BrainMap

Mr. Silviu Iulian Drob

Ph.D.

Researcher II - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher

Researcher with 15 years of experience in the field of Electrochemistry and Corrosion, specializing in Titanium and Magnesium alloys for use in implantology.

Web of Science ResearcherID: X-6284-2019

Curriculum Vitae (30/04/2025)

Expertise & keywords

3D laser printed absorbable scaffolds with a prolonged biomechanical stability in human body fluids. Call name: P 4 - Proiecte de Cercetare Exploratorie, 2020
PN-III-P4-ID-PCE-2020-0992 2021 - 2023

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation:

Project website: https://www.icf.ro/pr_2020/PCE-234-2021/index.html

Abstract:

Novel biomaterials for temporary orthopedic implants are one of the most challenging areas of exploratory research in advanced materials. Third generation biomaterials are designed to be both resorbable and bioactive, that is, the implant will be temporary, and once implanted, it will help the body heal itself. The aim of this project is to progress toward a novel absorbable scaffold biomaterial for temporary orthopedic implants, through hierarchically structured surfaces that protect the scaffold, effective to convey higher corrosion tolerance and increased scaffold strength retention for extended periods in body fluids while at the same time capable to stimulate human osteoblast cell proliferation behavior. Specific objectives are (i) the design and fabrication of 3D printed scaffold structures with biocompatible elements by rapid solidification from melt through laser additive manufacturing-3D printing; (ii) the development of original cost-effective surface modification procedures for surface protected scaffolds (SPS) with enhanced corrosion tolerance and bioactivity; (iii) the determination of bare and SPS corrosion rates and corrosion mechanisms in human physiological fluids of pH and chloride concentrations reproducing the most exigent conditions for implant use; and (iv) the assessment of the scaffold-cell constructs to initiate tissue repair processes and osteogenesis; contributing to Romanian research with: 1 patent, 4 scientific articles, 6 conference presentations

Ternary alloy with antibacterial properties and non-toxic alloying elements for various implants. Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente
PN-III-P1-1.1-TE-2019-1054 2020 - 2022

Role in this project: Project coordinator

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: https://www.icf.ro/pr_2019/ZIRTAAG/Zirtaag.html

Abstract:

The project seeks to promote young researchers or future researchers that are eager to improve the quality of life by creating and testing out new non-toxic alloys with antibacterial properties. Through theoretical modelling and utilizing modern casting techniques we will obtain an alloy that has superior properties and lower costs than existing ones and that can be used for orthopedic and dental implants alike. The alloy is to be subjected to specific electrochemichal and corrosion tests and also in-vitro cell growth tests. Surface analysis wil be made using modern techniques such as SEM, XPS and AFM.

Improving oral and systemic health using dental works from modified alloys Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0869 2014 - 2017

Role in this project: Partner team leader

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA BUCURESTI (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); DENTAL ART GROUP SRL (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://cercetare-umf.ro/proiecte_parteneriate

Abstract:

The project proposal entitled “Improving oral and systemic health using dental restorations from modified alloys” is addressed to the priority field 4 Health and has as goal the improvement of oral and systemic health of the population through implementing new methods of prevention and intervention at national level having capacity of international expansion. Having the central objective the improvement of the health level mainly through the offer of medical services of prevention, the project will contribute to the reduction of costs in the field of health. The offer is elaborated under the competent and representative direction of the University of Medicine and Pharmacy “Carol Davila”, the Faculty of Dental Medicine, another 2 Universities, 1 Institute of research of the Romanian Academy and 2 co-financing SMEs. This consortium is by definition inter- and pluri-disciplinary and exhibits synergy and complementarity due to the contribution of Medicine, Chemistry and Biology to the achievement of the central objective and it shall benefit of the un-financed support of an European partner (Universita’ del Piemonte Orientale “Amedeo Avogadro”) well known in the field of oral pathology, partner which shall participate to the activity of research and dissemination of results. This partner with experience and tradition will enhance the chances of the project both at level of the choice of the best methods of prevention and intervention in oral health and also at the level growing the visibility of the research. As derived objectives to achieve the central goal, the project takes into consideration the formation of target groups of patients according to the following criteria of selection: the detection of lichenoid reactions, of a metallic pigmentary lesions; the existence of dental alloys (CoCr, CoCrMo, etc. used at mass level) which favoured the release of ions and the absorption due to materials imperfections. The project will also form proof-lots including in the study a high number of patients comprising also patients who did not use dental alloys, fact which will allow the set out of the cause of the diseases and of the most appropriate treatments for all the studied cases. Both the scientific background and the expertise of the 6 partners as well as the richness of human and material resources represent a warranty that it is possible to overlap the knowledge about the creation of an improved alloy (CoCrZr or Nb) capable to reduce the potential for serious diseases such as Lichen Planus. The project analyses the sick tissue and the amount of ions released chemically and biologically and to compare the behaviour of the existing materials with that of our new alloy. The improvement of the dental alloy will aim at both the composition as well as the surface state at micro- and nano- level. The trial of these materials will be performed in simulating conditions respecting the corresponding regulations form the European space of operation including the norms of bio-ethics and bio-security and the informed agreement of the patient. The results of the project will be disseminated and exploited both at level of health services as well as at level of co-financing partners who will develop technology and innovating dental works from improved alloys at reduced costs, fact that emphasizes the co-relation between the thematic of the project and the strategy of development of the SMEs partners. Obtaining a patent and publishing 5 research works in international publications of high impact is a prognosis of result indicators that complete the process indicators. The benefits of implementing the project and its exploitation after ending will grow the quality of life through precocious detection of diseases and their treatment and also through the proposal of a new less dangerous and less toxic alloy. The co-financing SMEs will develop as well the commercialisation capacity subsequent to the production of materials with high market potential.

Improvement of biomedical implant properties by surface nano-architecturing and antibacterial protection Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0855 2014 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL NATIONAL DE CERCETARE CANTACUZINO (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); TEHNOMED IMPEX CO S.A. (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2014/PN-II-PT-PCCA-2013-4-0855/SursaDeFinantare.html

Abstract:

This project proposes the obtaining of a novel, advanced, biocompatible Ti-Ta-Ag bioalloy for orthopaedic and maxillofacial implants with complete innovative composition and properties. Two Research Institutes, one University and two SMEs will resolve in synergetic, multi and inter-disciplinary way the following main scientific objectives: a) elaboration of a novel, original ternary Ti-Ta-Ag bioalloy that contains only non-toxic and non-allergenic elements (Ti and Ta) and an antibacterial element (Ag), assuring increased corrosion resistance, very low ion release, high bioactivity and bacteriostatic activity to avoid adverse reactions in the human body; b) the functionalisation of the alloy surface by introduction of antibacterial nano-particles to increase the antibacterial properties; c) nano-architecturing of the alloy surface with nano /-tubes, /-channels, /-fibres which will stimulate the implant direct attachment and rapid bone healing; d) assessment of the alloy chemical composition and structural characteristics by high level techniques; e) determination of the alloy mechanical properties by static and dynamic tests; f) alloy long-term electrochemical behaviour and corrosion resistance in artificial human biofluids simulating the severe functional conditions of an implant, using modern electrochemical methods; g) monitoring of the quantity of ions (specially Ag+ ions) released into biofluids by high level techniques to know the release rate of Ag+ ions from the bulk alloy; h) establishment of the nano-architecture with the most optimal properties of the stability, roughness, porosity by world level techniques; i) determination of the bacteriostatic capacity of the new alloy before and after its surface functionalisation and nano-architecturing; j) evaluation of the alloy biocompatibility in as-cast, functionalised and nano-architectured state by in vitro and in vivo studies. The project technological objectives are: a) laboratory technology of the alloy synthesis by the modern melting method in vacuum levitation furnace with cold crucible; b) laboratory technology for the surface functionalisation with antibacterial nano-particles having suitable properties of the stability and antibacterial ability; c) laboratory technology for the surface nano-architecturing by the application of nano /-tubes, /-channels, /-fibres; e) two technologies for the orthopaedic and maxillofacial implants obtaining; d) fabrication of the orthopaedic and maxillofacial implants – demonstrator products. The original and innovative contributions of the project are: a) novel, biocompatible ternary Ti-Ta-Ag alloy; b) a new, complex functionalisation and nano-architecturing of the alloy surface; c) elaboration of the original mechanisms of electrochemical behaviour for the as-cast, functionalised and nano-architectured alloy in simulated physiological solutions; d) scientific novelties concerning the modelling of the physical processes at the interface between new bioalloy and simulated biofluids; e) monitoring of the bacteriostatic activity by the modern techniques; f) prime novelty determination of the bare and structured alloy biocompatibility by in vitro and in vivo tests; g) original data bank regarding physico-mechanical, electrochemical, anticorrosive, surface, biocompatible, antibacterial characteristics of the novel bioalloy. The obtained orthopaedic and maxillofacial implants will fulfill the multiple, complete functions and properties of a good implant, actually non-existing on market.

Rapid, innovative, soft-solution advanced processing of a new bioalloy surface for the improvement of its interactions with human fluids Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0510 2011 - 2016

Role in this project: Key expert

Coordinating institution: Institutul de Chimie Fizica "Ilie Murgulescu"

Project partners: Institutul de Chimie Fizica "Ilie Murgulescu" (RO)

Affiliation: Institutul de Chimie Fizica "Ilie Murgulescu" (RO)

Project website: http://www.icf.ro/pr_2011/JC/Index.html

Abstract:

Project theme is the elaboration of an innovative procedure for the controlled surface processing of a new bioalloy by combining for the first time of the chemical, electrochemical and bacteriostatic methods. This project represents a scientific novelty and enlarges the interdisciplinary research areas concerning the surface science, physical chemistry and electrochemistry in accordance with the international trends of increased bioactivity of bioalloy surfaces. Main objectives are: obtaining of nanoporous, controlled surface structures for the increase of the bioactivity, antibacterial action and life time of the implants (innovative procedures); complex and complete characterization (scientific novelties) of the new nanostructured surfaces by modern world-level techniques; modelling for the first time of the interfaces: structured metallic surface/human fluids by electrochemical methods (internationally competitive) demonstrating the improved bioactivity of new processed surfaces; analysis of the bioactivity and bacteriostatic properties on new functionalized surfaces (progress in the field); increase of Romanian research capacity and performance by: patent (1), scientific papers (6). Long term objectives are: improvement of the life quality and health state of the patients by the utilisation of the new implant biomaterial with nanostructured surfaces; an efficient utilisation of the natural resources by the increase of the „service life” of the processed surfaces.

Development of innovative methods for osseointegrative biofunctionalization of new titanium bioalloys surfaces Call name: Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0169 2013 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2012/TE0619/Index.html

Abstract:

The project topic refers to development of innovative methods for osseointegrative biofunctionalisation of new titanium bioalloys surfaces. The necessity for long term implantation success requires surface coatings with bioactivity, osseoconductivity and strong adhesion to the metallic substrate. Project approaches these three demands by the surface hydroprocessing, obtaining the alloy surface architecturing by electrochemical (for adhesion), chemical (for bioactivity) and biomimetic (for biomimetism) methods. The originality and innovations of the project objectives are: advanced electrochemical procedure (with optimized parameters) for the primary adherent layer; biofunctionalisation by the chemical deposition (adapted innovative method) for the secondary layer; biomimetic chemical deposition of the osseoconductive factor; obtaining of multi-layer coating with tailored properties, which simultaneously exhibit controlled biomolecule release and bioactive behaviour; modeling of the biomimetic coating / simulated biofluids interface by modern electrochemical methods; monitoring of the coating stability using high level electrochemical, microscopic and spectroscopic techniques. The project will contribute to enhance the world level of knowledge in the high interest field of advanced implant biomaterials with improved osseointegration. The original results will impact the scientific national and international community by 1 patent proposal, 4 communications, 4 scientific papers.

NEW CONCEPTS AND STRATEGIES FOR THE DEVELOPMENT OF KNOWLEDGE OF NEW BIOCOMPATIBLE STRUCTURES IN BIOENGINEERING Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0248 2010 - 2013

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA

Project partners: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA NICOLAE SIMIONESCU-LABORATORUL DE CELULE STEM SI TERAPIE CELULARA (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-FACULTATEA DE CHIMIE APLICATA SI STIINTA MATERIALELOR (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-CENTRUL NATIONAL DE CONSULTANTA PENTRU PROTECTIA MEDIULUI (RO); INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOMATERIALE, INSTITUTUL DE CERCETARI EXPERIMENTALE SI INTERDISCIPLINARE (RO); INSTITUTUL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE SI PETROCHIMIE BUCURESTI (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO)

Project website: http://www.pcce248.weebly.com

Abstract:

IN TISSUE ENGINEERING (TE) THE COMBINED KNOWLEDGE FROM BIOLOGY AND ENGINEERING

IS DIRECTED TOWARDS THE POSSIBILITY TO RESTORE LOST OR DAMAGED TISSUE. THE

GENERAL AIM OF THIS PROJECT IS TO CONSOLIDATE A CROSS-DISCIPLINARY TEAM OF

COLLABORATING INVESTIGATORS TO CARRY OUT SOME CELL-SUPPORT CONSTRUCTS (CSC)

WITH POSSIBLE APPLICATIONS IN REGENERATION/REPAIR OF SOFT AND HARD TISSUES AND IT

DOES NOT ASSUME PRE-CLINICAL AND CLINICAL TRIALS. THIS APPLICATION CONTAINS THREE

SPECIFIC OBJECTIVES: 1- OBTAINMENT OF NEW SUPPORT 3-D STRUCTURES DESIGNED TO

CULTIVATE OSTEOBLASTS AND HUMAN MESENCHYMAL STEM CELLS (HMSC) TO OBTAIN CSCS

WITH CHARACTERIZED ARCHITECTURE AND MECHANICAL PROPERTIES, USEFUL IN BONE TISSUE

ENGINEERING; 2 - DEVELOPMENT OF REGENERATION STRATEGIES OF ADIPOSE TISSUE BY

IMPLANTATION OF PREADIPOCYTES IN 3-D HYDROGEL SCAFFOLDS, THAT MIMIC

EXTRACELLULAR MATRIX, DESTINED TO THE RECONSTRUCTION OF SOFT TISSUE DEFECTS

(SEVERE TRAUMAS, DEEP BURNS OR TUMOR RESECTIONS) AND 3 - STUDY OF THE EFFECTS OF 3-

D CULTURE AND GROWTH FACTORS ON THE CHONDROGENIC DIFFERENTIATION OF HMSC CELLS

TO OBTAIN SOME INVESTIGATION MODELS OF THEIR POTENTIAL IN CARTILAGE TISSUE

REGENERATION. THE PROJECT PRESENTS VIABILITY, INNOVATION, COMPLEXITY AND

INTERDISCIPLINARY EXCHANGE BECAUSE: 1 - IT IS A CONSORTIUM WHICH CONSISTS FROM

PARTNERS WITH COMPLEMENTALLY COMPETENCES WHO ENGAGE TO ACT AS A UNITY IN THE

FOLLOWING FIELDS: CELLULAR AND MOLECULAR BIOLOGY, CHEMISTRY AND PHYSICS OF

MATERIALS, ENGINEERING SCIENCES – IN ORDER TO GET ALL OBJECTIVES; 2 - THE PARTNERS

ARE STAFFS WITH A GOOD, STRONG REPUTATION ON THEIR FIELD, AND THEY HAVE THE

NECESSARY MANAGERIAL EXPERIENCE AS WELL AS THE HUMAN RESOURCES AND PERFORMING

EQUIPMENTS AND 3 - THE PARTNERSHIP WAS PARTIALLY CONSOLIDATED DURING PREVIOUS

COLLABORATIONS AND WHICH SUSTAIN IT. ACCOMPLISHMENT OF THE OBJECTIVES OF THIS

PROJECT CONSTITUTES A SCIENTIFIC CHALLENGE FOR ANY SCIENTIFIC TEAM AROUND THE

WORLD.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects