2011-3-0115 2012 - 2013

Role in this project:

Coordinating institution: Institutul National de Cercetare Dezvoltare pentru Fizica Laserilor Plasmei si Radiatiei (INFLPR)

Project partners: Institutul National de Cercetare Dezvoltare pentru Fizica Laserilor Plasmei si Radiatiei (INFLPR) (RO)

Affiliation: Institutul National de Cercetare Dezvoltare pentru Fizica Laserilor Plasmei si Radiatiei (INFLPR) (RO)

Project website: http://ppam.inflpr.ro/PD_100_en.htm

Abstract:

Nowadays, due to the industrial development, the environment’s pollution became a serious issue. Air pollution represents a major problem for the ecosystem due to the release of chemicals and particulates into the atmosphere. Tungsten oxides are a class of versatile materials used in gas sensors (O3, H2, H2S, Cl2), photo-catalysis, window for solar cells, electronic information displays and color memory devices etc. In particular, tungsten oxide showed superior sensitivity and selectivity in detecting NO2 gas. The project here presented proposes the use of alternative technologies with laser and plasma, namely RF plasma beam assisted pulsed laser deposition, for the obtainment of nanostructured tungsten oxides with high sensitivity to toxic gases. The material properties will be investigated and sensor tests will be carried out. This research aims to develop a reliable method to grow WOx as cluster assembled films with high specific area and controlled dimension size, for applications in toxic gases (nitrogen oxide) detection in order to combat air pollution.

DEPOSITION OF LAYERED DOUBLE HYDROXIDES THIN FILMS WITH FUNCTIONAL PROPERTIES Call name: Projects for Young Research Teams - TE-2010 call
PN-II-RU-TE-2010-0146 2010 - 2013

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI INFLPR DIN BUCURESTI

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI INFLPR DIN BUCURESTI (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI INFLPR DIN BUCURESTI (RO)

Project website: http://ppam.inflpr.ro/TE_98_ro.htm si http://ppam.inflpr.ro/TE_98_en.htm

Abstract:

A VAST NUMBER OF CLASSICAL MATERIALS AND DEVICES TEND TO REACH PHYSICAL LIMITATIONS CONCERNING THEIR PERFORMANCES. COMPLEX MATERIALS, WITH DIFFERENT AND COMPLEMENTARY FUNCTIONS CAN BE USED IN COMPACT AND MULTIFUNCTIONAL DEVICES, WITH CONTROLLED PROPERTIES DEPENDING ON THE DESIRED APPLICATION. THE CURRENT PROJECT CONCERNS THE INVESTIGATION OF MATERIALS DERIVED FROM HYDROTALCITE-LIKE COMPOUNDS (LAYERED DOUBLE HYDROXIDES - LDH) AND THEIR PROCESSING AS THIN FILMS.

LDHS ARE A CLASS OF LAMELLAR MATERIALS, WITH POSITIVELY CHARGED LAYERS AND ANIONS TRAPPED BETWEEN THESE LAYERS. POWDERED LDH HAS BEEN WIDELY STUDIED DUE TO THEIR APPLICATIONS AS CATALYSTS, ANIONIC EXCHANGERS OR HOST MATERIALS: ADSORBENTS FOR ENVIRONMENTAL CONTAMINANTS AND FOR THE IMMOBILIZATION OF BIOLOGICAL MATERIALS.

DIFFERENT METHODS TO GROW WELL-ORIENTED LDH THIN FILMS HAVE BEEN INVESTIGATED TO BE USED AS SENSORS, CORROSION-RESISTANT COATINGS, COMPONENTS OF OPTICAL AND MAGNETIC DEVICES.

THEREFORE, THE CURRENT PROJECT IS ALIGNED TO THE PRESENT RESEARCH PRIORITIES BY PROPOSING THE USE OF ALTERNATIVE TECHNOLOGIES, MORE SPECIFICALLY PULSED LASER DEPOSITION ASSISTED OR NOT BY RF PLASMA AND MATRIX ASSISTED PULSED LASER EVAPORATION, IN ORDER TO OBTAIN CRYSTALLINE LDH COMPOUNDS AND THEIR DERIVED MIXES OXIDES WITH CONTROLLED PROPERTIES, DEPENDING ON THE DESIRED APPLICATION.

THE PROJECT PRESENTS 3 CASE STUDIES: DEPOSITION OF THIN COMPOSITE LDH FILMS WITH: 1. METALLIC PARTICLES (AG/NI) FOR CATALYSIS EXPERIENTS, 2. DRUG (AMPICILIN), 3. POLYMER (POLYETHILEN GLYCOL), FOR POSSIBLE APLICATIONS IN FARMACY ETC.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects