BrainMap

Mrs. Speranta Valeria Tanasescu

Dr.

Researcher, Head of Laboratory - INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Researcher | Scientific reviewer | PhD supervisor

Dr. Speranta Tanasescu, PhD, is Senior Researcher I and Head of the Laboratory of Chemical Thermodynamics in the Institute of Physical Chemistry - Ilie Murgulescu of the Romanian Academy. Dr. Tanasescu obtained a PhD in Physical Chemistry from the Romanian Academy in 1979 and has served as a supervisor in Chemistry since 2002. She received the “Gh. Spacu” Award from the Romanian Academy in 1972 and “Diploma of honor” awarded by the Romanian Chemistry Society in 2019 for "special contributions to the promotion of chemistry" on the occasion of the 100th anniversary of its foundation. Her thematic research focuses on activities with impact in the following domains: materials science, nanoscience and nanotechnology, new sources of energies, nanosafety, and nanomedicine. Her research is significant for understanding processing-structure relationships, as well as for finding key parameters in relation to bio-reactivity of the nanomaterials with impact in nanosafety and nanomedicine research.

Curriculum Vitae (21/04/2025)

Expertise & keywords

TARGETED MULTIFUNCTIONAL NANOEMULSIONS TO INTERRUPT METASTATIC PROGRESSION Call name: P 3 - SP 3.2 - Proiecte ERA.NET - COFUND
COFUND-ERANET EURONANOMED 3-METASTARG 2019 - 2022

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); Consorcio Centro de Investigación Biomédica en Red, M.P. (ES); Aptus Biotech S.L. (ES); Internattional Iberian Nanotechnology Laboratory (PT); Fondazione IRCCS Istituto Nazionale dei Tumori (INT) (IT); Stanipharm (FR)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2019/METASTARG/index.html

Abstract:

Metastases are the major cause of death in cancer patients with solid tumors. In Non-Small Cell Lung Cancer (NSCLC), highly metastatic locally and in distal organs, the 5-year mean survival is lower than 5% in the metastatic setting. Occult micrometastases (OM) are, by definition, small clusters of metastatic cells, and can only be detected by highly invasive molecular methods, remaining largely untreated and eventually leading to the formation of metastases. Early detection of OM and treatment can interrupt progression to macroscopic metastasis, and ultimately improve survival.

METASTARG is an innovative solution relying on nanotechnology for the early detection and treatment of OM to cause a direct impact in the survival of the disease, quality of life, and health-economics. METASTARG Nanoemulsions are developed to identify OM by novel characteristic targets found in metastatic cells and Interrupt Metastasis Progression (NIMPs). This unique patient-driven approach has the potential to become a gold standard in the treatment and monitoring of NSCLC cancer.

We have developed sphingomyelin nanoemulsions (SN) that are easy to manufacture, stable, non-toxic, and can incorporate active ingredients and radionuclides. We have surface-decorated them with ligands to mediate a specific interaction with the biomarker Taste receptor type 1 member 3 (TAS1R3), identified by molecular analysis of metastatic cancer cells isolated from the blood of patients with NSCLC (Circulating Tumor Cells, CTCs). In this project, we address a multidisciplinary and translational research to i) optimize the technology to develop NIMPs with the ultimate aim of improving patient survival, ii) understand the biophysics of targeting metastasis to improve NIMPs interaction with OM, iii) generate the proof-of-concept for NIMPS activity in relevant in vitro and in vivo models representative of the micrometastatic situation in NSCLC, and iv) advance in the translation of NIMPs to a clinical setting.

Safety testing in the life cycle of nanotechnology-enabled medical technologies for health Call name:
Horizon 2020 , Grant nr. 814607 2019 - 2022

Role in this project: Partner team leader

Coordinating institution: TECNOLOGIA NAVARRA DE NANOPRODUCTOS S.L. (TECNAN)

Project partners: TECNOLOGIA NAVARRA DE NANOPRODUCTOS S.L. (TECNAN) (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website:

Abstract:

Development and implementation of Grouping and Safe-by-Design approaches within regulatory frameworks Call name:
H2020-NMP-2014-two-stage, H2020: Research & Innovation Actions, 2015 - 2018

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.nanoreg2.eu/

Abstract:

Research of the bone substitution with biocomposite materials processed by powder metallurgy specific techniques Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-2094 2014 - 2017

Role in this project: Partner team leader

Coordinating institution: UNIVERSITATEA DIN CRAIOVA

Project partners: UNIVERSITATEA DIN CRAIOVA (RO); TEHNOMED IMPEX CO S.A. (RO); SPITALUL CLINIC DE URGENTA " BAGDASAR-ARSENI " (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA LASERILOR, PLASMEI SI RADIATIEI - INFLPR RA (RO); INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO); UNIVERSITATEA POLITEHNICA DIN BUCURESTI (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://mecanica.ucv.ro/Cercetare/BONY/index.html

Abstract:

The research proposal is entitled “Research of the bone substitution with biocomposite materials processed by powder metallurgy specific techniques”, acronym BONY. Its general objective is to obtain advanced biocomposite materials, based on hydroxyapatite (HAP) matrix reinforced by Ti-based powder particles. The osseointegration process is accelerated by the natural organic esters of Bor, as a component of the biocomposite powders mixture. The applications aim the bone substitution by small-sized reconstructions for skull and vertebrae body.

BONY project matches the priority domain 7 (Materials, innovative processes and products), research area 7.1 (Advanced materials), research topic 7.1.6 (Advanced materials and biomaterials for life quality improvement (health, sport, education etc.)).

The project relevancy is underlined by the necessity to elaborate bone implants for skull and vertebrae by advanced biocomposites, with improved osseointegration capacity to the adjacent native bone tissue. Also, the technical and economical savings are important as far as the processing technologies concern.

The BONY project results are:

1. the innovative biocomposite material as bulk product for vertebral implant processed by micro-injection moulding technique;

2. the innovative biocomposite material as coating for skull implant processed by MAPLE technique on Titanium substrate;

3. the innovative material and method to accelerate the osseointegration process of the bone implants.

The innovative/original aspects of the BONY project are represented by:

- the innovative combination of metallic and ceramic powders, micrometric and nanometric sized. The advanced sintering techniques as well as the coating ones provide hybrid structured biocomposites that assure improved physical, mechanical, technological and biochemical properties relative to the native bone.

- using, for the first time, of the micro-injection moulding technique, to process complex shaped and small sized bone implants;

- the original an innovative application of MAPLE coating technique to process hybrid biocomposite coatings on Ti substratewith similar properties to the bulk biocomposites type.

- the original method to accelerate the osseointegration process by using special additives, Bor natural organic esters, in special technological procedures.

The BONY implant biocomposites provide the following advantages as follow: resorbability, geometrical stability, improved lifetime, micro-machinability for final geometrical adjustments, able to be processed as complex shapes and small dimensions, improved osseointegration.

The impact of the project results may be evaluated from the following points of view: scientifical (innovative biocomposite materials), technological (suitable processing technologies to the implants shape and size), research human resources training (young Ph.D. students or graduated, members of consortium), economical and social (improving the patient’s life quality).

The quality, expertise and research, innovative and entrepreneur skills of the BONY partners assure the successful fulfilment of the project objectives. The BONY consortium is represented by: CO – University of Craiova (UCV); P1 - S. C. Tehnomed Impex Co S.A., Bucuresti (IMM); P2 – The Emergency Clinic Hospital „Bagdasar-Arseni”, Bucharest; P3 – The National Institute for Laser, Plasma & Radiation Physics (INFLPR), Bucharest ; P4 – « Ilie Murgulescu » Institute of Physical Chemistry of the Romanian Academy (IPC), Bucharest ; P5 – Politehnica University of Bucharest (UPB).

Promoting the Implementation of Safe by Design Call name: EC - H2020
H2020-194431-646325 2015 - 2017

Role in this project: Partner team leader

Coordinating institution: MINISTERIE VAN INFRASTRUCTUUR EN WATERSTAAT

Project partners: MINISTERIE VAN INFRASTRUCTUUR EN WATERSTAAT (NL); VENETO NANOTECH SOCIETA CONSORTILEPER AZIONI (IT); INTERNATIONAL LIFE SCIENCES INSTITUTE EUROPEAN BRANCH AISBL (BE); TEMAS AG TECHNOLOGY AND MANAGEMENT SERVICES (CH); ISTITUTO SUPERIORE DI SANITA (IT); ECAMRICERT SRL (IT); INSTITUTE OF OCCUPATIONAL MEDICINE (UK); RIJKSINSTITUUT VOOR VOLKSGEZONDHEID EN MILIEU (NL); INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO); NANOTECHNOLOGY INDUSTRIES ASSOCIATION (BE); UMWELTBUNDESAMT (DE); CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS (FR); FUNDACAO PARA A CIENCIA E A TECNOLOGIA (PT); JRC -JOINT RESEARCH CENTRE- EUROPEAN COMMISSION (BE)

Affiliation: INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO)

Project website: https://app-prosafe.azurewebsites.net/

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator	Download (13.67 kb) 27/01/2018
List of research grants as partner team leader	Download (18.42 kb) 27/01/2018
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects