BrainMap

Teodora Radu

- INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Other affiliations

Researcher - UNIVERSITATEA BABES BOLYAI (Romania)

Researcher

Web of Science ResearcherID: http://www.researcherid.com/rid/C-2554-2012

Expertise & keywords

Industrial wastes as filler in bituminous materials for sealing of joints in roads pavement: towards circular economy Call name: P 2 - SP 2.1 - Proiect experimental - demonstrativ
PN-III-P2-2.1-PED-2021-1821 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); INSTITUTULUI DE CERCETARI PENTRU ECHIPAMENTE SI TEHNOLOGII IN CONSTRUCTII – ICECON S.A. (RO)

Affiliation:

Project website: https://www.itim-cj.ro/PNCDI/fillroads/

Abstract:

In search of solutions for the transition to an efficient circular economy in the construction materials sector that would reduce the use of natural resources and the impact of waste on the environment, we propose the development of a demonstration model for a bituminous mastic material as an alternative to the one currently used for sealing joints and cracks in road maintenance. The starting point of the project is the recent results of the implementation team in obtaining a composite based on industrial waste which can be used as a substitute for the mineral filler in the composition of bituminous mastic. The sealing compounds must have a certain density, water and frost resistance, good adhesion to the asphalt material surface and adequate elasticity. In order to preserve the physical and mechanical properties of the bituminous mastic, the proposed composite will gradually replace the initial concentration of the filler. The materials obtained will be evaluated in terms of physico-chemical properties and interaction with bitumen in a feedback loop to optimize the initial recipe. Furthermore they will be tested at laboratory level in relation to the corresponding standards in the field of bituminous products currently used on the market. In order to validate the expected performances and functionalities in the laboratory for this type of material evaluation of its behavior under simulation of relevant operating conditions and of the external environmental factors will be performed. To the knowledge of the members of the research team, combining this waste and incorporating them into the bitumen-based material to obtain a new product used in the road construction industry is a new idea both nationally and internationally. The results of this project proposal can generate many economic and environmental benefits by mitigating waste effects on the environment and reducing the consumption of materials from non-renewable sources.

Anticancer effects induced by magnetic nanoparticles linked with doxorubicin exposed to an alternative magnetic field Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0498 2022 - 2024

Role in this project:

Coordinating institution: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU"

Project partners: UNIVERSITATEA DE MEDICINA SI FARMACIE "IULIU HATIEGANU" (RO)

Affiliation:

Project website: https://crissiac.wixsite.com/pn-iii-te22-baldea

Abstract:

Mortality rates in cancer are still high, despite important advances in oncology, while the existing therapies often cause side effects or even lead to treatment interruption. However, the combination of magnetic hyperthermia (MH) with chemotherapy through one single versatile nano-platform represents a really promising technology in the treatment of cancer. In this project we propose to further extend the very recent advancements in both preparation and application of magnetic nanocluster (MNC) to cancer treatment with the precise goal of elaborating biofunctionalized hybrid MNC capable to be easily directed to the tumor site by magnetic field gradients thus increasing the drug concentration at the tumor site and decreasing the toxic side effects. Moreover, these hybrid MNC have a huge potential for synergistically increasing the antitumor activity of the chemotherapy by sensitizing the tumor cells through MH. The hybrid MNC will be prepared by employing solvothermal method where polydopamine analogues will be used as coating agent, which offer the possibility to easily attach doxorubicin (DOX) through non-covalent interactions. The intrinsic toxicity of DOX-MNC will be assessed by means of multiple complementary types of viability assays on different types of normal and cancer cells. In the final phase of the project, we will evaluate the magneto-chemotherapeutic antitumor effects of DOX-MNC using experimental models like cell pellets, tumor spheroids and “tumor on a chip”.

Polydopamine analogues as fluorescent coating for magnetic nanoparticles Call name: P 1 - SP 1.1 - Proiecte de cercetare pentru stimularea tinerelor echipe independente - TE-2021
PN-III-P1-1.1-TE-2021-0048 2022 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation:

Project website: https://www.itim-cj.ro/PNCDI/bright-surf/ro/home-romana/

Abstract:

The development of nanocomposites based on magnetic nanoparticles and fluorescent molecules is a fast growing research field in nanotechnology. These types of materials, however, possess some difficulties and challenges that need to be overcome, such as the quenching of the fluorescent entity by the magnetic core. That is why the coating systems have received a special importance by changing the hydrophilicity related with good dispensability or improving biocompatibility. As a coating, polydopamine fulfills these qualities being heavily investigated through both, in vivo and in vitro studies for many biomedical applications. But in terms of fluorescence this it is a breach of exploitation which is focused more on oxidation approached, degradation, conjugation, and carbonization of dopamine/polydopamine. In this project we propose a different approach by synthesizing new polydopamine analogues with extra heteroatoms in their structure. For this type of synthetic analogues we will systematically study the polymerization mechanism, adherence, and how the presence of N-type heteroatoms improves their fluorescence property. Coating the fluorescent new materials onto uniformly sized magnetic nanoparticles, fluorescent-magnetic nanocomposites will be engineered, which can serve as an all-in-one diagnostic and therapeutic tools with the additional advantage of being easy to control and monitor by fluorescent microscopy.

TiO2 nanotubes/graphene-based nanomaterials to address the emerging contaminants pollution Call name: EEA Grants - Proiecte Colaborative de Cercetare
RO-NO-2019-0616 2020 - 2024

Role in this project:

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); University of South-Eastern Norway (NO); INSTITUTUL NATIONAL DE CERCETARE - DEZVOLTARE PENTRU FIZICA SI INGINERIE NUCLEARA " HORIA HULUBEI " - IFIN - HH (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: https://www.itim-cj.ro/PNCDI/graftid/

Abstract:

For the past century, the environment suffers from rapid deterioration due to the explosive development of chemical and pharmaceutical industries. Large quantities of drugs, personal care products, detergents, pesticides, food additives have been released in the aquatic system. The pollutants of emerging concern are not yet monitored and well regulated by authorities while there is an increased awareness of their impact on human health. The United Nations World Water Development Report 2018 states that “An estimated 80% of all industrial and municipal wastewater is released to the environment without any prior treatment, resulting in a growing deterioration of overall water quality with detrimental impacts on human health and ecosystems”. Advanced Oxidation Processes (AOPs) based on photocatalysis are the most powerful and viable alternative to the conventional wastewater treatment technologies that still have some limitations (e.g., high operation costs, energy consumption, or reduce efficiency due to the chemical stability of pollutants and/or the complexity of their degradation). Thus, the development of solar-driven catalysts with improved photocatalytic activity for the environment-friendly and facile treatment of aquatic systems remains an important target to environment remediation.

Unprecedented polyesters as coating for solid surfaces with application in medicine and nanotechnology Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0654 2015 - 2017

Role in this project: Key expert

Coordinating institution: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M

Project partners: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://www.itim-cj.ro/PNCDI/ru319/

Abstract:

The main goal of the project is to develop new hybrid materials based on polyesters of α-hydroxy carboxylic acids (PAHCA) functionalized with molecules having different application in magnetic separation, biomedicine and chemical and pharmaceutical industry. The project focused on a complex research field, polymers, nanosciences and nanotechnologies, situated in the actual orientation for the development of functional hybrid nanostructured materials. Polyesters of α-hydroxy carboxylic acids, such as polylactic acid or polyglycolic acid have found widespread application in materials field, medicine and nanotechnology, but have also several limitations due to lack of reactive groups for linkage, and because of their easiness of biodegradation in environment and in biological medium. The project aims to overcome these obstacles and extends potential application of these polymers by preparing new functionalized PAHCA by polymerization reaction of new functionalized lactides synthesized in the project. The resulting composite materials attract fundamental interest by contributing to the understanding of physical processes and phenomena associated with nanostructures, intermolecular specific interactions, interface effects, phase transitions and applicative interest for medicine and nanotechnology.

New Heusler materials for spintronics applications Call name: Projects for Young Research Teams - RUTE -2014 call
PN-II-RU-TE-2014-4-0009 2015 - 2017

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://municheos.wix.com/dianabenea#!pn-ii-ru-te-2014-4-0009/c1pz

Abstract:

The spectacular development of application in the field of magnetic sensors and memories enhanced the interest for new materials able to optimize the performances of the related devices. In this context, the present project proposes the investigation of the electronic structures and magnetic properties of a several half-metal ferrimagnets of Heusler type. The half metal ferrimagnets with high spin polarization, presenting a Curie temperature above the room temperature would represent an ideal option for magnetoelectronic devices due to the very low energy losses. A special role in the fundamental research included in this project is attributed to the electronic band structure calculations in order to predict the magnetic and electronic properties of half-metal compounds. Complementarily, experimental research is proposed to investigate the compounds, some of them being proposed to be prepared for the first time. The combined approach used by our research team will contribute to understanding the mechanism of half-metallicity and ferrimagnetism within these compounds, driven by the chemical composition and by exchange interactions responsible the magnetic ordering. On the basis of our research, we expect (1) to be able to give predictions of new classes of HMFi materials and (2) to discover new materials with real potential for spintronic applications.

Security paper with imbedded magnetic nanoparticles Call name: Joint Applied Research Projects - PCCA 2013 - call
PN-II-PT-PCCA-2013-4-0560 2014 - 2017

Role in this project: Key expert

Coordinating institution: ACADEMIA ROMANA FILIALA TIMISOARA

Project partners: ACADEMIA ROMANA FILIALA TIMISOARA (RO); CEPROHART S.A. (RO); ROSEAL S.A. (RO); DATRONIC-NCIP S.R.L. (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO); UNIVERSITATEA POLITEHNICA TIMIŞOARA (RO)

Affiliation: INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE I N C D T I M (RO)

Project website: http://vsocoliuc.wordpress.com/projects/nanomagsecuritypaper/

Abstract:

Document forgery is a criminal activity that causes billion dollar losses each year worldwide. Security paper is among the most important ingredients used in the fight against the forgery of private or public documents. The continuous diversification and sophistication of the paper securing techniques is one of the most important ways to erect fences against forgery attempts. The NanoMagSecurityPaper project aims to expand the diversity of high tech means for paper securing. The project’s strategic objective is to bring magnetic security paper on the security paper market. It is estimated that the Romanian security paper market alone will demand for tens of tons of magnetic security paper each year.

NanoMagSecurityPaper brings in the idea to obtain magnetic security paper by dispersing superparamagnetic nanoparticles in the wet cellulose pulp. The superparamagnetic paper thus obtained gets the functionality of security paper only together with appropriate validation methods and instruments. In order to meet this goal, joint applied research from the following three fields is necessary: 1. paper making, 2. magnetic nanoparticle/composite synthesis, and 3. magnetic sensing and validation. In order to meet the highest security standards, the authenticity checking procedures should make possible both a fast, handy and reliable first instance validation, and a sophisticated, albeit laborious, high security level validation. The NanoMagSecurityPaper will elaborate and test methods to produce high security level magnetic paper, by embedding in the paper composition magnetic nanoparticles and, for white color paper, magnetic composites. A handy and high sensitivity first instance validation method and instrument will be developed.

NanoMagSecurityPaper will achieve its objectives by transferring fundamental and applied knowledge on magnetometry, magnetogranulometry, magnetic sensing and magnetic nanoparticle/composite synthesis, from three Romanian academic institutions to three Romanian industrial partners: SC CEPROHART SA - security paper producer, SC ROSEAL SA - magnetic nanoparticle/composite producer, and SC DATRONIC-NCIP SRL – electronic equipment producer. NanoMagSecurityPaper will provide high-tech added value to the product portfolio of the consortium industrial partners, as well as a deeper scientific knowledge transfer expertise to the academic institutions of the consortium.

NanoMagSecurityPaper will also open means for the development of securitization techniques for a wide range of diamagnetic materials like paints, textiles, polymeric composites, and others.

Genetic Evolution: New Evidences for the Study of Interconnected Structures. A Biomolecular Journey around the Carpathians from Ancient to Medieval Times Call name: Joint Applied Research Projects - PCCA-2011 call, Type 1
PN-II-PT-PCCA-2011-3.1-1153b 2013 - 2016

Role in this project: Key expert

Coordinating institution: INSTITUTUL DE BIOLOGIE

Project partners: INSTITUTUL DE BIOLOGIE (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://www.ibiol.ro/proiecte/PNII/GENESIS/index.htm

Abstract:

With the advent of molecular techniques, no biological discipline could remain the same. Today, classic theories and approaches are verified using methodologies involving molecular analyses. Often, the image presented by molecular techniques completely challenges past suppositions. Archaeology and history, two research areas apparently meant to remain in their “pure”, classic form, tend now towards interdisciplinarity. Being concerned with recounting and reconstructing past lives, they involve, at some point, the study of plant, animal and human remains, and thus, are also affected by the molecular revolution that sweeps other biological domains.

The extended team of this project reunites historians, archaeologists, biologists, MD’s and physicists who approach in a interdisciplinary manner the study of past human populations who occupied at diverse intervals and in diverse locations around the Carpathian mountains the territory of today’s Romania.

The objective of our project is to establish an autochthonous young interdisciplinary team to function beyond the end of the project in the field of bioarchaeology, with both scientific (academic research), commercial (expertise and analysis of samples for third parties) and formative (passing on information to the next generation of “bioarchaeologists” via courses, workshops, etc.) responsibilities.

Designing composite nanoarchitectures for H2 production and environmental depollution Call name: Exploratory Research Projects - PCE-2011 call
PN-II-ID-PCE-2011-3-0442 2011 - 2016

Role in this project:

Coordinating institution: UNIVERSITATEA BABES BOLYAI

Project partners: UNIVERSITATEA BABES BOLYAI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://www.phys.ubbcluj.ro/~lucian.baia/pagina%20proiect/index

Abstract:

The goal of the project is to obtain composite nanoarchitectures based on TiO2 and WO3 with Au or Pt nanoparticles controllably deposited on their surface. The composites will be obtained by three different methods (sol-gel, impregnation, zeta-potential driven association) in order to achieve different contact levels between the two oxides. Thus, the contact between TiO2 and WO3 can be explored, and several questions related to the in-deep understanding of the composite photoactive materials particularities (such as the nature, structure or role of the contact surface) will be answered. Metal nanoparticles will be selectively deposited, by two different methods, namely photodeposition and chemical reduction, on one of the oxide’s surface (TiO2 or WO3) pursuing the changes of the composite’s properties. The obtained catalysts will be characterized in all aspects (especially the nanoparticles interface) using conventional and modern techniques. Photocatalytic and H2 production experiments will be carried out to assess the applicability of these nanocatalysts in environmental depollution and future H2 generation.

New bioactive glasses and glass-ceramics doped with selenium and molybdenum: synthesis, structural and biological properties. Call name: Projects for Young Research Teams - TE-2011 call
PN-II-RU-TE-2011-3-0032 2011 - 2014

Role in this project:

Coordinating institution: Universitatea Babes Bolyai

Project partners: Universitatea Babes Bolyai (RO)

Affiliation: Universitatea Babes Bolyai (RO)

Project website: http://phys.ubbcluj.ro/~raluca.lucacel/pn-ii-ru-te-2011-3-0032.html

Abstract:

The research will focus on the synthesis and characterization of new classes of bioactive materials: silicate and phosphate - based glasses and glass-ceramics doped with molybdenum and selenium. Both, molybdenum and selenium are essential mineral trace of the human body and their influence on the structural properties and biological performance in silicate and phosphate-based glasses has not been reported in the scientific journal, yet. Moreover, we plan to investigate the possibility of development antibacterial and antifungal behavior in these glasses and glass- ceramics as a consequence of molybdenum and selenium ions presence inside. By season of complex interaction between materials and cells the category of bioactive glasses and glass ceramics are still an “unresolved case” so that, a research study in this field focused on a new bioglasses composition can only, to enriched the knowledge level and go forward the practical medical applications. Since we’ll investigate a new category of materials, there are a lot of open problems imposed by our goal: to establish appropriates methods of materials synthesis, to find the right preparation parameters (starting materials, temperature, period of melting, etc.), to establish the right thermal treatment parameters and their influence on the materials structure, to investigate structural and biological properties (in vitro tests).

Surface and Interface Science: Physics, chemistry, biology, applications. Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0076 2010 - 2013

Role in this project: Key expert

Coordinating institution: INSATITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA MATERIALELOR

Project partners: INSATITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA MATERIALELOR (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU INGINERIE ELECTRICA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE CAROL DAVILA DIN BUCURESTI (RO); UNIVERSITATEA ALEXANDRU IOAN CUZA DIN IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU FIZICA TEHNICA DIN IASI (RO); INSTITUTUL NATIONAL DE CERCETARE DEZVOLTARE PENTRU TEHNOLOGII IZOTOPICE SI MOLECULARE DIN CLUJ-NAPOCA (RO); UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA (RO); ACADEMIA ROMANA FILIALA TIMISOARA (RO); UNIVERSITATEA DE MEDICINA SI FARMACIE VICTOR BABES TIMISOARA (RO)

Affiliation: UNIVERSITATEA BABES-BOLYAI DIN CLUJ-NAPOCA (RO)

Project website: http://www.infim.ro/projects/siinta-suprafetelor-si-interfetelor-fizica-chimie-biologie-aplicatii

Abstract:

This project intends to provide a financial background for developing the community of Surface Science in Romania. Thematics from physics and chemistry of surfaces will be tackled together with applications of surface science in biology and in technology; also new standards will be proposed for consistent data interpretation. The Project clusterizes the most important Romanian teams with preoccupations in surface science, namely all X-ray photoelectron spectroscopy teams with most of the community of thin film deposition, cluster and nanoparticle physics, surface reactivity, surface chemistry and photochemistry, multilayer physics and applications, magnetic fluids, functionalization of surfaces, cell attachment, studies of cellular membrane. The research teams belong to highly prominent Universities and Research Institutes from practically all geographical areas of the country. The Consortium disposes of infrastructure exceeding 10 million euros, of more than one hundreed highly qualified scientists which have generated during the past years more than 3 % of the national scientific visibility. The research will concentrate into four main areas: (i) magnetic properties of surfaces and low-dimensional systems; (ii) electrical properties of surfaces and heterostructures; (iii) surface chemistry; (iv) application of surface science in functionalized systems and in biology, together with (v) an area concentrating on standardization in X-ray photoelectron spectroscopy, Auger electron spectroscopy and related techniques. Each area is divided into several thematics; each thematic has at least one in-charge scientist. This Project will foster the surface science community in Romania and will contribute strongly to the development of high-technological industrial preoccupation in all geographical areas concerned. Several cutting-edge applications are also foreseen by pursuing the fundamental research proposed.

NEW CONCEPTS AND STRATEGIES FOR THE DEVELOPMENT OF KNOWLEDGE OF NEW BIOCOMPATIBLE STRUCTURES IN BIOENGINEERING Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0248 2010 - 2013

Role in this project:

Coordinating institution: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA

Project partners: UNIVERSITATEA DIN BUCURESTI-DEPARTAMENTUL DE BIOCHMIE SI BIOLOGIE MOLECULARA (RO); INSTITUTUL DE BIOLOGIE SI PATOLOGIE CELULARA NICOLAE SIMIONESCU-LABORATORUL DE CELULE STEM SI TERAPIE CELULARA (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-FACULTATEA DE CHIMIE APLICATA SI STIINTA MATERIALELOR (RO); UNIVERSITATEA POLITEHNICA BUCURESTI-CENTRUL NATIONAL DE CONSULTANTA PENTRU PROTECTIA MEDIULUI (RO); INSTITUTUL DE CHIMIE FIZICA ILIE MURGULESCU (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOMATERIALE, INSTITUTUL DE CERCETARI EXPERIMENTALE SI INTERDISCIPLINARE (RO); INSTITUTUL DE CERCETARE-DEZVOLTARE PENTRU CHIMIE SI PETROCHIMIE BUCURESTI (RO)

Affiliation: UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOMATERIALE, INSTITUTUL DE CERCETARI EXPERIMENTALE SI INTERDISCIPLINARE (RO)

Project website: http://www.pcce248.weebly.com

Abstract:

IN TISSUE ENGINEERING (TE) THE COMBINED KNOWLEDGE FROM BIOLOGY AND ENGINEERING

IS DIRECTED TOWARDS THE POSSIBILITY TO RESTORE LOST OR DAMAGED TISSUE. THE

GENERAL AIM OF THIS PROJECT IS TO CONSOLIDATE A CROSS-DISCIPLINARY TEAM OF

COLLABORATING INVESTIGATORS TO CARRY OUT SOME CELL-SUPPORT CONSTRUCTS (CSC)

WITH POSSIBLE APPLICATIONS IN REGENERATION/REPAIR OF SOFT AND HARD TISSUES AND IT

DOES NOT ASSUME PRE-CLINICAL AND CLINICAL TRIALS. THIS APPLICATION CONTAINS THREE

SPECIFIC OBJECTIVES: 1- OBTAINMENT OF NEW SUPPORT 3-D STRUCTURES DESIGNED TO

CULTIVATE OSTEOBLASTS AND HUMAN MESENCHYMAL STEM CELLS (HMSC) TO OBTAIN CSCS

WITH CHARACTERIZED ARCHITECTURE AND MECHANICAL PROPERTIES, USEFUL IN BONE TISSUE

ENGINEERING; 2 - DEVELOPMENT OF REGENERATION STRATEGIES OF ADIPOSE TISSUE BY

IMPLANTATION OF PREADIPOCYTES IN 3-D HYDROGEL SCAFFOLDS, THAT MIMIC

EXTRACELLULAR MATRIX, DESTINED TO THE RECONSTRUCTION OF SOFT TISSUE DEFECTS

(SEVERE TRAUMAS, DEEP BURNS OR TUMOR RESECTIONS) AND 3 - STUDY OF THE EFFECTS OF 3-

D CULTURE AND GROWTH FACTORS ON THE CHONDROGENIC DIFFERENTIATION OF HMSC CELLS

TO OBTAIN SOME INVESTIGATION MODELS OF THEIR POTENTIAL IN CARTILAGE TISSUE

REGENERATION. THE PROJECT PRESENTS VIABILITY, INNOVATION, COMPLEXITY AND

INTERDISCIPLINARY EXCHANGE BECAUSE: 1 - IT IS A CONSORTIUM WHICH CONSISTS FROM

PARTNERS WITH COMPLEMENTALLY COMPETENCES WHO ENGAGE TO ACT AS A UNITY IN THE

FOLLOWING FIELDS: CELLULAR AND MOLECULAR BIOLOGY, CHEMISTRY AND PHYSICS OF

MATERIALS, ENGINEERING SCIENCES – IN ORDER TO GET ALL OBJECTIVES; 2 - THE PARTNERS

ARE STAFFS WITH A GOOD, STRONG REPUTATION ON THEIR FIELD, AND THEY HAVE THE

NECESSARY MANAGERIAL EXPERIENCE AS WELL AS THE HUMAN RESOURCES AND PERFORMING

EQUIPMENTS AND 3 - THE PARTNERSHIP WAS PARTIALLY CONSOLIDATED DURING PREVIOUS

COLLABORATIONS AND WHICH SUSTAIN IT. ACCOMPLISHMENT OF THE OBJECTIVES OF THIS

PROJECT CONSTITUTES A SCIENTIFIC CHALLENGE FOR ANY SCIENTIFIC TEAM AROUND THE

WORLD.

NANOMANIPULATION OF BIOMOLECULES BY ATOMIC FORCE MICROSCOPY Call name: Complex Exploratory Research Projects - PCCE-2008 call
PN-II-ID-PCCE-2008-0312 2010 - 2013

Role in this project: Key expert

Coordinating institution: UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOLOGIE MOLECULARA

Project partners: UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOLOGIE MOLECULARA (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, LABORATOR NANOTEHNOLOGII FIZICE (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, CENTRUL DE BIOMATERIALE (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, LABORATOR NANOFOTOBIOTICA (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, LABORATOR MODELARE MOLECULARA (RO); UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, LABORATOR SIMULARI NUMERICE (RO)

Affiliation: UNIVERSITATEA BABES-BOLYAI CLUJ-NAPOCA, LABORATOR NANOTEHNOLOGII FIZICE (RO)

Project website: http://granturi.ubbcluj.ro/idei_pcce2008

Abstract:

THE STRONG POINT OF NANOTECHNOLOGY IS THE NANOMANIPULATION: THE ABILITY TO HANDLE AND EXPLORE THE NANOSCALE OBJECTS. ATOMIC FORCE MICROSCOPY (AFM) IS A POWERFUL IMAGING TECHNIQUE THAT CAN VISUALIZE SINGLE MOLECULES BOTH IN AIR AND SOLUTION. USING THE AFM TIP AS AN END-EFFECTOR, AN ATOMIC FORCE MICROSCOPE CAN BE MODIFIED INTO A NANOROBOT. THE MAIN OBJECTIVE OF OUR RESEARCH PROJECT IS TO DEVELOP AN AUTOMATED AFM NANOMANIPULATION SYSTEM WITH VIRTUAL REALITY INTERFACE, WHICH CAN PROVIDE THE OPERATOR WITH REAL-TIME FORCE FEEDBACK AND REAL-TIME VISUAL DISPLAY DURING HANDLING. THIS AFM-BASED NANOROBOTIC SYSTEM WILL ENABLE US TO SIMULTANEOUSLY CONDUCT IN SITU IMAGING, SENSING, AND NANOMANIPULATION, AND WILL OPEN A PROMISING WAY TO INDIVIDUALLY STUDY THE DIFFERENT LIVE CELLS AND THE STRUCTURE-FUNCTION RELATIONSHIPS OF SOME BIOMOLECULES: DNA, PROTEINS, GLYCOPROTEINS. THE RELIABLE AND PRECISE NANOMANIPULATIONS WILL RENDER POSSIBLE THE SINGLE RECEPTOR RECOGNITION AND MONITORING THE RECEPTOR BEHAVIOR ON LIVING CELL SURFACE, AND THE DIRECT INVESTIGATIONS OF THE LIGAND-RECEPTOR INTERACTIONS BOTH IN VIVO AND IN VITRO. OUR NANOMANIPULATION SYSTEM WILL BE ALSO USED FOR THE CHARACTERIZATION AND ASSEMBLY OF NANOSTRUCTURES: FUNCTIONALIZED SILICATE MICROSPHERES AND GOLD NANOPARTICLES. IN THIS PROJECT A SERIES OF BOTTOM-UP AND TOP-DOWN NANOSTRUCTURATION METHODS WILL BE IMPLEMENTED TO ALLOW THE CONTROL OVER SIZE, SHAPE AND GEOMETRY OF NANOPARTICLES. THREE-DIMENSIONAL NANOPARTICLE ARRAYS WILL REPRESENT THE FOUNDATION OF FUTURE OPTICAL AND ELECTRONIC MATERIALS. A PROMISING WAY TO ASSEMBLE THEM IS THROUGH THE TRANSIENT PAIRINGS OF COMPLEMENTARY DNA STRANDS. DNA MEDIATED CRYSTALLIZATION APPROACH WILL FACILITATE BOTH THE CREATION OF NEW CLASSES OF ORDERED MULTICOMPONENT METAMATERIALS AND THE EXPLORATION OF THE PHASE BEHAVIOR OF HYBRID SYSTEMS WITH ADDRESSABLE INTERACTIONS. IN THE SAME TIME, THE MESOSCOPIC SCALE MODELING AND COMPUTER SIMULATIONS OF AFM-BASED NANOMANIPULATIONS WILL BE DONE.

Role in this project:

Coordinating institution: ACADEMIA ROMANA

Project partners: ACADEMIA ROMANA (RO); UNIVERSITATEA BABES BOLYAI (RO); UNIVERSITATEA "ALEXANDRU IOAN CUZA" IASI (RO)

Affiliation: UNIVERSITATEA BABES BOLYAI (RO)

Project website: http://in constructie, domeniu nealocat

Abstract:

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects