BrainMap

Viorel Chihaia

- INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Other affiliations

Senior Resercher - Jülich Supercomputing Centre (JSC) Institute for Advanced Simulation (IAS) (Germany)

Researcher | Scientific reviewer | Consultant

Web of Science ResearcherID: https://publons.com/researcher/2195181/viorel-chihaia/

Expertise & keywords

Structure, association and phase stability of complexes containing charged (bio)macromolecules investigated by Monte Carlo simulations Call name: Projects for Young Research Teams - TE-2012 call
PN-II-RU-TE-2012-3-0036 2013 - 2016

Role in this project: Partner team leader

Coordinating institution: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU

Project partners: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Affiliation: INSTITUTUL DE CHIMIE FIZICA - ILIE MURGULESCU (RO)

Project website: http://www.icf.ro/pr_2012/DA/DA_index.htm

Abstract:

The application proposes a fundamental computational research of the structure and organization of multicomponent systems in soft and biological field. The focus will be on two systems where the electrostatic interactions play a determinant role: A) polyelectrolyte complexes(PECs) constituted by comb-type copolymers and oppositely charged homopolymers and B) assemblies of nanoshells and virus-like nanoparticles. The project topic is justified by the perspective of obtaining new fundamental knowledge for prediction and designing of new colloidal structures with potential applications for efficient non- and viral gene therapy vectors. Coarse-grained model systems and Monte Carlo simulations will be utilised to identify the fundamental properties of these highly charged systems and the key parameters controlling the structure and phase behaviour. In the case of polyelectrolyte complexes, the advantage of the multifunctionality of the copolymer component will be considered in developing PECs with programmable properties. The computational simulations will also strive for identifying the main factors differentiating the complexation behavior of virus-like nanoparticles. As the assembly properties are dominated by electrostatics, the model systems will capture a correct description of interacting potentials and multivalency character of the comb copolymer or virus-based systems in order to reach the proposed goals.

FILE DESCRIPTION	DOCUMENT
List of research grants as project coordinator or partner team leader
Significant R&D projects for enterprises, as project manager
R&D activities in enterprises
Peer-review activity for international programs/projects