BrainMap

Ms. Sorina Dinescu

Lecturer, PhD

Lecturer, Researcher - UNIVERSITATEA BUCURESTI

Researcher | Teaching staff | Scientific reviewer

ResearcherID: H-1410-2016

Curriculum Vitae (08/12/2019)

Expertise & keywords

Improving oral and systemic health using dental works from modified alloys Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0869 2014 - 2017

Role in this project:

Coordinating institution: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA

Project partners: UNIV.DE MEDICINA SI FARMACIE - CAROL DAVILA (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA BUCURESTI (RO); R&D CONSULTANTA SI SERVICII S.R.L. (RO); DENTAL ART GROUP SRL (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://cercetare-umf.ro/proiecte_parteneriate

Abstract:

The project proposal entitled “Improving oral and systemic health using dental restorations from modified alloys” is addressed to the priority field 4 Health and has as goal the improvement of oral and systemic health of the population through implementing new methods of prevention and intervention at national level having capacity of international expansion. Having the central objective the improvement of the health level mainly through the offer of medical services of prevention, the project will contribute to the reduction of costs in the field of health. The offer is elaborated under the competent and representative direction of the University of Medicine and Pharmacy “Carol Davila”, the Faculty of Dental Medicine, another 2 Universities, 1 Institute of research of the Romanian Academy and 2 co-financing SMEs. This consortium is by definition inter- and pluri-disciplinary and exhibits synergy and complementarity due to the contribution of Medicine, Chemistry and Biology to the achievement of the central objective and it shall benefit of the un-financed support of an European partner (Universita’ del Piemonte Orientale “Amedeo Avogadro”) well known in the field of oral pathology, partner which shall participate to the activity of research and dissemination of results. This partner with experience and tradition will enhance the chances of the project both at level of the choice of the best methods of prevention and intervention in oral health and also at the level growing the visibility of the research. As derived objectives to achieve the central goal, the project takes into consideration the formation of target groups of patients according to the following criteria of selection: the detection of lichenoid reactions, of a metallic pigmentary lesions; the existence of dental alloys (CoCr, CoCrMo, etc. used at mass level) which favoured the release of ions and the absorption due to materials imperfections. The project will also form proof-lots including in the study a high number of patients comprising also patients who did not use dental alloys, fact which will allow the set out of the cause of the diseases and of the most appropriate treatments for all the studied cases. Both the scientific background and the expertise of the 6 partners as well as the richness of human and material resources represent a warranty that it is possible to overlap the knowledge about the creation of an improved alloy (CoCrZr or Nb) capable to reduce the potential for serious diseases such as Lichen Planus. The project analyses the sick tissue and the amount of ions released chemically and biologically and to compare the behaviour of the existing materials with that of our new alloy. The improvement of the dental alloy will aim at both the composition as well as the surface state at micro- and nano- level. The trial of these materials will be performed in simulating conditions respecting the corresponding regulations form the European space of operation including the norms of bio-ethics and bio-security and the informed agreement of the patient. The results of the project will be disseminated and exploited both at level of health services as well as at level of co-financing partners who will develop technology and innovating dental works from improved alloys at reduced costs, fact that emphasizes the co-relation between the thematic of the project and the strategy of development of the SMEs partners. Obtaining a patent and publishing 5 research works in international publications of high impact is a prognosis of result indicators that complete the process indicators. The benefits of implementing the project and its exploitation after ending will grow the quality of life through precocious detection of diseases and their treatment and also through the proposal of a new less dangerous and less toxic alloy. The co-financing SMEs will develop as well the commercialisation capacity subsequent to the production of materials with high market potential.

Developing new graphene-polymer composites biomaterials for scaffold fabrication with applicability in bone repair by coupling multiscale molecular modelling and experiments Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1538 2012 - 2016

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA POLITEHNICA DIN BUCURESTI

Project partners: UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO); UNIVERSITATEA "DUNAREA DE JOS" (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); UNIVERSITATEA BUCURESTI (RO); UNIVERSITATEA DE VEST "VASILE GOLDIŞ" ARAD (RO)

Affiliation: UNIVERSITATEA BUCURESTI (RO)

Project website: http://www.tsocm.pub.ro/cercetare/POLYGRAPH/

Abstract:

The main aims of this project are interdisciplinary efforts using complex computational tools of materials modelling and advanced experimental techniques for the knowledge-based design of novel, improved biopolymer-graphene scaffolds for bone repair. The key functionality of these materials is both physical and chemical cues to direct cells organization, growth, and differentiation in the process of forming functional tissue. The aim is pursued by developing and extensive application of multiscale computer-aided molecular design complemented with computer-assisted evaluation of the end-use performance of the materials in question. The resulting outputs will constitute the doorstep toward the fabrication of the biopolymer-graphene biomaterials of potential commercial values. This goal is achieved by the development of a complex protocol based on advanced experimental techniques. A method for graphene synthesis and modification by plasma treatment in order to introduce different chemical groups on the surface and graft peptides or proteins capable to facilitated cells adhesion, growth, and tissue remodelling will be establish. The end-use performance of these materials depends on several crucial factors such as graphene surface properties, polymer nature, and the methods used for biomaterial synthesis. On the frame of the experimental activity the research will be focus on modulating synthesis parameters in order to obtain a material suitable for bone repair scaffold. Extensive characterisation of biomaterials surface and bulk by physical-chemical techniques will be employed. The ultimate aim of present project should be the in vitro assessment of biocompatibility in terms of cellular morphology, adhesion, viability and proliferation, and the evaluation of differentiation potential of the new elaborated scaffolds. These studies will be complemented with in vivo assay regarding bone reconstruction with biopolymer-graphene scaffolds.

In vitro effects of beta-titanium alloys on biological behavior of macrophages and their cross-talk with osteoblasts Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0737 2011 - 2016

Role in this project:

Coordinating institution: Universitatea din Bucuresti

Project partners: Universitatea din Bucuresti (RO)

Affiliation: Universitatea din Bucuresti (RO)

Project website: http://www.unibuc.ro/prof/cimpean_a/Proiect-PCE-188-/

Abstract:

The project aims to elucidate the modulation of macrophage function and of the cross-talk between macrophages and osteoblasts by new beta-titanium alloys which are based on titanium and nontoxic alloying elements such as Ta, Nb/Zr. For comparative purposes, a commercial Ti-6Al-4V alloy, will be also investigated. In the first stage, we will investigate if the macrophages cultured in contact with the tested substrates display differences regarding cell viability, proliferation, apoptosis, cytoskeleton and adhesive structures (focal contact, podosomes) which may be important for the interpretation of macrophage function in chronic inflammatory responses. Next, we will evaluate macrophage cytokine, chemokine and matrixin expression at transcriptional and translational levels. The proposed project is an innovative approach which will bring new knowledge on signaling pathways (such as NFκB and MAP-Kinase) that could be activated by various Ti alloy compositions and on material effects upon the cross-talk between macrophages and osteoblasts using a Transwell co-culture model. This cross-talk will be studied in terms of modulation of: i) soluble factors involved in bone turnover (RANKL, OPG); ii) osteogenesis process (alkaline phosphatase activity, mineralization process); iii) macrophage and osteoblast cytokine production. These studies can conduct to the development of cellular models for in vitro assessment of the inflammatory response to osteoprothetic materials.

NEW CONCEPTS AND STRATEGIES FOR THE DEVELOPMENT OF KNOWLEDGE OF NEW BIOCOMPATIBLE STRUCTURES IN BIOENGINEERING Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0248 2010 - 2013

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA

Project partners: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA NICOLAE SIMIONESCU-LABORATORUL DE CELULE STEM SI TERAPIE CELULARA (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-FACULTATEA DE CHIMIE APLICATA SI STIINTA MATERIALELOR (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-CENTRUL NATIONAL DE CONSULTANTA PENTRU PROTECTIA MEDIULUI (RO); INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOMATERIALE, INSTITUTUL DE CERCETARI EXPERIMENTALE SI INTERDISCIPLINARE (RO); INSTITUTUL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE SI PETROCHIMIE BUCURESTI (RO)

Affiliation: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA (RO)

Project website: http://www.pcce248.weebly.com

Abstract:

IN TISSUE ENGINEERING (TE) THE COMBINED KNOWLEDGE FROM BIOLOGY AND ENGINEERING
IS DIRECTED TOWARDS THE POSSIBILITY TO RESTORE LOST OR DAMAGED TISSUE. THE
GENERAL AIM OF THIS PROJECT IS TO CONSOLIDATE A CROSS-DISCIPLINARY TEAM OF
COLLABORATING INVESTIGATORS TO CARRY OUT SOME CELL-SUPPORT CONSTRUCTS (CSC)
WITH POSSIBLE APPLICATIONS IN REGENERATION/REPAIR OF SOFT AND HARD TISSUES AND IT
DOES NOT ASSUME PRE-CLINICAL AND CLINICAL TRIALS. THIS APPLICATION CONTAINS THREE
SPECIFIC OBJECTIVES: 1- OBTAINMENT OF NEW SUPPORT 3-D STRUCTURES DESIGNED TO
CULTIVATE OSTEOBLASTS AND HUMAN MESENCHYMAL STEM CELLS (HMSC) TO OBTAIN CSCS
WITH CHARACTERIZED ARCHITECTURE AND MECHANICAL PROPERTIES, USEFUL IN BONE TISSUE
ENGINEERING; 2 - DEVELOPMENT OF REGENERATION STRATEGIES OF ADIPOSE TISSUE BY
IMPLANTATION OF PREADIPOCYTES IN 3-D HYDROGEL SCAFFOLDS, THAT MIMIC
EXTRACELLULAR MATRIX, DESTINED TO THE RECONSTRUCTION OF SOFT TISSUE DEFECTS
(SEVERE TRAUMAS, DEEP BURNS OR TUMOR RESECTIONS) AND 3 - STUDY OF THE EFFECTS OF 3-
D CULTURE AND GROWTH FACTORS ON THE CHONDROGENIC DIFFERENTIATION OF HMSC CELLS
TO OBTAIN SOME INVESTIGATION MODELS OF THEIR POTENTIAL IN CARTILAGE TISSUE
REGENERATION. THE PROJECT PRESENTS VIABILITY, INNOVATION, COMPLEXITY AND
INTERDISCIPLINARY EXCHANGE BECAUSE: 1 - IT IS A CONSORTIUM WHICH CONSISTS FROM
PARTNERS WITH COMPLEMENTALLY COMPETENCES WHO ENGAGE TO ACT AS A UNITY IN THE
FOLLOWING FIELDS: CELLULAR AND MOLECULAR BIOLOGY, CHEMISTRY AND PHYSICS OF
MATERIALS, ENGINEERING SCIENCES – IN ORDER TO GET ALL OBJECTIVES; 2 - THE PARTNERS
ARE STAFFS WITH A GOOD, STRONG REPUTATION ON THEIR FIELD, AND THEY HAVE THE
NECESSARY MANAGERIAL EXPERIENCE AS WELL AS THE HUMAN RESOURCES AND PERFORMING
EQUIPMENTS AND 3 - THE PARTNERSHIP WAS PARTIALLY CONSOLIDATED DURING PREVIOUS
COLLABORATIONS AND WHICH SUSTAIN IT. ACCOMPLISHMENT OF THE OBJECTIVES OF THIS
PROJECT CONSTITUTES A SCIENTIFIC CHALLENGE FOR ANY SCIENTIFIC TEAM AROUND THE
WORLD.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects